Clinical Epidemiology and Global Health最新文献

{"title":"“Something must kill a man”: Beliefs about condom use in prevention of Human Papilloma Virus among men at Kpong community","authors":"Evans Appiah Osei ,&nbsp;Stella Appiah ,&nbsp;Adodoadji Esther Kaki ,&nbsp;Hawah Amadu Toure ,&nbsp;Jamilatu B. Kappiah ,&nbsp;Samuel Kontoh ,&nbsp;Serge Emmanuel Tchouchu","doi":"10.1016/j.cegh.2024.101773","DOIUrl":"10.1016/j.cegh.2024.101773","url":null,"abstract":"<div><h3>Background</h3><p>Human papillomavirus (HPV) infection is highly prevalent among sexually active individuals. A report by the Ghana Aids Commission highlights low condom usage among Ghana's sexually active youth. Despite this, there has been no exploration of views regarding condom use for preventing HPV infection. The purpose of the study was to examine the beliefs about condom use in preventing the human papillomavirus among men at Kpong community.</p></div><div><h3>Methods</h3><p>The study utilized a qualitative approach with an exploratory design, employing purposive sampling to select 40 participants. Data collection involved face-to-face interviews using a semi-structured interview guide. The interviews were recorded, transcribed verbatim, and analyzed through content analysis.</p></div><div><h3>Results</h3><p>The study produced three main themes and 8 subthemes. Despite most participants having used condoms before, primarily once (57.5 %) with a preference for “kiss condoms\" (42.5 %). The primary reason for condom use was pregnancy prevention (45 %), instead of HPV infections (22.5 %). Most participants rarely used condoms, aiming to enhance sexual pleasure or assuming their partners were HPV-free. Some cited religious reasons, viewing condom use as sinful.</p></div><div><h3>Conclusion</h3><p>Participants commonly do not use condoms to prevent HPV infections. Additionally, men have various religious and personal reasons for not using condoms to protect against HPV and other infections. This underscores the need for increased awareness of HPV transmission among men.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101773"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002707/pdfft?md5=e2152dfc3e1591ed5a0067f2fd0aa9e2&pid=1-s2.0-S2213398424002707-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142151555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What caregiver’ count as neonatal danger signs? A systematic review and meta-analysis of South East Asian countries","authors":"Sugandha Jauhari ,&nbsp;Pratyaksha Pandit ,&nbsp;Monika Agarwal ,&nbsp;Abhishek Singh ,&nbsp;Arunima Saini ,&nbsp;Ginic Gupta ,&nbsp;Shambhavi Mishra","doi":"10.1016/j.cegh.2024.101766","DOIUrl":"10.1016/j.cegh.2024.101766","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the prevalence of Knowledge of caregivers for neonatal danger signs. Registered in PROSPERO [CDR42022338605.]</p></div><div><h3>Methodology</h3><p>PubMed, Embase, Scopus and Google Scholar were searched, Cochrane I² statistics for heterogeneity and Random effects model for reporting the results was used. Egger tests with funnel plots were used to investigate publication bias.</p></div><div><h3>Result</h3><p>Overall pooled prevalence of caregiver's knowledge towards IMNCI and other neonatal danger signs was 36.6 % (95 % CI = 28, 46.1) and 55.1 % [95 % CI = 46.9, 53] respectively.</p></div><div><h3>Conclusion</h3><p>The knowledge of caregivers towards neonatal danger signs was inadequate.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101766"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221339842400263X/pdfft?md5=d4089ece49d35f7d5546cc86899ec2e8&pid=1-s2.0-S221339842400263X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study association of urinary Club Cell Protein with air pollution-related pulmonary function compromised among children","authors":"Avinash Pagdhune ,&nbsp;Ankit Sheth ,&nbsp;Sarang Dhatrak ,&nbsp;Ankit Viramgami","doi":"10.1016/j.cegh.2024.101776","DOIUrl":"10.1016/j.cegh.2024.101776","url":null,"abstract":"<div><h3>Background</h3><p>Childhood exposure to air pollution exacerbates respiratory conditions and even carries deleterious effects on lung functions in adulthood. It is desirable to establish a non-invasive screening test for children to predict early lung insult with air pollution exposure. The association between serum club cell protein (CC16) and obstructive airway diseases is known, but the same is not explored with air-pollution-related lung insult and pulmonary function test (PFT) parameters.</p></div><div><h3>Aim</h3><p>To investigate the association between urinary CC16 and PFT parameters in children exposed to differing levels of air pollution.</p></div><div><h3>Methods</h3><p>This cross-sectional study recruited 107 children from critically-polluted area (CPA) and 96 age-sex-matched children from non-polluted area (NPA). PFT and urinary CC16 were determined with standard techniques. Air quality parameters were estimated with adherence to National Ambient Air Quality Standards (NAAQS).</p></div><div><h3>Results</h3><p>CPA was observed with 2.5 times poorer Air-Quality-Index compared to NPA. Urinary CC16 levels of children were four-fold higher in CPA compared to NPA (<em>p</em> &lt; 0.001). CPA children were significantly deprived in PFT parameters [FVC(L)-1.86 v/s 2.02, <em>p</em> = 0.01; FEV₁(L/s)-1.71 v/s 1.86, <em>p</em> = 0.01 &amp; PEFR(L/s)- 3.25 v/s 3.69, <em>p</em> &lt; 0.001]. While adjusted for physiological parameters, urinary CC16 observed with significant negative association with PFT parameters (FVC: <em>β</em> = −0.02, <em>p=0.03;</em> FEV₁: <em>β</em> = −0.03, <em>p=0.001 &amp;</em> FEF_25–75 %: <em>β</em> = −0.05, <em>p=0.04</em>).</p></div><div><h3>Conclusion</h3><p>The significant decline in lung function parameters and elevated urinary CC16 levels among children in polluted areas underscore the need for further research to validate urinary CC16 as a reliable screening tool for respiratory health monitoring among children.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101776"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002732/pdfft?md5=37aa02e47801f48f67f2bae0e9d502c4&pid=1-s2.0-S2213398424002732-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the menstrual mind: Exploring proprioceptive proficiency, reaction responsiveness, and motor mastery in premenstrual syndrome versus Non-PMS cohorts: A two-arm parallel non-blinded cross-sectional study","authors":"Anshu Sharma ,&nbsp;Simranjeet Kaur ,&nbsp;Parveen Kumar ,&nbsp;Nidhi Sharma","doi":"10.1016/j.cegh.2024.101782","DOIUrl":"10.1016/j.cegh.2024.101782","url":null,"abstract":"<div><h3>Introduction</h3><p>Premenstrual syndrome (PMS) is characterized by cyclical physical and mood disturbances during the luteal phase. Symptoms gradually intensify during this phase and typically subside a few days after menstruation begins. PMS encompasses neuromuscular and psychological symptoms that can significantly affect the quality of life of affected females. This study aims to compare proprioception, reaction time, and coordination between females with PMS and those with non-PMS.</p></div><div><h3>Material and methods</h3><p>A cross-sectional study, conducted in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines, recruited 998 females with PMS and without PMS, aged 18–40 years based on premenstrual dysphoric disorder criteria. Participants underwent assessments of proprioception and reaction time using the Sensbalance Miniboard. Coordination was assessed using Lower Extremity Motor Coordination Test. Data analysis utilized the Kolmogorov-Smirnov test to determine the normality of the data while Mann Whitney-U test was used to compare the between group differences of the variables.</p></div><div><h3>Results</h3><p>Significant differences were observed with p-value &lt;0.05 for all the variables, proprioception (front, back, right and left), reaction time (front, back, right and left), coordination (right and left) between the PMS and non-PMS groups.</p></div><div><h3>Conclusions</h3><p>Females with PMS were associated with great variation in proprioception, reaction time and coordination when compared with females without PMS.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101782"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002793/pdfft?md5=1c3d5fd5f8092b9b8fac4dce6c71ed8e&pid=1-s2.0-S2213398424002793-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological, clinical and evolutive profile of tuberculosis patients: Case of the region of Guelmim in Morocco","authors":"Ahmed Oubaasri ,&nbsp;Asmae Labyad ,&nbsp;Fatima Zahra El mskini ,&nbsp;Wafae Belokda ,&nbsp;Aicha Madkour ,&nbsp;Nouriya El Ghoulam ,&nbsp;Daoud Daoudi ,&nbsp;Aichetou Bouh ,&nbsp;Slimane Mehdad ,&nbsp;Souad Benaich","doi":"10.1016/j.cegh.2024.101769","DOIUrl":"10.1016/j.cegh.2024.101769","url":null,"abstract":"<div><h3>Background and aim</h3><p>Tuberculosis is an infectious, contagious disease caused mainly by <em>Mycobacterium tuberculosis</em>. The objective of our study is to describe the epidemiological, clinical and evolutionary profiles of tuberculosis patients at the Diagnostic Center for Tuberculosis and Respiratory Diseases (DCTRD) in the Guelmim region, Morocco.</p></div><div><h3>Methods</h3><p>This is a retrospective study examining the medical records of tuberculosis patients at the Guelmim DCTRD from January 1, 2018, to April 28, 2022.</p></div><div><h3>Results</h3><p>A total of 825 cases were collected, comprising 488 cases of ETB and 337 cases of PTB. The median age of ETB patients was 31.5 [21–47] years, compared to 37 [26.5–52] years for PTB patients. ETB was more common than PTB in both age groups (&lt;10 and ≥ 10 years) (p &lt; 0.001). Females were more affected by ETB in 73 % of cases. Clinical signs were more prevalent in PTB than in ETB patients (p &lt; 0.001). Tobacco and alcohol consumption were higher in the PTB group than in the ETB group (p &lt; 0.001). Asthma and diabetes were more prevalent in the ETB group at 58 % and 51 %, respectively (p &lt; 0.001). HIV serology was largely negative in both groups, with a non-negligible proportion of unknown status (p &lt; 0.001). Therapeutic outcomes were favorable in 61 % of PTB patients versus 39 % of ETB patients (p &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Our study highlighted the predominance of ETB. PTB patients had more clinical signs and tobacco/alcohol consumption. HIV serology was mostly negative, and therapeutic outcomes were favorable, suggesting a need for better management.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101769"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002665/pdfft?md5=379a0d8df141ca63a5372b973be5d815&pid=1-s2.0-S2213398424002665-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of food consumption among women with breast cancer: A multicenter study in Indonesia","authors":"Ricvan Dana Nindrea","doi":"10.1016/j.cegh.2024.101778","DOIUrl":"10.1016/j.cegh.2024.101778","url":null,"abstract":"<div><h3>Background</h3><p>Breast cancer (BC) is a leading cancer among women globally, with a rising incidence in Indonesia. Dietary habits are implicated in BC development and progression, yet there is limited understanding among Indonesian women. This study aims to evaluate the patterns of food consumption among Indonesian women with BC.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted among Indonesian women with BC at three national hospitals. The sample size was determined to be 362 participants. Each participant was provided with information and asked to provide written informed consent before face-to-face interviews. Dietary behaviors were assessed using a food frequency questionnaire (FFQ) adapted to local cuisine. Exploratory factor analysis was used to describe dietary behavior patterns. All analyses were performed using R version 4.3.0 with the <em>epicalc</em> and <em>psych</em> packages.</p></div><div><h3>Results</h3><p>Participants were predominantly aged 50 years or older, had middle incomes, and exhibited varied dietary habits. We identified three dietary patterns: the “Carnivorous and Sugar” diet, the “Vegetables and Snacks” diet, and the “Traditional” diet. The “Carnivorous and Sugar” diet was characterized by a high consumption of meat, poultry, sweetened drinks or condiments, and desserts. The “Vegetables and Snacks” diet involved more frequent consumption of leafy green vegetables, yellow or orange vegetables, packaged snacks, and unpackaged snacks. The “Traditional” diet was marked by a high intake of tubers, eggs, and soybean products.</p></div><div><h3>Conclusion</h3><p>This study's findings enhance our understanding of dietary patterns among Indonesian women with BC and their potential impact on BC risk. These findings highlight the importance of promoting healthy dietary habits, such as consuming more fruits, and vegetables while reducing the intake of red and processed meats, and sugary foods for BC prevention.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101778"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002756/pdfft?md5=f578bd9be536fe875d9de2ff73965796&pid=1-s2.0-S2213398424002756-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142129789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications and implications of Caesarean delivery: Facts and perceptions","authors":"Javeed A. Golandaj,&nbsp;Mallikarjun S. Kampli,&nbsp;Manish Kumar,&nbsp;Jyoti S. Hallad","doi":"10.1016/j.cegh.2024.101770","DOIUrl":"10.1016/j.cegh.2024.101770","url":null,"abstract":"<div><h3>Background/objectives</h3><p>Caesarean delivery (CD), though considered a life-saving surgical procedure, poses a public health problem and puts mothers and babies at higher risk of post-delivery complications. The present study aims to explore the post-delivery maternal complications among CD and normal vaginal delivery (NVD) mothers in India.</p></div><div><h3>Methods</h3><p>The present study is a PAN-India study conducted across various Indian states, considering a significant increase in CD rates. Data was collected from face-to-face interviews of 1407 recently delivered mothers during January–March 2023.</p></div><div><h3>Results</h3><p>The findings indicate that 22 % of CD mothers reported post-delivery complications compared to 15 % of NVD mothers. Notable complications among CD mothers include body/abdominal pain (12.9 %), infection/pain in the suture area (6.2 %), and high blood pressure (1.1 %). Conversely, higher proportion of NVD mothers reported pelvic pain (3.3 %). Further, a greater proportion of NVD (22 %) and CD (28 %) mothers reported pain in the pelvic area and infection/pain in the suture area, respectively. Socio-economic and demographic factors such as age, education, and residence significantly influenced the incidence of self-reported maternal complications. Mothers aged 25 and above, with at least ten years of education, and those residing in urban areas reported higher complications. Additionally, CD mothers also experienced longer hospital stays, higher costs, and delays in breastfeeding initiation.</p></div><div><h3>Conclusion</h3><p>The study underscores the necessity for targeted healthcare interventions to mitigate the specific risks associated with CDs and improve maternal outcomes through appropriate policy formation to address the rising trend of CDs and their implications on maternal health.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101770"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002677/pdfft?md5=29a71258c5ec002aee4079ca8e0625cf&pid=1-s2.0-S2213398424002677-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health literacy, attitude, and help seeking intention among a particularly vulnerable tribe","authors":"Flavia Sharlet Noronha ,&nbsp;Tessy Treesa Jose ,&nbsp;Linu Sara George ,&nbsp;Rajeshkrishna Panambur Bhandary ,&nbsp;Samir Kumar Praharaj ,&nbsp;Ravishankar ,&nbsp;Prasanna Naik","doi":"10.1016/j.cegh.2024.101706","DOIUrl":"10.1016/j.cegh.2024.101706","url":null,"abstract":"<div><h3>Background</h3><p>Mental health, when compared to physical health and wellbeing, is the most neglected area. The health status of the tribal population is in pitiable condition and is heavily influenced by its socio-cultural factors and poor health care delivery system. The study aimed to assess the knowledge, attitude, mental help seeking intention for common mental health problems and factors associated with the study variables among the tribal population.</p></div><div><h3>Method</h3><p>ology: House-to-house survey was done between January to April 2022. Data was collected using standardized tools like Mental Health Knowledge Questionnaire (MHKQ), Community Attitude towards Mentally Ill scale (CAMIS), and Mental Help Seeking Intention scale (MHSIS).</p></div><div><h3>Results</h3><p>Only six participants out of 400 reported that they are aware of someone in their community suffering from mental health problems. The majority (80 %) of the participants had fairly good knowledge regarding mental health, and 68 % of them had a favorable attitude towards mentally ill. It was also found that 79.2 % of the participants hold favorable attitude with an OR = 1.40 (0.50,3.90) suggesting that there is a statistically difference in the odds of favorable attitude being present among illiterate people (p = 0.003). When comparing the odds ratio between the groups, keeping females as reference for comparison, it is evident that males OR = 0.44 (0.21,0.94) are less likely to have good knowledge. Moderately strong (statistically significant at p = .05) relationship was seen between the subscales of attitude towards mentally ill and knowledge regarding mental health among the Koraga population.</p></div><div><h3>Conclusion</h3><p>It has been found that awareness regarding common mental disorders is increasing among the tribals, but it is not accompanied by a favorable attitude. The study concluded that interventional research is needed to reduce the stigma and the treatment gap in mental illness.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101706"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002021/pdfft?md5=7c5d0b85671ed212b21c2c7e4b03c6ab&pid=1-s2.0-S2213398424002021-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Nutrition Supplementation on linear growth among 12–18 months children of Belagavi city: A randomized control trial","authors":"Akshay A. Kolakar ,&nbsp;Niranjana Mahantashetti ,&nbsp;Mubashir Angolkar ,&nbsp;Madan M. Godbole ,&nbsp;Deshna Oswal","doi":"10.1016/j.cegh.2024.101774","DOIUrl":"10.1016/j.cegh.2024.101774","url":null,"abstract":"<div><h3>Background</h3><p>Adequate nutrition is one of the most important factors influencing growth &amp; immunity. Bovine colostrum (BC) is the first milk produced after birth of a calf and is a rich natural source of macronutrients, micronutrients, immunoglobulins, growth factors and peptides with anti-microbial activity.</p></div><div><h3>Objective</h3><p>The current study was conducted to test the hypothesis whether BC supplementation would lead to an increase in linear growth of children of age 12–18 months. The secondary objectives were 1) To measure biomedical parameters among 12–18 months children in the 2 groups, i.e., BC and control group. 2) To assess the acceptability and tolerability of BC among children.</p></div><div><h3>Materials &amp; methods</h3><p>A double blinded randomized control trial was conducted among children in the age group of 12–18 months. A total of 78 participants were included and were randomly divided into experiment and control groups. Anthropometric measurements and biochemical parameters were measured before and after intervention. The acceptability and tolerability of BC was assessed through a questionnaire filled by the mothers of study participant.</p></div><div><h3>Results</h3><p>There was a significant difference observed in Body mass index (BMI), Chest circumference and Mid upper arm circumference in the BC group but there was not any significant difference found in biochemical parameters. Mothers of study participant reported high acceptability and no side effects of the intervention.</p></div><div><h3>Conclusion</h3><p>Supplementation of BC in children's diet lead to improved anthropometric outcomes in children of Belagavi city and was acceptable by them.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101774"},"PeriodicalIF":2.3,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002719/pdfft?md5=6fa1e5176c5598b88495f9474605b330&pid=1-s2.0-S2213398424002719-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes over the last two decades in Hemophilia A and B management in a Tertiary Care Pediatric Centre","authors":"M.P. Esposto ,&nbsp;E. Bonetti ,&nbsp;R. Balter ,&nbsp;V. Pezzella ,&nbsp;A. Zaccaron ,&nbsp;V. Vitale ,&nbsp;G. Caddeo ,&nbsp;M. Chinello ,&nbsp;G. Tridello ,&nbsp;G. Poli ,&nbsp;S. Cesaro","doi":"10.1016/j.cegh.2024.101762","DOIUrl":"10.1016/j.cegh.2024.101762","url":null,"abstract":"<div><h3>Objective</h3><p>The treatment of Hemophilia A and B has significantly evolved.</p></div><div><h3>Study design</h3><p>we conducted a retrospective, observational study among patients with HA and HB managed in a Pediatric Hematology and Oncology Unit for almost 22 years for a total of 34 patients.</p></div><div><h3>Results</h3><p>Until 2009, more than 80 % of patients were treated only on demand, while in 2022,100 % of patients with moderate and severe disease were receiving continuous prophylaxis. The median age at the start of prophylaxis passed from 10,9 to 1,65 years. In 2022, only one patient was on Standard-half-life-rFVIII, 7 patients were on Extended Half-Life (EHL)-rFVIII/rFIX and 7 patients were on Emicizumab; 1 patient was on Concizumab. The mean ABR passed from 5,7 in the period 2001–2009 to 0,8 in the period 2019–2022. We performed 106 ultrasonographic exams in 19 patients to evaluate the HEAD-US score: a percentage of 45,3 % of these exams revealed a score of 0 and the HEAD-US score resulted inferior in patients who started prophylaxis at an age below the median age at the initiation of prophylaxis. The score showed a tendency to correlate with the number of previous hemarthrosis. In our cohort, the overall prevalence of inhibitors is 0,09 among all patients, and 0,14 in severe HA/HB. 4 patients needed a Central Venous Line (CVL), and 3 patients developed at least one severe complication. Before 2017, we observed 4 cases of life-threatening bleeding in children less than 2 years old not on prophylaxis.</p></div><div><h3>Results</h3><p>our real-life experience reflects the changes in hemophilia management in the last two decades. In the future, other drugs are expected.</p></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"29 ","pages":"Article 101762"},"PeriodicalIF":2.3,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2213398424002598/pdfft?md5=65f4d58bc023f7bf4b1e5c99be0a56bd&pid=1-s2.0-S2213398424002598-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142084401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}