Bone regeneration and biosorption patterns of different bone substitutes: an in vivo study in rabbit skulls.

IF 2.2 4区 医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE
Seunghee Lee, Jungwoo Jung, Jungwon Lee, Young-Chang Ko, Dongseob Lee, Ki-Tae Koo, Yang-Jo Seol, Yong-Moo Lee
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Abstract

Purpose: This study aimed to analyze the bone regeneration and biosorption patterns of different bone substitutes in a rabbit skull defect model.

Methods: Four circular 8 mm-defects were created in the cranium of 12 New Zealand white rabbits, each weighing approximately 3 kg. Each defect was randomly assigned to one of 4 treatment groups: cortical deproteinized porcine bone mineral (DPBM), cancellous DPBM, biphasic calcium phosphate (BCP) with a 6:4 ratio of hydroxyapatite (HA) to β-tricalcium phosphate (β-TCP) (TCP4), and BCP with a 2:8 ratio of HA to β-TCP (TCP8). The rabbits were euthanized at either 6 weeks (n=6) or 12 weeks (n=6) post-surgery. The harvested specimens were then analyzed both radiographically and histomorphometrically.

Results: In the micro-computed tomography analysis, no statistically significant differences were observed among the 4 groups, except in the bone graft volume/tissue volume (GV/TV) at 12 weeks. Cortical DBPM exhibited a higher GV/TV ratio than cancellous DBPM at the same time point. The histomorphometric analysis revealed increased biosorption in cancellous DBPM compared to cortical DBPM at 12 weeks. However, the percentage of newly formed bone did not significantly differ among the 4 groups.

Conclusions: All types of bone substitutes demonstrated similar patterns of bone regeneration at both 6 and 12 weeks of observation. However, cancellous DPBM exhibited a higher rate of bioabsorption compared to other bone substitutes, suggesting that it may have different indications or applications in guided bone regeneration protocols.

不同骨替代物的骨再生和生物吸收模式:兔颅骨体内研究。
目的:研究不同骨替代物在兔颅骨缺损模型中的骨再生和生物吸附规律。方法:在12只新西兰大白兔头盖骨上制造4个8 mm圆形缺损,每只约3 kg。每个缺陷随机分为4个处理组:皮质脱蛋白猪骨矿物质(DPBM)、松质DPBM、双相磷酸钙(BCP)(羟基磷灰石(HA)与β-磷酸三钙(β-TCP)的比例为6:4)和HA与β-TCP的比例为2:8的BCP (TCP8)。分别于术后6周(n=6)或12周(n=6)实施安乐死。然后对收获的标本进行放射学和组织形态学分析。结果:在显微计算机断层扫描分析中,除12周时植骨体积/组织体积(GV/TV)差异外,4组间差异无统计学意义。在同一时间点,皮质DBPM比松质DBPM表现出更高的GV/TV比值。组织形态计量学分析显示,与皮质DBPM相比,松质DBPM在12周时生物吸收增加。而新生骨百分率在4组间无显著差异。结论:在6周和12周的观察中,所有类型的骨替代物均表现出相似的骨再生模式。然而,与其他骨替代品相比,松质DPBM表现出更高的生物吸收率,这表明它可能在引导骨再生方案中具有不同的适应症或应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Periodontal and Implant Science
Journal of Periodontal and Implant Science DENTISTRY, ORAL SURGERY & MEDICINE-
CiteScore
3.30
自引率
5.30%
发文量
38
期刊介绍: Journal of Periodontal & Implant Science (JPIS) is a peer-reviewed and open-access journal providing up-to-date information relevant to professionalism of periodontology and dental implantology. JPIS is dedicated to global and extensive publication which includes evidence-based original articles, and fundamental reviews in order to cover a variety of interests in the field of periodontal as well as implant science.
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