Journal of Periodontal and Implant Science最新文献

{"title":"Periodontal health and orthodontic mini-screws: a cross-sectional study.","authors":"Mehmet Selim Yildiz, Pelin Acar Ulutas, Aliye Akcalı","doi":"10.5051/jpis.2503060153","DOIUrl":"10.5051/jpis.2503060153","url":null,"abstract":"<p><strong>Purpose: </strong>Orthodontic mini-screws (OMSs) are widely used as temporary anchorage devices in orthodontics because they facilitate complex tooth movements without relying on patient compliance. Despite their advantages, concerns have been raised regarding potential adverse effects on periodontal health. This cross-sectional study aimed to assess the relationship between OMS and periodontal parameters in patients undergoing orthodontic treatment.</p><p><strong>Methods: </strong>A total of 132 patients with 160 OMS placements were included. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), recession depth, bleeding on probing (BOP), mucosal discomfort (MD), mucosal redness (MR), keratinized tissue width (KTW), supracrestal tissue height, and transmucosal soft tissue thickness, were evaluated at site-specific and full-mouth levels 3 months post-placement.</p><p><strong>Results: </strong>Significant differences were identified between site-level and full-mouth periodontal measurements, with site-level evaluations revealing higher PI, GI, PD, and BOP values (<i>P</i><0.05). Lower KTW and tension gauge (TG) values were correlated with higher MD and MR (<i>P</i><0.05). Moreover, lower TG values were associated with elevated periodontal inflammation markers, such as PI and PD, at both the site-specific and full-mouth levels (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>These results highlight significant biomechanical and inflammatory interactions between OMS and periodontal tissues, emphasizing the need for meticulous mini-screw placement and careful periodontal monitoring. The findings also underscore the importance of individualized treatment plans that consider periodontal conditions to optimize OMS stability and minimize periodontal risks.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT07052747.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"297-307"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between periodontal disease severity and the risk of medication-related osteonecrosis of the jaw: a systematic review and meta-analysis by the Korean Academy of Periodontology.","authors":"Jae-Hong Lee, Yun-Jeong Kim, Young Woo Song, Sungtae Kim, Jong-Hyuk Chung, Yang-Jo Seol, Hyo-Jung Lee","doi":"10.5051/jpis.2602140107","DOIUrl":"10.5051/jpis.2602140107","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis quantitatively synthesized the available evidence on the association between periodontal disease (PD) and the risk of medication-related osteonecrosis of the jaw (MRONJ). We also examined whether MRONJ risk varied according to PD severity among patients receiving antiresorptive or antiangiogenic therapy.</p><p><strong>Methods: </strong>MEDLINE, Web of Science, Embase, Scopus, and Google Scholar were comprehensively searched for studies published through November 30, 2025, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible studies were required to provide a reproducible definition of PD based on clinical, radiographic, guideline-based, or predefined administrative-code criteria. Studies relying on non-operationalized clinical labels without sufficient diagnostic detail were excluded. A random-effects meta-analysis was performed using log-transformed relative-effect estimates and their standard errors. To address heterogeneity in exposure definitions, studies were stratified into a severe/procedure-linked group and a moderate-to-mixed group.</p><p><strong>Results: </strong>Eight observational studies met the eligibility criteria and were included in the quantitative synthesis. The primary meta-analysis showed a statistically significant association between PD and MRONJ, indicating that patients with PD had an approximately threefold higher risk of developing MRONJ than those without PD (pooled relative-effect estimate, 3.02; 95% confidence interval [CI], 1.99-4.56). In subgroup analyses, the severe/procedure-linked group had a higher pooled relative-effect estimate (4.26; 95% CI, 1.96-9.24) than the moderate-to-mixed group (2.39; 95% CI, 1.45-3.94). However, the between-subgroup difference was not statistically significant; therefore, the subgroup findings should be interpreted as exploratory.</p><p><strong>Conclusions: </strong>Current evidence supports an association between PD and increased MRONJ risk in patients receiving antiresorptive or antiangiogenic therapy. Although the subgroup findings suggest that more advanced periodontal breakdown may be associated with greater risk, this severity-based pattern should be interpreted cautiously and confirmed in future studies with larger sample sizes and standardized diagnostic criteria.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 4","pages":"269-283"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148876100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial wound healing following interrupted closing sutures with versus without tension-relieving mattress suture in guided bone regeneration: a preliminary randomized clinical trial.","authors":"Gwan-Jung Kim, Yon-Soo Joo, Dong-Woon Lee, Jung-Seok Lee","doi":"10.5051/jpis.2504900245","DOIUrl":"10.5051/jpis.2504900245","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective clinical study aimed to evaluate whether adding a tension-relieving horizontal mattress suture to simple interrupted sutures influences the occurrence and severity of postoperative wound dehiscence in horizontal guided bone regeneration (GBR) procedures.</p><p><strong>Methods: </strong>Forty patients requiring horizontal GBR, either prior to or simultaneous with implant placement, were randomly allocated to 2 groups. Group \"S\" received simple interrupted sutures only, whereas group \"S+H\" received additional horizontal mattress sutures placed prior to interrupted sutures to relieve flap tension. At 2 weeks postoperatively, wound dehiscence width (DW), wound dehiscence length (DL), and the wound dehiscence length/incision-line ratio (DL/i) were measured. The occurrence rate of any dehiscence was also recorded. DW was designated as the primary outcome, whereas DL, DL/i, and dehiscence occurrence were secondary outcomes. Statistical analyses included the Shapiro-Wilk test for normality, the Mann-Whitney <i>U</i> test for comparisons of DW and DL, and the χ² test for dehiscence occurrence. A significance level of <i>P</i><0.05 was applied.</p><p><strong>Results: </strong>No statistically significant differences were observed between the groups for DW (group S: 2.92±2.73 mm; group S+H: 2.17±2.51 mm), DL (group S: 5.32±5.49 mm; group S+H: 4.37±4.65 mm), or DL/i (group S: 0.42±0.41; group S+H: 0.34±0.38) (all <i>P</i>>0.05). The occurrence rate of wound dehiscence was 60% in group S and 55% in group S+H, with no statistically significant difference between groups (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>Both simple interrupted sutures alone and simple interrupted sutures combined with an additional tension-relieving horizontal mattress suture may be considered clinically acceptable approaches for achieving primary closure in horizontal GBR procedures.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0010574.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"324-337"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning model for periodontitis based on integrative gene expression analysis: validation in an independent patient cohort.","authors":"Shin-Kyu Lee, Jung-Min Oh, Sae-A Lee, Ji-Young Joo, Hyun-Joo Kim","doi":"10.5051/jpis.2504280214","DOIUrl":"10.5051/jpis.2504280214","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a gene expression-based prediction model for periodontitis by identifying a compact set of predictive genes and to validate the model using an independent cohort of patient samples analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR).</p><p><strong>Methods: </strong>Using a total of 9 Gene Expression Omnibus (GEO) series, we first performed feature selection through differential expression analysis and SHapley Additive exPlanations (SHAP) values in 2 GEO series (GSE10334 and GSE16134). The remaining datasets were then integrated to construct an extended multi-cohort dataset (680 samples: 193 healthy and 487 with periodontitis) for model development using the XGBoost classifier. An exhaustive search with nested cross-validation (CV) was conducted to identify the optimal gene subset. Model performance was estimated using repeated 10-fold CV and summarized by the area under the receiver operating characteristic curve (AUC) with corresponding standard deviations. Gene-level interpretation was performed using SHAP rankings and univariate analyses. Validation was conducted in a newly collected RT-qPCR patient cohort (n=20; 10 healthy individuals and 10 patients with periodontitis) derived from gingival tissue samples, using z-score-transformed ΔCt values without model retraining.</p><p><strong>Results: </strong>The optimal 4-gene model (tissue inhibitor of metalloproteinases-4 [<i>TIMP4</i>], RNA binding motif protein 25 [<i>RBM25</i>], TLC domain containing 3A [<i>TLCD3A</i>], and TSR1 ribosome maturation factor [<i>TSR1</i>]) achieved an AUC of 0.936±0.031 in repeated 10-fold CV. Among individual genes, <i>TIMP4</i> demonstrated the strongest discriminatory performance (AUC=0.867), followed by <i>TLCD3A</i> (AUC=0.849), <i>TSR1</i> (AUC=0.782), and <i>RBM25</i> (AUC=0.728). In the independent RT-qPCR cohort, the 4-gene model yielded an AUC of 0.790 (95% confidence interval, 0.548-0.979).</p><p><strong>Conclusions: </strong>The compact 4-gene XGBoost model provides reproducible and interpretable prediction of periodontitis across GEO datasets and demonstrates moderate performance in a newly collected RT-qPCR patient cohort, suggesting preliminary cross-platform feasibility. However, the wide confidence intervals underscore the need for larger prospective cohorts to confirm its clinical utility.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"284-296"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical agreement between scale-aligned damping capacity and resonance frequency analyses for implant stability: a retrospective method-comparison study.","authors":"Gwang-Young Jung, Inpyo Hong, Nicolas P A Müller, Franz J Strauss, Jung-Seok Lee","doi":"10.5051/jpis.2505340267","DOIUrl":"10.5051/jpis.2505340267","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the clinical agreement between resonance frequency analysis (RFA) and 2 scale-aligned damping capacity analysis (DCA) devices for assessing implant stability.</p><p><strong>Methods: </strong>In this retrospective method-comparison study (890 implants from 600 patients), implant stability was measured at up to 4 time points (T0-T3) using 1 RFA device and 2 DCA devices. Correlations between devices were assessed using Pearson's correlation coefficient. Agreement was evaluated using modified Bland-Altman analysis, and diagnostic accuracy was determined using receiver operating characteristic (ROC) curve analysis with an implant stability quotient threshold of 70. Changes in stability according to initial torque and simultaneous guided bone regeneration (GBR) or sinus grafting were analyzed using non-parametric statistical methods.</p><p><strong>Results: </strong>Significant moderate positive correlations were observed between RFA and each DCA device (<i>r</i>≈0.4; <i>P</i><0.001), and a strong correlation was observed between the 2 DCA devices (<i>r</i>=0.7; <i>P</i><0.001). Modified Bland-Altman analysis revealed systematic discrepancies, with DCA devices tending to overestimate stability in lower stability ranges relative to RFA. ROC analysis demonstrated fair diagnostic accuracy for both DCA devices (area under the curve≈0.70). Initial insertion torque and simultaneous GBR significantly influenced early implant stability; however, these differences diminished after 3 months.</p><p><strong>Conclusions: </strong>Scale-aligned DCA devices demonstrated acceptable clinical agreement and fair diagnostic accuracy relative to RFA. However, systematic discrepancies between DCA and RFA were observed, particularly in implants with lower stability. Clinicians should therefore interpret DCA measurements with caution in such cases.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"338-350"},"PeriodicalIF":3.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-specific plasma levels of IL-17 and Del-1 and their response to nonsurgical periodontal treatment.","authors":"Eunkyoung Kim, Ji-Young Joo, Jung-Min Oh, Ju-Youn Lee, Shin-Kyu Lee, Hyun-Joo Kim","doi":"10.5051/jpis.2600760038","DOIUrl":"https://doi.org/10.5051/jpis.2600760038","url":null,"abstract":"<p><strong>Purpose: </strong>Interleukin-17 (IL-17) and developmental endothelial locus-1 (Del-1) are involved in neutrophil transendothelial migration in periodontitis. This study compared plasma IL-17 and Del-1 levels according to periodontitis severity and evaluated the effects of nonsurgical periodontal treatment on their concentrations.</p><p><strong>Methods: </strong>This study included 89 patients with periodontitis: 26 with stage I, 32 with stage II, and 31 with stage III disease. Blood collection and clinical periodontal examinations were performed at baseline. Patients received nonsurgical periodontal treatment and oral hygiene instructions over 2 or 4 visits. At 4-6 weeks after treatment, 48 patients, with 16 in each stage group, returned for follow-up blood collection and clinical periodontal examination. Plasma IL-17 and Del-1 levels were measured using enzyme-linked immunosorbent assays. The χ² test, one-way analysis of variance followed by Duncan's test, and the paired <i>t</i>-test were used. Pearson correlation coefficients were calculated to analyze correlations among IL-17, Del-1, and other variables.</p><p><strong>Results: </strong>As periodontitis severity increased, IL-17 levels increased significantly, whereas Del-1 levels decreased significantly (<i>P<</i>0.001). After periodontal treatment, IL-17 levels decreased in all stages, and Del-1 levels increased except in stage I. The increase in Del-1 level was significant in stage III (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>IL-17 and Del-1 may be candidate biomarkers of periodontitis severity. The observed changes after nonsurgical periodontal treatment also suggest that plasma IL-17 and Del-1 levels may reflect treatment response.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar ridge preservation using an intentionally exposed xenogeneic collagen matrix seal in sockets with varying proportions of vertical bone resorption: a pilot study.","authors":"Xinyi Zhou, Yuping Hong, Yang Yang, Hyun-Chang Lim, Yingying Wu, Yi Man","doi":"10.5051/jpis.2500240012","DOIUrl":"https://doi.org/10.5051/jpis.2500240012","url":null,"abstract":"<p><strong>Purpose: </strong>This pilot study investigated the effects of different extraction-socket bone-resorption patterns on alveolar ridge preservation (ARP) performed with an open-wound healing technique.</p><p><strong>Methods: </strong>Sites were divided into two groups according to cone-beam computed tomography (CBCT) findings obtained immediately after ARP surgery (T1): group 1 included sockets with vertical bone resorption >1/3 of the buccal/labial or lingual/palatal bone wall, and group 2 included sockets with vertical bone resorption ≤1/3 of the buccal/labial and lingual/palatal bone walls. Follow-up CBCT was performed approximately 5 months after surgery (T3). Hard-tissue changes were measured by superimposing CBCT images obtained at T0 (before tooth extraction), T1, and T3. Soft-tissue healing was evaluated at suture removal (T2), and biopsy specimens were collected before implant placement.</p><p><strong>Results: </strong>Sixteen participants with 19 sites completed this pilot study. All included patients underwent ARP with an intentionally exposed xenogeneic collagen matrix seal; however, one patient did not undergo implant-placement surgery at our hospital. Overall, CBCT measurements of ridge alterations showed excellent intra-rater reliability and minimal systematic bias. Bone resorption occurred in both groups (<i>P</i><0.05), reflecting the natural bone-remodeling process. However, no intergroup differences were observed in horizontal or vertical dimensional changes. In addition, locally estimated scatterplot smoothing analysis identified bootstrap median inflection points below the 1/3 threshold, suggesting a possible nonlinear relationship between the vertical resorption proportion and three-dimensional changes. No statistically significant differences were observed in soft-tissue healing or implant-related outcomes. Histomorphometric evaluation of biopsy specimens showed new bone formation without signs of inflammation or fibrous encapsulation.</p><p><strong>Conclusions: </strong>Within the limitations of this study, intentionally exposing the xenogeneic collagen matrix seal yielded comparable outcomes in non-contained and contained sockets. This finding may reflect the material's ability to reduce the adverse effects of socket-wall resorption; however, larger multicenter studies are warranted.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry Identifier: ChiCTR2300078331.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review by the Korean Academy of Periodontology on collagen matrices for peri-implant soft tissue augmentation.","authors":"Jin-Young Park, Young Woo Song, Sungtae Kim, Jong-Hyuk Chung, Yang-Jo Seol, Hyun-Chang Lim","doi":"10.5051/jpis.2601940097","DOIUrl":"https://doi.org/10.5051/jpis.2601940097","url":null,"abstract":"<p><p>This narrative review critically evaluates clinical and histological evidence on peri-implant soft tissue augmentation with xenogeneic collagen-based soft tissue substitutes. Particular attention is given to mucosal thickness (MT) and supracrestal tissue height (STH), with the goal of developing evidence-based clinical recommendations. A narrative literature review was conducted using preclinical and clinical studies that examined MT and STH augmentation around dental implants. The outcomes of interest were changes in MT, soft tissue contour, STH, peri-implant bone levels, keratinized tissue width, esthetic outcomes, histological findings, and patient-reported outcome measures. Because study design, surgical protocols, healing approaches, and outcome-assessment methods differed substantially across studies, the evidence was synthesized qualitatively. Several xenogeneic collagen-based soft tissue substitutes have been evaluated, but the amount and quality of evidence vary by material. Collagen-based substitutes generally increased MT, with the greatest dimensional change occurring during early healing and relative stability thereafter. Autogenous connective tissue grafts (CTGs) usually produced larger MT gains and showed greater predictability. Evidence for the use of substitutes to increase STH was sparse and methodologically heterogeneous, precluding firm conclusions. When esthetic outcomes and patient satisfaction were reported, findings were generally comparable between CTGs and collagen matrices. Collagen matrices were also associated with shorter surgical time and lower patient morbidity. CTGs remain the gold standard when the clinical goal is to maximize peri-implant MT and STH stability. Xenogeneic collagen-based soft tissue substitutes are clinically acceptable alternatives in selected cases. Further well-designed clinical trials using standardized outcome measures, especially for STH, are needed to clarify the role of collagen matrices in peri-implant soft tissue augmentation.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethylene glycol-chitosan hydrogel as a clinician-friendly alternative to collagen membranes for guided tissue regeneration of class II furcation defects: a preclinical pilot study.","authors":"Inpyo Hong, Seung-Hyun Park, Young Woo Song, So-Ra Yoon, Jin-Young Park, Jae-Kook Cha, Ui-Won Jung","doi":"10.5051/jpis.2601920096","DOIUrl":"https://doi.org/10.5051/jpis.2601920096","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluated the regenerative potential of a novel polyethylene glycol (PEG)-chitosan hydrogel as an alternative to a conventional collagen membrane for guided tissue regeneration (GTR) of class II furcation defects in a canine model.</p><p><strong>Methods: </strong>Standardized class II furcation defects were created in the maxillary third and fourth premolars of 6 beagle dogs. Sites were randomly allocated to 4 groups: 1) sham control, 2) particulate biphasic calcium phosphate (BCP) with a cross-linked collagen membrane (O3CM), 3) collagenated BCP with a collagen membrane (O3ColCM), and 4) particulate BCP with PEG-chitosan hydrogel (O3TG). After 8 weeks, specimens were processed for histological and histomorphometric analyses. The primary outcome was hard tissue area (HTA) within a predefined 3-mm region of interest.</p><p><strong>Results: </strong>Histologically, O3TG showed consolidated graft particles in close contact with the surrounding tissues and new bone formation extending coronally from the defect base, with no notable inflammatory response. Histomorphometric analysis revealed no statistically significant differences among the groups. Median HTA values ranged from 1.55 mm² in O3TG to 1.92 mm² in the control group (<i>P</i>=0.997). The non-filled area tended to be smaller in O3CM (0.68 mm²) and O3TG (0.66 mm²) than in the control group (1.14 mm²) and O3ColCM (1.58 mm²), although the difference was not statistically significant (<i>P</i>=0.258).</p><p><strong>Conclusions: </strong>Within the limitations of this study, PEG-chitosan hydrogel achieved regenerative outcomes comparable to those of collagen membrane-based GTR while stabilizing BCP particles without adverse inflammation. Given its ease of handling and biocompatibility, PEG-chitosan hydrogel may represent a clinician-friendly alternative to collagen membranes for periodontal regeneration in class II furcation defects.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiographic comparison of minimally invasive nonsurgical and surgical approaches with enamel matrix derivatives in periodontal intrabony defects: a 3-arm randomized clinical trial.","authors":"Seung-Hyun Park, Da-Mi Kim, Young Woo Song, Jin-Young Park, Ui-Won Jung","doi":"10.5051/jpis.2505660283","DOIUrl":"https://doi.org/10.5051/jpis.2505660283","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the clinical and radiographic efficacy of nonsurgical treatment with enamel matrix derivative (EMD), EMD-assisted surgical treatment, and nonsurgical treatment alone for intrabony defects.</p><p><strong>Methods: </strong>Sixty patients with intrabony defects were randomly assigned to one of the following groups: (i) nonsurgical subgingival debridement alone (negative control [NC]), (ii) minimally invasive surgical technique (MIST) with EMD application (positive control [PC]), or (iii) nonsurgical subgingival debridement with EMD application (test group). Clinical and radiographic measurements, along with optical impressions, were obtained at baseline and during the 6-month follow-up period.</p><p><strong>Results: </strong>All 60 patients completed the trial, with 20 participants in each group. The proportion of patients achieving the composite outcome (final probing pocket depth ≤4 mm and reduction in clinical attachment loss ≥3 mm) did not differ significantly among the groups (NC: 9/20; PC: 8/20; test: 11/20; <i>P</i> = 0.626). However, bleeding on probing was significantly lower in the test group than in the PC group at both 3 and 6 months (<i>P</i>=0.029 for both timepoints). Gingival recession assessed using optical impressions demonstrated mean changes from baseline of 0.24±0.27 mm, 0.51±0.56 mm, and 0.20±0.18 mm at 6 months in the NC, PC, and test groups, respectively, with significant intergroup differences over time (<i>P</i>=0.038). The amount of radiographic bone gain did not differ significantly among the groups (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>The nonsurgical application of EMD resulted in clinical and radiographic improvements comparable to those achieved with EMD-assisted MIST procedures.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0007436.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}