Association between dengue and pediatric AUF: A study from Chennai and kochi, south India

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-05-15 DOI:10.1016/j.cegh.2025.102063

Sara Chandy , Divya Narayanan , Anand Manoharan , Vignesh Moorthy , Gowridevi Vankayala , Hemalatha Ramachandran , Rohitha Chandra

{"title":"Association between dengue and pediatric AUF: A study from Chennai and kochi, south India","authors":"Sara Chandy , Divya Narayanan , Anand Manoharan , Vignesh Moorthy , Gowridevi Vankayala , Hemalatha Ramachandran , Rohitha Chandra","doi":"10.1016/j.cegh.2025.102063","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically and has infectious and non-infectious causes. Early and accurate diagnosis of AUF requires good diagnostic tools. Dengue remains the most common infectious cause of AUF in India, followed by scrub typhus. All the four dengue serotypes (DEN1, DEN2, DEN3 and DEN4) cause disease in children and adults with clinical presentation ranging from febrile illness to severe dengue manifested as shock and multi-organ failure.</div></div><div><h3>Methods</h3><div>This study, done in South India, explores the dengue burden in AUF cases, dominant serotypes, and their clinical manifestations.</div></div><div><h3>Results</h3><div>Our study indicates that from 2022 to 2023, DEN2 remained the most common circulating serotype closely followed by DEN3. DEN3 is emerging fast and likely to become the most predominant serotype in Chennai.</div></div><div><h3>Conclusion</h3><div>Multiplex real time PCR is currently accepted as an affordable and sensitive tool for diagnosis of infectious causes of AUF. Serotype surveillance is important for controlling outbreaks and for clinical management of pediatric patients.</div></div>","PeriodicalId":46404,"journal":{"name":"Clinical Epidemiology and Global Health","volume":"34 ","pages":"Article 102063"},"PeriodicalIF":2.3000,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Epidemiology and Global Health","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213398425001526","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Acute Undifferentiated Fever (AUF) is a common clinical presentation at hospitals in tropical and subtropical countries. Both children and adults present with this clinical condition which is difficult to diagnose clinically and has infectious and non-infectious causes. Early and accurate diagnosis of AUF requires good diagnostic tools. Dengue remains the most common infectious cause of AUF in India, followed by scrub typhus. All the four dengue serotypes (DEN1, DEN2, DEN3 and DEN4) cause disease in children and adults with clinical presentation ranging from febrile illness to severe dengue manifested as shock and multi-organ failure.

Methods

This study, done in South India, explores the dengue burden in AUF cases, dominant serotypes, and their clinical manifestations.

Results

Our study indicates that from 2022 to 2023, DEN2 remained the most common circulating serotype closely followed by DEN3. DEN3 is emerging fast and likely to become the most predominant serotype in Chennai.

Conclusion

Multiplex real time PCR is currently accepted as an affordable and sensitive tool for diagnosis of infectious causes of AUF. Serotype surveillance is important for controlling outbreaks and for clinical management of pediatric patients.

查看原文本刊更多论文

登革热与儿童AUF之间的关系：一项来自印度南部钦奈和高知的研究

背景急性未分化热（AUF）是热带和亚热带国家医院常见的临床表现。儿童和成人都有这种临床症状，临床诊断困难，有传染性和非传染性原因。早期准确诊断AUF需要良好的诊断工具。登革热仍然是印度最常见的AUF感染原因，其次是丛林斑疹伤寒。所有四种登革热血清型（DEN1、DEN2、DEN3和DEN4）均可在儿童和成人中引起疾病，临床表现从发热性疾病到表现为休克和多器官衰竭的重症登革热。方法本研究在印度南部开展，探讨AUF病例的登革热负担、主要血清型及其临床表现。结果从2022年到2023年，DEN2仍然是最常见的循环血清型，其次是DEN3。DEN3正在迅速出现，并可能成为金奈最主要的血清型。结论多重实时PCR是目前公认的诊断AUF感染原因的一种经济、灵敏的工具。血清型监测对于控制疫情和儿科患者的临床管理非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.