Case Reports in Hematology最新文献

Acute Myeloid Leukemia With NPM1 Mutation Presenting With Rapidly Progressing Hypereosinophilia. 急性髓性白血病伴NPM1突变，表现为快速进展的嗜酸性粒细胞增多症。

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Case Reports in Hematology Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI: 10.1155/crh/5125740

S Einarsdottir, G Orrsjö, L von Bahr, A Staffas, L Fogelstrand

引用次数: 0

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis in a Young Polynesian Male. 原发性皮肤γ - δ t细胞淋巴瘤一例年轻波利尼西亚男性表现为噬血细胞性淋巴组织细胞增多症。

IF 0.7

Case Reports in Hematology Pub Date : 2025-05-23 eCollection Date: 2025-01-01 DOI: 10.1155/crh/8582804

Saeed Arabi, Victoria Vardell, Timothy Hanley, Scott Florell, Ahmad Halwani, Ming Lim

{"title":"Primary Cutaneous Gamma-Delta T-Cell Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis in a Young Polynesian Male.","authors":"Saeed Arabi, Victoria Vardell, Timothy Hanley, Scott Florell, Ahmad Halwani, Ming Lim","doi":"10.1155/crh/8582804","DOIUrl":"10.1155/crh/8582804","url":null,"abstract":"Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare subtype of cutaneous T-cell lymphoma. We report the case of a young Polynesian male who presented with fever and an abdominal wall rash and highlight the workup leading to the diagnosis of PCGD-TCL. As PCGD-TCL is rare and mimics other medical conditions, its diagnosis requires a high index of suspicion and can be challenging. Hemophagocytic lymphohistiocytosis (HLH) occurs with PCGD-TCL and can be a marker of more invasive disease. There are no well-defined treatment guidelines, but the most common treatment approach is anthracycline-based multiagent chemotherapy followed by allogeneic stem cell transplant. Targeted therapies are being increasingly used as well. Prognosis remains poor and 5-year survival is < 20%, particularly in more invasive disease. We highlight how this patient's demographic varies from the published literature and discuss some unique particulars of the diagnostic evaluation and treatment, especially in the presence of concurrent HLH.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"8582804"},"PeriodicalIF":0.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report. 儿童白血病伴阴道出血的罕见表现：1例报告。

IF 0.7

Case Reports in Hematology Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.1155/crh/9949125

Şule Çalışkan Kamış

{"title":"Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report.","authors":"Şule Çalışkan Kamış","doi":"10.1155/crh/9949125","DOIUrl":"10.1155/crh/9949125","url":null,"abstract":"Introduction: This case report describes a 17-year-old female patient who initially presented with vaginal bleeding, weight loss, and nonspecific symptoms, which led to the diagnosis of B-cell acute lymphoblastic leukemia (B-ALL). This unusual presentation highlights the importance of considering hematological malignancies in patients with atypical symptoms. Case Presentation: The patient, married for 2 weeks, experienced vaginal bleeding following her first sexual intercourse, which did not resolve spontaneously. She also reported a 6 kg weight loss over the past 3-4 months, hair loss, and a history of dysmenorrhea and an ovarian cyst detected 2 years prior. Laboratory investigations revealed leukocytosis (WBC: 16,500/μL), anemia (Hb: 11.4 g/dL), and thrombocytopenia (Plt: 44,000/μL). Bone marrow aspiration (BMA) and flow cytometry confirmed the diagnosis of B-ALL, revealing a high percentage of atypical lymphoid cells. Discussion: This case underscores the rarity of diagnosing hematological malignancies in patients with vaginal bleeding. The patient's symptoms, including weight loss and thrombocytopenia, should have prompted a more comprehensive evaluation. Early recognition of B-ALL is crucial as prompt treatment significantly improves outcomes. The patient was started on prednisolone and alkalinized fluids, and her condition was closely monitored. Conclusion: Vaginal bleeding in young patients should not be dismissed as a minor issue, especially when accompanied by other systemic symptoms like weight loss and thrombocytopenia. Early diagnosis of B-ALL in such cases can lead to better management and prognosis.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"9949125"},"PeriodicalIF":0.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Thrombocytopenia Secondary to Severe Iron Deficiency Anemia due to Menorrhagia. 月经过多引起的严重缺铁性贫血继发的严重血小板减少症。

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Case Reports in Hematology Pub Date : 2025-05-18 eCollection Date: 2025-01-01 DOI: 10.1155/crh/3894943

Tyler E Russeth, Amanda Luong, Mandi Liu, Mihir Shah, Nicole Desai

引用次数: 0

Unusual Long-Term Survival in an Adult Patient With Langerhans Cell Histiocytosis and Central Nervous System Involvement: A Case Report. 朗格汉斯细胞组织细胞增多症并累及中枢神经系统的成人患者异常的长期生存率：1例报告。

IF 0.7

Case Reports in Hematology Pub Date : 2025-05-16 eCollection Date: 2025-01-01 DOI: 10.1155/crh/6031427

María José Miranda Pallarés, Tomás Álvaro Naranjo, Anna Vidal Rodriguez, Francisca Martínez Madueño

{"title":"Unusual Long-Term Survival in an Adult Patient With Langerhans Cell Histiocytosis and Central Nervous System Involvement: A Case Report.","authors":"María José Miranda Pallarés, Tomás Álvaro Naranjo, Anna Vidal Rodriguez, Francisca Martínez Madueño","doi":"10.1155/crh/6031427","DOIUrl":"10.1155/crh/6031427","url":null,"abstract":"Langerhans cell histiocytosis (LCH) in adults is a rare condition. The disease presents with focal or multifocal involvement of a single organ/system or focal or disseminated multisystem disease. Involvement of the central nervous system (CNS) is also infrequent, with diabetes insipidus as a common manifestation of posterior pituitary lesions. Biopsy-proven diagnosis with the observation of characteristic Langerhans cells infiltrate with positive immunohistochemistry of S100 protein, CD1a, and CD68 cells. The patient presented generalized lymphadenopathy and was diagnosed with low-risk single-system LCH-based distinctive pathological findings in a lymph node biopsy. During the disease, CNS involvement was documented and the patient received different sequential therapeutic schemes, achieving complete remission that has been maintained for 8 years. The prolonged duration of remission with disappearance of lymphadenopathy and CNS lesions in an adult patient with LCH is an unusual clinical observation.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"6031427"},"PeriodicalIF":0.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pseudohyponatremia in the Setting of Pegaspargase-Induced Hypertriglyceridemia in an Adult T-Cell Lymphoblastic Leukemia Patient. 成人t淋巴细胞白血病患者在飞天冬氨酸诱导的高甘油三酯血症背景下发生假性低钠血症1例。

IF 0.7

Case Reports in Hematology Pub Date : 2024-12-29 eCollection Date: 2024-01-01 DOI: 10.1155/crh/7154679

Asim Ahmad, Matthew Joseph

引用次数: 0

Acute Myeloid Leukemia (AML) With T-Cell Differentiation Arising From Chronic Myelomonocytic Leukemia (CMML). 由慢性粒单核细胞白血病（CMML）演变而来的 T 细胞分化型急性髓细胞白血病（AML）。

IF 0.7

Case Reports in Hematology Pub Date : 2024-12-14 eCollection Date: 2024-01-01 DOI: 10.1155/crh/5584297

Anthony Crymes, Mark G Evans, Deepa Jeyakumar, Jerry J Lou, Xiaohui Zhao, Sherif A Rezk

{"title":"Acute Myeloid Leukemia (AML) With T-Cell Differentiation Arising From Chronic Myelomonocytic Leukemia (CMML).","authors":"Anthony Crymes, Mark G Evans, Deepa Jeyakumar, Jerry J Lou, Xiaohui Zhao, Sherif A Rezk","doi":"10.1155/crh/5584297","DOIUrl":"10.1155/crh/5584297","url":null,"abstract":"Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood monocytosis and bone marrow dysplasia. In approximately one-fourth of cases, CMML can demonstrate progression to acute myeloid leukemia (AML), referred to as AML ex CMML. We present a 58-year-old woman with a past medical history of idiopathic thrombocytopenic purpura (ITP) who demonstrated 24% bone marrow blasts on a repeat biopsy obtained two years after being diagnosed with CMML. By the flow cytometric analysis, the blasts expressed partial CD34, CD13, CD117, partial MPO, and partial CD123 with coexpression of the T-lymphoid markers CD2, CD5, CD7, partial CD4, cytoplasmic CD3, partial cytoplasmic TDT, and CD38, suggestive of AML with rare mixed myeloid/T-cell phenotype. Treatment with various agents including decitabine, cytarabine, daunorubicin, etoposide, and venetoclax, and two experimental bromodomain and extraterminal (BET) inhibitors did not produce sustained remissions, and the patient eventually succumbed to her disease. T-cell phenotype is an exceedingly rare feature of AML ex CMML, and whether this unique differentiation pathway contributed to the aggressive disease course remains unclear. Trial Registration: ClinicalTrials.gov identifier: NCT02543879, NCT03360006.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2024 ","pages":"5584297"},"PeriodicalIF":0.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. 揭露被误诊为骨髓增生异常综合征的维生素B12缺乏症。

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Case Reports in Hematology Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3258227

Maria Jamil, Zeinab Nasser, Dawood Jamil, Jawad Z Sheqwara

{"title":"Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome.","authors":"Maria Jamil, Zeinab Nasser, Dawood Jamil, Jawad Z Sheqwara","doi":"10.1155/2024/3258227","DOIUrl":"10.1155/2024/3258227","url":null,"abstract":"Background: Pancytopenia is characterized by a decrease in all three types of blood cells. Instead of being a standalone disease, it acts as a common outcome resulting from various factors, including infections, autoimmune disorders, genetic issues, nutritional deficiencies, and malignancies. Pinpointing the root cause of pancytopenia poses a challenge but is essential for devising an effective treatment plan and predicting the likely prognosis. Vitamin B12 deficiency is a common cause of megaloblastic anemia, pancytopenia, and various neuropsychiatric symptoms. However, diagnosing vitamin B12 deficiency lacks a definitive gold standard. Case Presentation: We present two cases where patients initially exhibited pancytopenia with seemingly normal vitamin B12 levels. Based on a bone marrow biopsy, they were initially diagnosed with myelodysplastic syndrome (MDS). Subsequent investigations revealed elevated serum methylmalonic acid (MMA) levels, leading to a revised diagnosis of vitamin B12 deficiency. Both patients showed positive responses to adequate vitamin B12 supplementation. Conclusion: Our case series highlights the importance of ruling out alternative causes of dysplasia in MDS when solely morphological abnormalities are observed on a bone marrow biopsy. It also underscores the crucial aspect of assessing MMA and homocysteine levels in individuals with normal vitamin B12 levels when there is a high clinical suspicion of B12 deficiency.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2024 ","pages":"3258227"},"PeriodicalIF":0.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KIT V560D-Mutated Systemic Mastocytosis Associated With High-Risk Myelodysplastic Syndrome: A Unique Case of Systemic Mastocytosis-Associated Hematologic Neoplasm. KIT v560d突变全身性肥大细胞增多症与高危骨髓增生异常综合征相关：全身性肥大细胞增多症相关血液学肿瘤的一个独特病例

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Case Reports in Hematology Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.1155/crh/4360304

Georgio Medawar, Krishna Sakalabaktula, Jenna Magri, Elizabeth Rinker, Praneeth Baratam

引用次数: 0

Widespread Cutaneous Indeterminate Dendritic Cell Tumor (IDCT) With ETV3::NOAC2 Rearrangement Successfully Treated With PUVA Therapy: A Case Report. PUVA成功治疗伴有ETV3: NOAC2重排的广泛皮肤不确定树突状细胞瘤1例。

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Case Reports in Hematology Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1155/crh/8013335

Akshay Deshpande, Zbigniew Rudzki, Jaideep Bhat, Matthew Pugh, Susan Rose, Shankara Paneesha

引用次数: 0