{"title":"Effect of exercise intervention on chronic primary pelvic pain syndrome: A network meta-analysis","authors":"Bailin Shen,Ziang Zhao,Wenrui Huang,Hongwen Wei","doi":"10.1016/j.jshs.2026.101179","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101179","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"47 1","pages":"101179"},"PeriodicalIF":11.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise mitigates cardiac dysfunction post MI in ovariectomized mice via miR-21/Sox7-mediated suppression of cardiac fibroblast activation","authors":"Meiyu Hu,Hui Wang,Yueyuan Mao,Junwen Tang,Tianxiang Yin,Ruoting Teng,Hao Yang,Qiqi Zhang,Wenqin Zhou,Shuyi Qiu,Richard Y. Cao,Dongchao Lu,Lei Wang,Peng Ji,Juan Gao,Junjie Xiao,Qiulian Zhou","doi":"10.1016/j.jshs.2026.101175","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101175","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"11 1","pages":"101175"},"PeriodicalIF":11.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhining Zhou,Xiaoyu Wei,Xinwen Zhang,Barbara E. Ainsworth,Jiaojiao Lü,Yu Liu
{"title":"Response to Commentary by Liang et al. on “Effects of different types of exercise over 24 weeks on bone mineral density in postmenopausal women: A systematic review with pairwise and network meta-analysis of randomized controlled trials”","authors":"Zhining Zhou,Xiaoyu Wei,Xinwen Zhang,Barbara E. Ainsworth,Jiaojiao Lü,Yu Liu","doi":"10.1016/j.jshs.2026.101180","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101180","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"93 1","pages":"101180"},"PeriodicalIF":11.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transforming tai ji quan into next-generation, evidence-based exercise medicine: A translational roadmap for falls prevention.","authors":"Fuzhong Li","doi":"10.1016/j.jshs.2026.101169","DOIUrl":"10.1016/j.jshs.2026.101169","url":null,"abstract":"<p><p>A substantial body of research provides compelling evidence that tai ji quan, a mind-body exercise rooted in traditional Chinese medicine, is effective in reducing falls and improving mobility and has gained increasing recognition as a form of evidence-based exercise medicine within mainstream healthcare. Despite this strong evidence base and growing policy support, the translation of tai ji quan from research into routine clinical practice remains limited. Addressing this evidence-to-practice gap will require innovative translational strategies that more effectively integrate evidence-based tai ji quan with evolving models of healthcare delivery and emerging digital health technologies. This article reviews the current state of tai ji quan research in falls prevention and proposes an integrated translational roadmap to advance its adoption as a routinely prescribed, clinically embedded, technology-driven intervention. The roadmap is built upon 3 interrelated pillars: embedding tai ji quan within routine clinical workflows, expanding evidence generation through decentralized virtual trial designs, and augmenting implementation through responsibly governed artificial intelligence (AI)-enabled tools and systems. The framework presented may also serve as a generalizable model for applying evidence-based exercise medicine to the prevention, treatment, and management of other chronic conditions associated with aging.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101169"},"PeriodicalIF":13.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James J McCormick, Kelli E McCormick, Kristina-Marie T Janetos, Glen P Kenny
{"title":"Short-term passive heat acclimation modulates autophagy and cellular stress responses in older active adults.","authors":"James J McCormick, Kelli E McCormick, Kristina-Marie T Janetos, Glen P Kenny","doi":"10.1016/j.jshs.2026.101170","DOIUrl":"10.1016/j.jshs.2026.101170","url":null,"abstract":"<p><strong>Background: </strong>Age-related impairments in thermoregulatory and cardiovascular function contribute to a heightened vulnerability to heat-related morbidity and mortality. While passive heat acclimation is highly effective at improving heat loss mechanisms in older adults, its effects on autophagic regulation remain unknown. Given autophagy represents a critical cellular survival mechanism and declines with advancing age, we sought to assess whether short-term passive heat acclimation via warm-water immersion modulates autophagic regulation and accompanying cellular stress pathways in older adults.</p><p><strong>Methods: </strong>Twelve healthy older males (median interquartile range (IQR): 68 (64‒73) years) completed 7 days of passive heat acclimation via warm-water immersion (∼40°C), with core temperature maintained at 38.5°C for 60 min. Before and after acclimation, participants completed an exercise-heat stress test in 40°C (∼13% relative humidity) consisting of three 30-min cycling bouts (150, 200, and 250 W/m<sup>2</sup>), each separated by 15-min rest. Changes in protein content and gene expression were assessed in peripheral blood mononuclear cells (PBMC) before and after each exercise-heat stress test, as well as Days 1, 4, and 7 of the acclimation protocol.</p><p><strong>Results: </strong>Across acclimation days, microtubule-associated light chain 3B (LC3)-II, LC3-II/I ratio, and lysosome-associated membrane protein-2A proteins progressively increased (p ≤ 0.019), while sequestosome-1/p62 decreased (p = 0.003), consistent with enhanced autophagic activity. Conversely, apoptotic-related cleaved-caspase-3 progressively declined with acclimation (p = 0.004). Post-acclimation exercise-heat stress responses elicited greater elevations in protein and gene markers of autophagy, as well as reduced apoptotic responses.</p><p><strong>Conclusion: </strong>Short-term passive heat acclimation increased PBMC markers associated with autophagy while reducing markers of apoptotic signaling in healthy, active older males.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101170"},"PeriodicalIF":13.1,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yonghui Chen, Borui Zhang, Jiaqi Zhang, Stephen Heung-Sang Wong, Eric Tsz-Chun Poon
{"title":"Exercise in hot or thermoneutral conditions? Comparative effectiveness on aerobic performance and physiological adaptations in the heat: A meta-analysis.","authors":"Yonghui Chen, Borui Zhang, Jiaqi Zhang, Stephen Heung-Sang Wong, Eric Tsz-Chun Poon","doi":"10.1016/j.jshs.2026.101168","DOIUrl":"10.1016/j.jshs.2026.101168","url":null,"abstract":"<p><strong>Background: </strong>Exercise in hot conditions (ExH) is traditionally used to improve heat resilience. Emerging evidence suggests that exercise in thermoneutral conditions (ExN) may elicit comparable adaptations, challenging the benefits of heat exposure. However, synthesized comparative evidence is lacking. Accordingly, this study aimed to compare the effects of ExH and ExN on markers of heat adaptation and aerobic performance in the heat, and to conduct exploratory analyses of within-group changes.</p><p><strong>Methods: </strong>Five databases (PubMed, SPORTDiscus, Cochrane Library, Scopus, and Web of Science) were searched up to November 20, 2025. Data extracted included key physiological outcomes (e.g., core temperature (T<sub>core</sub>), heart rate (HR), skin temperature (T<sub>sk</sub>), and sweat rate (SR)) and aerobic performance in the heat. Effect sizes were calculated as Hedges' g. Multilevel meta-analyses were employed to examine the within- and between-group effects. Subgroup analyses were conducted to examine potential moderators, such as training status and performance outcome type.</p><p><strong>Results: </strong>Twenty-three studies were included. Compared with ExN, ExH induced greater reductions in resting T<sub>core</sub> (g = 0.51), exercise T<sub>core</sub> (g = 0.55), and exercise HR (g = 0.69), and greater increases in SR (g = 0.56) and aerobic performance (g = 0.56), but it did not significantly affect exercise T<sub>sk</sub> (g = 0.47). Relative to baseline, ExH elicited moderate-to-large improvements in all heat-related outcomes, while ExN showed significant improvements in exercise T<sub>core</sub> (g = 0.41) and exercise HR (g = 0.57). Subgroup analyses indicated the additional benefits of ExH were more pronounced in elite athletes (Tier 3) and longer intervention periods, with no other significant moderators (all p > 0.05).</p><p><strong>Conclusion: </strong>Additional heat exposure during exercise confers greater physiological adaptations to heat and improvements in aerobic performance in the heat compared with ExN, although no additional benefit was observed for exercise T<sub>sk</sub>. These effects were moderated by intervention duration and training status. Notably, ExN can also induce modest improvements in key thermoregulatory and cardiovascular outcomes.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101168"},"PeriodicalIF":13.1,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148814609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles Faselis, Peter Kokkinos, Immanuel Babu Henry Samuel, Raylyn Murphy, Andreas Pittaras, Alexandros Ladas, Lydia Korompeli, Sophie Collier, Jonathan Myers
{"title":"Cardiorespiratory fitness and male breast cancer association: The ETHOS Cohort.","authors":"Charles Faselis, Peter Kokkinos, Immanuel Babu Henry Samuel, Raylyn Murphy, Andreas Pittaras, Alexandros Ladas, Lydia Korompeli, Sophie Collier, Jonathan Myers","doi":"10.1016/j.jshs.2026.101167","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101167","url":null,"abstract":"<p><strong>Background: </strong>Male breast cancer is a rare but increasingly recognized disease with limited data on modifiable risk factors. Specifically, it is not known if the inverse association between cardiorespiratory fitness (CRF) and breast cancer risk reported in women is similar to the association between CRF and breast cancer in men. The study aimed to evaluate the association between CRF and the incidence of male breast cancer in a large, nationally representative cohort of U.S. Veterans.</p><p><strong>Methods: </strong>We analyzed data from 777,618 male Veterans who completed an exercise treadmill testing (ETT) between 1999 and 2024 within the Veterans Health Administration and had no evidence of breast cancer prior to the ETT. CRF was expressed in peak metabolic equivalents (METs). The cohort was categorized into 4 age-adjusted CRF categories based on the peak METs achieved. The primary outcome was incident male breast cancer, ascertained through the Veterans Affairs Computerized Patient Record System. Cox proportional hazards models were used to estimate hazard ratios (HRs) for breast cancer incidence across CRF categories, adjusted for age, race, body mass index, hypertension, diabetes (T2DM), chronic kidney disease, smoking, and alcohol use.</p><p><strong>Results: </strong>Over a median follow-up of 10.7 years 518 men were diagnosed with breast cancer. After multivariable adjustment, age (HR = 1.24, 95% confidence interval (95%CI): 1.14-1.36) per decade, chronic kidney disease (HR = 2.13; 95%CI:1.41-3.23), hypertension (HR = 1.57; 95%CI: 1.28-1.92), T2DM (HR = 1.24; 95%CI: 1.02-1.51), and poor CRF (HR = 1.69; 95%CI: 1.24-2.30) were the strongest predictors of breast cancer. Compared to patients in the lowest CRF category, breast cancer risk was 41% lower for individuals in the highest CRF quartile (HR = 0.59; 95%CI: 0.44-0.81).</p><p><strong>Conclusion: </strong>Higher CRF was independently associated with a substantially lower risk of breast cancer in men. These findings suggest that CRF may represent a modifiable risk factor in the prevention of male breast cancer, underscoring the broader importance of physical fitness in reducing cancer risk across sexes.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101167"},"PeriodicalIF":13.1,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charles Faselis, Peter Kokkinos, Immanuel Babu Henry Samuel, Raylyn Murphy, Andreas Pittaras, Alexandros Ladas, Lydia Korompeli, Sophie Collier, Jonathan Myers
{"title":"Cardiorespiratory fitness and male breast cancer association: The ETHOS Cohort","authors":"Charles Faselis, Peter Kokkinos, Immanuel Babu Henry Samuel, Raylyn Murphy, Andreas Pittaras, Alexandros Ladas, Lydia Korompeli, Sophie Collier, Jonathan Myers","doi":"10.1016/j.jshs.2026.101167","DOIUrl":"https://doi.org/10.1016/j.jshs.2026.101167","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"161 1","pages":"101167"},"PeriodicalIF":11.7,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lu Wan, Chaeryon Kang, Peter J Gianaros, Kirk I Erickson
{"title":"Response to the commentary: Exercise as a brake on brain aging-promise and unresolved questions.","authors":"Lu Wan, Chaeryon Kang, Peter J Gianaros, Kirk I Erickson","doi":"10.1016/j.jshs.2026.101166","DOIUrl":"10.1016/j.jshs.2026.101166","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101166"},"PeriodicalIF":13.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lu Wan, Chaeryon Kang, Peter J Gianaros, Kirk I Erickson
{"title":"Response to the comment on \"Fitness and exercise effects on brain age: A randomized clinical trial\".","authors":"Lu Wan, Chaeryon Kang, Peter J Gianaros, Kirk I Erickson","doi":"10.1016/j.jshs.2026.101165","DOIUrl":"10.1016/j.jshs.2026.101165","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101165"},"PeriodicalIF":13.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}