Journal of Periodontal and Implant Science最新文献

{"title":"Modified tunnel technique with and without enamel matrix derivative for deep and narrow gingival recession in the mandibular anterior region: a 3-year longitudinal and retrospective cohort population-based study.","authors":"Jae-Hong Lee, Yeon-Tae Kim","doi":"10.5051/jpis.2400760038","DOIUrl":"https://doi.org/10.5051/jpis.2400760038","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to evaluate the 3-year predictability and validity of the modified tunnel technique, both with and without the use of enamel matrix derivative (EMD), for treating deep and narrow gingival recession defects (GRDs) in the mandibular anterior region.</p><p><strong>Methods: </strong>Overall, 31 GRDs were treated using the modified tunnel technique combined with subepithelial connective tissue graft. The cohort was divided into 2 groups: one with the adjunctive use of EMD (n=16) and the other without EMD (n=15). Clinical outcomes, including recession depth (RD), keratinized tissue width (KTW), mean root coverage (MRC), and complete root coverage (CRC), were evaluated at baseline, as well as at 6 months, 1 year, and 3 years postoperatively. Patient discomfort was assessed with a self-report questionnaire 2 weeks after surgery.</p><p><strong>Results: </strong>At the 3-year follow-up, no statistically significant differences were observed between the 2 treatment modalities in clinical parameters, including RD (EMD, -6.47±2.23 mm; non-EMD, -5.10±3.23 mm), KTW (EMD, 1.03±0.96 mm; non-EMD, 1.00±1.02 mm), MRC (EMD, 86.62%±21.18%; non-EMD, 80.24%±38.73%), and CRC (EMD, 62.5%; non-EMD, 73.3%). Furthermore, no significant differences were found between the groups in terms of early and subjective postoperative discomfort, including pain and swelling.</p><p><strong>Conclusions: </strong>Within the limitations of this study, the modified tunnel technique, whether used alone or in conjunction with EMD, demonstrated benefits in the treatment and maintenance of deep and narrow GRDs.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure, biology, and function of peri-implant soft tissues in health and disease: a comprehensive review of the literature.","authors":"Néstor Ríos-Osorio, Luis Gabriel Ladino, Mario Guerrero-Torres","doi":"10.5051/jpis.2402080104","DOIUrl":"https://doi.org/10.5051/jpis.2402080104","url":null,"abstract":"<p><p>The morphogenesis of peri-implant soft tissues following surgical trauma, along with the nature, topography, and design of implant-prosthetic material surfaces, leads to peri-implant tissues that exhibit unique histological and morphological characteristics. It has been shown that mucosal phenotypes with a mucosal thickness of at least 2 mm and a keratinised mucosa width of at least 2 mm promote proper integration and a biological seal at the mucosa-implant interface. This seal prevents pathogen penetration, protects the underlying peri-implant bone, and reduces susceptibility to inflammatory peri-implant diseases (IPDs). Furthermore, even under ideal conditions, peri-implant soft tissues demonstrate less mechanical resistance, stability, and hermeticity compared to periodontal tissues. These deficiencies are directly associated with both the onset and progression of IPDs such as peri-implant mucositis (PM) and peri-implantitis (PI). Over recent decades, the prevalence of PM and PI has risen, making them the primary causes of implant failure. Given that the characteristics of peri-implant mucosa are closely linked to the progression of these diseases, a deep understanding of the biology of peri-implant soft tissues is crucial for developing strategies to either avoid or minimise the impact of IPDs on implant therapy outcomes. This comprehensive review of the literature aims to provide a precise and detailed description of the structure, biology, and function of peri-implant soft tissues, starting from their formation process and linking their morphogenic characteristics to the establishment and evolution of IPDs. Additionally, the composition of the microbiome and the most relevant anti/pro-inflammatory mediators involved in the development of IPDs are summarised.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of flap tension with flap design and graft volume in soft tissue augmentation: a cadaveric study in pigs.","authors":"Miha Pirc, Leonardo Mancini, Nicolas Müller, Hyun-Chang Lim, Ronald E Jung, Daniel S Thoma, Stefan P Bienz","doi":"10.5051/jpis.2402540127","DOIUrl":"https://doi.org/10.5051/jpis.2402540127","url":null,"abstract":"<p><strong>Purpose: </strong>This study was performed to evaluate the effects of flap design, grafting material, and graft dimension on flap tension and the initial volume increase achieved in soft tissue augmentation.</p><p><strong>Methods: </strong>Six fresh porcine jaw cadavers were used in this study. Each side of the jaw was randomly assigned to receive either a standard split-thickness flap or a split-thickness flap with a palatal island. Following flap preparation, random allocation was employed to determine the order of 4 treatment modalities: 3 mm of a volume-stable collagen matrix (VCMX), 6 mm VCMX, 3 mm of a subepithelial connective tissue graft (SCTG), and 6 mm SCTG. Flap tension was measured and the wound was closed after the insertion of each specimen. Intraoral scans were taken before flap preparation and after closure to facilitate profilometric analysis.</p><p><strong>Results: </strong>The palatal island flap exhibited significantly greater overall (<i>P</i>=0.010) and crestal (<i>P</i>=0.007) volume gains compared to the split-thickness flap, regardless of the use of VCMX or SCTG. The palatal island flap was associated with significantly lower flap tension force values (0.6 N; <i>P</i>=0.035) than the split-thickness flap. Both materials (VCMX and SCTG) demonstrated comparable volume gains.</p><p><strong>Conclusions: </strong>The findings of this cadaveric study indicate that the use of a palatal island flap effectively reduces flap tension. While both materials (VCMX and SCTG) yielded similar increases in volume, the palatal island flap demonstrated greater volume gains than the split-thickness flap for each grafting material.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> evaluation of prosthesis-level implant stability using 'BracketPeg'.","authors":"Hyunkyung Kim, Gwanhwi Noh, Hyunjae Kim, Hee-Seung Han, Sungtae Kim, Young-Dan Cho","doi":"10.5051/jpis.2403620181","DOIUrl":"https://doi.org/10.5051/jpis.2403620181","url":null,"abstract":"<p><strong>Purpose: </strong>A small magnetic peg, named \"BracketPeg,\" has been developed as an attachment magnet for implant prostheses. This study aimed to determine the feasibility of measuring implant stability at the prosthesis level, evaluate the reliability and accuracy of BracketPeg, and examine the consistency of measurements obtained using other devices for damping capacity assessment (DCA) and resonance frequency analysis (RFA).</p><p><strong>Methods: </strong>Forty implants were installed into artificial bone blocks, with each block representing 1 of 4 different diameters (3.5, 4.0, 4.5, and 5.5 mm; 10 implants per diameter). Each implant was paired with a customized zirconia prosthesis that matched the implant diameter. Implant stability was measured at both the fixture and prosthesis levels using Anycheck™ (Neobiotech) for DCA and Osstell™ Beacon (W&H) and ChecQ™ (Dentis) for RFA. To obtain prosthesis-level measurements using RFA devices, BracketPeg was attached to the coronal, middle, and apical thirds of the prosthesis to evaluate implant stability.</p><p><strong>Results: </strong>The implant stability quotient (ISQ) was significantly lower at the prosthesis level than at the fixture level (<i>P</i><0.001), reflecting the impact of the increased mass and size of the prosthesis. RFA values varied depending on the position of BracketPeg, with lower stability values observed at the coronal position than at the apical position. The 2 RFA devices demonstrated reasonable agreement between ISQ measurements, with a mean difference of -0.58 (95% confidence interval: ±0.31).</p><p><strong>Conclusions: </strong>BracketPeg provides reliable and consistent implant stability measurements at the prosthesis level compared to other devices, making it a practical and feasible tool for the clinical evaluation of implants.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of partial-mouth periodontal examinations for diagnosing periodontal disease.","authors":"Bohee Kang, Jae Suk Jung, Sunjin Kim, Geum Hee Choi, Heelim Lee, Bumhee Park, Hyelynn Jeon, Suk Ji","doi":"10.5051/jpis.2403400170","DOIUrl":"https://doi.org/10.5051/jpis.2403400170","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the reliability of partial-mouth periodontal examinations (PMPEs) for 1) identifying the presence of periodontitis, 2) staging periodontal disease, and 3) reflecting mean clinical parameters.</p><p><strong>Methods: </strong>All patients were diagnosed using 8 different exam types: (A) full-mouth periodontal examination (FMPE), (B) Community Periodontal Index of Treatment Needs (CPITN) codes, (C) panoramic radiographs only, (D) clinical parameters only, (E) 6 teeth, including the first molar (#11, #16, #26, #31, #36, #46), (F) CPITN index teeth (#11, #16, #17, #26, #27, #31, #36, #37, #46, #47), (G) Ramfjord teeth (#16, #21, #24, #36, #41, #44), and (H) 10 modified Ramfjord teeth, including all first premolars and first molars (#16, #14, #21, #24, #26, #36, #34, #41, #44, #46). Case definitions were established according to the criteria outlined in the 2018 American Academy of Periodontology/European Federation of Periodontology classification of periodontal diseases. The accuracy of diagnosis and diagnostic performance were assessed using the kappa coefficient and area under the curve (AUC)/receiver operating characteristic analyses, respectively. To compare the mean clinical parameters, intraclass correlation coefficients (ICCs) were calculated between 4 types of PMPEs (E, F, G, H) and FMPE.</p><p><strong>Results: </strong>In total, 218 subjects (130 female, 88 male) were included in this study. Exam type F achieved perfect agreement (kappa coefficient: 1.0) in identifying the presence of periodontitis, and it showed almost perfect agreement in staging periodontal disease (0.85≤ kappa ≤0.98) except for the healthy category, with AUCs ≥0.97. Exam type H demonstrated the highest correlations of all mean clinical parameters with FMPE (ICCs ≥0.96).</p><p><strong>Conclusions: </strong>PMPEs using the CPITN index teeth can be an excellent alternative for diagnosing periodontitis and staging its severity.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral health and handgrip strength: a systematic review.","authors":"Gargi Sarode, Aishwarya Joshi, Shruti Singh, Namrata Sengupta, Rahul Anand, Vini Mehta, Sachin Sarode","doi":"10.5051/jpis.2303560178","DOIUrl":"https://doi.org/10.5051/jpis.2303560178","url":null,"abstract":"<p><strong>Objective: </strong>It is well-established that muscle mass strength is a key factor in healthy physical functioning and is necessary for an active lifestyle. Handgrip strength (HGS) is the most convenient and cost-effective method for evaluating overall muscle strength in the body. Various studies have investigated the direct impact of inflammatory oral diseases on HGS, but with conflicting results. This systematic review investigated previous study data and analysed the causal factors in oral disease that affect HGS.</p><p><strong>Methods: </strong>The PubMed, Scopus, and Web of Science databases were searched for articles using relevant keywords. Based on the inclusion criteria, 8 cross-sectional studies were selected, and the extracted data was interpreted and analysed systematically. Quality assessment was done using the National Institutes of Health Quality Assessment Tool.</p><p><strong>Results: </strong>Although 4 studies were shown to have used good quality assessment tools, heterogeneity in the methodology and data analysis prevented us from conducting a meta-analysis. Most of the studies were conducted between 2020 to 2022 and 7 were from Asian countries. The findings of these studies indicated a positive correlation between good oral health and strong HGS. Poor oral habits and oral conditions such as periodontitis and tooth loss inversely affected HGS, as did intrinsic factors like age and sex.</p><p><strong>Conclusions: </strong>Limited global studies and heterogeneous study data emerged as the major shortcomings in our systematic study review and precluded meta-analysis. Therefore, further studies are needed with standard methodologies and outcome measures as well as good global representation.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42023441854.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regeneration and biosorption patterns of different bone substitutes: an <i>in vivo</i> study in rabbit skulls.","authors":"Seunghee Lee, Jungwoo Jung, Jungwon Lee, Young-Chang Ko, Dongseob Lee, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee","doi":"10.5051/jpis.2402840142","DOIUrl":"https://doi.org/10.5051/jpis.2402840142","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the bone regeneration and biosorption patterns of different bone substitutes in a rabbit skull defect model.</p><p><strong>Methods: </strong>Four circular 8 mm-defects were created in the cranium of 12 New Zealand white rabbits, each weighing approximately 3 kg. Each defect was randomly assigned to one of 4 treatment groups: cortical deproteinized porcine bone mineral (DPBM), cancellous DPBM, biphasic calcium phosphate (BCP) with a 6:4 ratio of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) (TCP4), and BCP with a 2:8 ratio of HA to β-TCP (TCP8). The rabbits were euthanized at either 6 weeks (n=6) or 12 weeks (n=6) post-surgery. The harvested specimens were then analyzed both radiographically and histomorphometrically.</p><p><strong>Results: </strong>In the micro-computed tomography analysis, no statistically significant differences were observed among the 4 groups, except in the bone graft volume/tissue volume (GV/TV) at 12 weeks. Cortical DBPM exhibited a higher GV/TV ratio than cancellous DBPM at the same time point. The histomorphometric analysis revealed increased biosorption in cancellous DBPM compared to cortical DBPM at 12 weeks. However, the percentage of newly formed bone did not significantly differ among the 4 groups.</p><p><strong>Conclusions: </strong>All types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between bone quality and shrinkage in maxillary sinus augmentation using synthetic alloplast versus xenograft.","authors":"Rachad Kudsi, Dolphus R Dawson, Octavio A Gonzalez, Ahmad Kutkut, Michelle A Tucci, Rosario Porras-Aguilar, Ana Espinosa Momox, Mohanad Al-Sabbagh","doi":"10.5051/jpis.2401320066","DOIUrl":"https://doi.org/10.5051/jpis.2401320066","url":null,"abstract":"<p><strong>Purpose: </strong>This clinical study evaluated differences in bone quality within the maxillary sinus when either alloplast or xenograft material was applied.</p><p><strong>Methods: </strong>Twenty participants requiring lateral sinus approach augmentation for delayed implant placement were divided into 2 groups. The first group received a silica-calcium phosphate composite (SCPC) alloplast, while the second received a bovine bone xenograft (Bio-Oss). Cone-beam computed tomography (CBCT) was used to measure changes in bone height and area immediately after surgery and 5 months after augmentation. Picrosirius red staining of bone biopsies, obtained during implant placement, was analyzed under polarized microscopy. A MATLAB algorithm was used for analysis following image acquisition.</p><p><strong>Results: </strong>CBCT measurements revealed a statistically significant reduction in linear bone height among xenograft recipients (<i>P</i>≤0.001). This finding indicated greater resorption compared to the alloplast group, which exhibited no significant difference in bone height at 5 months following sinus augmentation. Furthermore, 40% of xenograft recipients displayed an absence of mineralized tissue formation, indicating a limited osteoconductive effect compared to the alloplast group, in which mineralized bone tissue was present in all samples. Polarized light microscopy and color intensity measurements of picrosirius red-stained bone biopsies revealed a significantly higher ratio of mineralized collagen I to collagen III in the newly formed bone for alloplast compared to xenograft recipients. Trichrome staining demonstrated collagen I mineralization with the presence of osteoblasts and osteocytes, indicating new bone formation. The newly formed bone in the alloplast group exhibited markers of maturation, including the formation of reversal lines, Haversian systems, and blood vessels. Resorption of the SCPC alloplast-grafted granules was also observed.</p><p><strong>Conclusions: </strong>The increased formation and maturation of new bone appear responsible for the preservation of bone height in alloplast group recipients.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly accurate measurement of the relative abundance of oral pathogenic bacteria using colony-forming unit-based qPCR.","authors":"Jiyoung Hwang, Jeong-Hoo Lee, Yeon-Jin Kim, Inseong Hwang, Young-Youn Kim, Hye-Sung Kim, Do-Young Park","doi":"10.5051/jpis.2304520226","DOIUrl":"10.5051/jpis.2304520226","url":null,"abstract":"<p><strong>Purpose: </strong>Quantitative polymerase chain reaction (qPCR) has recently been employed to measure the number of bacterial cells by quantifying their DNA fragments. However, this method can yield inaccurate bacterial cell counts because the number of DNA fragments varies among different bacterial species. To resolve this issue, we developed a novel optimized qPCR method to quantify bacterial colony-forming units (CFUs), thereby ensuring a highly accurate count of bacterial cells.</p><p><strong>Methods: </strong>To establish a new qPCR method for quantifying 6 oral bacteria namely, <i>Porphyromonas gingivalis</i>, <i>Treponema denticola</i>, <i>Tannerella forsythia</i>, <i>Prevotella intermedia</i>, <i>Fusobacterium nucleatum</i>, and <i>Streptococcus mutans</i>, the most appropriate primer-probe sets were selected based on sensitivity and specificity. To optimize the qPCR for predicting bacterial CFUs, standard curves were produced by plotting bacterial CFU against Ct values. To validate the accuracy of the predicted CFU values, a spiking study was conducted to calculate the recovery rates of the predicted CFUs to the true CFUs. To evaluate the reliability of the predicted CFU values, the consistency between the optimized qPCR method and shotgun metagenome sequencing (SMS) was assessed by comparing the relative abundance of the bacterial composition.</p><p><strong>Results: </strong>For each bacterium, the selected primer-probe set amplified serial-diluted standard templates indicative of bacterial CFUs. The resultant Ct values and the corresponding bacterial CFU values were used to construct a standard curve, the linearity of which was determined by a coefficient of determination (<i>r</i>²) >0.99. The accuracy of the predicted CFU values was validated by recovery rates ranging from 95.1% to 106.8%. The reliability of the predicted CFUs was reflected by the consistency between the optimized qPCR and SMS, as demonstrated by a Spearman rank correlation coefficient (<i>ρ</i>) value of 1 for all 6 bacteria.</p><p><strong>Conclusions: </strong>The CFU-based qPCR quantification method provides highly accurate and reliable quantitation of oral pathogenic bacteria.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"444-457"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the biocompatibility and osteogenesis potential of whitlockite and an activin A/BMP2 chimera using a rat calvarial defect model: a pilot study.","authors":"Jung-Tae Lee, Sungtae Kim","doi":"10.5051/jpis.2304280214","DOIUrl":"10.5051/jpis.2304280214","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate bone regeneration using whitlockite (WH) nanoparticles, collagenated bovine bone mineral, and an activin A/BMP2 chimera (AB204) on calvarial defects in rats.</p><p><strong>Methods: </strong>This study was conducted using 8 rats. Five-millimeter circular defects were formed on each side of the calvaria. The defects were randomly assigned to 3 groups (BO group: BioOss collagen, BO/WH group: BO + WH, and BO/WH/AB204 group: BO + WH + AB204). After healing periods of 2 and 4 weeks, histological and histomorphometric analyses were performed after sacrifice.</p><p><strong>Results: </strong>The BO/WH/AB204 group showed superior bone healing compared to the other 2 groups (BO and BO/WH). In the BO and BO/WH groups, new bone formation was found in the defect margin. However, in the BO/WH/AB204 group, new bone was observed on the upper and lower surfaces of the grafted area. The new bone area of the BO/WH/AB204 group at 4 weeks was significantly higher than that of the same group at 2 weeks. At 4 weeks, the total augmented area and material area in the BO/WH/AB204 group were significantly lower than the corresponding values at 2 weeks.</p><p><strong>Conclusions: </strong>The BO/WH/AB204 group showed superior results of bone regeneration at 2 and 4 weeks compared to the BO and BO/WH groups. AB204 seems to play an important role in bone regeneration.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"432-443"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}