Case Reports in Hematology最新文献_第10页

Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase. bcr - abl1阳性慢性髓性白血病缓解期患者的全身肥大细胞增多症

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Case Reports in Hematology Pub Date : 2022-11-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7251658

Christos Fokoloros, Periklis Foukas, Nikolaos Georgakopoulos, Zoi Tsakiraki, Anthi Bouchla, Vasilliki Pappa, Alexandros Katoulis, Michael Makris, Sotirios Papageorgiou

引用次数: 0

Paraneoplastic Pemphigus: A Striking Complication of Undiagnosed Lymphoma. 副肿瘤天疱疮:未确诊淋巴瘤的显著并发症。

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Case Reports in Hematology Pub Date : 2022-10-25 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3641474

Blake O Adnani, Kathleen O' Brien, Zaw W Myint, Brandon L Adler

{"title":"Paraneoplastic Pemphigus: A Striking Complication of Undiagnosed Lymphoma.","authors":"Blake O Adnani, Kathleen O' Brien, Zaw W Myint, Brandon L Adler","doi":"10.1155/2022/3641474","DOIUrl":"https://doi.org/10.1155/2022/3641474","url":null,"abstract":"A 49-year-old male with no past medical history presented with acute-onset painful mucosal erosions along with flaccid bullae on his trunk, scalp, and intertriginous areas. The patient initially underwent a skin biopsy which demonstrated suprabasilar acantholysis and lichenoid interface dermatitis. This was followed by a computed tomography scan which identified a large abdominal lymph node. Core needle biopsy of this node demonstrated follicular lymphoma. Lastly, indirect immunofluorescence (IIF) in rat bladder was positive (titer 1 : 10,240). This finding confirmed the diagnosis of paraneoplastic pemphigus (PNP) in the setting of follicular lymphoma. The patient's cutaneous disease was treated with a combination of intravenous immunoglobulin and methylprednisolone, along with intravenous rituximab, with a resolution of his cutaneous symptoms. His lymphoma was treated with six cycles of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with an interval decrease in his tumor burden. PNP is an autoimmune-mediated mucocutaneous disease associated with underlying neoplasm, most commonly non-Hodgkin lymphoma or chronic lymphocytic leukemia. Affected patients develop variable autoantibodies to antigens on keratinocytes and the basement membrane zone. Severe intractable stomatitis is characteristic, in addition to polymorphous cutaneous eruptions including bullae and erosions. Mortality rates can reach up to 90% due to malignancy, sepsis, or bronchiolitis obliterans, an irreversible and often lethal cause of pulmonary insufficiency. We highlight PNP manifesting in a patient with lymphoma, who responded well to the skin- and malignancy-directed treatments. PNP is an exceedingly rare diagnosis that should be considered in a patient with intractable stomatitis.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"3641474"},"PeriodicalIF":0.7,"publicationDate":"2022-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9626227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40443777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Secondary Hemophagocytic Lymphohistiocytosis Presenting with Severe Dyserythropoeisis in a Patient with Autoimmune Hemolysis. 自身免疫性溶血患者继发嗜血球性淋巴组织细胞增多症伴严重红细胞增多症1例。

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Case Reports in Hematology Pub Date : 2022-10-19 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8505823

Kai J Rogers, Sharathkumar Bhagavathi

引用次数: 0

Long-Term Zidovudine Therapy and Whether It is a Trigger of Vitamin B12 Deficiency: A Case Study of Megaloblastic Anemia at the University of Zambia Teaching Hospital. 长期齐多夫定治疗及其是否引发维生素B12缺乏症:赞比亚大学教学医院巨幼细胞性贫血病例研究

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Case Reports in Hematology Pub Date : 2022-10-07 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3827616

Natasha Mupeta Kaweme, Sahar Mounir Nagib Butress, Hamakwa Muluti Mantina

{"title":"Long-Term Zidovudine Therapy and Whether It is a Trigger of Vitamin B12 Deficiency: A Case Study of Megaloblastic Anemia at the University of Zambia Teaching Hospital.","authors":"Natasha Mupeta Kaweme, Sahar Mounir Nagib Butress, Hamakwa Muluti Mantina","doi":"10.1155/2022/3827616","DOIUrl":"https://doi.org/10.1155/2022/3827616","url":null,"abstract":"Macrocytic anemia is frequently observed in adult HIV-infected patients treated with nucleoside reverse transcriptase inhibitors and with vitamin B12 and folate deficiency. In this case report, we discuss a 52-year-old nonvegetarian male on long-term antiretroviral therapy for 5 years, presenting with severe macrocytic anemia (hemoglobin, 3.7 g/dL; mean corpuscular volume, 119.6 fL) and leukopenia (2.71∗109/L), who was diagnosed with megaloblastic anemia caused by vitamin B12 deficiency following laboratory investigations. Parenteral vitamin B12 replacement therapy was initiated, with an early response observed. Notwithstanding, the treatment response was not sustained as the patient later presented with refractory anemia and persistence of macrocytosis. Discontinuation of zidovudine with concurrent vitamin B12 administration promptly improved the patient's clinical deficiency symptoms. At the end of 3 months, the patient had a complete hematological recovery. The deficiency of vitamin B12 disrupts DNA synthesis inhibiting effective hematopoiesis in all cell lines, particularly erythroid precursors and further promotes reversible bone marrow failure. Long-term ART therapy with zidovudine causes cytotoxicity in myeloid and erythroid precursors and induces bone marrow suppression. Whether long-term zidovudine consumption induced lower levels of vitamin B12 and subsequent megaloblastic anemia requires in-depth research and exploration.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"3827616"},"PeriodicalIF":0.7,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9568349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Rare Case of BCL2-Positive Multiple Myeloma Complicated with Follicular Lymphoma. bcl2阳性多发性骨髓瘤合并滤泡性淋巴瘤1例。

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Case Reports in Hematology Pub Date : 2022-10-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3076968

Yutaka Tsutsumi, Shinich Ito, Mirei Kobayashi, Takanori Teshima

引用次数: 1

A Single-Centre Experience of Post-COVID-19 Vaccine-Related Immune-Mediated Complications. covid -19后疫苗相关免疫介导并发症的单中心研究

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Case Reports in Hematology Pub Date : 2022-09-30 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4742639

David Palmer, Lauren Davis, Helena Sivaloganathan, Timothy Chevassut

{"title":"A Single-Centre Experience of Post-COVID-19 Vaccine-Related Immune-Mediated Complications.","authors":"David Palmer, Lauren Davis, Helena Sivaloganathan, Timothy Chevassut","doi":"10.1155/2022/4742639","DOIUrl":"https://doi.org/10.1155/2022/4742639","url":null,"abstract":"The significant impact of the COVID-19 pandemic has resulted in a worldwide effort to develop effective vaccines. In the United Kingdom, the COVID-19 vaccine development and roll-out has been overwhelmingly successful in reducing infections and deaths. However, case reports have emerged of a rare syndrome of vaccine-induced immune thrombocytopenia and thrombosis (VITT), as well as cases of immune thrombocytopenia (ITP). This has necessitated a better understanding of these conditions. However, as both VITT and \"vaccine-associated ITP\" are emerging conditions, evidence on the clinical features, epidemiology, and management is still evolving. Subsequently, with the initiation of the COVID-19 vaccine booster program, it has become increasingly important to continue to collect accurate data on post-COVID-19 vaccine complications to aid with their prompt recognition and management. In this case series, we report on the presentations and management of seven cases of post-COVID-19 vaccine-related immune-mediated complications which occurred at our center between the months of March and July 2021.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"4742639"},"PeriodicalIF":0.7,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9546669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33517182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone. 达拉单抗、波马度胺、长春新碱、丙卡嗪、地塞米松联合治疗瘦脑膜骨髓瘤病例1例

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Case Reports in Hematology Pub Date : 2022-08-31 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4081971

Jew Win Kuan, Sing Ling Chai, Pathmanathan Rajadurai, Lee Gong Lau, Joseph Uchang, Sharifah Noor Akmal Syed Husain

{"title":"A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone.","authors":"Jew Win Kuan, Sing Ling Chai, Pathmanathan Rajadurai, Lee Gong Lau, Joseph Uchang, Sharifah Noor Akmal Syed Husain","doi":"10.1155/2022/4081971","DOIUrl":"https://doi.org/10.1155/2022/4081971","url":null,"abstract":"Central nervous system (CNS) involvement in multiple myeloma (MM) (MM-CNS) in the form of leptomeningeal myelomatosis or brain parenchyma plasmacytoma is rare, causing challenges in clinical diagnosis and treatment. We would like to report a case of leptomeningeal myelomatosis and illustrated the challeges. A 61-year-old man was diagnosed with MM with left paravertebral plasmacytoma, R-ISS II with high suspicion of double-hit MM, either biallelic aberrancy of TP53 or del(17p) and IGH aberrancy depending on the definition chosen, treated with lenalidomide-bortezomib-dexamethasone and local radiotherapy, later developed systemic relapse and progression to MM-CNS in the form of leptomeningeal myelomatosis. A modified CNS-based treatment not reported before, consisting of daratumumab, pomalidomide, vincristine, procarbazine, and dexamethasone, brought a rapid clinical improvement and warrants a further study. Incorporation of intrathecal thiotepa into the regimen would likely increase the efficacy.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"4081971"},"PeriodicalIF":0.7,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9453015/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33461150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bortezomib Use for a Critically Ill Patient with Angioimmunoblastic T-Cell Lymphoma. 硼替佐米用于血管免疫母细胞t细胞淋巴瘤危重患者。

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Case Reports in Hematology Pub Date : 2022-08-31 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6079633

Motoharu Shibusawa

引用次数: 2

SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition. 口服Xa因子抑制治疗SARS-CoV-2感染相关主动脉血栓形成

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Case Reports in Hematology Pub Date : 2022-08-25 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7805900

Alena Strýčková, Jakub Benko, Martin Jozef Péč, Monika Péčová, Jana Žolková, Monika Brunclíková, Tomáš Bolek, Ján Staško, Matej Samoš, Marián Mokáň

{"title":"SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition.","authors":"Alena Strýčková, Jakub Benko, Martin Jozef Péč, Monika Péčová, Jana Žolková, Monika Brunclíková, Tomáš Bolek, Ján Staško, Matej Samoš, Marián Mokáň","doi":"10.1155/2022/7805900","DOIUrl":"https://doi.org/10.1155/2022/7805900","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"7805900"},"PeriodicalIF":0.7,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40348258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Thrombocytopenia Associated with Dengue Fever: An Evidence-Based Approach to Management of Thrombocytopenia. 与登革热相关的严重血小板减少:以证据为基础的血小板减少管理方法。

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Case Reports in Hematology Pub Date : 2022-08-12 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3358325

Sulagna Das, Charles Abreu, Micah Harris, John Shrader, Satish Sarvepalli

引用次数: 3