Emerging Topics in Life Sciences最新文献

Copper management strategies in obligate bacterial symbionts: balancing cost and benefit. 强制性细菌共生体的铜管理策略：平衡成本与效益。

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20230113

Alex Rivera-Millot, Luke B Harrison, Frédéric J Veyrier

{"title":"Copper management strategies in obligate bacterial symbionts: balancing cost and benefit.","authors":"Alex Rivera-Millot, Luke B Harrison, Frédéric J Veyrier","doi":"10.1042/ETLS20230113","DOIUrl":"10.1042/ETLS20230113","url":null,"abstract":"Bacteria employ diverse mechanisms to manage toxic copper in their environments, and these evolutionary strategies can be divided into two main categories: accumulation and rationalization of metabolic pathways. The strategies employed depend on the bacteria's lifestyle and environmental context, optimizing the metabolic cost-benefit ratio. Environmental and opportunistically pathogenic bacteria often possess an extensive range of copper regulation systems in order to respond to variations in copper concentrations and environmental conditions, investing in diversity and/or redundancy as a safeguard against uncertainty. In contrast, obligate symbiotic bacteria, such as Neisseria gonorrhoeae and Bordetella pertussis, tend to have specialized and more parsimonious copper regulation systems designed to function in the relatively stable host environment. These evolutionary strategies maintain copper homeostasis even in challenging conditions like encounters within phagocytic cells. These examples highlight the adaptability of bacterial copper management systems, tailored to their specific lifestyles and environmental requirements, in the context of an evolutionary the trade-off between benefits and energy costs.","PeriodicalId":46394,"journal":{"name":"Emerging Topics in Life Sciences","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10903467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metalloproteome plasticity - a factor in bacterial pathogen adaptive responses? 金属蛋白组可塑性--细菌病原体适应性反应的一个因素？

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20230116

Alastair G McEwan

引用次数: 0

The nitric oxide paradox: antimicrobial and inhibitor of antibiotic efficacy. 一氧化氮悖论:抗菌药物和抑制剂的抗生素疗效。

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20230114

Calum M Webster, Mark Shepherd

引用次数: 0

Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis. 晚餐日期:淋病奈瑟菌中心碳代谢及发病机制。

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20220111

Aimee D Potter, Alison K Criss

{"title":"Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis.","authors":"Aimee D Potter, Alison K Criss","doi":"10.1042/ETLS20220111","DOIUrl":"10.1042/ETLS20220111","url":null,"abstract":"Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated by the exchange of nutrient resources that allow for N. gonorrhoeae growth in the human genital tract. What N. gonorrhoeae 'eats' and the pathways used to consume these nutrients have been a topic of investigation over the last 50 years. More recent investigations are uncovering the impact of N. gonorrhoeae metabolism on infection and inflammatory responses, the environmental influences driving N. gonorrhoeae metabolism, and the metabolic adaptations enabling antimicrobial resistance. This mini-review is an introduction to the field of N. gonorrhoeae central carbon metabolism in the context of pathogenesis. It summarizes the foundational work used to characterize N. gonorrhoeae central metabolic pathways and the effects of these pathways on disease outcomes, and highlights some of the most recent advances and themes under current investigation. This review ends with a brief description of the current outlook and technologies under development to increase understanding of how the pathogenic potential of N. gonorrhoeae is enabled by metabolic adaptation.","PeriodicalId":46394,"journal":{"name":"Emerging Topics in Life Sciences","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9889540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacterial acetate metabolism and its influence on human epithelia. 细菌的醋酸代谢及其对人体上皮细胞的影响

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20220092

Jennifer Hosmer, Alastair G McEwan, Ulrike Kappler

引用次数: 0

Resisting death by metal: metabolism and Cu/Zn homeostasis in bacteria. 抵御金属带来的死亡：细菌的新陈代谢和铜/锌平衡。

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2024-02-22 DOI: 10.1042/ETLS20230115

Matthew J Sullivan, Ignacio Terán, Kelvin G K Goh, Glen C Ulett

引用次数: 0

Sleep and cardiovascular disease. 睡眠与心血管疾病

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2023-12-22 DOI: 10.1042/ETLS20230111

Michelle A Miller, Nathan E Howarth

{"title":"Sleep and cardiovascular disease.","authors":"Michelle A Miller, Nathan E Howarth","doi":"10.1042/ETLS20230111","DOIUrl":"10.1042/ETLS20230111","url":null,"abstract":"This review centres around the recent evidence in examining the intersection of sleep and cardiovascular disease (CVD). Sleep in this review will be further subdivided to consider both sleep quantity and quality along and will also consider some of the more common sleep disorders, such as insomnia and obstructive sleep apnoea, in the context of CVD. Sleep disorders have been further explored in several specific populations which are both at risk of sleep disorders and CVD. Secondly, the review will present some of the risk factors for CVD that are affected by sleep and sleep disorders which include hypertension, diabetes, and obesity. It will also examine the potential underlying mechanisms including inflammation, appetite control, endocrine, and genetic processes that are affected by sleep and sleep disorders leading to increased risk of CVD development. In addition, we will consider the observed bi-directional relationships between sleep and cardiovascular risk factors. For example, obesity, a risk factor for CVD can be affected by sleep, but in turn can increase the risk of certain sleep disorder development which disrupts sleep, leading to further risk of obesity development and increased CVD risk. Finally, the review will explore emerging evidence around lifestyle interventions that have included a sleep component and how it impacts the management of CVD risk factor. The need for increased awareness of the health effects of poor sleep and sleep disorders will be discussed alongside the need for policy intervention to improve sleep to facilitate better health and well-being.","PeriodicalId":46394,"journal":{"name":"Emerging Topics in Life Sciences","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10754327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138812145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How do the sleep features that characterise depression impact memory? 抑郁症的睡眠特征如何影响记忆？

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2023-12-22 DOI: 10.1042/ETLS20230100

Marcus O Harrington, Sarah Reeve, Joanne L Bower, Louis Renoult

引用次数: 0

Sleep and memory consolidation in healthy, neurotypical children, and adults: a summary of systematic reviews and meta-analyses. 健康、神经畸形儿童和成人的睡眠与记忆巩固：系统综述和荟萃分析摘要。

IF 3.4

Emerging Topics in Life Sciences Pub Date : 2023-12-22 DOI: 10.1042/ETLS20230110

Anna Weighall, Ian Kellar

{"title":"Sleep and memory consolidation in healthy, neurotypical children, and adults: a summary of systematic reviews and meta-analyses.","authors":"Anna Weighall, Ian Kellar","doi":"10.1042/ETLS20230110","DOIUrl":"https://doi.org/10.1042/ETLS20230110","url":null,"abstract":"This review systematically assesses the impact of sleep on memory and cognition in healthy individuals across different life stages. It specifically examines how sleep affects memory processes in children, adults, and older adults. The methodology involved a comprehensive literature search, starting with 46 known papers. Keywords and Mesh terms related to sleep and memory consolidation were derived using the Word Frequency Analysis tool in SR Accelerator and Mesh on Demand. A detailed search on PubMed yielded a large set of records. Classifier training on 4854 decisions, these were narrowed down to 1437 papers for full-text screening, culminating in 19 systematic reviews and meta-analyses. Sleep enhances memory consolidation, especially for complex declarative information. While the role of sleep in procedural memory consolidation in children remains less robust compared to declarative memory, findings suggest potential but inconsistent benefits. Sleep improves prospective memory consolidation and aids in complex associative memory tasks. Memory reactivation during sleep, specifically slow-wave sleep, and spindles are implicated in memory consolidation. Meta-analytic evidence suggests that while sleep benefits both emotional and neutral memory consolidation, there is no strong preferential effect of sleep on emotional memory in comparison to neutral memory. In older adults, there is a noticeable reduction in sleep-dependent memory consolidation, particularly for declarative memory, likely linked to a decline in slow-wave sleep. This suggests a decrease in the benefits of sleep for memory consolidation with aging. Overall, the review underscores the importance of sleep in memory processes across all ages, highlighting variations in its impact on different types of memory and across age groups. It points to future research directions for enhancing understanding and practical applications in clinical and educational settings.","PeriodicalId":46394,"journal":{"name":"Emerging Topics in Life Sciences","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2023-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142298336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnoea-hypopnoea syndrome. 阻塞性睡眠呼吸暂停-低通气综合征。

IF 3.8

Emerging Topics in Life Sciences Pub Date : 2023-12-22 DOI: 10.1042/ETLS20180939

Nicola Read, Callum Jennings, Alanna Hare

引用次数: 0