Journal of Sport and Health Science最新文献

{"title":"Long-term aerobic exercise enhances circulating exosomal miR-214-3p to promote endothelial progenitor cell-mediated repair of endothelial damage induced by obesity.","authors":"Junhao Huang,Peilun Li,Bing Shen,Huiwen Gao,Shen Wang,Pingyu Wang,Weiji Deng,Dongdong Gao,Min Hu","doi":"10.1016/j.jshs.2025.101094","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101094","url":null,"abstract":"BACKGROUNDExercise training may counteract the detrimental effects of obesity on endothelial function by enhancing the reparative capabilities of endothelial progenitor cells (EPC); however, the underlying mechanisms of exercise-induced EPC-mediated endothelial repair are still unclear. The present study aimed to determine the mechanisms by which exercise-induced circulating exosomes protect against endothelial dysfunction induced by obesity.METHODSAn 8-week aerobic exercise intervention in both obese human participants and high-fat diet-induced obese rats was conducted. Circulating exosomes were isolated and characterized. microRNA sequencing, molecular biology techniques, and functional assays (including proliferation, migration, and luciferase reporter assays) were employed to identify key exosomal microRNAs and their downstream targets. A microRNA-214-3p (miR-214-3p) knockout rat model was used to validate its role in vivo.RESULTSExercise promoted EPC-mediated repair of endothelial damage and upregulated exosomal miR-214-3p in both obese humans and rats, without altering exosome quantity. miR-214-3p enhanced EPC proliferation and migration directly, by upregulating collagen type I alpha 2 chain (COL1A2) expression, and indirectly, through the phosphatase and tensin homolog, phosphatidylinositol 3-kinase, serine/threonine kinase (PTEN-PI3K-Akt) signaling pathway. Knockout of miR-214-3p abolished the exercise-induced improvements in endothelial and EPC functionalities. The myocardium was identified as an important source of the exercise-induced increase in circulating exosomal miR-214-3p.CONCLUSIONLong-term aerobic exercise promotes endothelial repair in obesity by enriching circulating exosomes with miR-214-3p, which enhances EPC function via the PTEN-PI3K-Akt pathway and direct regulation of COL1A2. These findings reveal a novel exosome-mediated mechanism through which exercise improves vascular health and suggest potential therapeutic strategies for obesity-related endothelial dysfunction.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"85 1","pages":"101094"},"PeriodicalIF":11.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating physical activity research in complex terrains: Reflections on the challenges, opportunities, and future directions.","authors":"Ding Ding","doi":"10.1016/j.jshs.2025.101093","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101093","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"35 1","pages":"101093"},"PeriodicalIF":11.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney betaine: A potential broad spectrum exercise mimetic against aging.","authors":"Hongyun Wang,Xiaoying Yang,Chi Jin,T Scott Bowen,Junjie Xiao","doi":"10.1016/j.jshs.2025.101092","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101092","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"22 1","pages":"101092"},"PeriodicalIF":11.7,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145254712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise training-induced extracellular miR-136-3p modulates glucose uptake and myogenesis through targeting of NRDC in human skeletal muscle.","authors":"Mutsumi Katayama,Elena Caria,Dimitri Van Simaeys,Anna Yagüe Sanz,Romain Barrès,Kenneth Caidahl,Oscar Pb Wiklander,Samir El-Andaloussi,Per-Olof Berggren,Juleen R Zierath,Anna Krook","doi":"10.1016/j.jshs.2025.101091","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101091","url":null,"abstract":"BACKGROUNDRegular physical training induces adaptive effects across multiple organ systems, highlighting the existence of inter-organ communication networks. However, the molecular mechanisms underlying both exercise-induced adaptations and organ-to-organ signaling are not fully characterized. Circulating extracellular vesicles (EVs), including exosomes, carry molecules like microRNAs (miRNAs) that may mediate tissue crosstalk. This study aimed to identify specific exercise training-responsive miRNAs that affect skeletal muscle function.METHODSmiRNA expression profiles of serum-derived EVs were analyzed in healthy young individuals before and after 3 weeks endurance exercise training. Exercise training-responsive miRNAs were then validated for a functional role in cellular metabolic processes in human myotubes.RESULTSWe identified several exercise training-responsive miRNAs within exosome-rich EVs in serum, including miR-136-3p. In human myotubes, miR-136-3p enhanced glucose uptake and targeted the nardilysin convertase (NRDC) gene. Transfection of miR-136-3p or silencing of NRDC induced a shift towards glycolytic metabolism in mitochondria and modulated gene expressions related to myogenesis. Pancreatic islets were identified as a potential source of miR-136-3p based on in silico analysis of gene expression and a molecular analysis of conditioned media from isolated pancreatic islets.CONCLUSIONMiR-136-3p is an endurance training-responsive molecular transducer that modulates glucose metabolism and cellular proliferation in myocytes. Associated with EVs, extracellular miR-136-3p may serve as a molecular messenger to communicate islet-skeletal muscle crosstalk after exercise. Extracellular miR-136-3p may serve as a molecular messenger to communicate islet-skeletal muscle crosstalk. Our results highlight a miRNA-mediated mechanism that participates in inter-organ communication to fine tune the metabolic adaptations to exercise.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"21 1","pages":"101091"},"PeriodicalIF":11.7,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145229103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcomerogenesis: Evidence, context and key Stimuli - Response to the commentary by Power et al.","authors":"Anthony J Blazevich,Walter Herzog,João Pedro Nunes","doi":"10.1016/j.jshs.2025.101090","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101090","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"15 1","pages":"101090"},"PeriodicalIF":11.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mechanical loading environment associated with eccentric exercise is one of the key stimuli to trigger sarcomerogenesis: It's a stretch to say eccentric exercise does not promote serial sarcomerogenesis.","authors":"Geoffrey A Power,Martino V Franchi,Avery Hinks","doi":"10.1016/j.jshs.2025.101089","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101089","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"11 1","pages":"101089"},"PeriodicalIF":11.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short bouts of accumulated exercise: Review and consensus statement on definition, efficacy, feasibility, practical applications, and future directions.","authors":"Mingyue Yin,Yongming Li,Abdul Rashid Aziz,Aidan Buffey,David J Bishop,Dapeng Bao,George P Nassis,Hashim Islam,Hongying Wang,Jackson J Fyfe,Jianfang Xu,Jianxiu Liu,Jiexiu Zhao,Jingwei Cao,Jonathan P Little,Junqiang Qiu,Keith M Diaz,Lijuan Wang,Liye Zou,Max J Western,Meynard L Toledo,Min Hu,Minghui Quan,Neville Owen,Niels B J Vollaard,Olivier Girard,Qingde Shi,Richard S Metcalfe,Rodrigo Ramirez-Campillo,Ru Wang,Waris Wongpipit,Weimo Zhu,Wenfei Zhu,Weigang Xu,Xiaochun Wang,Xiaoping Chen,Xiong Wang,Xu Wen,Yang Liu,Ying Gao,Yue Fu,Zhaowei Kong,Zhenbo Cao,Zhengzhen Wang,Peijie Chen,Lijuan Mao","doi":"10.1016/j.jshs.2025.101088","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101088","url":null,"abstract":"BACKGROUNDInsufficient physical activity and prolonged sedentary behavior have emerged as major global public health challenges. Short bouts (≤10 min) of accumulated exercise (SBAE) throughout the day may be a promising strategy to mitigate the adverse effects of prolonged sitting and promote physical activity, ultimately promoting overall health. However, previous ambiguity in defining this concept has resulted in a fragmented and inconsistent evidence base, impeding practical applications, the development of guidelines, and policymaking. The purpose of this study is to establish an operational definition of SBAE by synthesizing systematic reviews and research trials alongside an expert consensus. Additionally, it seeks to evaluate acute and long-term efficacy and feasibility, providing evidence-based recommendations for practice and future research directions.METHODSA literature search was performed across PubMed and Web of Science, followed by systematic screening and summarization of eligible studies based on predefined inclusion criteria. Inclusion criteria encompassed various modes/types of SBAE (bouts lasting ≤10 min, performed multiple times daily with ≥30 min intervals); both aerobic and resistance exercise were considered. Relevant systematic reviews and research trials were included. Methodological quality, risk of bias, and evidence certainty were assessed. Expert consensus was obtained through a survey to evaluate recommendations and agreement levels on findings.RESULTSAfter analyzing 27 systematic reviews, 135 research studies, and an expert consensus involving 48 researchers from 11 countries, SBAE is defined as any exercise mode of activity, regardless of intensity, that is accumulated in either continuous or intermittent bouts lasting ≤10 min per session (including multiple intermittent sets) that are performed multiple times (≥2 sessions/day) per day, with intervals of ≥30 min between bouts or otherwise sufficient time for recovery. When used to interrupt prolonged periods of sedentary time, SBAE mitigates the acute adverse effects of sedentary behavior on more than 10 clinical biomarkers of endocrine, cardiovascular, and brain health/function among adults of diverse ages and conditions. Moreover, SBAE was superior for improving acute glycemic control compared to a single continuous exercise session. As a long-term intervention (average of 11 weeks), SBAE can improve over 20 health outcomes, including peak oxygen uptake, resting blood pressure, and metabolic health. Additionally, SBAE might be more effective than continuous exercise for improving longer-term glycemic control and body composition. Long-term completion rates for SBAE interventions are generally high (95%), with low dropout rates (12%) and high adherence rates even without supervision (85%), and its safety has been preliminarily validated.CONCLUSIONAn operational definition of SBAE is provided along with its classification and acute and long-term efficacy. Practica","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"38 1","pages":"101088"},"PeriodicalIF":11.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145089759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity influences immunity with an assist from the gut microbiome.","authors":"David C Nieman","doi":"10.1016/j.jshs.2025.101086","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101086","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"80 1","pages":"101086"},"PeriodicalIF":11.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of physical activity interventions on fundamental movement skills and cognitive function in early childhood: A systematic review and network meta-analysis.","authors":"Shan Jiang,Nan Zeng,Johan Y Y Ng,Kar Hau Chong,Taoran Zeng,Suzannie K Y Leung,Amy S Ha","doi":"10.1016/j.jshs.2025.101085","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101085","url":null,"abstract":"BACKGROUNDHealth benefits have been reported for many physical activity (PA) interventions for improving fundamental movement skills (FMS) and cognitive function (CF), but the most effective type of PA interventions for enhancing FMS and CF in early childhood remain unknown. Thus, the study aims to determine the effects of PA interventions in enhancing FMS and CF among young children and to establish the optimal types of PA interventions.METHODSSix electronic databases (PubMed, Ovid, SPORTDiscus, Scopus, Web of Science, Cochrane Central Register of Controlled Trials) were searched for studies from inception to March 17, 2024. Randomized controlled trials (RCTs) were included in this study if they reported outcomes related to FMS, CF, or both associated with PA interventions. Effect sizes were calculated and performed as Hedges g. The hierarchy of competing interventions was established using the surface under the cumulative ranking curve (SUCRA). Risk of bias was independently assessed using the Cochrane Risk-of-Bias 2.RESULTSThis analysis included 38 studies with 5237 young children, with sample sizes ranging from 32 to 897 participants. The types of PA interventions analyzed included active play/free play/unstructured PA (AP), general structured PA (GSPA), fundamental movement skills-targeted PA programs (FMS-programs), cognitively-engaging PA programs (CPA), multilevel PA interventions (MPA), and exergaming. PA interventions had a large, pooled effect size for total FMS (g = 0.96; 95%CI: 0.45 - 1.46; p< 0.01; I² = 94%). For CF, a small-to-moderate pooled effect size was found (g = 0.39; 95% CI: 0.18 - 0.60; p < 0.01; I² = 88%). PA interventions longer than 3 months showed fewer benefits for FMS (P < 0.01). The network meta-analysis showed that FMS-programs (standardized mean difference (SMD) = 1.55, 95%CI: 0.98 - 2.11, SUCRA = 98.3%) and GSPA (SMD = 0.94, 95%CI: 0.05 - 1.85, SUCRA = 69.8%) significantly improved total FMS compared to AP. For locomotor skills (LMS), exergaming ranked highest (SUCRA = 79.3%), followed by FMS-programs (75.9%) and GSPA (61.6%). However, despite its top ranking, exergaming's effect estimate was not statistically significant (SMD = 1.38, 95%CI: -0.08 to 2.85). For object control skills (OCS), exergaming again ranked highest (SUCRA = 91.9%) and showed the largest significant effect (SMD = 2.38, 95%CI: 0.96 - 3.80), followed by FMS-programs (78.5%) and GSPA (53.7%). FMS-programs, GSPA, MPA, and UC also significantly improved OCS compared to AP. While no significant differences were observed across PA interventions for most CF domains, exergaming had a significant positive effect on working memory (SMD = 1.41, 95%CI: 0.07 - 2.75). The certainty of evidence varied from low to moderate.CONCLUSIONThese findings emphasize the importance of PA interventions in improving FMS and CF in early childhood. FMS-programs and GSPA appear to be the most effective approaches for enhancing total FMS, while exergaming showed the highest","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"21 1","pages":"101085"},"PeriodicalIF":11.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain\" [J Sport Health Sci 13 (2024) 245-255].","authors":"Cecilie Skarstad Norevik,Aleksi M Huuha,Ragnhild N Røsbjørgen,Linda Hildegard Bergersen,Kamilla Jacobsen,Rodrigo Miguel-Dos-Santos,Liv Ryan,Belma Skender,Jose Bianco N Moreira,Asgeir Kobro-Flatmoen,Menno P Witter,Nathan Scrimgeour,Atefe R Tari","doi":"10.1016/j.jshs.2025.101084","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101084","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"15 1","pages":"101084"},"PeriodicalIF":11.7,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}