Journal of Periodontal and Implant Science最新文献

{"title":"BMP9 promotes peri-implant osseointegration in beagle defects.","authors":"Hee-Seung Han, Dong Woo Lee, Sungtae Kim, Jue Yeon Lee, Yoon Jeong Park, Chong Pyung Chung, Young-Dan Cho","doi":"10.5051/jpis.2505500275","DOIUrl":"https://doi.org/10.5051/jpis.2505500275","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the <i>in vivo</i> efficacy of bone morphogenetic protein 9 (BMP9) relative to bone morphogenetic protein 2 (BMP2) in a beagle peri-implant critical-size defect model.</p><p><strong>Methods: </strong>Peri-implant defects were created in beagle dogs and treated with either a collagen sponge (CS) or deproteinized bovine bone mineral with collagen (OCS-B Xenomatrix collagen [OCS-BC]), with or without BMP2 or BMP9. After 8 weeks, bone regeneration and osseointegration were evaluated using radiographic, histological, and biomechanical analyses.</p><p><strong>Results: </strong>Radiographic analysis demonstrated that BMP treatment significantly increased peri-implant mineralization, with bone mineral density increasing from 0.597±0.151 (control) to 0.896±0.173 in the CS+BMP9 group (<i>P</i><0.0001). Histological and histomorphometric analyses corroborated these findings, showing greater new bone formation and higher bone-to-implant contact (BIC) (7.943±7.048 vs. 68.90±20.27 in the CS+BMP9 group; <i>P</i><0.05) without overt inflammatory reactions. Region-of-interest (ROI)-based micro-computed tomography analysis (200 μm) and resonance frequency analysis further supported improved osseointegration and stability, with osseointegration increasing from 20.32±6.976 to 70.37±0.785 in the CS+BMP9 group (<i>P</i><0.0001) and the implant stability quotient (ISQ) peaking at 70.92±3.523 in the OCS-BC+BMP9 group (<i>P</i><0.0001). Two-way analysis of variance indicated scaffold-dependent magnitudes for bulk endpoints, whereas interaction terms were not significant for BIC, ROI-based osseointegration, or ISQ, supporting preservation of BMP9-associated benefits across scaffold types for these outcomes.</p><p><strong>Conclusions: </strong>BMP9 produced overall improvements comparable to BMP2 and may provide more reproducible osseointegration-related outcomes across scaffold types.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regenerative therapy using molded collagenated equine bone mineral with rhBMP-2 in a canine peri-implantitis model: a proof of concept.","authors":"Hyun Ju Kim, Kyoung-Hwa Kim, Jin Uk Choi, Yong-Moo Lee, Yang-Jo Seol","doi":"10.5051/jpis.2501820091","DOIUrl":"10.5051/jpis.2501820091","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to establish a proof of concept for the guided bone regeneration (GBR) procedure using molded collagenated equine bone mineral (CEBM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) in a canine peri-implantitis model, and to identify the key factors essential for effective bone regeneration in peri-implant defects.</p><p><strong>Methods: </strong>Twelve dental implants were placed in the mandibles of 4 adult male beagle dogs. Each implant was randomly assigned to 1 of 3 groups: GBR with molded CEBM soaked in rhBMP-2 solution (CEBM/BMP2 group, n=4); GBR with molded CEBM alone (CEBM group, n=4); or open flap debridement (OFD group, n=4). Peri-implantitis was induced using cotton retraction cords following osseointegration. After ligature removal, all groups underwent OFD with implant surface decontamination, and GBR was subsequently performed according to group allocation. No further treatment was provided in the OFD group. Clinical and radiographic evaluations were conducted at 4-week intervals, and at 16 weeks, histological, fluorescent labeling, and micro-computed tomographic (micro-CT) analyses were performed.</p><p><strong>Results: </strong>The CEBM/BMP2 group demonstrated a significantly higher bone volume fraction in micro-CT analysis, alongside superior histomorphometric outcomes, including greater first bone-to-implant contact height, crestal height, and new bone area. The mean re-osseointegration ratio was notably higher in the CEBM/BMP2 group (buccal: 74%, lingual: 94%) compared to both the CEBM (buccal: 20%, lingual: 35%) and OFD groups (buccal: 12%, lingual: 45%).</p><p><strong>Conclusions: </strong>The GBR procedure using molded CEBM with rhBMP-2 substantially enhanced new bone formation and implant re-osseointegration in peri-implantitis-associated defects, compared to molded CEBM alone or OFD without GBR.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"145-160"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regenerative capacity of the newly synthesized material QG3030: an <i>in vitro</i> and <i>in vivo</i> study.","authors":"Nguyen Pham-Hanh Luong, Kyoung-Hwa Kim, Ji-Eun Kook, Yang-Jo Seol","doi":"10.5051/jpis.2502920146","DOIUrl":"10.5051/jpis.2502920146","url":null,"abstract":"<p><strong>Purpose: </strong>Current bone grafting materials often lack inherent osteoinductive properties, underscoring the need for new therapeutic agents that promote regeneration. In this study, we evaluated the effects of QG3030, a novel osteoinductive derivative of lappaconitine, on the proliferation and osteogenic differentiation of rat bone marrow-derived stem cells (BMSCs) <i>in vitro</i>. Furthermore, we examined its influence on bone regeneration <i>in vivo</i> using a rat calvarial critical-sized defect model.</p><p><strong>Methods: </strong>The effects of QG3030 on BMSC proliferation and osteogenic differentiation were assessed <i>in vitro</i> using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the alkaline phosphatase (ALP) activity assay, and alizarin red S staining. For <i>in vivo</i> evaluation, 18 Sprague-Dawley rats with 8-mm critical-sized calvarial defects were randomly assigned to 3 groups (n=6 per group): deproteinized bovine bone mineral (DBBM; Bio-Oss) alone (B0, control), DBBM combined with 100 mg/mL QG3030 (B100), and DBBM combined with 300 mg/mL QG3030 (B300). Bone regeneration was analyzed after 8 weeks by micro-computed tomography (micro-CT), histology, and histomorphometry.</p><p><strong>Results: </strong><i>In vitro</i>, QG3030 improved BMSC viability, significantly increased ALP activity, and promoted matrix mineralization within the tested non-cytotoxic range. On <i>in vivo</i> micro-CT analysis, the B100 group exhibited significantly higher bone mineral density and new bone volume fraction (new bone volume/total volume) than the B0 group (<i>P</i>=0.043 for both). Furthermore, histomorphometry revealed significantly greater new bone area (<i>P</i>=0.046) and percentage of new bone (<i>P</i>=0.032) in the B300 group compared to the B0 group.</p><p><strong>Conclusions: </strong>Combining QG3030 with DBBM significantly enhanced bone regeneration in a rat calvarial critical-sized defect model, with QG3030 demonstrating distinct osteogenic effects both <i>in vitro</i> and <i>in vivo</i>. Accordingly, the combination of QG3030 and DBBM represents a promising therapeutic approach for bone regeneration strategies, especially in periodontology and implant dentistry, and warrants further investigation.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"129-144"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.","authors":"Yerim Oh, Bo Hyun Jung, Ki-Yeon Yoo, In-Kyung Hwang, Jong-Bin Lee, Heung-Sik Um, Jae-Kwan Lee","doi":"10.5051/jpis.2501080054","DOIUrl":"10.5051/jpis.2501080054","url":null,"abstract":"<p><strong>Purpose: </strong>Fusion of molar roots is a common variation of root morphology known to adversely affect periodontal disease prognosis. Among methods for inducing experimental periodontal disease in animal models, the ligature-induced periodontitis (LIP) mouse model is most frequently employed. However, few studies have examined root abnormalities in experimental mice. This study aimed to investigate the incidence of root fusion in the maxillary second molars of mice and determine its relationship with alveolar bone loss, offering new insights into animal LIP models.</p><p><strong>Methods: </strong>From 2019 to February 2024, 222 Institute of Cancer Research mice (444 maxillary second molars), which served as control animals in periodontitis experiments conducted by the Department of Periodontology and the Department of Anatomy at the College of Dentistry, Gangneung-Wonju National University, were initially examined. After excluding fractured or missing teeth, 402 teeth were included in the final analysis. Root fusion was evaluated using micro-computed tomography and categorized by the degree of fusion. To examine the relationship between fused roots and alveolar bone loss, the distance from the cementoenamel junction to the alveolar bone crest was measured on the mesial and distal sides of the maxillary second molars.</p><p><strong>Results: </strong>Root fusion was found in 10.4% of animals and 6.5% of teeth. Two types of fusion were observed: mesio-palatal (MP) and disto-palatal. Partial root fusion was more frequent than complete fusion. Within the ligation group, teeth with MP fusion exhibited greater alveolar bone loss than those without root fusion (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, maxillary second molars with MP root fusion accelerated alveolar bone loss in ligated teeth in a LIP mouse model. Future research should consider deviations resulting from MP root fusion.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"119-128"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the occasion of the 10th 'scaling with love' event to promote oral health for persons with disabilities.","authors":"Kyoung-Man Min","doi":"10.5051/jpis.265602edi01","DOIUrl":"10.5051/jpis.265602edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"56 2","pages":"83-86"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147822576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early healing outcomes of re-entry sinus floor elevation after prior complete sinus membrane perforation: a pilot preclinical study in a rabbit sinus model.","authors":"Hyun-Chang Lim, Seungil Shin, Jong-Hyuk Chung, Yeek Herr","doi":"10.5051/jpis.2501980099","DOIUrl":"10.5051/jpis.2501980099","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the early healing outcomes of re-entry sinus floor elevation (SFE) after previous complete sinus membrane perforation.</p><p><strong>Methods: </strong>In six rabbits, the sinus membrane of one maxillary sinus was intentionally perforated (≥10 mm), and a collagen matrix was applied. SFE was performed on both sinuses after 8 weeks, establishing 2 groups: SFE after previous complete sinus membrane perforation (group SFE_ComPerf) and SFE with an intact sinus membrane (group SFE). The animals were euthanized 4 weeks after SFE. Micro-computed tomographic (micro-CT), histological, and histomorphometric analyses were performed.</p><p><strong>Results: </strong>On micro-CT, no statistically significant differences were observed in total augmented volume or mineralized tissue volume. Histologically, impaired new bone formation was observed near the sinus membrane in the SFE_ComPerf group. Histomorphometric analysis revealed that the area of newly formed bone was significantly smaller in group SFE_ComPerf than in group SFE (5.8±2.7 mm² vs. 10.5±1.9 mm², <i>P</i><0.05). Such reduced bone formation in the SFE_ComPerf group was also evident in one region of interest (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Complete sinus membrane perforation (>10 mm) may compromise new bone formation in re-entry SFE.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"161-171"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of xenogeneic collagen matrices and autogenous graft-based techniques to increase mucosal thickness and keratinised mucosa width at implant sites: are autologous grafts still the gold standard? A systematic review and meta-analysis of randomised clinical trials.","authors":"Néstor Ríos-Osorio, Mangriveth Orozco-Agudelo, Iván Cespedes-Moreno, Marcela Contreras-Ibarra, Mario Guerrero-Torres, Adriana Castro-Calderón, Marggie Grajales, Oscar Jiménez-Peña","doi":"10.5051/jpis.2500260013","DOIUrl":"10.5051/jpis.2500260013","url":null,"abstract":"<p><p>This systematic review compares xenogeneic collagen matrices (XCMs) and autogenous graft-based techniques, focusing on 1) the effectiveness of XCMs (non-crosslinked XCM [XCM*] and crosslinked XCM [VCMX]) vs. connective tissue graft (CTG) for increasing buccal mucosal thickness (MT), and 2) the effectiveness of XCM* vs. free gingival graft (FGG) in augmenting buccal keratinised mucosa width (KMW) at implant sites. MEDLINE (PubMed), Web of Science, and Scopus were searched from inception to August 2024. Randomised controlled trials (RCTs) involving systemically healthy patients with peri-implant mucosal deficiencies (MT <2 mm and/or KMW <2 mm) were included. Studies were required to have 2 parallel control groups comparing XCMs with CTG and/or XCM* with FGG, and a minimum follow-up of 3 months. Data were extracted and analysed using a random-effects model, with risk of bias evaluated via the Cochrane risk of bias tool 2. Seventeen RCTs met inclusion criteria for qualitative synthesis (XCMs vs. CTG, n=12; XCMs vs. FGG, n=5), with 14 RCTs included in the meta-analysis (XCMs vs. CTG, n=9; XCMs vs. FGG, n=5). Subgroup analysis of XCM* or VCMX vs. CTG showed a significantly greater MT increase with CTG than with XCM* (pooled mean difference [MD], 0.27; 95% confidence interval [CI], 0.05 to 0.49; <i>P</i>=0.01). No significant difference in MT was observed between VCMX and CTG (pooled MD, 0.02; 95% CI, -0.17 to 0.22; <i>P</i>=0.83). For KMW, FGG provided a significantly greater increase than XCM* (pooled MD, 1.47; 95% CI, 0.63 to 2.30; <i>P</i>=0.0006). RCTs on XCMs vs. CTG showed moderate risk of bias, while those on XCM* vs. FGG showed low risk. XCM* is less effective than CTG for increasing MT at buccal implant sites, and less effective than FGG for increasing buccal KMW. No statistical difference was found between VCMX and CTG for MT augmentation. Trial Registration: PROSPERO Identifier: CRD42023495454.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"87-118"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145662400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of microbiome profiles across sample types in patients with peri-implantitis using 16S rRNA sequencing.","authors":"Da-Mi Kim, Inpyo Hong, Joo-Yeon Lee, Seulbin Im, Kyeong-Won Paeng, Ui-Won Jung, Jae-Kook Cha","doi":"10.5051/jpis.2501680084","DOIUrl":"10.5051/jpis.2501680084","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous studies have applied microbial analyses to peri-implantitis, including analyses of samples collected from various sites. While characteristics of the peri-implantitis microbiome have been identified, differences in sampling methods between studies have not been considered. The present study aimed to (1) characterize microbial similarities among saliva, gingival crevicular fluid (GCF), subgingival plaque (SGP) and inflammatory connective tissue (ICT) within the same participant with peri-implantitis; and (2) determine the microbial profiles of peri-implantitis sites.</p><p><strong>Methods: </strong>Saliva, GCF, and SGP samples were collected from 18 patients undergoing peri-implantitis surgery, and ICT samples were obtained after flap elevation. The collected samples were analyzed using 16S rRNA sequencing.</p><p><strong>Results: </strong>The sampling sites showed a mean bone loss of 6.9 mm and a maximum probing depth (PD) of 8.3 mm. Alpha diversity did not differ significantly among ICT, GCF, and SGP, whereas saliva exhibited a distinct diversity profile. Additionally, beta diversity analyses indicated that the microbial community structure differed significantly between saliva and the other samples. In taxonomic analyses, the microbial profiles of ICT, GCF, and SGP were clearly distinguishable from those of saliva. Saliva had lower proportions of Bacteroidetes and higher proportions of Proteobacteria and Actinobacteria species, especially at sites with deep PD. Pearson correlation analyses revealed strong correlations between ICT and both GCF and SGP, but not between ICT and saliva. Pathogenic species such as <i>Porphyromonas gingivalis</i>, <i>Tannerella forsythia</i>, <i>Treponema denticola</i>, <i>Campylobacter rectus</i>, <i>Filifactor alocis</i>, and <i>Porphyromonas endodontalis</i> were more abundant in ICT than in saliva.</p><p><strong>Conclusions: </strong>ICT, GCF, and SGP shared similar microbial profiles, whereas saliva exhibited a significantly different profile. ICT, GCF, and SGP had higher abundances of peri-implant pathogenic species, whereas saliva tended to have lower abundances; this difference was especially pronounced in deep pockets.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"172-186"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146158330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical agreement between scale-aligned damping capacity and resonance frequency analyses for implant stability: a retrospective method-comparison study.","authors":"Gwang-Young Jung, Inpyo Hong, Nicolas P A Müller, Franz J Strauss, Jung-Seok Lee","doi":"10.5051/jpis.2505340267","DOIUrl":"https://doi.org/10.5051/jpis.2505340267","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the clinical agreement between resonance frequency analysis (RFA) and 2 scale-aligned damping capacity analysis (DCA) devices for assessing implant stability.</p><p><strong>Methods: </strong>In this retrospective method-comparison study (890 implants from 600 patients), implant stability was measured at up to 4 time points (T0-T3) using 1 RFA device and 2 DCA devices. Correlations between devices were assessed using Pearson's correlation coefficient. Agreement was evaluated using modified Bland-Altman analysis, and diagnostic accuracy was determined using receiver operating characteristic (ROC) curve analysis with an implant stability quotient threshold of 70. Changes in stability according to initial torque and simultaneous guided bone regeneration (GBR) or sinus grafting were analyzed using non-parametric statistical methods.</p><p><strong>Results: </strong>Significant moderate positive correlations were observed between RFA and each DCA device (<i>r</i>≈0.4; <i>P</i><0.001), and a strong correlation was observed between the 2 DCA devices (<i>r</i>=0.7; <i>P</i><0.001). Modified Bland-Altman analysis revealed systematic discrepancies, with DCA devices tending to overestimate stability in lower stability ranges relative to RFA. ROC analysis demonstrated fair diagnostic accuracy for both DCA devices (area under the curve≈0.70). Initial insertion torque and simultaneous GBR significantly influenced early implant stability; however, these differences diminished after 3 months.</p><p><strong>Conclusions: </strong>Scale-aligned DCA devices demonstrated acceptable clinical agreement and fair diagnostic accuracy relative to RFA. However, systematic discrepancies between DCA and RFA were observed, particularly in implants with lower stability. Clinicians should therefore interpret DCA measurements with caution in such cases.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial wound healing following interrupted closing sutures with versus without tension-relieving mattress suture in guided bone regeneration: a preliminary randomized clinical trial.","authors":"Gwan-Jung Kim, Yon-Soo Joo, Dong-Woon Lee, Jung-Seok Lee","doi":"10.5051/jpis.2504900245","DOIUrl":"https://doi.org/10.5051/jpis.2504900245","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective clinical study aimed to evaluate whether adding a tension-relieving horizontal mattress suture to simple interrupted sutures influences the occurrence and severity of postoperative wound dehiscence in horizontal guided bone regeneration (GBR) procedures.</p><p><strong>Methods: </strong>Forty patients requiring horizontal GBR, either prior to or simultaneous with implant placement, were randomly allocated to 2 groups. Group \"S\" received simple interrupted sutures only, whereas group \"S+H\" received additional horizontal mattress sutures placed prior to interrupted sutures to relieve flap tension. At 2 weeks postoperatively, wound dehiscence width (DW), wound dehiscence length (DL), and the wound dehiscence length/incision-line ratio (DL/i) were measured. The occurrence rate of any dehiscence was also recorded. DW was designated as the primary outcome, whereas DL, DL/i, and dehiscence occurrence were secondary outcomes. Statistical analyses included the Shapiro-Wilk test for normality, the Mann-Whitney <i>U</i> test for comparisons of DW and DL, and the χ² test for dehiscence occurrence. A significance level of <i>P</i><0.05 was applied.</p><p><strong>Results: </strong>No statistically significant differences were observed between the groups for DW (group S: 2.92±2.73 mm; group S+H: 2.17±2.51 mm), DL (group S: 5.32±5.49 mm; group S+H: 4.37±4.65 mm), or DL/i (group S: 0.42±0.41; group S+H: 0.34±0.38) (all <i>P</i>>0.05). The occurrence rate of wound dehiscence was 60% in group S and 55% in group S+H, with no statistically significant difference between groups (<i>P</i>>0.05).</p><p><strong>Conclusions: </strong>Both simple interrupted sutures alone and simple interrupted sutures combined with an additional tension-relieving horizontal mattress suture may be considered clinically acceptable approaches for achieving primary closure in horizontal GBR procedures.</p><p><strong>Trial registration: </strong>Clinical Research Information Service Identifier: KCT0010574.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147677862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}