Journal of Periodontal and Implant Science最新文献

{"title":"Association between oral health and handgrip strength: a systematic review.","authors":"Gargi Sarode, Aishwarya Joshi, Shruti Singh, Namrata Sengupta, Rahul Anand, Vini Mehta, Sachin Sarode","doi":"10.5051/jpis.2303560178","DOIUrl":"10.5051/jpis.2303560178","url":null,"abstract":"<p><strong>Objective: </strong>It is well-established that muscle mass strength is a key factor in healthy physical functioning and is necessary for an active lifestyle. Handgrip strength (HGS) is the most convenient and cost-effective method for evaluating overall muscle strength in the body. Various studies have investigated the direct impact of inflammatory oral diseases on HGS, but with conflicting results. This systematic review investigated previous study data and analysed the causal factors in oral disease that affect HGS.</p><p><strong>Methods: </strong>The PubMed, Scopus, and Web of Science databases were searched for articles using relevant keywords. Based on the inclusion criteria, 8 cross-sectional studies were selected, and the extracted data was interpreted and analysed systematically. Quality assessment was done using the National Institutes of Health Quality Assessment Tool.</p><p><strong>Results: </strong>Although 4 studies were shown to have used good quality assessment tools, heterogeneity in the methodology and data analysis prevented us from conducting a meta-analysis. Most of the studies were conducted between 2020 to 2022 and 7 were from Asian countries. The findings of these studies indicated a positive correlation between good oral health and strong HGS. Poor oral habits and oral conditions such as periodontitis and tooth loss inversely affected HGS, as did intrinsic factors like age and sex.</p><p><strong>Conclusions: </strong>Limited global studies and heterogeneous study data emerged as the major shortcomings in our systematic study review and precluded meta-analysis. Therefore, further studies are needed with standard methodologies and outcome measures as well as good global representation.</p><p><strong>Trial registration: </strong>PROSPERO Identifier: CRD42023441854.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"169-179"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of susceptibility modules and genes for peri-implantitis compared to periodontitis within the same host environment using weighted gene co-expression network analysis.","authors":"Ju-Young Lee, Yeongjoo Kim, Jung-Min Oh, Yun Hak Kim, Hyun-Joo Kim","doi":"10.5051/jpis.2401500075","DOIUrl":"10.5051/jpis.2401500075","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to identify new susceptibility modules and genes by analyzing the transcriptional profiles of peri-implantitis and periodontitis within the same host environment, using weighted gene co-expression network analysis (WGCNA).</p><p><strong>Methods: </strong>Gingival tissue samples were collected from 10 patients, each presenting with both periodontitis and peri-implantitis sites, and were used for RNA sequencing. We conducted WGCNA to identify key modules that showed distinct transcriptional expression profiles between periodontitis and peri-implantitis. Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analyses were carried out using R software. Genes with an adjusted <i>P</i> value greater than 0.05 were excluded from gene selection using the Pearson correlation method.</p><p><strong>Results: </strong>A total of 2,226 regulated genes were identified, and those with similar expression patterns were grouped into 5 color-coded functional modules using WGCNA. Among these, 3 modules showed distinct differences in expression profiles between peri-implantitis and periodontitis. The turquoise and yellow modules were associated with upregulation in peri-implantitis, while the blue module was linked to periodontitis. This finding suggests that peri-implantitis and periodontitis have significantly different transcriptional signatures. Over-representation analysis was conducted to explore the component genes of the established modules. The top-ranked genes, selected based on their network connectivity within the modules, were identified using DESeq2 and were considered hub genes.</p><p><strong>Conclusions: </strong>WGCNA revealed distinct modular gene patterns in peri-implantitis and periodontitis, highlighting transcriptional differences between the 2 conditions. Notably, we identified 10 key genes from each of the 3 modules-the blue module associated with periodontitis-dominant pathways, and the turquoise and yellow modules associated with peri-implantitis-dominant pathways. The hub genes and pathways unveiled in this research are likely key contributors to the progression of peri-implantitis and warrant further exploration as promising candidates.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"217-231"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polynucleotide with cross-linked hyaluronic acid reduces inflammation and increases collagen synthesis.","authors":"Hee-Seung Han, Hye-Rim Shin, Sungtae Kim, Young-Dan Cho","doi":"10.5051/jpis.2402520126","DOIUrl":"10.5051/jpis.2402520126","url":null,"abstract":"<p><strong>Purpose: </strong>Gingival fibroblasts are a major cellular component of the connective tissue and play a crucial role in wound healing and tissue regeneration through collagen synthesis. This study aimed to assess the effect of polynucleotide (PN) combined with cross-linked hyaluronic acid (HA) on the proliferation, differentiation, and anti-inflammatory responses of human gingival fibroblasts-1 (HGF-1).</p><p><strong>Methods: </strong>In this <i>in vitro</i> experimental study, HGF-1 cells were cultured with PN/HA, PN, HA, and enamel matrix derivative (EMD). Cell proliferation and migration were assessed at 24 hours and 48 hours, respectively. Long-term cultures were evaluated for collagen and proteoglycan deposition using sirius red and alcian blue staining. Levels of phospho-nuclear factor-κB (NF-κB) p65, collagen type I (Col 1), and interleukin-6 (IL-6) were measured using Western blot analysis or enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>All experimental groups exhibited increased cellular proliferation and migration compared to the control group. Similar to EMD, PN/HA promoted the synthesis of Col 1 and proteoglycans. At concentrations of 2.5 mg/mL for PN and HA, and 1.0 mg/mL for PN/HA, significant anti-inflammatory effects were observed. These effects included reductions in phospho-NF-κB p65 levels and IL-6 production when exposed to lipopolysaccharides from <i>Porphyromonas gingivalis</i>. EMD, however, did not demonstrate these anti-inflammatory effects.</p><p><strong>Conclusions: </strong>Within the limitations of this study, we concluded that PN/HA improves gingival tissue healing by promoting cell proliferation and migration, facilitating rapid collagen deposition, and exerting anti-inflammatory effects.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"206-216"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of the menstrual cycle on inflammatory markers: the cytokines Il-1β, IL-6, and TNF-α in the gingival crevicular fluid.","authors":"Jules Julien Ndjoh, Metogo Ntsama Junie Annick, Campbell Ngoumusi Etone, Zilefac Brian Ngokwe, Sandra Lydie Akena Ndeng, Réné Ngoulma, Lawrence Essama Eno Belinga, Vicky Ama Moor","doi":"10.5051/jpis.2400820041","DOIUrl":"10.5051/jpis.2400820041","url":null,"abstract":"<p><strong>Purpose: </strong>Hormonal fluctuations, primarily in progesterone and estrogen during the menstrual cycle, may influence periodontal tissues, with inflammatory cytokines playing a crucial role. Therefore, our primary objective was to assess clinical periodontal parameters and measure levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in gingival crevicular fluid (GCF) throughout the menstrual cycle.</p><p><strong>Methods: </strong>This longitudinal prospective study was conducted from February to April 2022 and included 50 participants. We assessed clinical periodontal parameters-plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL), and tooth mobility-at three stages of the menstrual cycle: menstruation day, ovulation day, and premenstrual day. Additionally, GCF samples were collected using paper points. These samples were then stored and analyzed for levels of IL-1β, IL-6, and TNF-α using enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>There were 25 participants in our study. The GI, PD, and CAL increased significantly during the menstrual cycle and were significantly higher during the premenstrual phase than in the ovulation phase (<i>P</i><0.05). The levels of GCF IL-1β (<i>P</i>=0.012), IL-6 (<i>P</i>=0.002), and TNF-α (<i>P</i>=0.015) showed statistically significant throughout the menstrual cycle compared to baseline which was the menstrual (follicular) phase. Furthermore, the GCF levels of IL-1β and IL-6 reached their peak during the luteal or premenstrual phase, whereas TNF-α peaked during the ovulation phase. The increase in biological markers was more pronounced between the menstruation phases than the clinical periodontal markers.</p><p><strong>Conclusions: </strong>All clinical periodontal parameters, except for the PI, showed a slight increase from the follicular phase to the luteal phase, with significant differences observed between each phase. The levels of GCF IL-1β (<i>P</i>=0.012), IL-6 (<i>P</i>=0.002), and TNF-α (<i>P</i>=0.015) were statistically significant, with increases in IL-1β and IL-6 throughout the menstrual cycle, peaking in the luteal phase. This demonstrates the influence of the menstrual cycle on clinical periodontal and GCF inflammatory markers.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 3","pages":"180-190"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone regeneration and biosorption patterns of different bone substitutes: an <i>in vivo</i> study in rabbit skulls.","authors":"Seunghee Lee, Jungwoo Jung, Jungwon Lee, Young-Chang Ko, Dongseob Lee, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee","doi":"10.5051/jpis.2402840142","DOIUrl":"10.5051/jpis.2402840142","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the bone regeneration and biosorption patterns of different bone substitutes in a rabbit skull defect model.</p><p><strong>Methods: </strong>Four circular 8 mm-defects were created in the cranium of 12 New Zealand white rabbits, each weighing approximately 3 kg. Each defect was randomly assigned to one of 4 treatment groups: cortical deproteinized porcine bone mineral (DPBM), cancellous DPBM, biphasic calcium phosphate (BCP) with a 6:4 ratio of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) (TCP4), and BCP with a 2:8 ratio of HA to β-TCP (TCP8). The rabbits were euthanized at either 6 weeks (n=6) or 12 weeks (n=6) post-surgery. The harvested specimens were then analyzed both radiographically and histomorphometrically.</p><p><strong>Results: </strong>In the micro-computed tomography analysis, no statistically significant differences were observed among the 4 groups, except in the bone graft volume/tissue volume (GV/TV) at 12 weeks. Cortical DBPM exhibited a higher GV/TV ratio than cancellous DBPM at the same time point. The histomorphometric analysis revealed increased biosorption in cancellous DBPM compared to cortical DBPM at 12 weeks. However, the percentage of newly formed bone did not significantly differ among the 4 groups.</p><p><strong>Conclusions: </strong>All types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"191-205"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> evaluation of prosthesis-level implant stability using 'BracketPeg'.","authors":"Hyunkyung Kim, Gwanhwi Noh, Hyunjae Kim, Hee-Seung Han, Sungtae Kim, Young-Dan Cho","doi":"10.5051/jpis.2403620181","DOIUrl":"10.5051/jpis.2403620181","url":null,"abstract":"<p><strong>Purpose: </strong>A small magnetic peg, named \"BracketPeg,\" has been developed as an attachment magnet for implant prostheses. This study aimed to determine the feasibility of measuring implant stability at the prosthesis level, evaluate the reliability and accuracy of BracketPeg, and examine the consistency of measurements obtained using other devices for damping capacity assessment (DCA) and resonance frequency analysis (RFA).</p><p><strong>Methods: </strong>Forty implants were installed into artificial bone blocks, with each block representing 1 of 4 different diameters (3.5, 4.0, 4.5, and 5.5 mm; 10 implants per diameter). Each implant was paired with a customized zirconia prosthesis that matched the implant diameter. Implant stability was measured at both the fixture and prosthesis levels using Anycheck™ (Neobiotech) for DCA and Osstell™ Beacon (W&H) and ChecQ™ (Dentis) for RFA. To obtain prosthesis-level measurements using RFA devices, BracketPeg was attached to the coronal, middle, and apical thirds of the prosthesis to evaluate implant stability.</p><p><strong>Results: </strong>The implant stability quotient (ISQ) was significantly lower at the prosthesis level than at the fixture level (<i>P</i><0.001), reflecting the impact of the increased mass and size of the prosthesis. RFA values varied depending on the position of BracketPeg, with lower stability values observed at the coronal position than at the apical position. The 2 RFA devices demonstrated reasonable agreement between ISQ measurements, with a mean difference of -0.58 (95% confidence interval: ±0.31).</p><p><strong>Conclusions: </strong>BracketPeg provides reliable and consistent implant stability measurements at the prosthesis level compared to other devices, making it a practical and feasible tool for the clinical evaluation of implants.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"232-244"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New developments and future directions of the <i>Journal of Periodontal & Implant Science</i>.","authors":"Yong-Gun Kim, Shin-Young Park, Jae-Kook Cha, Dae-Young Kang, Hwan Tae Ahn, Jun-Beom Park","doi":"10.5051/jpis.255503edi01","DOIUrl":"10.5051/jpis.255503edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 3","pages":"167-168"},"PeriodicalIF":2.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive effect of soft tissue grafting in the surgical treatment of peri-implantitis: clinical and radiographic outcomes from a preclinical canine experiment.","authors":"Young Woo Song, Jin-Young Park, Ui-Won Jung, Wan Zhen Lee, Daniel S Thoma, Nadja Naenni","doi":"10.5051/jpis.2500440022","DOIUrl":"https://doi.org/10.5051/jpis.2500440022","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to clinically and radiographically investigate the effect of soft tissue grafting as an adjunct in the surgical treatment of ligature-induced peri-implantitis lesions in canines.</p><p><strong>Methods: </strong>Seven Mongrel dogs received implant placements on both sides of the posterior mandible (3 fixtures per side). After inducing peri-implantitis via ligation with suture material, surgical treatment was performed on each implant according to randomly assigned groups: DI, implantoplasty only; DIB, implantoplasty followed by collagenated, deproteinized bovine bone mineral (DBBM-C) grafting; DIC, implantoplasty followed by autogenous connective tissue graft (CTG); DIV, implantoplasty followed by volume-stable collagen matrix (VCMX) grafting; DIBC, implantoplasty followed by DBBM-C grafting and CTG; and DIBV, implantoplasty followed by DBBM-C and VCMX grafting. Clinical and radiographic outcomes were evaluated. Composite treatment success was defined by the following criteria: absence of bleeding on probing at 12 weeks post-surgery; a reduction in probing depth (PD) or an increase of 1 mm or less in PD at 12 weeks post-surgery; and absence of additional bone loss ≥0.5 mm at 12 weeks post-surgery compared to radiographic baseline. Statistical significance was set at <i>P</i><0.05.</p><p><strong>Results: </strong>All groups exhibited clinical and radiographic improvement after surgery. Clinical parameters, radiographic bone levels, and mucosal thickness did not significantly differ among the groups. The DI and DIV groups demonstrated higher composite treatment success rates (71.4%) compared to the other 4 groups. Adjunctive soft tissue grafting resulted in fewer changes in peri-implant mucosa. The effect of hard tissue grafting on bone regeneration was minimal, and combining hard and soft tissue grafting did not yield better outcomes than implantoplasty alone.</p><p><strong>Conclusions: </strong>The surgical treatment of peri-implantitis lesions remains challenging. Soft tissue grafting showed clinical benefits by reducing changes in the peri-implant mucosa. The effect of hard tissue grafting on bone regeneration was very limited.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Root coverage and patient-reported outcomes of de-epithelialized gingival graft with and without leukocyte platelet-rich fibrin in multiple recession defects: a split-mouth randomized trial.","authors":"Ahu Uraz Corekci, Cansu Gursoy, Deniz Ozbay Cetiner, Berceste Guler Ayyildiz, Serpil Cula","doi":"10.5051/jpis.2404300215","DOIUrl":"https://doi.org/10.5051/jpis.2404300215","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to compare the clinical efficacy and patient-reported outcomes of de-epithelialized gingival graft (DGG) alone versus DGG combined with leukocyte platelet-rich fibrin (L-PRF) for the treatment of multiple adjacent gingival recessions using a coronally advanced flap technique.</p><p><strong>Methods: </strong>In this split-mouth randomized controlled trial, 15 patients with multiple gingival recessions affecting at least 3 adjacent teeth were treated on one side with DGG only (termed the DGG group) and on the contralateral side with DGG and L-PRF (the DGG+PRF group). Clinical parameters-recession depth, recession width, probing depth, clinical attachment level, keratinized tissue width, gingival thickness, and percentage of root coverage (RC%)-were recorded at 1 month, 3 months, and 6 months postoperatively. Patient-reported outcome measures, including Oral Health Impact Profile-14 scores, postoperative pain, bleeding, discomfort, and analgesic consumption, were also assessed.</p><p><strong>Results: </strong>At T6, the mean RC% was 93.30%±6.97% in the DGG group and 95.28%±4.99% in the DGG+PRF group, with no statistically significant difference observed. Patients receiving DGG+PRF reported significantly lower discomfort on days 2, 3, and 5 and reduced pain on days 6 and 7 relative to the DGG group.</p><p><strong>Conclusions: </strong>Combining L-PRF with DGG achieves root coverage outcomes comparable to DGG alone, while significantly reducing early postoperative discomfort and morbidity.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the quality and empathy of responses to patient questions on the Korean Academy of Periodontology's online question and answer section: a cross-sectional study comparing periodontists and an AI-powered chatbot.","authors":"Jae-Hong Lee, So-Hae Oh, Falk Schwendicke, Akhilanand Chaurasia, Young-Taek Kim","doi":"10.5051/jpis.2402220111","DOIUrl":"https://doi.org/10.5051/jpis.2402220111","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate and compare the responses of an artificial intelligence (AI)-powered chatbot and professional periodontists to patient queries in periodontology and implantology, using the Korean Academy of Periodontology's (KAP) online question and answer (Q&A) section.</p><p><strong>Methods: </strong>In this comparative cross-sectional study, we analyzed 219 patient-submitted periodontal and implant knowledge questions from the KAP online Q&A section. A panel of 10 evaluators-5 periodontists and 5 laypersons-rated both the periodontist's and the AI chatbot's responses using standardized scales. We applied the <i>t</i>-test and Spearman correlation coefficients to compare response quality, empathy, consistency, and evaluator preferences.</p><p><strong>Results: </strong>Ten evaluators judged the AI chatbot's responses to be significantly superior in quality and empathy compared to periodontist replies. A higher proportion of periodontist responses fell below acceptable quality (\"very poor\" or \"poor\") than chatbot responses (28.7% vs. 15.0%; <i>P</i><0.001), and more chatbot replies were rated \"empathetic\" or \"very empathetic\" (62.5% vs. 42.8%; <i>P</i><0.001). Overall response consistency was deemed satisfactory at 64.2%, with no significant difference in consistency or preference between periodontist and lay evaluators.</p><p><strong>Conclusions: </strong>AI-powered chatbots can deliver more accurate and empathetic answers than human periodontists, suggesting their potential role as consultation assistants merits further investigation. The high intraclass correlation coefficient values (0.79-0.93) indicate a high level of agreement among evaluators in both the periodontist and lay evaluator groups, thus confirming the reliability and robustness of the study's assessment methodology.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144276372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}