健身和运动对脑年龄的影响:一项随机临床试验。

IF 10.3 1区 医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM
Lu Wan, Cristina Molina-Hidalgo, Mary E Crisafio, George Grove, Regina L Leckie, Thomas W Kamarck, Chaeryon Kang, Mia DeCataldo, Anna L Marsland, Matthew F Muldoon, Mark R Scudder, Javier Rasero, Peter J Gianaros, Kirk I Erickson
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引用次数: 0

摘要

背景:包括体力活动在内的中年生活方式因素与晚年大脑健康有关,但有氧运动对成年早期和中期大脑结构健康的作用仍知之甚少。本研究旨在探讨有氧运动对脑结构老化的影响,并探讨可能的调节因素。方法:在一项为期12个月的单盲随机临床试验中,130名年龄在26-58岁的健康参与者被随机分为中高强度有氧运动组和常规护理对照组。锻炼组每周在实验室环境中参加两次有监督的60分钟锻炼,再加上在家锻炼,每周锻炼150分钟。在基线和12个月时评估脑预测年龄差异(brain-PAD)和心肺适能(CRF)。进行意向治疗(ITT)和完成者分析(包括完成干预后评估的参与者)。结果:130例患者(67.7%为女性)年龄41.28±9.93岁(平均±SD)。在基线时,较高的CRF(峰值摄氧量,vo2峰值)与较小的脑pad相关(β = -0.309,p = 0.012)。干预后,运动组脑外pad下降(估计平均差值(EMD) = -0.60;95%置信区间(95% ci): -1.15 ~ -0.04;p = 0.034)与对照组相比(EMD = 0.35;95%CI: -0.21 ~ 0.92; = 0.217页);时间 × 组间相互作用(组间差异(BGD) = -0.95;95%CI: -1.72 ~ -0.17; = 0.019页)。运动组vo2峰值提高(EMD = 1.60;95%置信区间:0.29—-2.90;p = 0.017)与对照组相比(EMD = -0.78;95%CI: -2.17 ~ 0.60; = 0.265页);时间 × 组间相互作用(BGD = 2.38;95%置信区间:0.52—-4.25; = 0.015页)。身体成分、血压和脑源性神经营养因子水平未受影响。所有提出的途径都没有统计学意义上介导运动对脑- pad的影响。完成者的结果也类似。结论:参加12个月的中高强度运动可以减少早期到中年成年人的大脑pad。这些效应发生的途径尚不清楚。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fitness and exercise effects on brain age: A randomized clinical trial.

Background: Midlife lifestyle factors, including physical activity, are associated with late-life brain health, yet the role of aerobic exercise on structural brain health in early and mid-adulthood remains poorly understood. This study aimed to examine the effect of aerobic exercise on structural brain age and to explore potential mediators.

Methods: In a single-blind, 12-month randomized clinical trial, 130 healthy participants aged 26-58 years were randomized into a moderate-to-vigorous intensity aerobic exercise group or a usual-care control group. The exercise group attended two supervised 60-min sessions per week in a laboratory setting plus engaged in home-based exercise to achieve 150 min of exercise per week. Brain-predicted age difference (brain-PAD) and cardiorespiratory fitness (CRF) were assessed at baseline and 12 months. Both intention-to-treat (ITT) and completers analyses (including participants who completed post-intervention assessments) were performed.

Results: The 130 participants (67.7% female) had an age of 41.28 ± 9.93) years (mean ± SD). At baseline, higher CRF (peak oxygen uptake, VO2peak) was associated with smaller brain-PAD (β = -0.309, p = 0.012). After the intervention, the exercise group showed a decrease in brain-PAD (estimated mean difference (EMD) = -0.60; 95% confidence interval [95% CI]: -1.15 to -0.04; p = 0.034) compared to the control group (EMD = 0.35; 95% CI: -0.21 to 0.92; p = 0.217); time × group interaction (between-group difference [BGD] = -0.95; 95% CI: -1.72 to -0.17; p = 0.019). VO2peak improved in the exercise group (EMD = 1.60; 95% CI: 0.29-2.90; p = 0.017) compared to the control group (EMD = -0.78; 95% CI: -2.17 to 0.60; p = 0.265); time × group interaction (BGD = 2.38; 95% CI: 0.52-4.25; p = 0.015). Body composition, blood pressure, and brain-derived neurotrophic factor levels were unaffected. None of the proposed pathways statistically mediated the effect of exercise on brain-PAD. The results from completers were similar.

Conclusion: Engaging in 12 months of moderate-to-vigorous exercise reduced brain-PAD in early-to-midlife adults. The pathways by which these effects occur remain unknown.

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来源期刊
CiteScore
18.30
自引率
1.70%
发文量
101
审稿时长
22 weeks
期刊介绍: The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers. With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards. Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.
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