Edson M Kato-Junior, Carlos R Padovani, Roberta L F S Meneghim, Silvana A Schellini
{"title":"Congenital anophthalmia treated with a dermis fat graft combined with a skin graft in the upper lid in early childhood.","authors":"Edson M Kato-Junior, Carlos R Padovani, Roberta L F S Meneghim, Silvana A Schellini","doi":"10.4103/sjopt.sjopt_344_25","DOIUrl":"10.4103/sjopt.sjopt_344_25","url":null,"abstract":"<p><p>Three infants with unilateral congenital anophthalmia and contracted sockets received early dermis fat and eyelid skin grafts, plus progressive conformer therapy. This approach expanded socket volume, improved periorbital and eyelid dimensions, and enhanced facial esthetics. All patients successfully adapted to ocular prostheses, showing the benefits of timely intervention and reconstruction.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"275-277"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria P Laezza, Maria L Passaro, Francesco Matarazzo, Antonella D'Aponte, Raffaele Piscopo, Giuseppe Mariniello, Diego Strianese
{"title":"Hemophagocytic lymphohistiocytosis of the ocular adnexal mimicking orbital cellulitis in a patient with unknown X-linked lymphoproliferative syndrome type 1 (XLP1): Case report and literature review.","authors":"Maria P Laezza, Maria L Passaro, Francesco Matarazzo, Antonella D'Aponte, Raffaele Piscopo, Giuseppe Mariniello, Diego Strianese","doi":"10.4103/sjopt.sjopt_147_25","DOIUrl":"10.4103/sjopt.sjopt_147_25","url":null,"abstract":"<p><p>A 5-year-old boy presented with severe acute bilateral periorbital edema. Initial misdiagnosis was made as preseptal orbital cellulitis, and he failed to respond to conventional antibiotic therapy. Magnetic resonance imaging revealed thickening of the anterior orbital adipose tissue bilaterally, with hyperintensity on T2-weighted imaging. The biopsy unveiled lymphoma-associated hemophagocytic syndrome, specifically Epstein-Barr virus related. The patient was administered rituximab, resulting in a significant amelioration. A family history, coupled with genetic investigation, ultimately led to the diagnosis of X-linked lymphoproliferative syndrome type 1 due to a large deletion of exons 2-4 of *SH2D. Reported ocular manifestation of XLP1 includes retinal hemorrhages, disc edema, acute posterior multifocal placoid pigment epitheliopathy, and macular edema. No ocular adnexal involvement has been previously reported. This case documents a case of XLP1 syndrome affecting the ocular adnexa and emphasizes the critical need to consider underlying immunodeficiencies in patients who do not respond to conventional therapies.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"256-258"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Khizar Rana, Lee Shien S Yong, Devanshu Garg, Sandy Patel, James Slattery, Garry Davis, Weng Onn Chan, Dinesh Selva
{"title":"Asymmetric thyroid eye disease.","authors":"Khizar Rana, Lee Shien S Yong, Devanshu Garg, Sandy Patel, James Slattery, Garry Davis, Weng Onn Chan, Dinesh Selva","doi":"10.4103/sjopt.sjopt_138_25","DOIUrl":"10.4103/sjopt.sjopt_138_25","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to evaluate asymmetric thyroid eye disease (TED) using an objective, radiological-based definition of asymmetry.</p><p><strong>Methods: </strong>We conducted a retrospective study on TED patients with computed tomography (CT) orbits. Demographic, biochemical, and clinical presentation data were collected. Extraocular muscle volumes were determined by manually segmenting the muscles in consecutive slices. The extraocular muscle volumes were summed in the right and left orbits. Asymmetry was defined by a ratio of ≥1.4 between the total muscle volumes of both orbits. Unilateral disease was present if there was no muscle enlargement in the opposite orbit. Hertel exophthalmometry was performed on participants, and the difference between the right and left globe protrusion was compared.</p><p><strong>Results: </strong>Fifteen out of 100 patients had asymmetric disease, of which 9 had unilateral disease. The mean age of participants was 55 ± 15 years, and 66 were female. No correlation was found between asymmetry and age, sex, thyroid status, or hormone levels. The exophthalmos difference was significantly greater in asymmetric orbits compared to nonasymmetric orbits. A cutoff of 2.75 mm for the exophthalmos difference gave a sensitivity of 0.87, specificity of 0.79, and an area under the curve of 0.83 for identifying radiologically defined asymmetric TED.</p><p><strong>Conclusion: </strong>There is currently no universally accepted definition for asymmetric TED. Current definitions rely on differences in clinical signs and symptoms between orbits which are unreliable. We present a cohort of asymmetric TED defined using an objective radiological marker of extraocular muscle volumes from CT scans.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"235-237"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Erratum: Correction of author name.","authors":"","doi":"10.4103/sjopt.sjopt_374_25","DOIUrl":"10.4103/sjopt.sjopt_374_25","url":null,"abstract":"<p><p>[This corrects the article on p. 306 in vol. 38, PMID: 39943959.][This corrects the article on p. 332 in vol. 38, PMID: 39943945.][This corrects the article on p. 322 in vol. 38, PMID: 39943953.][This corrects the article on p. 391 in vol. 38, PMID: 39943950.].</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"286"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hirohiko Kakizaki, Naoyuki Morishige, Kan Ishijima, Shinsuke Konno, Atsuya Miki, Yasuhiro Takahashi, Blanche X H Lim
{"title":"Lymphatic characteristics of the outflow tract of aqueous humor: An anatomical study in humans.","authors":"Hirohiko Kakizaki, Naoyuki Morishige, Kan Ishijima, Shinsuke Konno, Atsuya Miki, Yasuhiro Takahashi, Blanche X H Lim","doi":"10.4103/sjopt.sjopt_213_25","DOIUrl":"10.4103/sjopt.sjopt_213_25","url":null,"abstract":"<p><strong>Purpose: </strong>To microscopically examine the lymphatic characteristics of the outflow tract of aqueous humor in humans.</p><p><strong>Methods: </strong>Central sagittal sections (12 o'clock direction) of 15 ocular angle areas with sclera and conjunctiva (8 right, 5 left) from 14 Japanese cadavers, aged 36-94 years (average age: 73.0 years) were histologically examined. The specimens were fixed in 10% formalin. Staining with D2-40 was utilized to identify lymphatic channels.</p><p><strong>Results: </strong>The trabecular meshwork and Schlemm's canal exhibited D2-40 staining in all specimens. The collector channels demonstrated three staining patterns. Type 1 (2 specimens) showed strong staining that was distributed from the trabecular meshwork to the subconjunctival lymphatics throughout the sclera. Type 2 (6 specimens) had strong staining around the trabecular meshwork, Schlemm's canal, and proximal collector channels, but had thinner staining across the sclera. In the third type (7 specimens), the staining was limited to the trabecular meshwork, the Schlemm's canal, and/or the proximal collector channels. Specimens from individuals younger than 70 years predominantly exhibited type 1 and type 2 patterns. In contrast, older specimens from individuals older than 70 years of age mostly displayed type 2 and type 3 patterns, indicating reduced lymphatic staining of the sclera with age.</p><p><strong>Conclusion: </strong>The outflow pathway of the aqueous humor demonstrated lymphatic characteristics, with D2-40 staining of the trabecular meshwork, Schlemm's canal, and proximal collector channels in all specimens. However, the extent of collector channel staining varied, with older specimens showing less staining in the sclera. This suggests age-related changes in lymphatic distribution.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"213-216"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Taimur Siddiqui, Sarah M Kamal, Katherine J Williams, Jiwei Sheng, Richard C Allen
{"title":"Extrusion rates and postoperative emergency visits in tied and untied bicanalicular silicone stents in pediatric lacrimal surgery.","authors":"Taimur Siddiqui, Sarah M Kamal, Katherine J Williams, Jiwei Sheng, Richard C Allen","doi":"10.4103/sjopt.sjopt_292_25","DOIUrl":"10.4103/sjopt.sjopt_292_25","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose is to compare rates of stent extrusion and emergency visits in tied and untied Crawford stents for pediatric lacrimal surgery.</p><p><strong>Methods: </strong>This retrospective chart review included 166 eyes of 129 patients from 2018 to 2022. Data collected included tied/untied status, premature prolapse, retention, and time of removal, number of postoperative visits, emergent visits before scheduled follow-up, final follow-up, and surgical success.</p><p><strong>Results: </strong>Of 166 eyes, 97 received tied stents and 69 received untied stents. Success rates, defined by need for additional surgery and symptoms, were similar between groups. However, untied stents prolapsed more often (<i>P</i> < 0.05) but led to fewer total follow-up visits (<i>P</i> < 0.05), including emergency, clinic, and telemedicine encounters. Of the 32 early visits in the tied group, 15 were emergency room visits; none of the 9 early visits in the untied group were. Patients with tied stents had significantly more postoperative visits (mean 1.9 vs. 1.1; <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Untied Crawford stents for standard nasolacrimal duct intubation have similar success rates to tied Crawford stents. Untied stents had a significantly lower healthcare burden with fewer postoperative ER visits.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"225-228"},"PeriodicalIF":1.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mosaad Alhassan, Haroon Alhijji, Khalaf Alruways, Afnan Baashen, Ahmed Alageel, Hatoon Badukhen, Balsam Alabdulkader, Essam Almutleb, Tahani Alqahtani, Ali Almustanyir
{"title":"Prevalence of refractive errors and non-strabismic binocular vision anomalies in symptomatic and asymptomatic university students in Saudi Arabia.","authors":"Mosaad Alhassan, Haroon Alhijji, Khalaf Alruways, Afnan Baashen, Ahmed Alageel, Hatoon Badukhen, Balsam Alabdulkader, Essam Almutleb, Tahani Alqahtani, Ali Almustanyir","doi":"10.4103/sjopt.sjopt_109_25","DOIUrl":"10.4103/sjopt.sjopt_109_25","url":null,"abstract":"<p><strong>Purpose: </strong>This study was conducted to estimate the prevalence of refractive errors and nonstrabismic binocular vision anomalies in young adult university students with and without symptoms in Saudi Arabia.</p><p><strong>Methods: </strong>This study was conducted at the Department of Optometry at King Saud University, including 304 participants aged 16-35 years. The participants were categorized into symptomatic and asymptomatic groups based on the total score of the Convergence Insufficiency (CI) Symptom Survey. Full and comprehensive optometric assessments-including subjective refraction, accommodation, and vergence-were performed, and a diagnosis was established by comparing various parameters specific to each patient.</p><p><strong>Results: </strong>Among the 304 patients, 165 were female and 134 were male. The prevalence of all types of refractive errors was 46%, with myopic errors being the most common type. The prevalences of all types of accommodation and vergence anomalies were 33.50% and 50%, respectively. The most commonly observed accommodative anomaly was accommodative infacility, followed by accommodative insufficiency. The most commonly observed vergence anomaly was CI, followed by vergence infacility. Most participants reported symptoms; however, the differences in prevalence rates between symptomatic and asymptomatic participants were not statistically significant.</p><p><strong>Conclusion: </strong>Although refractive errors were fully corrected and visual acuity was within normal limits, full and comprehensive optometric assessments were crucial to detect different types of visual system anomalies. Early identification and management offer the best chance for academic success among symptomatic university individuals.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"40 3","pages":"268-273"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulaziz K Alotaibi, Lujain A Albadr, Fahad M Alsufiani, Mohammed S Alrajeh
{"title":"Immunoglobulin G4-related dacryoadenitis in a pediatric patient: Case report and literature review.","authors":"Abdulaziz K Alotaibi, Lujain A Albadr, Fahad M Alsufiani, Mohammed S Alrajeh","doi":"10.4103/sjopt.sjopt_136_25","DOIUrl":"10.4103/sjopt.sjopt_136_25","url":null,"abstract":"<p><p>Immunoglobulin G4 (IgG4)-related disease is a recently recognized inflammatory condition characterized by the infiltration of IgG4-positive plasma cells in various tissues, often presenting with systemic manifestations. While predominantly observed in adults, cases in pediatric patients are rare. This report details an unusual case of dacryoadenitis in an 8-year-old girl, who presented with a left superior-temporal orbital swelling unresponsive to initial treatments. Comprehensive clinical, radiological, and histopathological evaluations confirmed the diagnosis of IgG4-related dacryoadenitis. The patient was successfully treated with systemic corticosteroids, followed by the introduction of a steroid-sparing agent due to side effects. This case highlights the importance of recognizing IgG4-related disease in pediatric populations, emphasizing the need for a thorough diagnostic approach and tailored management strategies to improve outcomes and minimize complications.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"39 3","pages":"266-268"},"PeriodicalIF":1.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12578421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrical shock-induced central serous chorioretinopathy.","authors":"Ibrahim E Yilmaz, Mehmet C Hiraali","doi":"10.4103/sjopt.sjopt_187_24","DOIUrl":"10.4103/sjopt.sjopt_187_24","url":null,"abstract":"<p><p>Central serous chorioretinopathy (CSCR) is a common ophthalmic condition characterized by subretinal fluid accumulation at the macula, causing visual disturbances. While the aetiology is multifactorial, the association between CSCR and electrical shock injury remains rare and poorly understood. This paper presents a rare case of CSCR following electric shock and critically analyze the existing literature on this topic, exploring potential mechanisms, clinical features, and management considerations for CSCR following electrical shock.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"40 3","pages":"310-313"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between myopia severity, near exophoria, vergence, and accommodation amplitude in children.","authors":"Saif H Alrasheed","doi":"10.4103/sjopt.sjopt_352_24","DOIUrl":"10.4103/sjopt.sjopt_352_24","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between myopia severity, near exophoria, near point of convergence (NPC), and accommodation amplitude (AA) in children.</p><p><strong>Methods: </strong>This descriptive, cross-sectional, hospital-based study included 117 myopic children with a mean age of 11.32 ± 2.87 years. Refraction was measured with an autorefractometer and confirmed by retinoscopy. Slit-lamp biomicroscopy and ophthalmoscopy were performed to ensure participants met the study's inclusion criteria. AA and NPC were measured using a Royal Air Force ruler. Near exophoria was assessed with a prism bar and cover test.</p><p><strong>Results: </strong>Of the 117 myopic children, 95 (81.2%) had a parental history of myopia, with no significant difference between genders (<i>P</i> = 0.185). The mean myopic spherical equivalent was -1.76 ± 0.90 D in the right eye and -1.79 ± 0.97 D in the left eye (<i>P</i> = 0.277). A significant positive correlation was found between near exophoria and the spherical equivalent of myopia (<i>r</i> = 0.281**, <i>P</i> = 0.002). Positive but nonsignificant correlations were observed between monocular (<i>r</i> = 0.086) and binocular (<i>r</i> = 0.118) accommodation amplitudes with myopia severity (<i>P</i> > 0.05). Conversely, a weak inverse correlation (<i>r</i> = -0.020) was found between the NPC and the severity of myopia, which was not statistically significant (<i>P</i> = 0.833).</p><p><strong>Conclusion: </strong>The study found a significant positive correlation between near exophoria and the severity of myopia in children, suggesting that binocular vision anomalies may contribute to myopia progression or that myopia itself may influence near exophoria. Therefore, comprehensive eye examinations for myopic children should include binocular vision assessments to guide effective management strategies.</p>","PeriodicalId":46810,"journal":{"name":"Saudi Journal of Ophthalmology","volume":"40 3","pages":"274-279"},"PeriodicalIF":1.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148991866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}