Journal of Sport and Health Science最新文献

{"title":"Feasibility and clinical potential of exercise interventions during neoadjuvant chemoradiotherapy in patients with esophageal and rectal cancer.","authors":"Isa H Mast,Elske C Gootjes,Heidi Rütten,Mariska D den Hartogh,Calvin G Brouwer,Iris D Nagtegaal,Rachel S van der Post,Maria T E Hopman,Baukje van den Heuvel,Camiel Rosman,Johannes H W de Wilt,Bastiaan R Klarenbeek,Laurien M Buffart","doi":"10.1016/j.jshs.2025.101060","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101060","url":null,"abstract":"BACKGROUNDExercise during neoadjuvant chemoradiotherapy (NCRT) has potential to mitigate treatment-related declines in physical fitness, and to improve clinical outcomes, including toxicity and tumor response. However, optimal frequency and timing of exercise remains to be determined. Therefore, this pilot trial aimed to assess feasibility of 2 different exercise interventions during NCRT in patients with esophageal and rectal cancer and to evaluate potential clinical effects.METHODSPatients were randomized into 1 of 3 study arms during NCRT: (a) 30-min aerobic exercise in-hospital within 1 h prior to each radiotherapy fraction (ExPR), (b) two 60-min supervised combined aerobic and resistance exercise sessions per week (AE+RE), and (c) usual care (UC). Feasibility was assessed by examining participation rate and exercise adherence. Intervention effects on physical fitness, health-related quality of life, treatment-related toxicity, and tumor response in patients with esophageal cancer were explored using regression analyses and 85% confidence intervals (85%CI).RESULTSThirty-seven patients with esophageal cancer (participation rate: 45%) and 2 patients with rectal cancer (participation rate: 14%) were included. Median session attendance was 98% (interquartile range (IQR): 96-100) in the ExPR and 78% (IQR: 33-100) in the AE+RE group. We found clinically relevant benefits of exercise on maximal oxygen uptake (VO2max)(ExPR: β = 9.7 mL/kg/min, 85%CI: 6.9-12.6; AE+RE: β = 5.6 mL/kg/min, 85%CI: 2.6-8.5) and treatment-related toxicity (ExPR: β = -2.8, 85%CI: -5.4 to -0.2; AE+RE: β = -2.6, 85%CI: -5.3 to 0.0). Additionally, good tumor response was found in 70% in AE+RE and ExPR vs. 55% in UC (OR = 1.9, 85%CI: 0.5-7.7).CONCLUSIONStarting prehabilitation during NCRT is feasible, can increase starting fitness of traditional pre-surgical programs, and has potential to improve clinical outcomes.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"29 1","pages":"101060"},"PeriodicalIF":11.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged passive vibration of Achilles and patellar tendons decreases effort perception during subsequent cycling tasks.","authors":"Florian Marchand,Benjamin Pageaux,Nicolas Forestier,Florian Monjo","doi":"10.1016/j.jshs.2025.101061","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101061","url":null,"abstract":"BACKGROUNDThe perception of effort is a key determinant of endurance performance and a barrier to physical activity in inactive populations. From a neurophysiological viewpoint, effort perception is thought to arise from the brain processing of an efference copy of the motor command in sensory areas. However, recent research suggests that feedback from muscle spindles plays a significant role in this perception. In this study, tendon vibration protocols were employed to attenuate sensory feedback during subsequent cycling exercises. The aim was to assess whether vibration would increase cycling power output, muscle activation, and heart rate at fixed perceived effort intensities.METHODSFifteen healthy young participants completed 2 experimental visits (vibration and sham). In each visit, participants performed two 3-min cycling bouts, 1 at a moderate perceived effort intensity and 1 at a strong perceived effort intensity, before (pre) and after (post) an actual or a sham vibration protocol. Vibration was applied bilaterally on the patellar and Achilles tendons for 10 min. Power output, heart rate, and vastus lateralis electromyography (VL EMG) were recorded and averaged for each bout. Absolute values as well as relative change (%) between pre and post conditions were compared across sham and vibration conditions.RESULTSAt moderate perceived effort, power output, heart rate, and VL EMG increased post-vibration compared to pre-vibration (p < 0.05), while no difference was observed in the sham condition. At strong perceived effort, power output and VL EMG decreased post-sham (p < 0.05) but remained unchanged post-vibration. Moreover, the relative change between pre and post conditions was significantly higher in the vibration conditions compared to the sham condition for all variables.CONCLUSIONThis study shows that tendon vibration reduces effort perception during subsequent cycling bouts. This effect is likely a consequence of vibration-induced reduction in muscle spindle reafferent signaling to the brain, but this mechanism remains to be further elucidated. From an applied perspective, these findings highlight tendon vibration as a promising tool for enhancing physical activity engagement.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"51 1","pages":"101061"},"PeriodicalIF":11.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse-normal immunopurification: An effective approach for purifying recombinant erythropoietin from its analogues in doping analysis.","authors":"Sen He,Die Wu,Chengshuai Niu,Xinchao Liu,Jie Zhang,Liangzhi Xie,Laurent Martin,Kaifeng Liu,Xinmiao Zhou,Lisi Zhang","doi":"10.1016/j.jshs.2025.101062","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101062","url":null,"abstract":"BACKGROUNDRecombinant erythropoietin (rEPO) is commonly used in therapy but may be abused in sports to enhance endurance. In doping analysis, rEPO can be detected in human urine or blood samples at picogram (pg) levels based on its slightly higher molecular weight (MW) than that of endogenous EPO using western blotting (WB). However, a type of variant erythropoietin (VAR-EPO) encoded by the EPO c.577del variant has a similar MW to rEPO, and these 2 molecules cannot be distinguished using conventional analytical methods. A fit-for-purpose method needs to be developed immediately.METHODSIn this study, we introduced a reverse-normal immunopurification technique for sample pretreatment to remove VAR-EPO from samples to eliminate its interference with rEPO detection. Firstly, a rabbit monoclonal antibody (mAb) that can specifically recognize trace amounts of VAR-EPO with high affinity was generated. Then, using this antibody to enrich VAR-EPO, we developed reverse-normal immunopurification coupled with WB on the purpose of analyzing rEPO in urine and serum samples Next, the method was fully validated and evaluated using blank samples, spiked samples and rEPO excreted samples. Finally, the identification criteria of rEPO was established.RESULTSA specific anti-VAR mAb with high affinity was developed. Using it, we developed the doping analytical method for rEPO. Our method effectively detects and removes VAR-EPO, enabling accurate rEPO detection.CONCLUSIONA method has already been applied for rEPO confirmation in routine doping analyses.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"26 1","pages":"101062"},"PeriodicalIF":11.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-year follow-up of glycemic control and cardiovascular risk factors after a one-year intensive lifestyle intervention in type 2 diabetes: An extension of the randomized U-TURN trial.","authors":"Mette Yun Johansen,Cody Garett Durrer,Nanna Skytt Pilmark,Grit Elster Legaard,Kristian Karstoft,Katrine Bagge Hansen,Christopher Scott MacDonald,Thomas Peter Almdal,Jakob Bue Bjorner,Nicolai J Wewer Albrechtsen,Allan Arthur Vaag,Robin Christensen,Bente Klarlund Pedersen,Mathias Ried-Larsen","doi":"10.1016/j.jshs.2025.101059","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101059","url":null,"abstract":"PURPOSEThis study aimed to describe the effects of a 1-year lifestyle intervention on hemoglobin A1c (HbA1c) and cardiovascular risk factors 5 years after cessation of the lifestyle intervention in persons with type 2 diabetes (T2D).METHODSFrom April 2015 to August 2016, 98 persons with T2D (duration < 10 years) were randomly allocated (2:1, stratified by sex) to a 1-year lifestyle intervention group (INT) (n = 64) or a standard care group (StC) (n = 34). All participants received standard care with blinded, target-driven medical therapy. INT included up to 5-6 weekly supervised aerobic and strength training sessions and dietary plans targeting a body mass index ≤ 25 kg/m². No intervention was given during the follow-up period. Forty-nine (77%) and 19 (56%) participants in INT and StC attended the 6-year follow-up. Based on the original intention-to-treat population, the primary outcome was the change in HbA1c from baseline to 6-year follow-up. Secondary outcomes included weight, Low density lipoprotein (LDL) cholesterol, blood pressure (BP), and cardiorespiratory fitness.RESULTSNinety-eight participants (mean age 54.6 years; 46% women; mean baseline Hemoglobin A1c (HbA1c): 49.8 mmol/mol) were analyzed. HbA1c changed 6% and 13% in the INT and StC from baseline to 6-year follow-up (between group difference: -6% (95%CI: -14 to 3); p = 0.18). While no differences were observed for most secondary outcomes, the diastolic BP decreased 6.0 (95%CI: 2.1 to 9.8) mmHg more in the StC compared to INT.CONCLUSIONThe sustained effect of the lifestyle intervention on glycemic control and cardiovascular risk factors was marginal, and it was surprisingly associated with inferior diastolic BP regulation.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"45 1","pages":"101059"},"PeriodicalIF":11.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metrics of concussion-related vision disorders among children and adolescents with persisting post-concussive symptoms using an objective eye tracking device.","authors":"Christina L Master,Mitchell Scheiman,Olivia E Podolak,Matthew F Grady,David Howell","doi":"10.1016/j.jshs.2025.101058","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101058","url":null,"abstract":"BACKGROUNDEarly identification of concussion-related vision disorders (CRVDs) may improve outcomes by enabling earlier management, referral, and treatment. Objective eye tracking may provide additional data to support the diagnose of CRVDs. The purpose of this study was to determine the utility of objective infrared eye tracking in identifying CRVDs among adolescents experiencing persisting post-concussive symptoms (PPCS) more than 28 days after injury.METHODSThis was a prospective study of adolescents with PPCS evaluated with visio-vestibular examination (VVE), comprehensive vision examination, and an eye tracking device.RESULTSOf the 108 adolescents enrolled, 67 (62%) were diagnosed with a CRVD by comprehensive vision examination. On VVE, the near point of convergence break (5.5 ± 3.2 cm (mean ± SD) vs. 3.9 ± 1.7 cm, p < 0.001) and recovery (8.1 ± 3.3 cm vs. 6.8 ± 2.3 cm, p = 0.02) distinguished between those with and without CRVD. Concussion symptom provocation on VVE with horizontal saccades (35 (52%) vs. 12 (29%), p = 0.02) and horizontal vestibulo-ocular reflex testing (37 (55%) vs. 14 (34%), p = 0.03), and sway on tandem gait under the forward eyes closed condition (25 (37%) vs. 6 (15%), p = 0.01) also identified those with CRVD. From the eye tracking device, the BOX score (8.1 ± 5.8 vs. 5.2 ± 4.1, p = 0.007) and a metric of the left eye tracking along the bottom of the visual target (0.094 ± 0.500 vs. -0.124 ± 0.410, p = 0.02) identified those with CRVD, with a multivariable receiver operating characteristic curve analysis, including the BOX score, achieving an area under the receiver operating characteristic curve of 0.7637.CONCLUSIONCRVDs are common in those with PPCS, with impact on recovery after concussion. Novel eye-tracking metrics can serve as an aid in the identification of those with CRVDs who would benefit from referral for comprehensive diagnosis and treatment.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"59 1","pages":"101058"},"PeriodicalIF":11.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the comment on \"Does ischemic preconditioning enhance sports performance more than placebo or no intervention? A systematic review with meta-analysis\".","authors":"Hiago L R Souza, Géssyca T Oliveira, Anderson Meireles, Marcelo P Dos Santos, João G Vieira, Rhai A Arriel, Stephen D Patterson, Moacir Marocolo","doi":"10.1016/j.jshs.2025.101057","DOIUrl":"10.1016/j.jshs.2025.101057","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101057"},"PeriodicalIF":9.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"are changes in pain intensity related to changes in balance control in individuals with chronic non-specific low back pain? A systematic review and meta-analysis\" version of record: 23 January 2025.","authors":"Daniel K Y Zheng,Jae Q J Liu,Jeremy R Chang,Jeffrey C Y Ng,Zhixing Zhou,Jinlong Wu,Chelsia K C Cheung,Frank F Huang,Sabina M Pinto,Dino Samartzis,Manuela L Ferreira,Kanchana Ekanayake,Stephen Lord,Xueqiang Wang,Arnold Y L Wong","doi":"10.1016/j.jshs.2025.101053","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101053","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"32 1","pages":"101053"},"PeriodicalIF":11.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Does ischemic preconditioning enhance sports performance more than placebo or no intervention? A systematic review with meta-analysis\".","authors":"Yilin Zhang, Hao Kong, Kai Xu, Mingyue Yin, Yun Xie","doi":"10.1016/j.jshs.2025.101056","DOIUrl":"10.1016/j.jshs.2025.101056","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101056"},"PeriodicalIF":9.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity, genetic predisposition, and incident cardiovascular disease: Prospective analyses of the UK Biobank.","authors":"Matthew N Ahmadi,Hamish D Mundell,Greg T Sutherland,Mark Hamer,Elina Sillanpää,Joanna M Blodgett,Borja Del Pozo Cruz,Emmanuel Stamatakis","doi":"10.1016/j.jshs.2025.101055","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101055","url":null,"abstract":"BACKGROUNDIt is unclear whether physical activity can benefit participants with high genetic predisposition to cardiovascular disease. We examined the joint associations of intensity-specific physical activity and genetic predisposition (based on polygenetic risk score) with incident coronary heart disease (CHD), stroke, and atrial fibrillation (AF).METHODSThis prospective cohort study included 303,950 adults (age = 56.4 ± 8.0 years, mean ± SD; 52.5% females) from the UK Biobank with physical activity and disease-related genotypes. Moderate-to-vigorous physical activity (MVPA) and intensity-specific activity was classified according to volume (e.g., MVPA was classified as none, low, medium, and high). Genetic predisposition for CHD, stroke, and AF were classified as low (Quintile 1), intermediate (Quintiles 2-4), and high (Quintile 5).RESULTSDuring 11.6 ± 2.1 years of follow-up: 19,865 CHD; 7907 stroke; and 16,688 AF events occurred. Compared to the no MVPA and high genetic risk group, we observed lower CHD risk for increasing levels of MVPA over and above genetic risk groupings. These associations were primarily driven by vigorous-intensity activity. For example, in the high genetic risk group, those with low vigorous-intensity activity levels (compared to none) had a hazard ratio (HR) of 0.78 (95% confidence interval (95%CI):0.72-0.86) compared to an HR of 0.90 (95%CI: 0.83-0.98) for low moderate-intensity activity levels. For stroke incidence, we observed a protective association for MVPA across genetic risk groups that was mostly driven by moderate-intensity activity volume. Among the high genetic risk group, low moderate-intensity had an HR of 0.77 (95%CI:0.66-0.90), whereas low vigorous-intensity had no association (HR = 0.95, 95%CI:0.82-1.09). We did not observe a consistent joint association of MVPA and AF genetic predisposition.CONCLUSIONSWe observed lower CHD and stroke risk for low to high MVPA among participants with high genetic predisposition. The associations of moderate- and vigorous-intensity activity volume differed considerably across cardiovascular disease sub-types. Overall, our findings suggest vigorous intensity activity may mitigate genetic predisposition for CHD while moderate intensity activity may be associated with similar effects for stroke. Joint associations were less consistent across AF genetic predisposition groups. Our results inform precision medicine approaches and future lifestyle modification interventions by quantifying the potential benefits of physical activity among at-risk individuals.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"8 1","pages":"101055"},"PeriodicalIF":11.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to \"Do compression garments enhance running performance? An updated systematic review and meta-analysis\" Version of Record: 26 March 2025.","authors":"Wei Wang,Yana Wang,Yufeng Zhang,Dongyang Si,Xingyang Li,Qingsong Liang,Qianteng Li,Lingyan Huang,Shutao Wei,Yu Liu","doi":"10.1016/j.jshs.2025.101050","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101050","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"2 1","pages":"101050"},"PeriodicalIF":11.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}