Journal of Periodontal and Implant Science最新文献

{"title":"Modified tunnel technique with and without enamel matrix derivative for deep and narrow gingival recession in the mandibular anterior region: a 3-year longitudinal and retrospective cohort population-based study.","authors":"Jae-Hong Lee, Yeon-Tae Kim","doi":"10.5051/jpis.2400760038","DOIUrl":"10.5051/jpis.2400760038","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to evaluate the 3-year predictability and validity of the modified tunnel technique, both with and without the use of enamel matrix derivative (EMD), for treating deep and narrow gingival recession defects (GRDs) in the mandibular anterior region.</p><p><strong>Methods: </strong>Overall, 31 GRDs were treated using the modified tunnel technique combined with subepithelial connective tissue graft. The cohort was divided into 2 groups: one with the adjunctive use of EMD (n=16) and the other without EMD (n=15). Clinical outcomes, including recession depth (RD), keratinized tissue width (KTW), mean root coverage (MRC), and complete root coverage (CRC), were evaluated at baseline, as well as at 6 months, 1 year, and 3 years postoperatively. Patient discomfort was assessed with a self-report questionnaire 2 weeks after surgery.</p><p><strong>Results: </strong>At the 3-year follow-up, no statistically significant differences were observed between the 2 treatment modalities in clinical parameters, including RD (EMD, -6.47±2.23 mm; non-EMD, -5.10±3.23 mm), KTW (EMD, 1.03±0.96 mm; non-EMD, 1.00±1.02 mm), MRC (EMD, 86.62%±21.18%; non-EMD, 80.24%±38.73%), and CRC (EMD, 62.5%; non-EMD, 73.3%). Furthermore, no significant differences were found between the groups in terms of early and subjective postoperative discomfort, including pain and swelling.</p><p><strong>Conclusions: </strong>Within the limitations of this study, the modified tunnel technique, whether used alone or in conjunction with EMD, demonstrated benefits in the treatment and maintenance of deep and narrow GRDs.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"295-305"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between bone quality and shrinkage in maxillary sinus augmentation using synthetic alloplast versus xenograft.","authors":"Rachad Kudsi, Dolphus R Dawson, Octavio A Gonzalez, Ahmad Kutkut, Michelle A Tucci, Rosario Porras-Aguilar, Ana Espinosa Momox, Mohanad Al-Sabbagh","doi":"10.5051/jpis.2401320066","DOIUrl":"10.5051/jpis.2401320066","url":null,"abstract":"<p><strong>Purpose: </strong>This clinical study evaluated differences in bone quality within the maxillary sinus when either alloplast or xenograft material was applied.</p><p><strong>Methods: </strong>Twenty participants requiring lateral sinus approach augmentation for delayed implant placement were divided into 2 groups. The first group received a silica-calcium phosphate composite (SCPC) alloplast, while the second received a bovine bone xenograft (Bio-Oss). Cone-beam computed tomography (CBCT) was used to measure changes in bone height and area immediately after surgery and 5 months after augmentation. Picrosirius red staining of bone biopsies, obtained during implant placement, was analyzed under polarized microscopy. A MATLAB algorithm was used for analysis following image acquisition.</p><p><strong>Results: </strong>CBCT measurements revealed a statistically significant reduction in linear bone height among xenograft recipients (<i>P</i>≤0.001). This finding indicated greater resorption compared to the alloplast group, which exhibited no significant difference in bone height at 5 months following sinus augmentation. Furthermore, 40% of xenograft recipients displayed an absence of mineralized tissue formation, indicating a limited osteoconductive effect compared to the alloplast group, in which mineralized bone tissue was present in all samples. Polarized light microscopy and color intensity measurements of picrosirius red-stained bone biopsies revealed a significantly higher ratio of mineralized collagen I to collagen III in the newly formed bone for alloplast compared to xenograft recipients. Trichrome staining demonstrated collagen I mineralization with the presence of osteoblasts and osteocytes, indicating new bone formation. The newly formed bone in the alloplast group exhibited markers of maturation, including the formation of reversal lines, Haversian systems, and blood vessels. Resorption of the SCPC alloplast-grafted granules was also observed.</p><p><strong>Conclusions: </strong>The increased formation and maturation of new bone appear responsible for the preservation of bone height in alloplast group recipients.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"306-320"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of partial-mouth periodontal examinations for diagnosing periodontal disease.","authors":"Bohee Kang, Jae Suk Jung, Sunjin Kim, Geum Hee Choi, Heelim Lee, Bumhee Park, Hyelynn Jeon, Suk Ji","doi":"10.5051/jpis.2403400170","DOIUrl":"10.5051/jpis.2403400170","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the reliability of partial-mouth periodontal examinations (PMPEs) for 1) identifying the presence of periodontitis, 2) staging periodontal disease, and 3) reflecting mean clinical parameters.</p><p><strong>Methods: </strong>All patients were diagnosed using 8 different exam types: (A) full-mouth periodontal examination (FMPE), (B) Community Periodontal Index of Treatment Needs (CPITN) codes, (C) panoramic radiographs only, (D) clinical parameters only, (E) 6 teeth, including the first molar (#11, #16, #26, #31, #36, #46), (F) CPITN index teeth (#11, #16, #17, #26, #27, #31, #36, #37, #46, #47), (G) Ramfjord teeth (#16, #21, #24, #36, #41, #44), and (H) 10 modified Ramfjord teeth, including all first premolars and first molars (#16, #14, #21, #24, #26, #36, #34, #41, #44, #46). Case definitions were established according to the criteria outlined in the 2018 American Academy of Periodontology/European Federation of Periodontology classification of periodontal diseases. The accuracy of diagnosis and diagnostic performance were assessed using the kappa coefficient and area under the curve (AUC)/receiver operating characteristic analyses, respectively. To compare the mean clinical parameters, intraclass correlation coefficients (ICCs) were calculated between 4 types of PMPEs (E, F, G, H) and FMPE.</p><p><strong>Results: </strong>In total, 218 subjects (130 female, 88 male) were included in this study. Exam type F achieved perfect agreement (kappa coefficient: 1.0) in identifying the presence of periodontitis, and it showed almost perfect agreement in staging periodontal disease (0.85≤ kappa ≤0.98) except for the healthy category, with AUCs ≥0.97. Exam type H demonstrated the highest correlations of all mean clinical parameters with FMPE (ICCs ≥0.96).</p><p><strong>Conclusions: </strong>PMPEs using the CPITN index teeth can be an excellent alternative for diagnosing periodontitis and staging its severity.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"273-284"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus statement on peri-implant disease from the Korean Academy of Periodontology.","authors":"Young Woo Song, Yun-Jeong Kim, Shin-Young Park, Jae-Kook Cha, Hyo-Jung Lee, Seung-Min Yang, Jun-Beom Park, Ki-Tae Koo","doi":"10.5051/jpis.2501920096","DOIUrl":"10.5051/jpis.2501920096","url":null,"abstract":"<p><p>This consensus report presents the first official position statement of the Korean Academy of Periodontology on peri-implant diseases, issued in response to South Korea's rapidly aging population and the associated rise in peri-implant disease management. It reviews the prevalence, classification, and definition of peri-implant diseases, emphasizing that these conditions progress more aggressively and unpredictably than periodontal diseases. The report also identifies systemic and local risk indicators, diagnostic criteria, and evidence-based treatment protocols for peri-implant mucositis and peri-implantitis, integrating international standards with Korea-specific clinical data. Clinical recommendations include structured maintenance programs, risk-based recall intervals, and patient education, with the goal of reducing disease recurrence and improving long-term implant success.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 4","pages":"247-254"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of flap tension with flap design and graft volume in soft tissue augmentation: a cadaveric study in pigs.","authors":"Miha Pirc, Leonardo Mancini, Nicolas Müller, Hyun-Chang Lim, Ronald E Jung, Daniel S Thoma, Stefan P Bienz","doi":"10.5051/jpis.2402540127","DOIUrl":"10.5051/jpis.2402540127","url":null,"abstract":"<p><strong>Purpose: </strong>This study was performed to evaluate the effects of flap design, grafting material, and graft dimension on flap tension and the initial volume increase achieved in soft tissue augmentation.</p><p><strong>Methods: </strong>Six fresh porcine jaw cadavers were used in this study. Each side of the jaw was randomly assigned to receive either a standard split-thickness flap or a split-thickness flap with a palatal island. Following flap preparation, random allocation was employed to determine the order of 4 treatment modalities: 3 mm of a volume-stable collagen matrix (VCMX), 6 mm VCMX, 3 mm of a subepithelial connective tissue graft (SCTG), and 6 mm SCTG. Flap tension was measured and the wound was closed after the insertion of each specimen. Intraoral scans were taken before flap preparation and after closure to facilitate profilometric analysis.</p><p><strong>Results: </strong>The palatal island flap exhibited significantly greater overall (<i>P</i>=0.010) and crestal (<i>P</i>=0.007) volume gains compared to the split-thickness flap, regardless of the use of VCMX or SCTG. The palatal island flap was associated with significantly lower flap tension force values (0.6 N; <i>P</i>=0.035) than the split-thickness flap. Both materials (VCMX and SCTG) demonstrated comparable volume gains.</p><p><strong>Conclusions: </strong>The findings of this cadaveric study indicate that the use of a palatal island flap effectively reduces flap tension. While both materials (VCMX and SCTG) yielded similar increases in volume, the palatal island flap demonstrated greater volume gains than the split-thickness flap for each grafting material.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"285-294"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned medium from cultured cementoblasts upregulates amelotin gene expression via the SOCS3 signaling pathway.","authors":"Yohei Nakayama, Kazuma Igarashi, Zhenyu Jin, Arisa Yamaguchi, Bernhard Ganss, Yorimasa Ogata","doi":"10.5051/jpis.2403080154","DOIUrl":"10.5051/jpis.2403080154","url":null,"abstract":"<p><strong>Purpose: </strong>The junctional epithelium (JE) covers the cervical areas of developing or existing teeth. It can re-establish itself even after being removed during periodontal therapies, followed by wound healing. However, the mechanisms that can maintain this universally conserved structure are still unclear.</p><p><strong>Methods: </strong>The molecular mechanisms of JE homeostasis were investigated by altering levels of JE-specific genes in a telomerase immortalized human gingival epithelial cell line (TIGKs) by exposing TIGKs to conditioned medium (C-CM) from cultivated human cementoblasts. The mRNA and protein levels of JE-associated genes in TIGKs were examined using real-time polymerase chain reaction (PCR) and immunocytochemistry (ICC) after treatment with C-CM. The candidate pathways related to differential mRNA and protein expression were analyzed with a DNA microarray and identified using Kyoto Encyclopedia of Genes and Genomes and WikiPathways. Real-time PCR and ICC were conducted to confirm the changes in the expressions of candidate genes.</p><p><strong>Results: </strong>mRNA levels and protein expressions of amelotin (<i>Amtn</i>) were upregulated after treatment with C-CM for 48 hours. DNA microarray analyses identified 595 genes that were upregulated >2-fold, and 820 genes that were downregulated >2-fold. C-CM promoted the expression of suppressor of cytokine signaling 3 and reduced the expression of an inactivator of Janus kinase 2. Both signaling molecules were found, using siRNA technology, to mediate the increase of <i>Amtn</i> mRNA and protein expression levels.</p><p><strong>Conclusions: </strong>The upregulation of <i>Amtn</i> in gingival epithelial cells by C-CM suggests that this regulatory pathway is associated with the homeostasis of JE structures by the cementum.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":"255-272"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap: the essential collaboration between orthodontists and periodontists.","authors":"Kee-Joon Lee","doi":"10.5051/jpis.255504edi01","DOIUrl":"10.5051/jpis.255504edi01","url":null,"abstract":"","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":"55 4","pages":"245-246"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144975278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.","authors":"Yerim Oh, Bo Hyun Jung, Ki-Yeon Yoo, In-Kyung Hwang, Jong-Bin Lee, Heung-Sik Um, Jae-Kwan Lee","doi":"10.5051/jpis.2501080054","DOIUrl":"https://doi.org/10.5051/jpis.2501080054","url":null,"abstract":"<p><strong>Purpose: </strong>Fusion of molar roots is a common variation of root morphology known to adversely affect periodontal disease prognosis. Among methods for inducing experimental periodontal disease in animal models, the ligature-induced periodontitis (LIP) mouse model is most frequently employed. However, few studies have examined root abnormalities in experimental mice. This study aimed to investigate the incidence of root fusion in the maxillary second molars of mice and determine its relationship with alveolar bone loss, offering new insights into animal LIP models.</p><p><strong>Methods: </strong>From 2019 to February 2024, 222 Institute of Cancer Research mice (444 maxillary second molars), which served as control animals in periodontitis experiments conducted by the Department of Periodontology and the Department of Anatomy at the College of Dentistry, Gangneung-Wonju National University, were initially examined. After excluding fractured or missing teeth, 402 teeth were included in the final analysis. Root fusion was evaluated using micro-computed tomography and categorized by the degree of fusion. To examine the relationship between fused roots and alveolar bone loss, the distance from the cementoenamel junction to the alveolar bone crest was measured on the mesial and distal sides of the maxillary second molars.</p><p><strong>Results: </strong>Root fusion was found in 10.4% of animals and 6.5% of teeth. Two types of fusion were observed: mesio-palatal (MP) and disto-palatal. Partial root fusion was more frequent than complete fusion. Within the ligation group, teeth with MP fusion exhibited greater alveolar bone loss than those without root fusion (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Within the limitations of this study, maxillary second molars with MP root fusion accelerated alveolar bone loss in ligated teeth in a LIP mouse model. Future research should consider deviations resulting from MP root fusion.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of L-shaped, loosely packed versus non-trimmed, compactly packed non-fixed collagenated bone blocks on the stability of augmented sites in chronic peri-implant dehiscence defects: a pre-clinical <i>in vivo</i> experimental study.","authors":"Dong-Woon Lee, Jae-Hong Lee","doi":"10.5051/jpis.2501840092","DOIUrl":"https://doi.org/10.5051/jpis.2501840092","url":null,"abstract":"<p><strong>Purpose: </strong>This pre-clinical study aimed to compare the efficacy of L-shaped, loosely packed soft block bone substitutes (BBS, LP group) with that of non-trimmed, compactly packed soft BBS (CP group), both covered with a non-fixed collagen membrane, on augmentation stability and new bone formation in chronic peri-implant dehiscence defects treated with guided bone regeneration (GBR).</p><p><strong>Methods: </strong>In 4 mongrel dogs, 4 standardized box-shaped buccal defects were surgically created in each jaw. Following a 4-week period of spontaneous healing, a total of 32 dental implants were placed, with 2 implants inserted into each defect. Each defect was randomly assigned to either the LP or CP group. Statistical comparisons between groups were conducted using the Mann-Whitney U test. Bland-Altman and Spearman correlation analyses were also performed to evaluate the relationship and agreement between micro-computed tomography (micro-CT) and histomorphometric measurements.</p><p><strong>Results: </strong>Micro-CT and histomorphometric analyses revealed no significant differences in bone width at any apical level between the LP and CP groups. Both groups exhibited similar increases in bone width, although bone retention in the coronal region remained limited. Additionally, micro-CT tended to slightly overestimate bone width (mean difference, 0.31 mm), but showed a strong correlation with histomorphometric analysis (<i>r</i>=0.971, <i>P</i><0.001), supporting the reliability of radiographic methods for bone assessment.</p><p><strong>Conclusions: </strong>Neither LP nor CP soft BBS effectively prevented morphological collapse in the coronal region of augmented sites when used without additional membrane fixation. These findings underscore the necessity of enhanced stabilization techniques to improve structural integrity and bone regeneration in GBR procedures.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The synergistic pro-inflammatory effect of butyric and propionic acid on human periodontal ligament cells via activation of G-protein-coupled receptor 41.","authors":"Xianjun Lu, Zijian Yuan, Wenling Huang, Jingjing Liu, Baoqi Chen, Lihong Guo","doi":"10.5051/jpis.2402200110","DOIUrl":"https://doi.org/10.5051/jpis.2402200110","url":null,"abstract":"<p><strong>Purpose: </strong>Periodontitis is a chronic disease that ultimately leads to tooth loss. This study aimed to investigate the inflammatory effects of short-chain fatty acids (SCFAs) on human periodontal ligament cells (hPDLCs).</p><p><strong>Methods: </strong>Immunofluorescence was employed to assess the expression of G protein-coupled receptors (GPRs) in hPDLCs. The Cell Counting Kit-8 and enzyme-linked immunosorbent assay kits were utilized to examine the regulatory effects of SCFAs on both the proliferation and secretion of pro-inflammatory factors in hPDLCs. Western blot analysis was performed to investigate the potential inflammatory responses in hPDLCs induced by SCFAs.</p><p><strong>Results: </strong>GPR41 was expressed on the surface of hPDLCs. The viability of hPDLCs was significantly reduced after exposure to both 7 mM butyric acid and 10 mM propionic acid. Additionally, a combination of 10 mM butyric acid and 10 mM propionic acid significantly increased the production of interleukin (IL)-6, IL-1β, and tumor necrosis factor-α in hPDLCs. Treatment with both 7 mM butyric acid and 10 mM propionic acid led to a significant increase in p65 phosphorylation in hPDLCs. There was no statistical difference in proliferation and pro-inflammatory effects after the addition of a GPR41 receptor inhibitor compared to the phosphate-buffered saline control.</p><p><strong>Conclusions: </strong>Butyric acid and propionic acid exhibited a synergistic effect in inhibiting the proliferation of hPDLCs and enhancing their pro-inflammatory responses. This may be mediated through the activation of GPR41. Additionally, these acids could synergistically activate the nuclear factor-κB signaling pathway via GPR41 in hPDLCs.</p>","PeriodicalId":48795,"journal":{"name":"Journal of Periodontal and Implant Science","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144838329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}