Case Reports in Hematology最新文献

Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report. 儿童白血病伴阴道出血的罕见表现：1例报告。

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Case Reports in Hematology Pub Date : 2025-05-20 eCollection Date: 2025-01-01 DOI: 10.1155/crh/9949125

Şule Çalışkan Kamış

{"title":"Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report.","authors":"Şule Çalışkan Kamış","doi":"10.1155/crh/9949125","DOIUrl":"10.1155/crh/9949125","url":null,"abstract":"Introduction: This case report describes a 17-year-old female patient who initially presented with vaginal bleeding, weight loss, and nonspecific symptoms, which led to the diagnosis of B-cell acute lymphoblastic leukemia (B-ALL). This unusual presentation highlights the importance of considering hematological malignancies in patients with atypical symptoms. Case Presentation: The patient, married for 2 weeks, experienced vaginal bleeding following her first sexual intercourse, which did not resolve spontaneously. She also reported a 6 kg weight loss over the past 3-4 months, hair loss, and a history of dysmenorrhea and an ovarian cyst detected 2 years prior. Laboratory investigations revealed leukocytosis (WBC: 16,500/μL), anemia (Hb: 11.4 g/dL), and thrombocytopenia (Plt: 44,000/μL). Bone marrow aspiration (BMA) and flow cytometry confirmed the diagnosis of B-ALL, revealing a high percentage of atypical lymphoid cells. Discussion: This case underscores the rarity of diagnosing hematological malignancies in patients with vaginal bleeding. The patient's symptoms, including weight loss and thrombocytopenia, should have prompted a more comprehensive evaluation. Early recognition of B-ALL is crucial as prompt treatment significantly improves outcomes. The patient was started on prednisolone and alkalinized fluids, and her condition was closely monitored. Conclusion: Vaginal bleeding in young patients should not be dismissed as a minor issue, especially when accompanied by other systemic symptoms like weight loss and thrombocytopenia. Early diagnosis of B-ALL in such cases can lead to better management and prognosis.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"9949125"},"PeriodicalIF":0.7,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144162748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Thrombocytopenia Secondary to Severe Iron Deficiency Anemia due to Menorrhagia. 月经过多引起的严重缺铁性贫血继发的严重血小板减少症。

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Case Reports in Hematology Pub Date : 2025-05-18 eCollection Date: 2025-01-01 DOI: 10.1155/crh/3894943

Tyler E Russeth, Amanda Luong, Mandi Liu, Mihir Shah, Nicole Desai

引用次数: 0

Unusual Long-Term Survival in an Adult Patient With Langerhans Cell Histiocytosis and Central Nervous System Involvement: A Case Report. 朗格汉斯细胞组织细胞增多症并累及中枢神经系统的成人患者异常的长期生存率：1例报告。

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Case Reports in Hematology Pub Date : 2025-05-16 eCollection Date: 2025-01-01 DOI: 10.1155/crh/6031427

María José Miranda Pallarés, Tomás Álvaro Naranjo, Anna Vidal Rodriguez, Francisca Martínez Madueño

{"title":"Unusual Long-Term Survival in an Adult Patient With Langerhans Cell Histiocytosis and Central Nervous System Involvement: A Case Report.","authors":"María José Miranda Pallarés, Tomás Álvaro Naranjo, Anna Vidal Rodriguez, Francisca Martínez Madueño","doi":"10.1155/crh/6031427","DOIUrl":"10.1155/crh/6031427","url":null,"abstract":"Langerhans cell histiocytosis (LCH) in adults is a rare condition. The disease presents with focal or multifocal involvement of a single organ/system or focal or disseminated multisystem disease. Involvement of the central nervous system (CNS) is also infrequent, with diabetes insipidus as a common manifestation of posterior pituitary lesions. Biopsy-proven diagnosis with the observation of characteristic Langerhans cells infiltrate with positive immunohistochemistry of S100 protein, CD1a, and CD68 cells. The patient presented generalized lymphadenopathy and was diagnosed with low-risk single-system LCH-based distinctive pathological findings in a lymph node biopsy. During the disease, CNS involvement was documented and the patient received different sequential therapeutic schemes, achieving complete remission that has been maintained for 8 years. The prolonged duration of remission with disappearance of lymphadenopathy and CNS lesions in an adult patient with LCH is an unusual clinical observation.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"6031427"},"PeriodicalIF":0.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Pseudohyponatremia in the Setting of Pegaspargase-Induced Hypertriglyceridemia in an Adult T-Cell Lymphoblastic Leukemia Patient. 成人t淋巴细胞白血病患者在飞天冬氨酸诱导的高甘油三酯血症背景下发生假性低钠血症1例。

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Case Reports in Hematology Pub Date : 2024-12-29 eCollection Date: 2024-01-01 DOI: 10.1155/crh/7154679

Asim Ahmad, Matthew Joseph

引用次数: 0

Acute Myeloid Leukemia (AML) With T-Cell Differentiation Arising From Chronic Myelomonocytic Leukemia (CMML). 由慢性粒单核细胞白血病（CMML）演变而来的 T 细胞分化型急性髓细胞白血病（AML）。

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Case Reports in Hematology Pub Date : 2024-12-14 eCollection Date: 2024-01-01 DOI: 10.1155/crh/5584297

Anthony Crymes, Mark G Evans, Deepa Jeyakumar, Jerry J Lou, Xiaohui Zhao, Sherif A Rezk

{"title":"Acute Myeloid Leukemia (AML) With T-Cell Differentiation Arising From Chronic Myelomonocytic Leukemia (CMML).","authors":"Anthony Crymes, Mark G Evans, Deepa Jeyakumar, Jerry J Lou, Xiaohui Zhao, Sherif A Rezk","doi":"10.1155/crh/5584297","DOIUrl":"10.1155/crh/5584297","url":null,"abstract":"Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm characterized by peripheral blood monocytosis and bone marrow dysplasia. In approximately one-fourth of cases, CMML can demonstrate progression to acute myeloid leukemia (AML), referred to as AML ex CMML. We present a 58-year-old woman with a past medical history of idiopathic thrombocytopenic purpura (ITP) who demonstrated 24% bone marrow blasts on a repeat biopsy obtained two years after being diagnosed with CMML. By the flow cytometric analysis, the blasts expressed partial CD34, CD13, CD117, partial MPO, and partial CD123 with coexpression of the T-lymphoid markers CD2, CD5, CD7, partial CD4, cytoplasmic CD3, partial cytoplasmic TDT, and CD38, suggestive of AML with rare mixed myeloid/T-cell phenotype. Treatment with various agents including decitabine, cytarabine, daunorubicin, etoposide, and venetoclax, and two experimental bromodomain and extraterminal (BET) inhibitors did not produce sustained remissions, and the patient eventually succumbed to her disease. T-cell phenotype is an exceedingly rare feature of AML ex CMML, and whether this unique differentiation pathway contributed to the aggressive disease course remains unclear. Trial Registration: ClinicalTrials.gov identifier: NCT02543879, NCT03360006.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2024 ","pages":"5584297"},"PeriodicalIF":0.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. 揭露被误诊为骨髓增生异常综合征的维生素B12缺乏症。

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Case Reports in Hematology Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.1155/2024/3258227

Maria Jamil, Zeinab Nasser, Dawood Jamil, Jawad Z Sheqwara

{"title":"Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome.","authors":"Maria Jamil, Zeinab Nasser, Dawood Jamil, Jawad Z Sheqwara","doi":"10.1155/2024/3258227","DOIUrl":"10.1155/2024/3258227","url":null,"abstract":"Background: Pancytopenia is characterized by a decrease in all three types of blood cells. Instead of being a standalone disease, it acts as a common outcome resulting from various factors, including infections, autoimmune disorders, genetic issues, nutritional deficiencies, and malignancies. Pinpointing the root cause of pancytopenia poses a challenge but is essential for devising an effective treatment plan and predicting the likely prognosis. Vitamin B12 deficiency is a common cause of megaloblastic anemia, pancytopenia, and various neuropsychiatric symptoms. However, diagnosing vitamin B12 deficiency lacks a definitive gold standard. Case Presentation: We present two cases where patients initially exhibited pancytopenia with seemingly normal vitamin B12 levels. Based on a bone marrow biopsy, they were initially diagnosed with myelodysplastic syndrome (MDS). Subsequent investigations revealed elevated serum methylmalonic acid (MMA) levels, leading to a revised diagnosis of vitamin B12 deficiency. Both patients showed positive responses to adequate vitamin B12 supplementation. Conclusion: Our case series highlights the importance of ruling out alternative causes of dysplasia in MDS when solely morphological abnormalities are observed on a bone marrow biopsy. It also underscores the crucial aspect of assessing MMA and homocysteine levels in individuals with normal vitamin B12 levels when there is a high clinical suspicion of B12 deficiency.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2024 ","pages":"3258227"},"PeriodicalIF":0.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KIT V560D-Mutated Systemic Mastocytosis Associated With High-Risk Myelodysplastic Syndrome: A Unique Case of Systemic Mastocytosis-Associated Hematologic Neoplasm. KIT v560d突变全身性肥大细胞增多症与高危骨髓增生异常综合征相关：全身性肥大细胞增多症相关血液学肿瘤的一个独特病例

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Case Reports in Hematology Pub Date : 2024-11-30 eCollection Date: 2024-01-01 DOI: 10.1155/crh/4360304

Georgio Medawar, Krishna Sakalabaktula, Jenna Magri, Elizabeth Rinker, Praneeth Baratam

引用次数: 0

Widespread Cutaneous Indeterminate Dendritic Cell Tumor (IDCT) With ETV3::NOAC2 Rearrangement Successfully Treated With PUVA Therapy: A Case Report. PUVA成功治疗伴有ETV3: NOAC2重排的广泛皮肤不确定树突状细胞瘤1例。

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Case Reports in Hematology Pub Date : 2024-11-29 eCollection Date: 2024-01-01 DOI: 10.1155/crh/8013335

Akshay Deshpande, Zbigniew Rudzki, Jaideep Bhat, Matthew Pugh, Susan Rose, Shankara Paneesha

引用次数: 0

Diagnostic Ambiguity Caused by an Atypical e18a2 BCR::ABL1 Transcript in a Chronic Myeloid Leukemia Patient. 慢性髓系白血病患者非典型e18a2 BCR::ABL1转录引起的诊断歧义

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Case Reports in Hematology Pub Date : 2024-11-25 eCollection Date: 2024-01-01 DOI: 10.1155/2024/9439134

Thomas Pretzsch, Steve Progscha, Thomas Burmeister

引用次数: 0

Bone Marrow Failure due to Aplastic Anemia, Associated With Serous Fat Atrophy, and Treated With Allogeneic, Haploidentical Stem Cell Transplantation: A Case Report. 再生障碍性贫血导致骨髓衰竭，伴有浆液性脂肪萎缩，采用异体同种干细胞移植治疗：病例报告。

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Case Reports in Hematology Pub Date : 2024-11-16 eCollection Date: 2024-01-01 DOI: 10.1155/crh/6526961

Matthew J Pisarcik, Cameron J Oswalt, Eric D Carlsen, Mitchell E Horwitz

{"title":"Bone Marrow Failure due to Aplastic Anemia, Associated With Serous Fat Atrophy, and Treated With Allogeneic, Haploidentical Stem Cell Transplantation: A Case Report.","authors":"Matthew J Pisarcik, Cameron J Oswalt, Eric D Carlsen, Mitchell E Horwitz","doi":"10.1155/crh/6526961","DOIUrl":"10.1155/crh/6526961","url":null,"abstract":"We describe the case of a 27-year-old male, previously healthy though with a social history notable for recreational cocaine use, who developed bone marrow failure due to aplastic anemia (AA) with associated serous fat atrophy (SFA). After the SFA was corrected with nutritional supplementation, the patient underwent successful allogeneic, haploidentical stem cell transplantation with a regimen designed to treat AA. To our knowledge, this is the first case of hematopoietic stem cell transplantation (HSCT) performed following correction of SFA. Herein we propose our novel hypothesis that SFA, once resolved, is not a contraindication to stem cell transplantation, which we believe adds valuable insight toward an improved understanding of nutrition's role in HSCT. Additionally, the AA is thought to be toxin-induced and specifically levamisole-mediated after exposure to levamisole-adulterated cocaine. We highlight potential connections between levamisole, AA, and SFA and call for further efforts to understand these relationships-especially as the use of levamisole as a cocaine adulterant continues to rise across the globe.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2024 ","pages":"6526961"},"PeriodicalIF":0.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0