Journal of Periodontal and Implant Science最新文献

{"title":"A prospective clinical study of immediate implant placement in the maxillary esthetic zone.","authors":"Hee-Seung Han, Sungtae Kim, Hyunjae Kim, Yuseung Yi, Young-Dan Cho","doi":"10.5051/jpis.2404240212","DOIUrl":"https://doi.org/10.5051/jpis.2404240212","url":null,"abstract":"<p><strong>Purpose: </strong>Immediate implant placement (IIP) offers several advantages, including minimizing hard and soft tissue deformation, reducing implant time and cost, and rapidly restoring tooth function. However, IIP is technically challenging due to the need to secure initial stability and limit functional loading during healing. Therefore, this study aimed to evaluate the clinical outcomes of a bone-level implant featuring a dual thread design-an upper U-shaped thread and a lower V-shaped thread-with an 11° internal hexagonal connection in IIP within the maxillary esthetic zone.</p><p><strong>Methods: </strong>This study included 20 patients. Implants were inserted immediately after tooth extraction. Soft tissue changes were evaluated before tooth extraction (V0), after IIP (V1), at prosthesis delivery (V5), at a 3-month follow-up after prosthesis delivery (V6), and at a 1-year follow-up (V8). Bone dimensional changes were assessed at V1 and V8 using cone beam computed tomography, and the marginal bone level (MBL) was evaluated at V6 and V8 using 2-dimensional.</p><p><strong>Results: </strong>Of the 20 patients, 3 dropped out due to osseointegration failure during the follow-up period. Although the horizontal dimensions of the soft and hard tissues decreased slightly, the gingival margin and MBL remained well maintained throughout the follow-up.</p><p><strong>Conclusions: </strong>Within this limited dataset, the lower V-shaped thread enabled favorable initial stability in IIP, and the esthetic outcomes were positive-with minimal gingival recession and marginal bone loss. Long-term follow-up is required to fully assess the impact of thread design and connection on esthetics.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0008231.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the causal association of periodontitis with biological aging and its underlying mechanisms: findings from Mendelian randomization and integrative genetic analysis.","authors":"Yu Cao, George Pelekos, Lijian Jin, An Li, Mi Du, Shixian Hu, Zuyun Liu, Ke Deng","doi":"10.5051/jpis.2403420171","DOIUrl":"https://doi.org/10.5051/jpis.2403420171","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic low-grade inflammation is linked to the biology of aging; however, evidence supporting a causal relationship between periodontitis-a dysbiotic biofilm-initiated inflammatory disease-and accelerated aging remains limited. This study investigated the causality between periodontitis and biological aging and identified potentially shared genomic loci, genes, and pathways.</p><p><strong>Methods: </strong>We conducted a 2-sample Mendelian randomization (MR) analysis to explore the causality of periodontitis on age acceleration measures (DNAm PhenoAge acceleration, GrimAge acceleration, Hannum age acceleration, and intrinsic epigenetic age acceleration) using a dataset from genome-wide association studies of European ancestry populations. Independent genetic variants associated with each trait were used as instrumental variables. The inverse variance-weighted (IVW) method served as the primary MR approach, supplemented by sensitivity testing. We also performed additional statistical genetic analyses to identify pleiotropic loci, shared functional genes, and potential biological pathways, integrating large-scale expression quantitative trait loci data from blood samples.</p><p><strong>Results: </strong>The MR analysis indicated a causal relationship between periodontitis and DNAm PhenoAge acceleration (IVW β=0.308; 95% confidence interval, 0.056-0.561; <i>P</i>=0.017), a finding corroborated by sensitivity analyses. There was a significant genetic overlap between periodontitis and age acceleration. Pleiotropic analysis revealed 24 shared SNPs associated with 242 genes, predominantly involved in immune functions and pathways related to cellular processes. Further integration analysis showed that 91 of these pleiotropic genes were causally linked to both conditions, with C6orf183 identified as a potential mediator.</p><p><strong>Conclusions: </strong>This study presents compelling genetic evidence supporting a causal relationship between periodontitis and accelerated aging. Further research is required to validate these findings and investigate the underlying mechanisms.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary sinus hypoplasia relevant to dental implant treatment: a narrative review.","authors":"Won-Bae Park, Sofya Sadilina, Ji-Young Han, Daniel S Thoma, Hyun-Chang Lim","doi":"10.5051/jpis.2403600180","DOIUrl":"https://doi.org/10.5051/jpis.2403600180","url":null,"abstract":"<p><p>This comprehensive narrative review provides an overview of the current scientific evidence regarding maxillary sinus hypoplasia (MSH). This review highlights several variants of MSH that are relevant to implant planning and treatment in daily clinical practice. MSH is characterized by a reduction in sinus volume, which contrasts with maxillary sinus pneumatization, a condition that has received more clinical attention. Nevertheless, certain types of MSH can significantly impact implant surgery and the management of associated complications. The maxillary sinus volume can be affected by factors such as infection, trauma, genetic predispositions, and changes within the sinus or adjacent anatomical structures, including the nasal cavity and the ethmoid sinus. In cases of MSH, the maxillary sinus floor is positioned more cranially than the nasal floor, and the distance between the lamina papyracea of the eye and the middle meatus antrostomy point increases horizontally. Several variants of MSH potentially affect implant therapy. Chronic maxillary sinus atelectasis, which results from persistent ostium blockage, may have clinical implications, particularly when implant-related infections occur in the MS. Inferior meatus pneumatization involves a lateral expansion of the nasal cavity, requiring a nasal floor elevation procedure when placing implants in the posterior maxilla. Additionally, the formation of an ethmomaxillary sinus may create a septum-like structure in the distal area of the maxillary sinus, necessitating two separate bone access windows during the sinus floor elevation procedure. Given these considerations, it is crucial for clinicians to be aware of MSH. Accurate diagnosis of MSH requires the use of 3-dimensional radiography techniques, such as cone-beam computed tomography.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From tradition to innovation: a bibliometric analysis of the evolution of periodontal plastic surgery.","authors":"Şeyma Çardakcı Bahar, Özlem Saraç Atagün, Seval Ceylan Şen, Gülbahar Ustaoğlu","doi":"10.5051/jpis.2404620231","DOIUrl":"https://doi.org/10.5051/jpis.2404620231","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to conduct a bibliometric analysis of the periodontal plastic surgery literature to identify trends, research gaps, and key themes within the field and to establish a perspective on documented research.</p><p><strong>Methods: </strong>This bibliometric study examined research outputs on mucogingival surgery indexed in the Web of Science database from 1990 to 2023. The Science Mapping Analysis Tool (SciMAT) software was used to visualize and predict research trends on this topic.</p><p><strong>Results: </strong>An analysis of publication distribution by year revealed a decline in the number of publications between 1984 and 1995, followed by an overall upward trend after 1996 despite occasional decreases. The United States contributed the most with 593 publications, and Wang HL (n=74) was the most prolific author. The most frequently used keyword was \"gingival recession\" (n=625). Overall, the publications received 44,859 citations, averaging 25.49 citations per publication.</p><p><strong>Conclusions: </strong>Researchers have made significant efforts to improve clinical practices and procedures in periodontal plastic surgery, resulting in an increase in studies over recent years. By analyzing thematic maps and clusters-using indicators such as frequency, citations, and centrality-researchers can identify the strengths, weaknesses, and gaps in current research.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-6 regulates human <i>ODAM</i> gene expression in gingival epithelial cells.","authors":"Zhenyu Jin, Arisa Yamaguchi, Hideki Takai, Yohei Nakayama, Yorimasa Ogata","doi":"10.5051/jpis.2402980149","DOIUrl":"https://doi.org/10.5051/jpis.2402980149","url":null,"abstract":"<p><strong>Purpose: </strong>Odontogenic ameloblast-associated protein (ODAM) is a small secretory protein produced by the junctional epithelium (JE) and mature ameloblasts. It plays a role in odontogenesis and mediates the adhesion of JE to enamel. We used human gingival epithelial cells to evaluate the mechanism of <i>ODAM</i> gene expression regulation in the JE by interleukin (IL)-6.</p><p><strong>Methods: </strong>Ca9-22, Sa3, and HSY cells were stimulated with IL-6 (10 ng/mL), after which total RNA and proteins were extracted. Real-time polymerase chain reaction and Western blot analyses were performed to assess the expression levels of ODAM mRNA and protein. Luciferase (LUC) assays were employed using LUC constructs with varying lengths of the <i>ODAM</i> gene promoter sequence. Gel mobility shift and chromatin immunoprecipitation (ChIP) analyses were conducted to investigate the binding of transcription factors to response elements within the gene promoter.</p><p><strong>Results: </strong>Treatment with IL-6 increased the expressions of ODAM mRNA and protein. Additionally, it induced promoter activity of the <i>ODAM</i> gene, while LUC activity was suppressed by inhibitors of protein kinase A, tyrosine kinase, MEK1/2, phosphatidylinositol 3-kinase, nuclear factor-κB, signal transducer and activator of transcription (STAT) 3, and glycoprotein 130. Gel mobility shift and ChIP analyses revealed that IL-6 induced the binding of yin yang 1 (YY1), CCAAT/enhancer-binding protein (C/EBP) β, GATA binding protein (GATA), and phospho-STAT3 to the YY1, C/EBP, GATA, and interferon-γ activated transcriptional element (GATE) 1-3 elements.</p><p><strong>Conclusions: </strong>These findings indicate that IL-6 upregulates <i>ODAM</i> gene expression by targeting the YY1, C/EBP, GATA, and GATE1-3 elements in the promoter region of the human <i>ODAM</i> gene.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard operating procedures for quality control of oral biospecimens at the Korea Oral Biobank Network.","authors":"Hye-Rim Shin, Sun-Young Kim, In-Hye Bae, Inseong Hwang, Jin Hoo Park, Soo-Min Ok, Young-Youn Kim, Young-Dan Cho","doi":"10.5051/jpis.2401920096","DOIUrl":"https://doi.org/10.5051/jpis.2401920096","url":null,"abstract":"<p><strong>Purpose: </strong>The Korean Oral Biobank Network (KOBN) collects, stores, and provides oral samples for research. Quality control (QC) of biospecimens is necessary to ensure that they meet the basic prerequisites before being sent to researchers. This study presents the standard operating procedures (SOPs) for the QC of biospecimens.</p><p><strong>Methods: </strong>QC methods using molecular genetic techniques according to sample types, including teeth, blood, oral soft tissue, oral tissue-derived cells, saliva, mouth rinse solution, dental plaque, and gingival crevicular fluid, are described in detail.</p><p><strong>Results: </strong>The KOBN established SOP for oral biospecimen QC and assessment methods.</p><p><strong>Conclusions: </strong>To ensure a stable supply of high-quality biospecimens for researchers, regular QC checks should be carried out according to the SOP following the specifications of the Korea Biobank Network under the Korea Disease Control and Prevention Agency.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cannabinoid receptor activation on <i>Porphyromonas gingivalis</i> lipopolysaccharide stimulation in human periodontal ligament stem cells <i>in vitro</i>.","authors":"Tim Leypold, Alix Herbsthofer, Rogerio B Craveiro, Michael Wolf, Justus P Beier, Tim Ruhl","doi":"10.5051/jpis.2303680184","DOIUrl":"10.5051/jpis.2303680184","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis is an inflammatory disease that results in the loss of periodontal tissue. The endocannabinoid system has anti-inflammatory properties and displays considerable potential for tissue regeneration. In this study, we aimed to explore whether the activation of this system can alleviate or reverse the inflammatory phenotype of human periodontal ligament stem cells (hPDLSCs) induced by exposure to the inflammagen lipopolysaccharide (LPS).</p><p><strong>Methods: </strong>We investigated the effects of activating specific cannabinoid receptors (CB1 and CB2) on the inflammatory phenotype of LPS-stimulated hPDLSCs. The exogenous ligands WIN55,212-2 and JWH-133 were employed to target the cannabinoid receptors. We conducted a thorough assessment of cell proliferation, metabolic activity, and adipogenic, osteogenic, and chondrogenic differentiation potential. Additionally, we measured cytokine release using enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>Exposure to <i>Porphyromonas gingivalis</i> lipopolysaccharide (Pg-LPS) caused an increase in cell proliferation while decreasing metabolic activity. While this exposure did not influence adipogenic or chondrogenic differentiation, it did result in reduced osteogenesis. Additionally, LPS induced the release of interleukin (IL)-6, IL-8, and monocyte chemoattractant protein 1. Immunolabeling revealed the presence of CB1 and CB2 on the cellular membrane, with these receptors playing distinct roles in hPDLSCs. The CB1 agonist WIN55,212-2 was found to increase metabolic activity and promote adipogenic differentiation, whereas the CB2 agonist JWH-133 promoted cell proliferation and osteogenic differentiation. When hPDLSCs were co-exposed to Pg-LPS and CB ligands, JWH-133 slightly ameliorated the inhibition of osteogenic differentiation and suppressed the release of inflammatory cytokines.</p><p><strong>Conclusions: </strong>This study clarifies the effects of specific CB receptor activation on hPDLCs and the inflammatory phenotype. Stimulation of the endocannabinoid system through the manipulation of endogenous or the application of exogenous cannabinoids <i>in vivo</i> may represent a potent therapeutic option for combating periodontal inflammatory disorders.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"18-34"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of variations in the nasopalatine canal on CBCT: considerations from an anatomical point of view.","authors":"Utkarsh Yadav, Nandita Shenoy, Junaid Ahmed, Nanditha Sujir, Archana M, Aarti Gupta","doi":"10.5051/jpis.2401300065","DOIUrl":"10.5051/jpis.2401300065","url":null,"abstract":"<p><strong>Purpose: </strong>The nasopalatine canal (NPC) is one of the most significant anatomical markers in the anterior maxillary region. Its location is quite important, especially for implant placement. Therefore, the purpose of this study was to use cone-beam computed tomography (CBCT) to evaluate the morphology, size, and anatomic variations of the NPC.</p><p><strong>Methods: </strong>A total of 150 individual CBCT images were assessed in various sections to evaluate the dimensions, morphology, and extent of the NPC. Reformatted sagittal images were chosen to classify the shape and course of the canal. The Student's <i>t</i>-test, the χ² test, and Pearson correlation coefficients were used.</p><p><strong>Results: </strong>The NPC was longer in males than in females, and the mediolateral diameter of the canal was greater in older adults. In sagittal sections, the canal predominantly exhibits a cylindrical shape, while a spindle shape is the least common. In coronal sections, a single shape is most frequently observed, with a Y-shape being the least common. Regarding the orientation of the canal, slanted canals are more prevalent, whereas vertically curved canals are rare. Typically, 2 canal openings are observed, with 4 openings being the least common.</p><p><strong>Conclusion: </strong>The current study highlights the challenges associated with identifying the anatomical appearance and variations of the NPC. Consequently, possessing a thorough understanding of this anatomy is essential before undertaking any surgical procedures, such as implant placement. This knowledge helps prevent complications such as nerve injury-related loss of sensation, bleeding due to blood vessel injury, and the development of a nasopalatine duct cyst following trauma to the canal during surgery.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"62-71"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate implant placement in the premolar maxillary area: a cone-beam computed tomography study.","authors":"Ali Najm, Amer Bihorac, Vinícius de Carvalho Machado, Bruno Ramos Chrcanovic","doi":"10.5051/jpis.2303580179","DOIUrl":"10.5051/jpis.2303580179","url":null,"abstract":"<p><strong>Purpose: </strong>This research aimed to investigate potential factors associated with the risk of perforation of the labial bone plate, nasal floor, or maxillary sinus floor during immediate implant placement (IIP) in the maxillary premolar area, utilizing a cone-beam computed tomography (CBCT) virtual study.</p><p><strong>Methods: </strong>CBCT exams from 179 eligible participants, encompassing 716 teeth, were included. Implants were virtually positioned in 2 orientations: along the long axis of the tooth (the prosthetically-driven position) and in an optimal position relative to adjacent anatomical structures (the bone-driven position). Binary logistic regression analysis was employed to assess potential associations between perforation or invasion and various covariates, including sex, age, tooth region, the distance from the tooth apex to the nasal floor or maxillary sinus floor, the angle between the prosthetically- and bone-driven positions (implant-line A angle [ILAA]), and the labial concavity angle (LCA).</p><p><strong>Results: </strong>The mean ILAA was 18.3°±8.0°, and the angle was significantly larger for the second premolar compared to the first premolar. The mean minimum implant length was 13.0±2.1 mm, with a bone anchorage of 4 mm. The incidence of perforation was 84.1% for the prosthetically-driven position and 40.5% for the bone-driven position. Factors associated with a higher risk of cortical bone wall perforation or invasion of the 2-mm safety margin from surrounding anatomical structures (in the bone-driven position) included female sex, older age, shorter distance from the tooth apex to the nasal cavity/maxillary sinus, and smaller LCA.</p><p><strong>Conclusions: </strong>A high prevalence of cortical bone wall perforation or invasion of the 2-mm safety margin is anticipated when performing IIP in the maxillary premolar region.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"72-84"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142510972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of implants placed within or beyond the boundaries of the alveolar ridge preservation: a retrospective case series with 10 weeks of observations in 28 patients.","authors":"Young-Chang Ko, Ki-Tae Koo, Ling Li, Dongseob Lee, Yong-Moo Lee, Yang-Jo Seol, Tae-Hyung Kim, Jungwon Lee","doi":"10.5051/jpis.2400800040","DOIUrl":"10.5051/jpis.2400800040","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the effect of implant vertical positioning within alveolar ridge preservation (ARP) sites on implant stability quotient (ISQ) values, which were measured 10 weeks post-implantation.</p><p><strong>Methods: </strong>Patients who underwent ARP using collagenized deproteinized bovine bone mineral, followed by implant placement in the posterior area, were divided into 2 groups: the within-ARP group and the beyond-ARP group. In the within-ARP group, osteotomy and implant placement occurred within the ARP boundary. In contrast, in the beyond-ARP group, these procedures were performed beyond the ARP boundary, incorporating 3 mm of pristine bone at the implant's apex. Bone quality was assessed by tactile sense, and both insertion torque during implant surgery and ISQ values at 10 weeks post-implant surgery were measured. Multiple linear regression analysis and Pearson correlation analysis were used to explore the relationship between insertion torque and ISQ values.</p><p><strong>Results: </strong>In total, 30 ARP sites in 28 patients were analyzed. There was no significant difference in bone quality, as determined by tactile sense, between the within-ARP and beyond-ARP groups. At the time of implant placement, the beyond-ARP group exhibited a higher insertion torque (33.33±13.39 Ncm) compared to the within-ARP group (17.08±11.17 Ncm). However, the ISQ values were similar between the 2 groups 10 weeks after implant placement. A positive correlation between insertion torque and ISQ values was confirmed at 10 weeks post-implant.</p><p><strong>Conclusions: </strong>The engagement of pristine bone may facilitate high insertion torque during the placement of implants in ARP sites. Nevertheless, by 10 weeks post-implantation, the ISQ values were found to be comparable, irrespective of the implant's position.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"50-61"},"PeriodicalIF":2.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141761920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}