Journal of Sport and Health Science最新文献

{"title":"Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation.","authors":"Sebastian Bass-Stringer,Bianca C Bernardo,Gunes S Yildiz,Aya Matsumoto,Helen Kiriazis,Claudia A Harmawan,Celeste M K Tai,Roger Chooi,Lauren Bottrell,Martin Ezeani,Daniel G Donner,Aascha A D'Elia,Jenny Y Y Ooi,Natalie A Mellett,Jieting Luo,Emma I Masterman,Kristel Janssens,Gavriel Olshansky,Erin J Howden,Jonathon H Cross,Christoph E Hagemeyer,Ruby C Y Lin,Colleen J Thomas,Graham W Magor,Andrew C Perkins,Thomas H Marwick,Hiroshi Kawakami,Peter J Meikle,David W Greening,Kate L Weeks,André La Gerche,Yow Keat Tham,Julie R McMullen","doi":"10.1016/j.jshs.2025.101023","DOIUrl":"https://doi.org/10.1016/j.jshs.2025.101023","url":null,"abstract":"BACKGROUNDElucidating mechanisms underlying atrial myopathy, which predisposes individuals to atrial fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified atrial enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase (PI3K) in cardiomyocytes. PI3K(p110α) is elevated in the heart with exercise and is critical for exercise-induced ventricular enlargement and protection, but the role in the atria was unknown. Physical inactivity and extreme endurance exercise can increase AF risk. Therefore, our objective was to investigate whether too little and/or too much PI3K alone induces cardiac pathology.METHODSNew cardiomyocyte-specific transgenic mice with increased or decreased PI3K(p110α) activity were generated. Multi-omics was conducted in mouse atrial tissue, and lipidomics in human plasma.RESULTSElevated PI3K led to an increase in heart size with preserved/enhanced function. Reduced PI3K led to atrial dysfunction, fibrosis, arrhythmia, increased susceptibility to atrial enlargement and thrombi, and dysregulation of monosialodihexosylganglioside (GM3), a lipid that regulates insulin-like growth factor-1 (IGF1)-PI3K signaling. Proteomic profiling identified distinct signatures and signaling networks across atria with varying degrees of dysfunction, enlargement, and thrombi, including commonalities with the human AF proteome. PI3K-related lipids were dysregulated in plasma from athletes with AF.CONCLUSIONPI3K(p110α) is a critical regulator of atrial biology and function in mice. This work provides a proteomic resource of candidates for further validation as potential new drug targets and biomarkers for atrial myopathy. Further investigation of PI3K-related lipids as markers for identifying individuals at risk of AF is warranted. Dysregulation of PI3K may contribute to the association between increased cardiac risk with physical inactivity and extreme endurance exercise.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"107 1","pages":"101023"},"PeriodicalIF":11.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"A systematic review and meta-analysis comparing objectively measured and estimated fitness to predict all-cause and cardiovascular disease mortality in adults\".","authors":"Barbara E Ainsworth, Zhenghua Cai","doi":"10.1016/j.jshs.2024.101022","DOIUrl":"10.1016/j.jshs.2024.101022","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101022"},"PeriodicalIF":9.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142915608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual dimorphism on the acute effect of exercise in the morning vs. evening: A randomized crossover study.","authors":"Raquel Sevilla-Lorente, Andres Marmol-Perez, Pilar Gonzalez-Garcia, María de Las Nieves Rodríguez-Miranda, Blanca Riquelme-Gallego, Jerónimo Aragon-Vela, Juan Manuel Martinez-Gálvez, Pablo Molina-Garcia, Juan Manuel A Alcantara, José Garcia-Consuegra, Sara Cogliati, Luis Miguel Salmeron, Jesús R Huertas, Luis C Lopez, Jonatan R Ruiz, Francisco José Amaro-Gahete","doi":"10.1016/j.jshs.2024.101021","DOIUrl":"10.1016/j.jshs.2024.101021","url":null,"abstract":"<p><strong>Background: </strong>Mammalian cells possess molecular clocks, the adequate functioning of which is decisive for metabolic health. Exercise is known to modulate these clocks, potentially having distinct effects on metabolism depending on the time of day. This study aimed to investigate the impact of morning vs. evening moderate-intensity aerobic exercise on glucose regulation and energy metabolism in healthy men and women. It also aimed to elucidate molecular mechanisms within skeletal muscle.</p><p><strong>Methods: </strong>Using a randomized crossover design, healthy men (n = 18) and women (n = 17) performed a 60-min bout of moderate-intensity aerobic exercise in the morning and evening. Glucose regulation was continuously monitored starting 24 h prior to the exercise day and continuing until 48 h post-exercise for each experimental condition. Energy expenditure and substrate oxidation were measured by indirect calorimetry during exercise and at rest before and after exercise for 30 min. Skeletal muscle biopsies were collected immediately before and after exercise to assess mitochondrial function, transcriptome, and mitochondrial proteome.</p><p><strong>Results: </strong>Results indicated similar systemic glucose, energy expenditure, and substrate oxidation during and after exercise in both sexes. Notably, transcriptional analysis, mitochondrial function, and mitochondrial proteomics revealed marked sexual dimorphism and time of day variations.</p><p><strong>Conclusion: </strong>The sexual dimorphism and time of day variations observed in the skeletal muscle in response to exercise may translate into observable systemic effects with higher exercise-intensity or chronic exercise interventions. This study provides a foundational molecular framework for precise exercise prescription in the clinical setting.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101021"},"PeriodicalIF":9.7,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does eccentric strength training add sarcomeres in series and subtract sarcomeres in parallel?","authors":"Bart Bolsterlee, Paolo Tecchio, Daniel Hahn, Brent J Raiteri","doi":"10.1016/j.jshs.2024.101020","DOIUrl":"10.1016/j.jshs.2024.101020","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101020"},"PeriodicalIF":9.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of adiposity and device-measured physical activity with cancer incidence: UK Biobank prospective cohort study.","authors":"Miguel Adriano Sanchez-Lastra, Tessa Strain, Ding Ding, Knut Eirik Dalene, Borja Del Pozo Cruz, Ulf Ekelund, Jakob Tarp","doi":"10.1016/j.jshs.2024.101018","DOIUrl":"10.1016/j.jshs.2024.101018","url":null,"abstract":"<p><strong>Background: </strong>High adiposity and low physical activity are associated with cancer risk. Whether different amounts and intensities of physical activity can mitigate this association is unclear. We aimed to examine the independent and combined associations of adiposity and device-measured physical activity levels of different intensities with cancer incidence and mortality.</p><p><strong>Methods: </strong>This prospective cohort study included data from 70,747 UK Biobank participants (mean age = 61.6 ± 7.9 years, mean ± SD; 56.4% women) with wrist-worn accelerometer measurements of physical activity and without chronic diseases or mobility limitations. Physical activity exposures included min per week of light intensity physical activity (LPA), moderate-to-vigorous intensity physical activity (MVPA), and vigorous intensity physical activity (VPA), along with total weekly volume. Body mass index (BMI) was calculated from anthropometric measurements. Participants were categorized into 9 groups based on joint tertiles of physical activity and BMI categories (normal weight, overweight, and obesity). Secondary analyses included adiposity using bio-impedance and waist circumference measurements. The outcome was incidence and death from cancer retrieved from national registries. Associations between adiposity, physical activity, and cancer hazard were calculated as subdistribution hazard ratios. A secondary analysis focused on cancer types strongly associated with physical activity.</p><p><strong>Results: </strong>We observed 2625 events (2572 non-fatal and 53 fatal) during a median follow-up of 6.1 years. Compared with the referent (normal weight and high physical activity), overweight and obesity were associated with a 6% to 36% higher cancer hazard across physical activity intensities. However, high MVPA and VPA (approximately 500 min and 32 min per week in the top tertiles, respectively) attenuated the hazard associated with overweight and obesity. Being normal weight was not associated with a higher cancer hazard regardless of physical activity level. The results were similar, although more pronounced, when modeling cancer types strongly associated with physical activity as the outcome.</p><p><strong>Conclusion: </strong>High MVPA and VPA levels may attenuate the association of overweight and obesity with cancer hazard, but maintaining a normal weight seems comparatively more important than physical activity to reduce the hazard. Maintaining a healthy body weight and engaging in physical activity is needed to minimize risk of some cancer types.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101018"},"PeriodicalIF":9.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions","authors":"Grant R. Tomkinson, Justin J. Lang, Lukáš Rubín, Ryan McGrath, Bethany Gower, Terry Boyle, Marilyn G. Klug, Alexandra J. Mayhew, Henry T. Blake, Francisco B. Ortega, Cristina Cadenas-Sanchez, Costan G. Magnussen, Brooklyn J. Fraser, Tetsuhiro Kidokoro, Yang Liu, Kaare Christensen, Darryl P. Leong, The iGRIPS (International handGRIP Strength) Group, Mette Aadahl, Edimansyah Abdin, Julian Alcazar, Aqeel Alenazi, Bader Alqahtani, Cledir De A. Amaral, Thatiana L.M. Amaral, Alex Andrade Fernandes, Peter Axelsson, Jennifer N. Baldwin, Karin Bammann, Aline R. Barbosa, Ameline Bardo, Inosha Bimali, Peter Bjerregaard, Martin Bobak, Colin A. Boreham, Klaus Bös, João Carlos Bouzas Marins, Joshua Burns, Nadezda Capkova, Lilia Castillo-Martínez, Liang-Kung Chen, Siu Ming Choi, Rebecca K.J. Choong, Susana C. Confortin, Cyrus Cooper, Jorge E. Correa-Bautista, Amandine Cournil, Grace Cruz, Eling D. de Bruin, José Antonio De Paz, Bruno De Souza Moreira, Luiz Antonio Dos Anjos, María Cristina Enríquez Reyna, Eduardo Ferriolli, Gillian Forrester, Elena Frolova, Abadi K. Gebre, Atef M. Ghaleb, Tiffany K. Gill, Yasuyuki Gondo, M. Cristina Gonzalez, Citlali Gonzalez Alvarez, Mary K. Hannah, Nicholas C. Harvey, Jean-Yves Hogrel, Marie-Theres Huemer, Toshiko Iidaka, Lewis A. Ingram, Dmitri A. Jdanov, Victoria L. Keevil, Wolfgang Kemmler, Rose Anne Kenny, Dae-Yeon Kim, Tracy L. Kivell, Ingirid G.H. Kjær, Alexander Kluttig, Rumi Kozakai, Danit Langer, Lisbeth A. Larsen, Wei-Ju Lee, David A. Leon, Eric Lichtenstein, Bertis B. Little, Roberto Alves Lourenço, Rahul Malhotra, Robert M. Malina, Kiyoaki Matsumoto, Tal Mazor-Karsenty, Marnee J. McKay, Sinéad McLoughlin, Abhishek L. Mensegere, Mostafa Mohammadian, Virgilio Garcia Moreira, Hiroshi Murayama, Anne Murray, Anita Liberalesso Neri, Claudia Niessner, Gabriel Núñez Othón, Gabriel Olveira, Suzanne G. Orchard, Andrezj Pajak, Chan Woong Park, Julie A. Pasco, Maria E. Peña Reyes, Leani Souza Máximo Pereira, Annette Peters, Eric Tsz-Chun Poon, Margareth C. Portela, Jedd Pratt, Robinson Ramírez-Vélez, Wendy Rodríguez-García, Joanne Ryan, Mauricio A. San-Martín, Francisco José Sánchez-Torralvo, Mahnaz Saremi, Arno Schmidt-Trucksäss, Satoshi Seino, Shamsul Azhar Shah, Marc Sim, Bjørn Heine Strand, Mythily Subramaniam, Charlotte Suetta, Sophia X. Sui, Jonas S. Sundarakumar, Koya Suzuki, Abdonas Tamosiunas, Maw Pin Tan, Yu Taniguchi, Barbara Thorand, Anna Turusheva, Anne Therese Tveter, Jonathan Wagner, Dao Wang, Stuart J. Warden, Julia Wearing, Shiou Liang Wee, Leo D. Westbury, Agnieszka Wiśniowska-Szurlej, Alexander Woll, Noriko Yoshimura, Ruby Yu","doi":"10.1016/j.jshs.2024.101014","DOIUrl":"https://doi.org/10.1016/j.jshs.2024.101014","url":null,"abstract":"Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability. Handgrip strength (HGS) using isometric dynamometry is a convenient, feasible, and widely used method of assessing muscular strength among people of all ages. While adult HGS norms have been published for many countries, no study has yet synthesized available data to produce international norms. The objective of this study was to generate international sex- and age-specific norms for absolute and body size-normalized HGS across the adult lifespan.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"5 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of exercise for patients with advanced lung cancer and cancer-related fatigue: A systematic review and meta-analysis","authors":"Yidan Hu, Shanshan Gu, Zhijun Bu, Zhaolan Liu, Jing Dong, Jiyan Shi, Yun Xu","doi":"10.1016/j.jshs.2024.101017","DOIUrl":"https://doi.org/10.1016/j.jshs.2024.101017","url":null,"abstract":"Cancer-related fatigue (CRF) is a significant burden for patients with advanced lung cancer. While exercise is recommended for managing CRF during pre- and active treatment phases, evidence supporting its efficacy in advanced stage remains limited. This systematic review and meta-analysis aimed to quantify the effects of exercise on CRF and its common complications in patients with advanced lung cancer.","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":"121 1","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large language models' performances regarding common patient questions about osteoarthritis: A comparative analysis of ChatGPT-3.5, ChatGPT-4.0, and perplexity.","authors":"Mingde Cao, Qianwen Wang, Xueyou Zhang, Zuru Lang, Jihong Qiu, Patrick Shu-Hang Yung, Michael Tim-Yun Ong","doi":"10.1016/j.jshs.2024.101016","DOIUrl":"10.1016/j.jshs.2024.101016","url":null,"abstract":"<p><strong>Background: </strong>Large Language Models (LLMs) have gained much attention and, in part, have replaced common search engines as a popular channel for obtaining information due to their contextually relevant responses. Osteoarthritis (OA) is a common topic in skeletal muscle disorders, and patients often seek information about it online. Our study evaluated the ability of 3 LLMs (ChatGPT-3.5, ChatGPT-4.0, and Perplexity) to accurately answer common OA-related queries.</p><p><strong>Methods: </strong>We defined 6 themes (pathogenesis, risk factors, clinical presentation, diagnosis, treatment and prevention, and prognosis) based on a generalization of 25 frequently asked questions about OA. Three consultant-level orthopedic specialists independently rated the LLMs' replies on a 4-point accuracy scale. The final ratings for each response were determined using a majority consensus approach. Responses classified as \"satisfactory\" were evaluated for comprehensiveness on a 5-point scale.</p><p><strong>Results: </strong>ChatGPT-4.0 demonstrated superior accuracy, with 64% of responses rated as \"excellent\", compared to 40% for ChatGPT-3.5 and 28% for Perplexity (Pearson's chi-squared test with Fisher's exact test, all p < 0.001). All 3 LLM-chatbots had high mean comprehensiveness ratings (Perplexity = 3.88; ChatGPT-4.0 = 4.56; ChatGPT-3.5 = 3.96, out of a maximum score of 5). The LLM-chatbots performed reliably across domains, except for \"treatment and prevention\" However, ChatGPT-4.0 still outperformed ChatGPT-3.5 and Perplexity, garnering 53.8% \"excellent\" ratings (Pearson's chi-squared test with Fisher's exact test, all p < 0.001).</p><p><strong>Conclusion: </strong>Our findings underscore the potential of LLMs, specifically ChatGPT-4.0 and Perplexity, to deliver accurate and thorough responses to OA-related queries. Targeted correction of specific misconceptions to improve the accuracy of LLMs remains crucial.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101016"},"PeriodicalIF":9.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are there sensitive periods for physical activity to influence the development of executive function in children?","authors":"Joseph M Northey, Lauren B Raine, Charles H Hillman","doi":"10.1016/j.jshs.2024.101015","DOIUrl":"10.1016/j.jshs.2024.101015","url":null,"abstract":"<p><p>Executive functions emerge throughout childhood and shape multiple cognitive and behavioral outcomes across the lifespan. Given the importance of these functions, there is considerable interest in understanding the role of environmental enrichment to support their development. The past 20 years have seen the emergence of a body of evidence around the beneficial effects of engaging in physical activity for executive functioning in children. Despite this, there are still unanswered questions, particularly about the confounding effects of the timing and dose of exercise-based interventions. During development, sensitive periods with heightened neural plasticity and sensitivity to environmental influences can offer an optimal time to introduce enrichment interventions. As such, sensitive periods for executive function could indicate an ideal time to introduce physical activity or be a potential confounder to study results if not considered. This narrative review discusses the potential presence of sensitive periods in preadolescent development where physical activity has greater benefits for executive function. Initially, we briefly review the largely parallel fields investigating the presence of sensitive periods for executive function and the effects of physical activity on executive function outcomes. We then bring together these 2 concepts to discuss the theoretical basis for developmentally sensitive periods during which children may be particularly amenable to physical activity-based interventions and offer potential ways forward to investigate this phenomenon. We hope this review will attract researchers to collaborate in the area and extend our current understanding of the development of executive functions as well as interventions like physical activity.</p>","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101015"},"PeriodicalIF":9.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Can changes in midsole bending stiffness of shoes affect the onset of joint work redistribution during a prolonged run?\" [J Sport Health Sci 11 (2022) 293-302].","authors":"Sasa Cigoja, Jared R Fletcher, Benno M Nigg","doi":"10.1016/j.jshs.2024.101013","DOIUrl":"10.1016/j.jshs.2024.101013","url":null,"abstract":"","PeriodicalId":48897,"journal":{"name":"Journal of Sport and Health Science","volume":" ","pages":"101013"},"PeriodicalIF":9.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142733787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}