强制性细菌共生体的铜管理策略:平衡成本与效益。

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Alex Rivera-Millot, Luke B Harrison, Frédéric J Veyrier
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引用次数: 0

摘要

细菌采用多种机制来管理环境中的有毒铜,这些进化策略可分为两大类:积累和代谢途径合理化。所采用的策略取决于细菌的生活方式和环境背景,从而优化新陈代谢的成本效益比。环境细菌和机会致病细菌通常拥有多种铜调节系统,以应对铜浓度和环境条件的变化,并投资于多样性和/或冗余性,以防范不确定性。相比之下,强制性共生细菌(如淋病奈瑟氏菌和百日咳博德特氏菌)往往拥有专门的、更简约的铜调节系统,以在相对稳定的宿主环境中发挥作用。这些进化策略即使在具有挑战性的条件下,如在吞噬细胞内,也能维持铜的平衡。这些例子凸显了细菌铜管理系统的适应性,这些系统是根据其特定的生活方式和环境要求量身定制的,并在进化过程中权衡收益和能量成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Copper management strategies in obligate bacterial symbionts: balancing cost and benefit.

Bacteria employ diverse mechanisms to manage toxic copper in their environments, and these evolutionary strategies can be divided into two main categories: accumulation and rationalization of metabolic pathways. The strategies employed depend on the bacteria's lifestyle and environmental context, optimizing the metabolic cost-benefit ratio. Environmental and opportunistically pathogenic bacteria often possess an extensive range of copper regulation systems in order to respond to variations in copper concentrations and environmental conditions, investing in diversity and/or redundancy as a safeguard against uncertainty. In contrast, obligate symbiotic bacteria, such as Neisseria gonorrhoeae and Bordetella pertussis, tend to have specialized and more parsimonious copper regulation systems designed to function in the relatively stable host environment. These evolutionary strategies maintain copper homeostasis even in challenging conditions like encounters within phagocytic cells. These examples highlight the adaptability of bacterial copper management systems, tailored to their specific lifestyles and environmental requirements, in the context of an evolutionary the trade-off between benefits and energy costs.

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CiteScore
7.70
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