Case Reports in Hematology最新文献_第10页

"A Dangerous Black Box:" Idiopathic Hemophagocytic Lymphohistiocytosis in Adult Patients-A Case Report and Review of the Literature. “一个危险的黑盒子:”成人患者的特发性噬血细胞淋巴组织细胞病-一例报告和文献综述。

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/5867129

Nada Agbariah, Javier Sanz, Alicia Rovó

{"title":"\"A Dangerous Black Box:\" Idiopathic Hemophagocytic Lymphohistiocytosis in Adult Patients-A Case Report and Review of the Literature.","authors":"Nada Agbariah, Javier Sanz, Alicia Rovó","doi":"10.1155/2022/5867129","DOIUrl":"https://doi.org/10.1155/2022/5867129","url":null,"abstract":"Hemophagocytic lymphohistiocytosis (HLH) is a rare potentially life-threatening condition characterized by aberrant inflammation that can be related to genetic or sporadic forms. In both forms, triggering factors may be involved. Early detection of the underlying cause is crucial for therapeutic decision, while early intervention might be associated with better outcomes. The largest descriptions in the literature on HLH refer to pediatric cases. Adolescents and adults may also be affected, but there is scarce evidence regarding their diagnosis and management. We describe here the case of a 68-year-old Swiss woman with HLH, in whom an extensive search for underlying causes was performed, but neither trigger nor pathogenic variant was found. An early intervention first with dexamethasone and later with cyclosporine was performed. The patient showed a favorable response and did not require further hospitalization; however, one year after diagnosis, it was not possible to suspend cyclosporine due to recurrence of laboratory inflammation signs by drug tapering. The occurrence of HLH idiopathic forms represents a challenge; failure to identify the underlying triggering cause generates uncertainty, endless diagnostic investigations, and consequently additional delays in the treatment. This manuscript addresses the difficulties on this issue.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"5867129"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9741541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10704928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chronic Eosinophilic Leukemia Presenting as Cardiac Failure. 慢性嗜酸性粒细胞白血病表现为心力衰竭。

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/7841310

Nii Boi-Doku Pepra-Ameyaw, William Kwasi Ghunney, Eugene Baafi Ampofo, Edeghonghon Olayemi

引用次数: 0

Successful Treatment of Concomitant Pleural Mucosa-Associated Lymphoid Tissue Lymphoma and Monoclonal Gammopathy of Undetermined Significance with Lenalidomide, Rituximab, and Dexamethasone. 来那度胺、利妥昔单抗和地塞米松成功治疗伴发性胸膜黏膜相关淋巴组织淋巴瘤和意义不明的单克隆伽玛病。

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/2027027

Yoshiki Uemura, Risa Maeda, Hiroyoshi Saegusa

{"title":"Successful Treatment of Concomitant Pleural Mucosa-Associated Lymphoid Tissue Lymphoma and Monoclonal Gammopathy of Undetermined Significance with Lenalidomide, Rituximab, and Dexamethasone.","authors":"Yoshiki Uemura, Risa Maeda, Hiroyoshi Saegusa","doi":"10.1155/2022/2027027","DOIUrl":"https://doi.org/10.1155/2022/2027027","url":null,"abstract":"Concomitant plasma cell and B cell neoplasms in a single patient have been infrequently reported. It is known that the prognosis of these patients is worse than that of patients with single-disease onset. Generally, the chemotherapy specific for each disease is provided sequentially. It has been suggested that the specific chemotherapy for lymphoma could lead to the occurrence of refractory multiple myeloma (MM). We present a case with the concomitant occurrence of mucosa-associated lymphoid tissue (MALT) lymphoma and monoclonal gammopathy of undetermined significance (MGUS). MGUS does not usually require aggressive treatment. However, the potential adverse effects of MGUS on the treatment course of the B cell lymphoma were concerning. Therefore, we explored a new therapeutic approach that is simultaneously effective against both diseases. Combination therapy of lenalidomide (LEN) and rituximab (RIT) gained indication for follicular lymphoma and MALT lymphoma recently. LEN is also a key drug in MM treatment. Both diseases in our patient were effectively treated with the combination of LEN, RIT, and dexamethasone. With this combination therapy, we expect a prognostic improvement in concomitant MM and B cell lymphoma cases.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"2027027"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10620256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Portal Vein Thrombosis following Total Colectomy due to Colonic Inertia: A Case Report and Evaluation of Risk Factors. 结肠惯性致全结肠切除术后门静脉血栓形成1例及危险因素评估。

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Case Reports in Hematology Pub Date : 2021-01-20 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8895206

Mohammad Bagher Jahantab, Saadat Mehrabi, Vahid Salehi, Lotfolah Abedini, Mohammad Javad Yavari Barhaghtalab

{"title":"Portal Vein Thrombosis following Total Colectomy due to Colonic Inertia: A Case Report and Evaluation of Risk Factors.","authors":"Mohammad Bagher Jahantab, Saadat Mehrabi, Vahid Salehi, Lotfolah Abedini, Mohammad Javad Yavari Barhaghtalab","doi":"10.1155/2021/8895206","DOIUrl":"https://doi.org/10.1155/2021/8895206","url":null,"abstract":"The portal vein could be occluded by blood clots partially or completely causing portal vein thrombosis (PVT). The acute episode may be asymptomatic or manifested by abdominal pain, increasing body temperature, and unspecific dyspeptic symptoms. The main causes of PVT are categorized into local, acquired, and genetic thrombophilic factors. To our knowledge, this is the 2nd recognized case of PVT following colectomy for colonic inertia successfully treated with an effective anticoagulation therapy. The patient received unfractionated heparin as soon the diagnosis was implemented. The patient was a 34-year-old lady with chief complaint of severe abdominal pain, nausea, vomiting, and anorexia 10 days after the first hospital admission for subtotal colectomy due to colonic inertia. Spiral abdominal CT scan with intravenous (IV) contrast showed thrombosis in main portal vein with its extension to right and left intrahepatic branches. Our case showed that we should keep in mind PVT in patients who present with upper gastrointestinal symptoms several days after a major surgery (open colectomy) as a risk factor and oral contraceptive pills (OCP) usage, postpregnancy, and immobility as other risk factors, that the protein C, S, and FVL deficiencies were secondary, and that the PVT can be managed by low molecular weight heparin plus oral warfarin therapy in the continue.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"8895206"},"PeriodicalIF":0.7,"publicationDate":"2021-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7840229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25325193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Diagnosis Is in the Smear: A Case and Review of Spur Cell Anemia in Cirrhosis. 在涂片中诊断:肝硬化骨刺细胞贫血1例回顾。

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Case Reports in Hematology Pub Date : 2021-01-01 DOI: 10.1155/2021/8883335

Gabriella A Raffa, Diana M Byrnes, John J Byrnes

{"title":"The Diagnosis Is in the Smear: A Case and Review of Spur Cell Anemia in Cirrhosis.","authors":"Gabriella A Raffa, Diana M Byrnes, John J Byrnes","doi":"10.1155/2021/8883335","DOIUrl":"https://doi.org/10.1155/2021/8883335","url":null,"abstract":"The etiology of anemia in liver cirrhosis is multifactorial; one less recognized cause is hemolytic anemia due to spur cells, known as spur cell anemia. We present the case of a 57-year-old woman with alcoholic cirrhosis who presented with symptomatic macrocytic anemia with a hemoglobin level of 7.4 g/dL and signs of decompensated liver disease. Notably, she had no signs of overt bleeding. Further workup was consistent with hemolysis, with peripheral smear demonstrating spur cells. The patient was treated with both steroids and IVIG, although she eventually expired. The characteristic morphology of spur cells is due to alteration of the lipid composition of the erythrocyte membrane, changing its shape and leading to splenic sequestration and destruction. Characteristic of this disorder is an increased ratio of cholesterol to phospholipid on the membrane, as well as low levels of apolipoproteins and low- and high-density lipoproteins. The presence of spur cells is an indicator of poor prognosis and high risk of mortality. Currently, the only definitive cure is liver transplantation. There is a paucity of literature on the prevalence of this phenomenon and even less about treatment. This case highlights the importance of recognition of spur cell anemia as a cause of anemia in cirrhosis as well as the importance of the peripheral smear in the diagnostic workup. Early recognition can lead to avoidance of unnecessary procedures. Further research is needed to elucidate the true prevalence of spur cell anemia and examine further treatment options.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2021 ","pages":"8883335"},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8019378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10346158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient. 免疫功能正常的老年患者与呼吸道合胞病毒感染相关的噬血细胞淋巴组织细胞增多症。

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Case Reports in Hematology Pub Date : 2020-12-08 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8833196

Ralph Kamel, Rubal Sharma, Divya Asti, Arshpal Gill, Yevgeniy Skaradinskiy

{"title":"Hemophagocytic Lymphohistiocytosis Associated with Respiratory Syncytial Virus Infection in an Immunocompetent Elderly Patient.","authors":"Ralph Kamel, Rubal Sharma, Divya Asti, Arshpal Gill, Yevgeniy Skaradinskiy","doi":"10.1155/2020/8833196","DOIUrl":"https://doi.org/10.1155/2020/8833196","url":null,"abstract":"Hemophagocytic lymphohistiocytosis is a serious and potentially fatal disorder characterized by excessive immune system activation. The disorder is diagnosed mainly based on laboratory, clinical, and pathologic criteria. The spectrum comprises hereditary or \"primary\" HLH that comprises genetically heterogeneous conditions, occurring during childhood. The secondary form presents later in life and is associated with several conditions mainly malignancy, autoimmune diseases, viral or bacterial infections, and hematological diseases. We present the case of an 80-year-old female patient who initially presented with an acute viral syndrome secondary to respiratory syncytial virus. The hospital course was complicated by disseminated intravascular coagulation and shock with multiorgan failure. Extensive workup revealed that several of the criteria for hemophagocytic lymphohistiocytosis were met. A review of literature fails to identify cases of hemophagocytic lymphohistiocytosis associated with respiratory syncytial virus in immunocompetent adults. This case report provides further insight on RSV as a possible etiologic agent associated with HLH and the importance of early recognition of this fatal disorder in RSV-positive patients who show unpredictable clinical decompensation.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":" ","pages":"8833196"},"PeriodicalIF":0.7,"publicationDate":"2020-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25316018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient-Initiated Discontinuation of Tyrosine Kinase Inhibitor for Chronic Myeloid Leukemia. 慢性髓性白血病患者主动停用酪氨酸激酶抑制剂。

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Case Reports in Hematology Pub Date : 2020-01-01 DOI: 10.1155/2020/9571691

Stephen E Langabeer, Rehman Faryal, Michael O'Dwyer, Sorcha Ní Loingsigh

{"title":"Patient-Initiated Discontinuation of Tyrosine Kinase Inhibitor for Chronic Myeloid Leukemia.","authors":"Stephen E Langabeer, Rehman Faryal, Michael O'Dwyer, Sorcha Ní Loingsigh","doi":"10.1155/2020/9571691","DOIUrl":"https://doi.org/10.1155/2020/9571691","url":null,"abstract":"The introduction of tyrosine kinase inhibitors (TKI) has revolutionised the management of patients with chronic myeloid leukemia (CML) over the last twenty years, but despite significant improvements in survival, patients exhibit long-term side effects that impact on quality of life. A major advance in CML management has been the ability to discontinue TKI therapy achieving a treatment-free remission (TFR), yet this option is only available to eligible patients who present with low-risk disease and who subsequently attain deep and sustained molecular responses. A case is described of a patient with CML who self-initiated stopping of TKI therapy when in a less than optimal molecular remission. Despite this action, the patient continues to experience a TFR with prospective close molecular monitoring performed. It is emphasized that this approach may lead to ineffective treatment discontinuation, molecular relapse, and increased patient anxiety. As TFR for patients with CML moves from clinical trials into routine clinical practice, emphasis is placed on adherence to (evolving) guidelines critical to ensure optimal counselling, selection, monitoring, and continued management of patients whether TFR is successful or not.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2020 ","pages":"9571691"},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9571691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10482689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An Unusual Initial Presentation of Diffuse Large B-Cell Lymphoma as Recurrent Syncope. 弥漫性大b细胞淋巴瘤复发性晕厥的不寻常首发表现。

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Case Reports in Hematology Pub Date : 2019-12-26 eCollection Date: 2019-01-01 DOI: 10.1155/2019/1082543

Kunhwa Kim, Harpreet Kaur, Matthew Chan, Manju Balasubramanian, Sorab Gupta, Vinicius M Jorge

引用次数: 3

A Massive Extradural Hematoma in Sickle Cell Disease and the Importance of Rapid Neuroimaging. 镰状细胞病的大量硬膜外血肿和快速神经成像的重要性。

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Case Reports in Hematology Pub Date : 2019-12-18 eCollection Date: 2019-01-01 DOI: 10.1155/2019/1742472

Per Ole Iversen, Mboka Jacob, Jamila Makame, Mclean Abisay, Mbonea Yonazi, Anna Schuh, Julie Makani

{"title":"A Massive Extradural Hematoma in Sickle Cell Disease and the Importance of Rapid Neuroimaging.","authors":"Per Ole Iversen, Mboka Jacob, Jamila Makame, Mclean Abisay, Mbonea Yonazi, Anna Schuh, Julie Makani","doi":"10.1155/2019/1742472","DOIUrl":"https://doi.org/10.1155/2019/1742472","url":null,"abstract":"Sickle cell disease (SCD) is an inherited hemoglobinopathy leading to several serious organ complications and early death. It is mostly found in equatorial countries like Tanzania. Extradural hematoma (EDH) is a rare, but serious complication to SCD and may have debilitating consequences. Hitherto, there is no report of EDH in SCD where neuroimaging has been available before, during, and after such an event. Here, we describe a young female SCD patient who developed EDH that required surgical evacuation. She had made full recovery after three months. Neuroimaging performed two years prior to this event was unremarkable except for multiple small cerebral infarcts. On admission, neuroimaging revealed a subgaleal hematoma, possibly indicating disruption of the skull cortex due to increased hematopoiesis. Three months after evacuation of the hematoma, neuroimaging showed evidence of brain atrophy and the previously reported cerebral infarcts and multifocal bone infarction, but no vasculopathy. Possibly, disruption of the skull cortex with subsequent bleeding caused the EDH. As the differential diagnoses of neurological complications in SCD are many and some complications are reversible, neuroimaging should be performed without delay.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2019 ","pages":"1742472"},"PeriodicalIF":0.7,"publicationDate":"2019-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2019/1742472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37535926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association of Immune Thrombocytopenia and T-Lymphoblastic Lymphoma in a Pediatric Patient. 儿童患者免疫性血小板减少症与t淋巴母细胞淋巴瘤的关系。

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Case Reports in Hematology Pub Date : 2019-12-17 eCollection Date: 2019-01-01 DOI: 10.1155/2019/1425151

Ryan A Denu, Daniel R Matson, Matthew J Davis, Natalie J Tedford, Christine E Brichta, Carol A Diamond, Margo L Hoover-Regan

引用次数: 1