细菌的醋酸代谢及其对人体上皮细胞的影响

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jennifer Hosmer, Alastair G McEwan, Ulrike Kappler
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引用次数: 0

摘要

短链脂肪酸是已知的宿主与微生物相互作用的调节剂,可影响人体健康、炎症和微生物感染的结果。醋酸是这些调节剂中含量最多但研究最少的一种,大多数研究都集中在丙酸酯和丁酸酯上,而丙酸酯和丁酸酯被认为更有效。在这篇微型综述中,我们总结了目前关于醋酸盐作为宿主与微生物之间相互作用的重要抗炎调节剂的知识。这包括概述细菌和人体细胞代谢醋酸酯的途径、醋酸酯在细菌细胞中的功能以及微生物衍生的醋酸酯对人体免疫功能的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bacterial acetate metabolism and its influence on human epithelia.

Short-chain fatty acids are known modulators of host-microbe interactions and can affect human health, inflammation, and outcomes of microbial infections. Acetate is the most abundant but least well-studied of these modulators, with most studies focusing on propionate and butyrate, which are considered to be more potent. In this mini-review, we summarize current knowledge of acetate as an important anti-inflammatory modulator of interactions between hosts and microorganisms. This includes a summary of the pathways by which acetate is metabolized by bacteria and human cells, the functions of acetate in bacterial cells, and the impact that microbially derived acetate has on human immune function.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
94
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