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IF 9.7 1区医学 Q1 HOSPITALITY, LEISURE, SPORT & TOURISM

Journal of Sport and Health Science Pub Date : 2025-02-26 DOI:10.1016/j.jshs.2025.101034

Marie Chambion-Diaz, Giorgio Manferdelli, Benjamin J Narang, Guido Giardini, Tadej Debevec, Vincent Pialoux, Grégoire P Millet

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引用次数: 0

摘要

背景：早产儿往往表现出较高的静息氧化应激，尽管有证据表明他们可能对急性缺氧引起的氧化还原平衡改变有较强的抵抗力。我们的目的是研究早产儿（胎龄≤ 32 周）和足月儿（胎龄≥ 38 周）健康成年人在 3375 米高海拔条件下 3 天低压缺氧暴露期间的氧化还原平衡变化：方法：在常氧状态下（暴露于海拔高度之前）、抵达海拔高度后立即以及随后的3个早晨采集静息静脉血。抗氧化剂（超氧化物歧化酶（SOD）、过氧化氢酶、谷胱甘肽过氧化物酶（GPx）和铁还原抗氧化力（FRAP））、促氧化剂（黄嘌呤氧化酶（XO）和髓过氧化物酶（MPO））酶活性、测量血浆中的氧化应激标记物（高级氧化蛋白产物（AOPP）和丙二醛（MDA））、一氧化氮（NO）代谢物（亚硝酸盐、硝酸盐、亚硝酸盐和硝酸盐总量（NOx））和硝基酪氨酸。结果显示只有早产儿组的 SOD 增加（p < 0.05）。早产儿组的过氧化氢酶在到达时增加（p < 0.05）。早产儿组的 XO 活性在第 3 天增加，而对照组的 XO 活性在到达时和第 1 天急剧增加。两组的 MPO 在 3 天内都有所增加（P < 0.05）。早产儿组的 AOPP 仅在到达时增加（p < 0.05），而对照组则在到达后至第 3 天减少（p < 0.05）。对照组的 MDA 从到达时开始下降。两组的亚硝基酪氨酸均下降（p < 0.05）。对照组亚硝酸盐在第 3 天升高（p < 0.05），早产儿组在第 1 天降低（p < 0.05）：这些数据表明，早产成人在缺氧情况下，抗氧化酶似乎会立即增加。相反，早产儿对长时间缺氧暴露的促氧化酶反应减弱，这表明早产儿对这些酶的敏感性可能较低。这些发现进一步支持了早产的潜在缺氧预处理效应。

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Oxidative stress and nitric oxide metabolism responses during prolonged high-altitude exposure in preterm born adults.

Background: Prematurely-born individuals tend to exhibit higher resting oxidative stress, although evidence suggests they may be more resistant to acute hypoxia-induced redox balance alterations. We aimed to investigate the redox balance changes across a 3-day hypobaric hypoxic exposure at 3375 m in healthy adults born preterm (gestational age ≤32 weeks) and their term-born (gestational age ≥38 weeks) counterparts.

Methods: Resting venous blood was obtained in normoxia (prior to altitude exposure), immediately upon arrival to altitude, and the following 3 mornings. Antioxidant (superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and ferric reducing antioxidant power (FRAP)), pro-oxidant (xanthine oxidase (XO) and myeloperoxidase (MPO)) enzyme activity, oxidative stress markers (advanced oxidation protein product (AOPP) and malondialdehyde (MDA)), nitric oxide (NO) metabolites (nitrites, nitrates, and total nitrite and nitrate (NOx)), and nitrotyrosine were measured in plasma.

Results: SOD increased only in the preterm group (p < 0.05). Catalase increased at arrival in preterm group (p < 0.05). XO activity increased at Day 3 for the preterm group, while it increased acutely (arrival and Day 1) in control group. MPO increased in both groups throughout the 3 days (p < 0.05). AOPP only increased at arrival in the preterm (p < 0.05) whereas it decreased at arrival up to Day 3 (p < 0.05) for control. MDA decreased in control group from arrival onward. Nitrotyrosine decreased in both groups (p < 0.05). Nitrites increased on Day 3 (p < 0.05) in control group and decreased on Day 1 (p < 0.05) in preterm group.

Conclusion: These data indicate that antioxidant enzymes seem to increase immediately upon hypoxic exposure in preterm adults. Conversely, the blunted pro-oxidant enzyme response to prolonged hypoxia exposure suggests that these enzymes may be less sensitive in preterm individuals. These findings lend further support to the potential hypoxic preconditioning effect of preterm birth.

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来源期刊

Journal of Sport and Health Science SPORT SCIENCES-

CiteScore

18.30

自引率

1.70%

发文量

101

审稿时长

22 weeks

期刊介绍： The Journal of Sport and Health Science (JSHS) is an international, multidisciplinary journal that aims to advance the fields of sport, exercise, physical activity, and health sciences. Published by Elsevier B.V. on behalf of Shanghai University of Sport, JSHS is dedicated to promoting original and impactful research, as well as topical reviews, editorials, opinions, and commentary papers. With a focus on physical and mental health, injury and disease prevention, traditional Chinese exercise, and human performance, JSHS offers a platform for scholars and researchers to share their findings and contribute to the advancement of these fields. Our journal is peer-reviewed, ensuring that all published works meet the highest academic standards. Supported by a carefully selected international editorial board, JSHS upholds impeccable integrity and provides an efficient publication platform. We invite submissions from scholars and researchers worldwide, and we are committed to disseminating insightful and influential research in the field of sport and health science.