Journal of Periodontal and Implant Science最新文献

{"title":"Standard operating procedures for quality control of oral biospecimens at the Korea Oral Biobank Network.","authors":"Hye-Rim Shin, Sun-Young Kim, In-Hye Bae, Inseong Hwang, Jin Hoo Park, Soo-Min Ok, Young-Youn Kim, Young-Dan Cho","doi":"10.5051/jpis.2401920096","DOIUrl":"https://doi.org/10.5051/jpis.2401920096","url":null,"abstract":"<p><strong>Purpose: </strong>The Korean Oral Biobank Network (KOBN) collects, stores, and provides oral samples for research. Quality control (QC) of biospecimens is necessary to ensure that they meet the basic prerequisites before being sent to researchers. This study presents the standard operating procedures (SOPs) for the QC of biospecimens.</p><p><strong>Methods: </strong>QC methods using molecular genetic techniques according to sample types, including teeth, blood, oral soft tissue, oral tissue-derived cells, saliva, mouth rinse solution, dental plaque, and gingival crevicular fluid, are described in detail.</p><p><strong>Results: </strong>The KOBN established SOP for oral biospecimen QC and assessment methods.</p><p><strong>Conclusions: </strong>To ensure a stable supply of high-quality biospecimens for researchers, regular QC checks should be carried out according to the SOP following the specifications of the Korea Biobank Network under the Korea Disease Control and Prevention Agency.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 2","pages":"127-138"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term assessment of a modified tunneling technique for root coverage in lower anterior gingival recession: a retrospective study.","authors":"Sungtae Kim, Hee-Seung Han, Hyunkyung Kim, Hyunjae Kim, Yang-Jo Seol, Young-Dan Cho","doi":"10.5051/jpis.2402660133","DOIUrl":"https://doi.org/10.5051/jpis.2402660133","url":null,"abstract":"<p><strong>Purpose: </strong>Root coverage (RC) procedures require long-term evaluation. This study assessed the clinical validity and long-term stability of a modified tunneling technique for lower anterior gingival recession (GR) using a subepithelial connective tissue graft (SCTG) and a volume-stable collagen matrix.</p><p><strong>Methods: </strong>Across 39 patients, 66 mandibular incisors with ≥1.0 mm of GR were examined before and after RC surgery. Clinical photographs documenting the results of RC were taken at baseline (T₀) and the most recent follow-up visit (T<i>_l</i>). Impressions were obtained either at baseline (T₀) or 3 weeks later (T₃). The recession depth, Miller classification, and rates of RC and complete root coverage (CRC) were assessed.</p><p><strong>Results: </strong>This study analyzed 66 GR sites across 39 patients, with an average follow-up period of 41.3 months. Overall, the mean RC achieved was 86.2%±15.7%. Among single recessions, the RC was 85.2%±25.6% for Miller class I, 91.5%±10.4% for class II, and 79.2%±18.3% for class III. Regarding multiple recessions, the RC was 85.1%±16.2% for Miller class I, 87.0%±12.5% for class II, and 89.8%±16.0% for class III. By Miller classification, the RC was 85.1%±16.8% for class I, 88.7%±11.6% for class II, and 85.8%±17.3% for class III. Furthermore, the RC varied by follow-up duration: 72.5%±15.1% at 12 months, 90.1%±12.6% at 25-36 months, 89.0%±16.7% at 37-48 months, 91.10%±9.88% at 49-60 months, and 97.6±4.79% for longer than 61 months, with 77.8% of the last group achieving CRC. RC also differed based on the initial recession depth, at 88.0%±16.8% for 1-3 mm, 83.1%±14.1% for 3-6 mm, and 80.2%±5.04% for depths exceeding 6 mm.</p><p><strong>Conclusions: </strong>A modified tunneling technique, utilizing SCTG and a volume-stable collagen matrix, appears to represent a reliable option for the long-term management of GR in the lower anterior region, even in cases involving multiple Miller class III GRs.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 2","pages":"115-126"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Gum Day\" of the Korean Academy of Periodontology.","authors":"Nam Yoon Kim","doi":"10.5051/jpis.255502edi01","DOIUrl":"https://doi.org/10.5051/jpis.255502edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 2","pages":"85-86"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development and validation of a Korean version of the oral hygiene-related self-efficacy tool.","authors":"Soo-Auk Park, Eun-Ae Kim, Jae-Young Lee","doi":"10.5051/jpis.2401780089","DOIUrl":"https://doi.org/10.5051/jpis.2401780089","url":null,"abstract":"<p><strong>Purpose: </strong>Self-efficacy is an important factor in the management of chronic oral diseases. This study aimed to develop a Korean version of a self-efficacy tool related to personal oral hygiene management, and verify its validity and reliability.</p><p><strong>Methods: </strong>This study evaluated the validity and reliability of a Korean version of the oral health-related self-efficacy measurement tool (OHSE-K). The sub-factors of this self-efficacy tool are tooth brushing, interdental hygiene management, and dental visits. The original items were translated into Korean, and their content validity was confirmed. Initially, a preliminary survey was conducted, followed by the main survey. The main survey comprised 19 content-verified items. The validity and reliability of the main survey were evaluated through repeated exploratory factor analyses. A randomly selected sample of Korean adults, aged 19 years or older, completed the OHSE-K online between May 10 and June 2, 2023. The study recruited 400 adults for the preliminary survey. Data were analyzed using PASW 25.0.</p><p><strong>Results: </strong>The OHSE-K demonstrated a high level of overall reliability (Cronbach's α=0.891). Exploratory factor analysis revealed 3 significant factors: tooth-brushing self-efficacy, interdental hygiene management self-efficacy, and dental visit self-efficacy, with a cumulative explanation rate of 65.114%. The criterion validity results indicated that oral healthcare awareness and behavior, as well as unmet dental treatment needs, were significant (<i>P</i><0.05). Additionally, the OHSE-K scores showed significant correlations with all 3 sub-factors (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>The OHSE-K is a reliable tool. Our results demonstrated its validity and reliability.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 2","pages":"104-114"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of tapered-straight-tapered dental implants: a retrospective analysis.","authors":"Hyunkyung Kim, Hee-Seung Han, Hyunjae Kim, Sungtae Kim, Young-Dan Cho","doi":"10.5051/jpis.2403220161","DOIUrl":"https://doi.org/10.5051/jpis.2403220161","url":null,"abstract":"<p><strong>Purpose: </strong>This retrospective study aimed to evaluate the long-term survival rate and marginal bone loss (MBL) of tapered-straight-tapered dental implants, considering various associated factors, over an observational period of ≥5 years.</p><p><strong>Methods: </strong>This study included 186 patients who underwent tapered-straight-tapered dental implant placement at Seoul National University Dental Hospital from 2014 to 2019. Digital panoramic radiographic images and dental records were examined. We evaluated multiple variables, such as sex, age, diabetes mellitus (DM), smoking status, placement region, jaw type (maxilla and mandible), implant diameter, implant length, staged surgery, immediate placement, splinted prosthesis, and implant placement depth (IPD). We first determined the implant survival rate using Kaplan-Meier analysis and analyzed potential risk factors for implant survival using mixed-effects Cox proportional hazards regression. Next, the Mann-Whitney and Kruskal-Wallis tests were used to examine differences in MBL across variables. Linear mixed-effects models with backward stepwise selection were used to identify associations between risk factors and MBL.</p><p><strong>Results: </strong>This study included 316 implants in 186 patients, monitored over a follow-up period of 7.0±1.36 years. The cumulative survival rate of the implants was 98.1%. The average mesial and distal MBLs were 0.59±1.36 mm and 0.68±1.36 mm, respectively. Linear mixed-effects models indicated that MBL exhibited statistically significant positive correlations with DM (Coeff.=0.614, <i>P</i>=0.026) and staged surgery (Coeff.=0.410, <i>P</i>=0.002). Additionally, greater mesial IPD was associated with reduced MBL (Coeff.=-0.143, <i>P</i>=0.046), and a similar trend was observed for distal IPD (Coeff.=-0.316, <i>P</i>=0.068).</p><p><strong>Conclusions: </strong>This study demonstrated a high cumulative survival rate for tapered-straight-tapered dental implants over a 5-year period. DM, staged surgery, and IPD showed strong associations with increased MBL. The results suggest that tapered-straight-tapered implants offer advantages in terms of peri-implant MBL and consistent clinical outcomes. These findings underscore the importance of considering these variables in clinical decision-making to optimize implant outcomes.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prospective clinical study of immediate implant placement in the maxillary esthetic zone.","authors":"Hee-Seung Han, Sungtae Kim, Hyunjae Kim, Yuseung Yi, Young-Dan Cho","doi":"10.5051/jpis.2404240212","DOIUrl":"https://doi.org/10.5051/jpis.2404240212","url":null,"abstract":"<p><strong>Purpose: </strong>Immediate implant placement (IIP) offers several advantages, including minimizing hard and soft tissue deformation, reducing implant time and cost, and rapidly restoring tooth function. However, IIP is technically challenging due to the need to secure initial stability and limit functional loading during healing. Therefore, this study aimed to evaluate the clinical outcomes of a bone-level implant featuring a dual thread design-an upper U-shaped thread and a lower V-shaped thread-with an 11° internal hexagonal connection in IIP within the maxillary esthetic zone.</p><p><strong>Methods: </strong>This study included 20 patients. Implants were inserted immediately after tooth extraction. Soft tissue changes were evaluated before tooth extraction (V0), after IIP (V1), at prosthesis delivery (V5), at a 3-month follow-up after prosthesis delivery (V6), and at a 1-year follow-up (V8). Bone dimensional changes were assessed at V1 and V8 using cone beam computed tomography, and the marginal bone level (MBL) was evaluated at V6 and V8 using 2-dimensional.</p><p><strong>Results: </strong>Of the 20 patients, 3 dropped out due to osseointegration failure during the follow-up period. Although the horizontal dimensions of the soft and hard tissues decreased slightly, the gingival margin and MBL remained well maintained throughout the follow-up.</p><p><strong>Conclusions: </strong>Within this limited dataset, the lower V-shaped thread enabled favorable initial stability in IIP, and the esthetic outcomes were positive-with minimal gingival recession and marginal bone loss. Long-term follow-up is required to fully assess the impact of thread design and connection on esthetics.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0008231.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.","authors":"Yu Cao, George Pelekos, Lijian Jin, An Li, Mi Du, Shixian Hu, Zuyun Liu, Ke Deng","doi":"10.5051/jpis.2403420171","DOIUrl":"https://doi.org/10.5051/jpis.2403420171","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic low-grade inflammation is linked to the biology of aging; however, evidence supporting a causal relationship between periodontitis-a dysbiotic biofilm-initiated inflammatory disease-and accelerated aging remains limited. This study investigated the causality between periodontitis and biological aging and identified potentially shared genomic loci, genes, and pathways.</p><p><strong>Methods: </strong>We conducted a 2-sample Mendelian randomization (MR) analysis to explore the causality of periodontitis on age acceleration measures (DNAm PhenoAge acceleration, GrimAge acceleration, Hannum age acceleration, and intrinsic epigenetic age acceleration) using a dataset from genome-wide association studies of European ancestry populations. Independent genetic variants associated with each trait were used as instrumental variables. The inverse variance-weighted (IVW) method served as the primary MR approach, supplemented by sensitivity testing. We also performed additional statistical genetic analyses to identify pleiotropic loci, shared functional genes, and potential biological pathways, integrating large-scale expression quantitative trait loci data from blood samples.</p><p><strong>Results: </strong>The MR analysis indicated a causal relationship between periodontitis and DNAm PhenoAge acceleration (IVW β=0.308; 95% confidence interval, 0.056-0.561; <i>P</i>=0.017), a finding corroborated by sensitivity analyses. There was a significant genetic overlap between periodontitis and age acceleration. Pleiotropic analysis revealed 24 shared SNPs associated with 242 genes, predominantly involved in immune functions and pathways related to cellular processes. Further integration analysis showed that 91 of these pleiotropic genes were causally linked to both conditions, with C6orf183 identified as a potential mediator.</p><p><strong>Conclusions: </strong>This study presents compelling genetic evidence supporting a causal relationship between periodontitis and accelerated aging. Further research is required to validate these findings and investigate the underlying mechanisms.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary sinus hypoplasia relevant to dental implant treatment: a narrative review.","authors":"Won-Bae Park, Sofya Sadilina, Ji-Young Han, Daniel S Thoma, Hyun-Chang Lim","doi":"10.5051/jpis.2403600180","DOIUrl":"https://doi.org/10.5051/jpis.2403600180","url":null,"abstract":"<p><p>This comprehensive narrative review provides an overview of the current scientific evidence regarding maxillary sinus hypoplasia (MSH). This review highlights several variants of MSH that are relevant to implant planning and treatment in daily clinical practice. MSH is characterized by a reduction in sinus volume, which contrasts with maxillary sinus pneumatization, a condition that has received more clinical attention. Nevertheless, certain types of MSH can significantly impact implant surgery and the management of associated complications. The maxillary sinus volume can be affected by factors such as infection, trauma, genetic predispositions, and changes within the sinus or adjacent anatomical structures, including the nasal cavity and the ethmoid sinus. In cases of MSH, the maxillary sinus floor is positioned more cranially than the nasal floor, and the distance between the lamina papyracea of the eye and the middle meatus antrostomy point increases horizontally. Several variants of MSH potentially affect implant therapy. Chronic maxillary sinus atelectasis, which results from persistent ostium blockage, may have clinical implications, particularly when implant-related infections occur in the MS. Inferior meatus pneumatization involves a lateral expansion of the nasal cavity, requiring a nasal floor elevation procedure when placing implants in the posterior maxilla. Additionally, the formation of an ethmomaxillary sinus may create a septum-like structure in the distal area of the maxillary sinus, necessitating two separate bone access windows during the sinus floor elevation procedure. Given these considerations, it is crucial for clinicians to be aware of MSH. Accurate diagnosis of MSH requires the use of 3-dimensional radiography techniques, such as cone-beam computed tomography.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From tradition to innovation: a bibliometric analysis of the evolution of periodontal plastic surgery.","authors":"Şeyma Çardakcı Bahar, Özlem Saraç Atagün, Seval Ceylan Şen, Gülbahar Ustaoğlu","doi":"10.5051/jpis.2404620231","DOIUrl":"https://doi.org/10.5051/jpis.2404620231","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to conduct a bibliometric analysis of the periodontal plastic surgery literature to identify trends, research gaps, and key themes within the field and to establish a perspective on documented research.</p><p><strong>Methods: </strong>This bibliometric study examined research outputs on mucogingival surgery indexed in the Web of Science database from 1990 to 2023. The Science Mapping Analysis Tool (SciMAT) software was used to visualize and predict research trends on this topic.</p><p><strong>Results: </strong>An analysis of publication distribution by year revealed a decline in the number of publications between 1984 and 1995, followed by an overall upward trend after 1996 despite occasional decreases. The United States contributed the most with 593 publications, and Wang HL (n=74) was the most prolific author. The most frequently used keyword was \"gingival recession\" (n=625). Overall, the publications received 44,859 citations, averaging 25.49 citations per publication.</p><p><strong>Conclusions: </strong>Researchers have made significant efforts to improve clinical practices and procedures in periodontal plastic surgery, resulting in an increase in studies over recent years. By analyzing thematic maps and clusters-using indicators such as frequency, citations, and centrality-researchers can identify the strengths, weaknesses, and gaps in current research.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 regulates human <i>ODAM</i> gene expression in gingival epithelial cells.","authors":"Zhenyu Jin, Arisa Yamaguchi, Hideki Takai, Yohei Nakayama, Yorimasa Ogata","doi":"10.5051/jpis.2402980149","DOIUrl":"https://doi.org/10.5051/jpis.2402980149","url":null,"abstract":"<p><strong>Purpose: </strong>Odontogenic ameloblast-associated protein (ODAM) is a small secretory protein produced by the junctional epithelium (JE) and mature ameloblasts. It plays a role in odontogenesis and mediates the adhesion of JE to enamel. We used human gingival epithelial cells to evaluate the mechanism of <i>ODAM</i> gene expression regulation in the JE by interleukin (IL)-6.</p><p><strong>Methods: </strong>Ca9-22, Sa3, and HSY cells were stimulated with IL-6 (10 ng/mL), after which total RNA and proteins were extracted. Real-time polymerase chain reaction and Western blot analyses were performed to assess the expression levels of ODAM mRNA and protein. Luciferase (LUC) assays were employed using LUC constructs with varying lengths of the <i>ODAM</i> gene promoter sequence. Gel mobility shift and chromatin immunoprecipitation (ChIP) analyses were conducted to investigate the binding of transcription factors to response elements within the gene promoter.</p><p><strong>Results: </strong>Treatment with IL-6 increased the expressions of ODAM mRNA and protein. Additionally, it induced promoter activity of the <i>ODAM</i> gene, while LUC activity was suppressed by inhibitors of protein kinase A, tyrosine kinase, MEK1/2, phosphatidylinositol 3-kinase, nuclear factor-κB, signal transducer and activator of transcription (STAT) 3, and glycoprotein 130. Gel mobility shift and ChIP analyses revealed that IL-6 induced the binding of yin yang 1 (YY1), CCAAT/enhancer-binding protein (C/EBP) β, GATA binding protein (GATA), and phospho-STAT3 to the YY1, C/EBP, GATA, and interferon-γ activated transcriptional element (GATE) 1-3 elements.</p><p><strong>Conclusions: </strong>These findings indicate that IL-6 upregulates <i>ODAM</i> gene expression by targeting the YY1, C/EBP, GATA, and GATE1-3 elements in the promoter region of the human <i>ODAM</i> gene.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}