A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm Occurred in Postchemotherapy of Breast Cancer.

IF 0.7 Q4 HEMATOLOGY
Jiankun Tong, Sergei Aksenov, Beth M Siegel, Lihong Wei, William H Rodgers
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Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic malignancy that arises from plasmacytoid dendritic cells. BPDCN typically presents with skin lesions and may involve peripheral blood, bone marrow, lymph nodes, or extranodal sites. It usually arises de novo, and some BPDCN cases are associated with or develop into myeloid neoplasms. Here, we report a case of a 57-year-old female presenting with cervical lymphadenopathy and skin rashes during the COVID-19 pandemic in 2021 following multiple types of postmastectomy therapy for breast cancer. The patient was ultimately diagnosed with BPCDN by lymph node biopsy. To the best of our knowledge, this is the first case report of BPDCN occurring postchemotherapy of breast cancer.

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乳腺癌化疗后发生母浆细胞样树突状细胞肿瘤1例。
母浆细胞样树突状细胞肿瘤(BPDCN)是一种罕见且高度侵袭性的血液恶性肿瘤,起源于浆细胞样树突状细胞。BPDCN通常表现为皮肤病变,可累及外周血、骨髓、淋巴结或结外部位。它通常是新发的,一些BPDCN病例与髓系肿瘤相关或发展为髓系肿瘤。在这里,我们报告了一例57岁的女性,在2021年COVID-19大流行期间,在多种类型的乳腺癌乳房切除术后治疗后,出现了颈部淋巴结病和皮疹。患者最终通过淋巴结活检诊断为BPCDN。据我们所知,这是首例乳腺癌化疗后出现BPDCN的病例报告。
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