Pedro Acosta-Manzano, Marta Flor-Alemany, Luis J Martínez-González, María Jesús Alvarez-Cubero, Laura Baena-García, Teresa Nestares, Mireille N M Van Poppel, Virginia A Aparicio
{"title":"怀孕期间监督运动训练计划对胎盘细胞因子的影响，以及胎儿性别和母亲体重状况的潜在作用。","authors":"Pedro Acosta-Manzano, Marta Flor-Alemany, Luis J Martínez-González, María Jesús Alvarez-Cubero, Laura Baena-García, Teresa Nestares, Mireille N M Van Poppel, Virginia A Aparicio","doi":"10.1016/j.jshs.2025.101082","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood. The objective of the current study is to ascertain the influence of a supervised concurrent exercise intervention from gestational week 17 until birth on key cytokines involved in placental development and function. Secondary aims were to explore: (a) the moderating effects of fetal sex and maternal weight status; and (b) whether gestational weight gain, lifestyle behaviors (diet, sleep patterns, and physical activity), and physical fitness (strength and cardiorespiratory fitness) mediated the effects of exercise on placental cytokines.</p><p><strong>Methods: </strong>Seventy-six pregnant women (33 ± 4 years, mean ± SD), divided into exercise (n = 40) and control (n = 36) groups, participated in this study. The exercise group followed a 60-min, 3 days/week (aerobic + resistance) training program of moderate-to-vigorous intensity. Placental cytokines-including granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), platelet-derived growth factor AA (PDGF-AA), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1), fractalkine, interleukin (IL)-8, IL-6, IL-1β, IL-1ra, IL-10, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were analyzed using Luminex multi-analyte profiling (xMAP) technology.</p><p><strong>Results: </strong>The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group (p < 0.05). Significant effects of exercise on placental G-CSF and TNF-α (p < 0.05) and a trend toward lower IL-6 (p = 0.08) were observed only in female placentas. Additionally, a reduction in weight gain partially mediated the effects of exercise on G-CSF (p < 0.05).</p><p><strong>Conclusion: </strong>Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels. Some exercise-induced effects are observed exclusively in female placentas, including increased G-CSF and lower TNF-α and IL-6 concentrations. Notably, the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101082"},"PeriodicalIF":10.3000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status.\",\"authors\":\"Pedro Acosta-Manzano, Marta Flor-Alemany, Luis J Martínez-González, María Jesús Alvarez-Cubero, Laura Baena-García, Teresa Nestares, Mireille N M Van Poppel, Virginia A Aparicio\",\"doi\":\"10.1016/j.jshs.2025.101082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood. The objective of the current study is to ascertain the influence of a supervised concurrent exercise intervention from gestational week 17 until birth on key cytokines involved in placental development and function. Secondary aims were to explore: (a) the moderating effects of fetal sex and maternal weight status; and (b) whether gestational weight gain, lifestyle behaviors (diet, sleep patterns, and physical activity), and physical fitness (strength and cardiorespiratory fitness) mediated the effects of exercise on placental cytokines.</p><p><strong>Methods: </strong>Seventy-six pregnant women (33 ± 4 years, mean ± SD), divided into exercise (n = 40) and control (n = 36) groups, participated in this study. The exercise group followed a 60-min, 3 days/week (aerobic + resistance) training program of moderate-to-vigorous intensity. Placental cytokines-including granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), platelet-derived growth factor AA (PDGF-AA), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1), fractalkine, interleukin (IL)-8, IL-6, IL-1β, IL-1ra, IL-10, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were analyzed using Luminex multi-analyte profiling (xMAP) technology.</p><p><strong>Results: </strong>The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group (p < 0.05). Significant effects of exercise on placental G-CSF and TNF-α (p < 0.05) and a trend toward lower IL-6 (p = 0.08) were observed only in female placentas. Additionally, a reduction in weight gain partially mediated the effects of exercise on G-CSF (p < 0.05).</p><p><strong>Conclusion: </strong>Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels. Some exercise-induced effects are observed exclusively in female placentas, including increased G-CSF and lower TNF-α and IL-6 concentrations. Notably, the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.</p>\",\"PeriodicalId\":48897,\"journal\":{\"name\":\"Journal of Sport and Health Science\",\"volume\":\" \",\"pages\":\"101082\"},\"PeriodicalIF\":10.3000,\"publicationDate\":\"2025-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Sport and Health Science\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jshs.2025.101082\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"HOSPITALITY, LEISURE, SPORT & TOURISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Sport and Health Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jshs.2025.101082","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HOSPITALITY, LEISURE, SPORT & TOURISM","Score":null,"Total":0}
The effects of a supervised exercise training program during pregnancy on placental cytokines, and the potential role of fetal sex and maternal weight status.
Background: The mechanisms underlying the beneficial effects of exercise on the human placenta are poorly understood. The objective of the current study is to ascertain the influence of a supervised concurrent exercise intervention from gestational week 17 until birth on key cytokines involved in placental development and function. Secondary aims were to explore: (a) the moderating effects of fetal sex and maternal weight status; and (b) whether gestational weight gain, lifestyle behaviors (diet, sleep patterns, and physical activity), and physical fitness (strength and cardiorespiratory fitness) mediated the effects of exercise on placental cytokines.
Methods: Seventy-six pregnant women (33 ± 4 years, mean ± SD), divided into exercise (n = 40) and control (n = 36) groups, participated in this study. The exercise group followed a 60-min, 3 days/week (aerobic + resistance) training program of moderate-to-vigorous intensity. Placental cytokines-including granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), platelet-derived growth factor AA (PDGF-AA), epidermal growth factor (EGF), monocyte chemoattractant protein-1 (MCP-1), fractalkine, interleukin (IL)-8, IL-6, IL-1β, IL-1ra, IL-10, tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ) were analyzed using Luminex multi-analyte profiling (xMAP) technology.
Results: The exercise group presented higher placental levels of G-CSF and lower concentrations of EGF and IL-1ra than the control group (p < 0.05). Significant effects of exercise on placental G-CSF and TNF-α (p < 0.05) and a trend toward lower IL-6 (p = 0.08) were observed only in female placentas. Additionally, a reduction in weight gain partially mediated the effects of exercise on G-CSF (p < 0.05).
Conclusion: Maternal exercise during pregnancy is related to increased placental levels of G-CSF and lower EGF and IL-1ra levels. Some exercise-induced effects are observed exclusively in female placentas, including increased G-CSF and lower TNF-α and IL-6 concentrations. Notably, the increased levels of G-CSF observed with exercise might be due to a more adequate gestational weight gain.
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The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers.
With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards.
Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.
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