Case Reports in Hematology最新文献_第7页

A Case Report of Premalignant Plasma Cell Dyscrasia-Induced Renal Failure in a 31-Year-Old Female 31岁女性癌前浆细胞病变致肾功能衰竭1例报告

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Case Reports in Hematology Pub Date : 2022-06-07 DOI: 10.1155/2022/2497380

Ayrton I Bangolo, MA Akhter, Amer Jarri, Manpreet Kaur, Ali Atoot, Parul Jandir, Mahmood Ibrahim, Lochana Manandhar, A. Atoot

引用次数: 1

Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein 靶向SARS-CoV-2刺突蛋白单克隆抗体治疗慢性难治性特发性血小板减少性紫癜后的短暂完全恢复

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Case Reports in Hematology Pub Date : 2022-06-07 DOI: 10.1155/2022/8335541

Pooja Gogia, Yiqing Xu

{"title":"Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein","authors":"Pooja Gogia, Yiqing Xu","doi":"10.1155/2022/8335541","DOIUrl":"https://doi.org/10.1155/2022/8335541","url":null,"abstract":"Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production (thrombopoietin receptor agonists), immunosuppression to reduce the autoantibody production, as well as splenectomy. Studies on autoantigens on the platelets suggested epitopes to be located predominantly on the GP IIb/IIIa receptor or integrin αIIbβ3, though the trigger for the development of ITP is unclear. We report a case here of a 37-year-old gentleman who has chronic ITP managed on eltrombopag, who after receiving monoclonal antibody against SARS-CoV-2 (mAb) i.e. casirivimab and imdevimab for his COVID-19 infection, demonstrated complete recovery of his platelet count for a short period of time. We discuss a few potential mechanisms of action and propose further studies to elucidate the therapeutic effect of COVID-19 mAb in ITP.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"3 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78294529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Extensive Cerebral Venous Sinus Thrombosis Complicated by Heparin-Induced Thrombocytopenia 广泛脑静脉窦血栓形成并发肝素性血小板减少症1例

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Case Reports in Hematology Pub Date : 2022-06-06 DOI: 10.1155/2022/7845786

Noman Ahmed Jang Khan, A. Farooqi, Mohamed Alsharedi

引用次数: 1

Spontaneous Regression of Plasmablastic Lymphoma in an Immunocompetent Patient: Case Report and Review of the Literature 免疫功能正常患者浆母细胞淋巴瘤的自发消退:病例报告和文献回顾

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Case Reports in Hematology Pub Date : 2022-05-30 DOI: 10.1155/2022/1142049

Kee Tat Lee, Nurul Akmar Misron, N. Abdul Aziz, Chin Hau Wong, H. Liew

引用次数: 0

Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome 亚洲-莫综合征患者进展为多发性骨髓瘤时肾脏单克隆γ病变的意义

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Case Reports in Hematology Pub Date : 2022-05-24 DOI: 10.1155/2022/8571536

David Alejandro Vargas Gutiérrez, K. I. Arias Callejas, Edwin Pavel Palacios Ruiz, Priscila Joseline Pérez Vinueza, Juan Diego Muñoz Vega, Ana Karen G. Mejía Geraldo, Ingrid Salinas Zaldívar

{"title":"Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome","authors":"David Alejandro Vargas Gutiérrez, K. I. Arias Callejas, Edwin Pavel Palacios Ruiz, Priscila Joseline Pérez Vinueza, Juan Diego Muñoz Vega, Ana Karen G. Mejía Geraldo, Ingrid Salinas Zaldívar","doi":"10.1155/2022/8571536","DOIUrl":"https://doi.org/10.1155/2022/8571536","url":null,"abstract":"Background Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltration of mineral oil for aesthetic purposes and presented with multiple episodes of urolithiasis resulting in renal impairment of her left kidney confirmed by scintigraphy and ending in unilateral nephrectomy. Retrospective renal piece analysis confirmed tubulointerstitial infiltration with light chains and plasma cells. Paraffin fixation prevented subsequent immunofluorescence analysis for better follow-up of the patient. Conclusion The presence of positive immunofixation kappa chains explained the sudden deterioration of renal function with monoclonal gammopathy of renal significance which concluded in an association between diseases, such as multiple light chain myeloma, as a final diagnosis.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"518 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77175440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancytopenia with Development of Persistent Neutropenia Secondary to COVID-19 全血细胞减少伴新冠肺炎继发持续性中性粒细胞减少

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Case Reports in Hematology Pub Date : 2022-05-11 DOI: 10.1155/2022/8739295

Kathie Wu, Yvonne Dansoa, Priyanka Pathak

引用次数: 3

Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation t(2;13)(q33;q12)易位的非典型慢性髓系白血病的诊断和治疗

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Case Reports in Hematology Pub Date : 2022-05-04 DOI: 10.1155/2022/4628183

John S. Wang, O. Elghawy, Brett Kurpiel, Michael G. Douvas

{"title":"Diagnosis and Management of Atypical Chronic Myeloid Leukemia with a t(2;13)(q33;q12) Translocation","authors":"John S. Wang, O. Elghawy, Brett Kurpiel, Michael G. Douvas","doi":"10.1155/2022/4628183","DOIUrl":"https://doi.org/10.1155/2022/4628183","url":null,"abstract":"Atypical chronic myeloid leukemia (aCML) is a rare myeloproliferative disorder that shares clinical features with chronic myeloid leukemia but lacks the classic t(9;22) BCR-ABL1 translocation and features prominent dysgranulopoiesis and granulocytic dysplasia. Challenges of this diagnosis include clinical and biologic heterogeneity, the high risk of transformation to acute myeloid leukemia, and the lack of standard treatment options. Allogeneic hematopoietic stem cell transplant is likely the preferred treatment, but this can be limited by patient psychosocial support, age, concomitant medical conditions, and availability of an appropriate donor. We report the case of a 61-year-old male with no significant past medical history diagnosed with aCML with a rare t(2;13)(q33;q12). He presented with weight loss, night sweats, splenomegaly, hyperleukocytosis, a leukoerythroblastic differential with a predominant neutrophilia, anemia, and thrombocytopenia. Subsequent peripheral blood and bone marrow studies lead to the diagnosis of aCML. He was recommended to undergo an allogeneic stem cell transplant evaluation and declined. He was initially treated with hydroxyurea and imatinib to which he responded for approximately three years. After clinical progression, he was treated with sorafenib, a multiprotein kinase inhibitor more commonly used in the treatment of hepatocellular and renal cell carcinoma due to its off target FLT3 inhibition. The patient achieved complete hematologic response which has been sustained for 7 years with tolerable side effects.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"13 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87041395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Age-Adjusted Schedules of Venetoclax and Hypomethylating Agents to Treat Extremely Elderly Patients with Acute Myeloid Leukemia Venetoclax和低甲基化药物治疗高龄急性髓性白血病患者的年龄调整方案

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Case Reports in Hematology Pub Date : 2022-04-26 DOI: 10.1155/2022/2802680

Aaron M. Lee, A. Goodman, J. Mangan

引用次数: 2

An Unusual Presentation of Extracavitary Primary Effusion Lymphoma: Internal Jugular Vein Occlusion, Intractable Symptoms of Intracranial Hypertension, and Prolonged Remission after Highly Active Antiretroviral Therapy 一种不寻常的腔外原发性积液性淋巴瘤的表现:颈内静脉阻塞，颅内高压的难治性症状，以及高效抗逆转录病毒治疗后的长期缓解

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Case Reports in Hematology Pub Date : 2022-04-23 DOI: 10.1155/2022/6046783

Anindita Ghosh, R. Zvavanjanja, J. Baalwa

{"title":"An Unusual Presentation of Extracavitary Primary Effusion Lymphoma: Internal Jugular Vein Occlusion, Intractable Symptoms of Intracranial Hypertension, and Prolonged Remission after Highly Active Antiretroviral Therapy","authors":"Anindita Ghosh, R. Zvavanjanja, J. Baalwa","doi":"10.1155/2022/6046783","DOIUrl":"https://doi.org/10.1155/2022/6046783","url":null,"abstract":"Primary involvement of the skeletal muscle by extracavitary primary effusion lymphoma (PEL) is an extremely rare phenomenon. We report an unusual case of PEL involving the jugulodigastric skeletal muscle without serous cavity involvement which resulted in complete occlusion of the ipsilateral proximal internal jugular vein, causing the patient to present with clinical features of intractable throbbing headache, photophobia, acute confusion state, sporadic syncopal attacks, and dyspnea without obvious palpable neck swellings. This led to an initial clinical suspicion, dedicated diagnostic workup, and empiric therapy for acute meningoencephalitis, severe atypical pneumonia, and acute pulmonary embolism. Owing to his refractory symptoms, exploratory CT imaging eventually revealed a heterogenous jugulodigastric mass, and finally, a pathologic diagnosis of extracavitary PEL was identified as the cause of his intracranial hypertension. The patient remains in remission 22 months after commencing a dolutegravir-based HAART regimen without any chemotherapeutic intervention.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"18 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82926840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Midostaurin-Associated Sweet's Syndrome 一例罕见的midoin相关的Sweet综合征

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Case Reports in Hematology Pub Date : 2022-04-22 DOI: 10.1155/2022/1099005

Hesham Yasin, Tessa Laytem, G. Sutamtewagul, S. Ayyappan

引用次数: 4