Effect of anti-resorptive therapy on implant failure: a systematic review and meta-analysis.

IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Journal of Periodontal and Implant Science Pub Date : 2025-04-01 Epub Date: 2024-07-10 DOI:10.5051/jpis.2304040202
Junho Jung, Gyu-Jo Shim, Jung Soo Park, Yong-Dae Kwon, Jae-In Ryu
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Abstract

Purpose: This review was conducted to systematically assess the impact of bisphosphonates (BPs) and denosumab, used as anti-resorptive therapies, on the incidence of dental implant failure.

Methods: Electronic and manual searches were performed in accordance with the described search protocol. Only articles that met the inclusion criteria were selected. The primary outcome was implant failure, while secondary outcomes included biological complications and comorbidities. Following data extraction, a quality assessment and meta-analysis were conducted.

Results: Fourteen eligible studies were included in the analysis following a qualitative evaluation. BP administration, regardless of the timing of anti-resorptive therapy, did not significantly increase the risk of implant failure (odds ratio [OR], 1.40; 95% confidence interval, 0.83-2.34). Subgroup analysis revealed a slightly higher, although statistically insignificant, risk of failure in patients with a follow-up period of 3 years or more compared to those with a follow-up duration of less than 3 years (with ORs of 2.82 and 1.53, respectively). Due to a lack of eligible studies, a meta-analysis for denosumab could not be conducted.

Conclusions: Our findings suggest that BP treatment does not compromise the survival of dental implants. Specifically, in patients with osteoporosis, implant failure rates were not significantly influenced by the administration of BPs before the placement of dental implants, suggesting that low-dose BP therapy may not contraindicate implant placement. Nevertheless, regular check-ups and maintenance periodontal treatment must not be neglected, and concomitant biological factors should be considered to ensure the long-term success of implant rehabilitation.

抗吸收治疗对种植体失败的影响:系统回顾和荟萃分析。
目的:本综述旨在系统评估双膦酸盐(bp)和地诺单抗作为抗吸收治疗对种植体失败发生率的影响。方法:按照所述检索方案进行电子检索和人工检索。只选择符合纳入标准的文章。主要结局是种植体失败,次要结局包括生物学并发症和合并症。数据提取后,进行质量评估和meta分析。结果:在定性评价后,14项符合条件的研究被纳入分析。无论何时进行抗吸收治疗,给药BP均未显著增加种植体失败的风险(优势比[OR], 1.40;95%置信区间为0.83-2.34)。亚组分析显示,与随访时间少于3年的患者相比,随访时间为3年及以上的患者失败风险略高(or分别为2.82和1.53),但在统计学上不显著。由于缺乏合格的研究,不能对denosumab进行荟萃分析。结论:我们的研究结果表明BP治疗不会影响种植体的存活。具体而言,骨质疏松患者种植体失败率不受植入牙种植体前施用BP的显著影响,提示低剂量BP治疗可能不是种植体植入的禁忌。然而,定期的牙周检查和牙周治疗不能被忽视,并应考虑伴随的生物学因素,以确保种植体康复的长期成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Periodontal and Implant Science
Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.30%
发文量
38
期刊介绍: Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.
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