Journal of Periodontal and Implant Science最新文献

{"title":"Periodontal health and orthodontic mini-screws: a cross-sectional study.","authors":"Mehmet Selim Yildiz, Pelin Acar Ulutas, Aliye Akcalı","doi":"10.5051/jpis.2503060153","DOIUrl":"https://doi.org/10.5051/jpis.2503060153","url":null,"abstract":"<p><strong>Purpose: </strong>Orthodontic mini-screws (OMSs) are widely used as temporary anchorage devices in orthodontics because they facilitate complex tooth movements without relying on patient compliance. Despite their advantages, concerns have been raised regarding potential adverse effects on periodontal health. This cross-sectional study aimed to assess the relationship between OMS and periodontal parameters in patients undergoing orthodontic treatment.</p><p><strong>Methods: </strong>A total of 132 patients with 160 OMS placements were included. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), recession depth, bleeding on probing (BOP), mucosal discomfort (MD), mucosal redness (MR), keratinized tissue width (KTW), supracrestal tissue height, and transmucosal soft tissue thickness, were evaluated at site-specific and full-mouth levels 3 months post-placement.</p><p><strong>Results: </strong>Significant differences were identified between site-level and full-mouth periodontal measurements, with site-level evaluations revealing higher PI, GI, PD, and BOP values (<i>P</i><0.05). Lower KTW and tension gauge (TG) values were correlated with higher MD and MR (<i>P</i><0.05). Moreover, lower TG values were associated with elevated periodontal inflammation markers, such as PI and PD, at both the site-specific and full-mouth levels (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>These results highlight significant biomechanical and inflammatory interactions between OMS and periodontal tissues, emphasizing the need for meticulous mini-screw placement and careful periodontal monitoring. The findings also underscore the importance of individualized treatment plans that consider periodontal conditions to optimize OMS stability and minimize periodontal risks.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT07052747.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning model for periodontitis based on integrative gene expression analysis: validation in an independent patient cohort.","authors":"Shin-Kyu Lee, Jung-Min Oh, Sae-A Lee, Ji-Young Joo, Hyun-Joo Kim","doi":"10.5051/jpis.2504280214","DOIUrl":"https://doi.org/10.5051/jpis.2504280214","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a gene expression-based prediction model for periodontitis by identifying a compact set of predictive genes and to validate the model using an independent cohort of patient samples analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR).</p><p><strong>Methods: </strong>Using a total of 9 Gene Expression Omnibus (GEO) series, we first performed feature selection through differential expression analysis and SHapley Additive exPlanations (SHAP) values in 2 GEO series (GSE10334 and GSE16134). The remaining datasets were then integrated to construct an extended multi-cohort dataset (680 samples: 193 healthy and 487 with periodontitis) for model development using the XGBoost classifier. An exhaustive search with nested cross-validation (CV) was conducted to identify the optimal gene subset. Model performance was estimated using repeated 10-fold CV and summarized by the area under the receiver operating characteristic curve (AUC) with corresponding standard deviations. Gene-level interpretation was performed using SHAP rankings and univariate analyses. Validation was conducted in a newly collected RT-qPCR patient cohort (n=20; 10 healthy individuals and 10 patients with periodontitis) derived from gingival tissue samples, using z-score-transformed ΔCt values without model retraining.</p><p><strong>Results: </strong>The optimal 4-gene model (tissue inhibitor of metalloproteinases-4 [<i>TIMP4</i>], RNA binding motif protein 25 [<i>RBM25</i>], TLC domain containing 3A [<i>TLCD3A</i>], and TSR1 ribosome maturation factor [<i>TSR1</i>]) achieved an AUC of 0.936±0.031 in repeated 10-fold CV. Among individual genes, <i>TIMP4</i> demonstrated the strongest discriminatory performance (AUC=0.867), followed by <i>TLCD3A</i> (AUC=0.849), <i>TSR1</i> (AUC=0.782), and <i>RBM25</i> (AUC=0.728). In the independent RT-qPCR cohort, the 4-gene model yielded an AUC of 0.790 (95% confidence interval, 0.548-0.979).</p><p><strong>Conclusions: </strong>The compact 4-gene XGBoost model provides reproducible and interpretable prediction of periodontitis across GEO datasets and demonstrates moderate performance in a newly collected RT-qPCR patient cohort, suggesting preliminary cross-platform feasibility. However, the wide confidence intervals underscore the need for larger prospective cohorts to confirm its clinical utility.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of lipopolysaccharide and titanium ions on monocytic myeloid-derived suppressor cell expansion in gingival tissue: implications for peri-implant bone health.","authors":"Eun-Young Jang, Seok Bin Yang, Jung-Mi Lee, Kyu Hwan Kwack","doi":"10.5051/jpis.2504480224","DOIUrl":"https://doi.org/10.5051/jpis.2504480224","url":null,"abstract":"<p><strong>Purpose: </strong>Titanium particles and ions detected in peri-implant tissues have been implicated in crestal bone loss around dental implants. However, their precise effects on adjacent peri-implant structures remain insufficiently understood. This study investigates the impact of foreign body reactions induced by titanium ions on peri-implant bone levels, with a specific focus on monocytic myeloid-derived suppressor cells (M-MDSCs), which have been reported to possess osteoclast precursor potential.</p><p><strong>Methods: </strong>Bone marrow, spleen, and gingival cells were exposed to titanium ions and lipopolysaccharide (LPS) to evaluate M-MDSC differentiation using flow cytometry. In addition, an <i>in vivo</i> mouse model with titanium implants was employed to assess M-MDSC proliferation, phenotypic characteristics, and associated peri-implant bone changes.</p><p><strong>Results: </strong>Titanium ions enhanced the differentiation of M-MDSCs and macrophages from bone marrow-derived precursors. <i>In vitro</i> experiments demonstrated that titanium ions and LPS synergistically increased M-MDSC populations. <i>In vivo</i>, mice with ligature-induced peri-implantitis surrounding titanium implants exhibited a significant increase in M-MDSCs within peri-implant tissues. Notably, these M-MDSCs showed upregulated expression of the osteoclastogenic receptor c-Fms (CD115), indicating a primed state for osteoclast differentiation. This cellular shift was accompanied by a corresponding reduction in peri-implant bone mineral density and bone volume when compared with mice bearing implants alone.</p><p><strong>Conclusions: </strong>Titanium ions and inflammatory stimuli synergistically promote not only the expansion of M-MDSCs but also their osteoclastogenic priming. These findings suggest that primed M-MDSCs may function as key cellular mediators in the pathogenesis of peri-implantitis. Furthermore, they highlight M-MDSCs as a potential therapeutic target for improving implant longevity and underscore the importance of controlling peri-implant inflammation.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pseudo-periosteum on hard and soft tissue regeneration following lateral bone augmentation using a titanium mesh: an experimental <i>in vivo</i> study.","authors":"Seung-Hyun Park, Kyeong-Won Paeng, So-Ra Yoon, Goran I Benic, Daniel S Thoma, Ui-Won Jung, Ronald E Jung","doi":"10.5051/jpis.2504020201","DOIUrl":"https://doi.org/10.5051/jpis.2504020201","url":null,"abstract":"<p><strong>Purpose: </strong>The aims of this study were 1) to evaluate the 16-week bone augmentation outcomes using a titanium mesh (TM), including an 8-week transmucosal healing period following TM removal, and 2) to investigate the impact of pseudo-periosteum formation on regenerative outcomes.</p><p><strong>Methods: </strong>Atrophic alveolar ridge defects were induced in 6 canine mandibles, and 5 peri-implant defects were created in each hemi-mandible. Bone augmentation was attempted using the following randomly allocated modalities: 1) Control: no treatment; 2) TM group: blood clot covered by TM; 3) TM + bone substitute (BS) group: synthetic BS covered by TM; 4) TM + collagen membrane (CM) group: blood clot covered by TM and CM; and 5) TM + BS + CM group: BS covered by TM and CM. TMs were removed after 8 weeks, followed by abutment connection and an additional 8-week healing period. After sacrifice, histomorphometric analyses of hard and soft tissues were conducted.</p><p><strong>Results: </strong>Regardless of early TM exposure (5/30), all implants achieved successful osseointegration and demonstrated comparable bone regeneration outcomes. No significant differences in horizontal or vertical bone gain were observed among the groups, whereas superiority of the TM + BS group over the control group showed a higher augmented bone percentage (<i>P</i>=0.021). The thickness of the pseudo-periosteum was not associated with hard or soft tissue regeneration outcomes.</p><p><strong>Conclusions: </strong>TM removal after 8 weeks did not significantly affect the histologic outcomes of lateral bone augmentation performed with simultaneous implant placement. The presence of a pseudo-periosteum did not adversely influence either hard or soft tissue regenerative outcomes.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations between early ultrasound markers and the outcomes of staged lateral guided bone regeneration.","authors":"Amanda Rodriguez Betancourt, Shan-Huey Yu, Jose Maria Ramos, Maria Masotti, Nataly Zambrana, Oliver Kripfgans, Hsun-Liang Chan","doi":"10.5051/jpis.2403380169","DOIUrl":"https://doi.org/10.5051/jpis.2403380169","url":null,"abstract":"<p><strong>Purpose: </strong>Guided bone regeneration (GBR) is a widely used strategy for augmenting lost jawbone. The extent of bone gain varies among patients and typically remains unknown until after a healing period of 4-6 months. This study aims to demonstrate the use of novel ultrasonography techniques to provide predictive values for bone gain.</p><p><strong>Methods: </strong>This study included 16 subjects with 20 edentulous ridges undergoing GBR for lateral bone deficiencies of 1-3 mm in the posterior mandible. Ultrasound (US) images were captured at the surgical site 10 days postoperatively. Four US-derived parameters were assessed: tissue perfusion, wound approximation, tissue swelling, and bone integrity. Each parameter was categorized as either \"yes\" or \"no.\" These parameters were then correlated with bone gain, measured from pre-intervention and 5-month post-intervention cone-beam computed tomography images.</p><p><strong>Results: </strong>This study assessed 20 sites (mean patient age, 58 years) with resorbable membranes and mixed mineralized/demineralized cortical allografts. The mean bone gain was 1.5 mm (standard deviation, 2.54 mm; range, -4.86 to 7.31 mm). Significantly greater bone gain was observed in cases with favorable wound approximation and biomaterial stability. The multivariate linear regression analysis revealed a significant association between biomaterial stability and bone gain, with an average gain of 4.56 mm (95% confidence interval, 2.28 to 6.84; <i>P</i>=0.001; R²=0.59).</p><p><strong>Conclusions: </strong>These newly developed US parameters could potentially predict bone gain as early as 10 days following GBR. While proper wound approximation is crucial, the stability of biomaterials may ultimately determine the outcome of GBR.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05013580.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profilometric and radiographic analyses after early implant placement in sites with ridge preservation or spontaneous healing: 3-year follow-up of an exploratory randomized controlled trial.","authors":"Nicolas P A Müller, Stefan P Bienz, Sofya Sadilina, Marc Balmer, Ronald E Jung, Daniel S Thoma","doi":"10.5051/jpis.2404280214","DOIUrl":"10.5051/jpis.2404280214","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this exploratory randomized controlled clinical trial was to compare profilometric and radiographic changes following early implant placement in sites treated with alveolar ridge preservation versus spontaneous healing (SH). Additionally, the study aimed to investigate clinical parameters of the implants up to 3 years following crown insertion.</p><p><strong>Methods: </strong>Thirty-five patients exhibiting either intact buccal bone plates or buccal dehiscence of up to 50% after single-tooth extraction of incisors, canines, or premolars were enrolled. Participants were randomly assigned to 1 of 3 groups: 1) deproteinized bovine bone mineral with 10% collagen covered by a collagen matrix (DBBM-C/CM), 2) deproteinized bovine bone mineral with 10% collagen alone (DBBM-C), or 3) SH. Implant placement occurred 8 weeks post-extraction. Profilometric analyses were performed utilizing impressions and digital scans. Patients underwent follow-up assessments for up to 3 years (FU-3Y) after the final crown insertion (fixed dental prosthesis insertion, FDPi).</p><p><strong>Results: </strong>The median contour changes between FDPi and FU-3Y were -0.23 mm for DBBM-C/CM, -0.21 mm for DBBM-C, and -0.33 mm for SH, demonstrating a statistically significant reduction over 3 years in all 3 groups (<i>P</i><0.05). Median radiographic changes observed up to FU-3Y were 0.02 mm for DBBM-C/CM, -0.5 mm for DBBM-C, and -0.18 mm for SH. These radiographic changes were neither statistically significant within groups nor between groups over time (<i>P</i>>0.05). Clinical parameters remained stable throughout the study period in all groups.</p><p><strong>Conclusions: </strong>The FU-3Y of this randomized clinical trial revealed stable clinical parameters and marginal bone levels in all evaluated groups. Although minor contour reductions were noted in all groups, these changes were deemed clinically acceptable.</p><p><strong>Trial registration: </strong>German Clinical Trials Register Identifier: DRKS00009496.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"57-71"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal contact loss between implants loaded for more than 10 years and adjacent teeth.","authors":"Hajin Kim, Jin-Un Yoon, Ju-Youn Lee","doi":"10.5051/jpis.2403300165","DOIUrl":"10.5051/jpis.2403300165","url":null,"abstract":"<p><strong>Purpose: </strong>Recent studies have reported a high long-term success rate of dental implants however, various complications have also been observed, including proximal contact loss (PCL) between the implant and the adjacent teeth. PCL is frequently observed clinically and can potentially harm both the implant and adjacent teeth. This study examined the prevalence of PCL between implants that had functioned for more than 10 years and adjacent teeth in Korean patients, particularly those with a history of periodontal disease.</p><p><strong>Methods: </strong>Fixed dental implants placed at the Department of Periodontics, Pusan National University Dental Hospital, were selected for this study. All implants selected had been functioning for more than 10 years, with at least 1 adjacent natural tooth in the mesial or distal position. Patient-, implant-, and tooth-related factors were evaluated. The chi-square test and Fisher exact test were used to assess the associations of PCL with these factors, with all statistical analyses performed using SPSS 29.0 and a significance level of 0.05.</p><p><strong>Results: </strong>This study included 142 implants and 188 adjacent teeth from 101 patients. The overall PCL rate was 53.7%, with 65.6% occurring on the mesial aspect, and 28.3% on the distal aspect. Among the factors analyzed in relation to PCL, implant placement in the molar region and several adjacent tooth-related factors namely plaque accumulation, mobility, bleeding on probing, and pocket depth of 4mm or greater were significantly associated with PCL (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Dental implants functioning for more than 10 years exhibited a high incidence of PCL, exceeding 50%, which occurred more frequently on the mesial side than on the distal side. Additionally, implant positioning in the posterior region and poor periodontal condition of the adjacent teeth were significantly correlated with PCL.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 1","pages":"31-38"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International collaboration as a shared path forward.","authors":"Seung-Yun Shin","doi":"10.5051/jpis.265601edi01","DOIUrl":"10.5051/jpis.265601edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 1","pages":"1-2"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.","authors":"Xianjun Lu, Zijian Yuan, Wenling Huang, Jingjing Liu, Baoqi Chen, Lihong Guo","doi":"10.5051/jpis.2402200110","DOIUrl":"10.5051/jpis.2402200110","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis is a chronic disease that ultimately leads to tooth loss. This study aimed to investigate the inflammatory effects of short-chain fatty acids (SCFAs) on human periodontal ligament cells (hPDLCs).</p><p><strong>Methods: </strong>Immunofluorescence was employed to assess the expression of G protein-coupled receptors (GPRs) in hPDLCs. The Cell Counting Kit-8 and enzyme-linked immunosorbent assay kits were utilized to examine the regulatory effects of SCFAs on both the proliferation and secretion of pro-inflammatory factors in hPDLCs. Western blot analysis was performed to investigate the potential inflammatory responses in hPDLCs induced by SCFAs.</p><p><strong>Results: </strong>GPR41 was expressed on the surface of hPDLCs. The viability of hPDLCs was significantly reduced after exposure to both 7 mM butyric acid and 10 mM propionic acid. Additionally, a combination of 10 mM butyric acid and 10 mM propionic acid significantly increased the production of interleukin (IL)-6, IL-1β, and tumor necrosis factor-α in hPDLCs. Treatment with both 7 mM butyric acid and 10 mM propionic acid led to a significant increase in p65 phosphorylation in hPDLCs. There was no statistical difference in proliferation and pro-inflammatory effects after the addition of a GPR41 receptor inhibitor compared to the phosphate-buffered saline control.</p><p><strong>Conclusions: </strong>Butyric acid and propionic acid exhibited a synergistic effect in inhibiting the proliferation of hPDLCs and enhancing their pro-inflammatory responses. This may be mediated through the activation of GPR41. Additionally, these acids could synergistically activate the nuclear factor-κB signaling pathway via GPR41 in hPDLCs.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"19-30"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.","authors":"Young Woo Song, Jin-Young Park, Ui-Won Jung, Wan Zhen Lee, Daniel S Thoma, Nadja Naenni","doi":"10.5051/jpis.2500440022","DOIUrl":"10.5051/jpis.2500440022","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to clinically and radiographically investigate the effect of soft tissue grafting as an adjunct in the surgical treatment of ligature-induced peri-implantitis lesions in canines.</p><p><strong>Methods: </strong>Seven Mongrel dogs received implant placements on both sides of the posterior mandible (3 fixtures per side). After inducing peri-implantitis via ligation with suture material, surgical treatment was performed on each implant according to randomly assigned groups: DI, implantoplasty only; DIB, implantoplasty followed by collagenated, deproteinized bovine bone mineral (DBBM-C) grafting; DIC, implantoplasty followed by autogenous connective tissue graft (CTG); DIV, implantoplasty followed by volume-stable collagen matrix (VCMX) grafting; DIBC, implantoplasty followed by DBBM-C grafting and CTG; and DIBV, implantoplasty followed by DBBM-C and VCMX grafting. Clinical and radiographic outcomes were evaluated. Composite treatment success was defined by the following criteria: absence of bleeding on probing at 12 weeks post-surgery; a reduction in probing depth (PD) or an increase of 1 mm or less in PD at 12 weeks post-surgery; and absence of additional bone loss ≥0.5 mm at 12 weeks post-surgery compared to radiographic baseline. Statistical significance was set at <i>P</i><0.05.</p><p><strong>Results: </strong>All groups exhibited clinical and radiographic improvement after surgery. Clinical parameters, radiographic bone levels, and mucosal thickness did not significantly differ among the groups. The DI and DIV groups demonstrated higher composite treatment success rates (71.4%) compared to the other 4 groups. Adjunctive soft tissue grafting resulted in fewer changes in peri-implant mucosa. The effect of hard tissue grafting on bone regeneration was minimal, and combining hard and soft tissue grafting did not yield better outcomes than implantoplasty alone.</p><p><strong>Conclusions: </strong>The surgical treatment of peri-implantitis lesions remains challenging. Soft tissue grafting showed clinical benefits by reducing changes in the peri-implant mucosa. The effect of hard tissue grafting on bone regeneration was very limited.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"39-56"},"PeriodicalIF":3.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12962818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}