Metalloproteome plasticity - a factor in bacterial pathogen adaptive responses?

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alastair G McEwan
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Abstract

Through homeostatic processes, bacterial cells maintain intracytoplasmic metal ions at concentrations which enable the 'correct' metal to be inserted into an enzyme, thereby ensuring function. However, fluctuations in intracytoplasmic metal ion concentrations mean that under different conditions certain enzymes may contain different metals at their active site. This perspective describes examples of such cases and suggests that metalloproteome plasticity may contribute to the dynamic adaptation of pathogens to stresses in the host environment.

金属蛋白组可塑性--细菌病原体适应性反应的一个因素?
通过平衡过程,细菌细胞将细胞质内的金属离子维持在一定浓度,使 "正确 "的金属能够插入酶中,从而确保其功能。然而,细胞质内金属离子浓度的波动意味着,在不同条件下,某些酶的活性位点可能含有不同的金属。本研究描述了此类情况的实例,并指出金属蛋白质组的可塑性可能有助于病原体动态适应宿主环境中的压力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
94
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