Case Reports in Hematology最新文献

A Hyperacute Presentation of Small Cell, Non-Nodal Mantle Cell Lymphoma. 小细胞非结套细胞淋巴瘤的超急性表现。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI: 10.1155/crh/9912698

Jodi Chiu, Mark Crowther

{"title":"A Hyperacute Presentation of Small Cell, Non-Nodal Mantle Cell Lymphoma.","authors":"Jodi Chiu, Mark Crowther","doi":"10.1155/crh/9912698","DOIUrl":"https://doi.org/10.1155/crh/9912698","url":null,"abstract":"Mantle cell lymphoma (MCL) is an aggressive mature B-cell non-Hodgkin lymphoma. Patients often present with lymphadenopathy, early satiety, and B-symptoms. Presentation with hyperleukocytosis is rare. The small cell, non-nodal variant of MCL tends to be less aggressive, have lower mitotic rates, and mimics morphology of chronic lymphocytic leukemia (CLL). We present a 79-year-old woman admitted to hospital with generalized weakness, gait instability, and dyspnea; she was found to have a white count of 550 × 109/L, hemoglobin of 30 g/L, and platelets of 49 × 109/L. She had biochemical evidence of poor tissue perfusion. Peripheral blood smear demonstrated lymphocytosis with smudge cells. After aggressive red blood cell transfusion, she was managed as leukostasis with concurrent tumour lysis syndrome (TLS). She was administered intravenous fluids, rasburicase, allopurinol, and escalating doses of prednisone for lymphoreduction. Her mentation and biochemical evidence of shock improved. Although we initially had high suspicion for CLL, her flow cytometry raised concerns for MCL. Cytogenetics confirmed t (11; 14) rearrangement. This case is the first to discuss a severe, aggressive presentation of a small variant, leukemic non-nodal MCL. We also review the role of steroids in leukostasis and concurrent warm autoimmune hemolytic anemia, in a centre where leukapheresis is unavailable.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"9912698"},"PeriodicalIF":0.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12297128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy in May-Hegglin Anomaly: Diagnostic Challenges and Management Considerations. 妊娠在May-Hegglin异常：诊断挑战和管理考虑。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI: 10.1155/crh/4997232

Metban Mastanzade, Alper Koç

{"title":"Pregnancy in May-Hegglin Anomaly: Diagnostic Challenges and Management Considerations.","authors":"Metban Mastanzade, Alper Koç","doi":"10.1155/crh/4997232","DOIUrl":"10.1155/crh/4997232","url":null,"abstract":"Introduction: May-Hegglin anomaly (MHA) is a rare autosomal dominant genetic disorder caused by mutations in the MYH9 gene, leading to the presence of Döhle-like inclusions in neutrophils, macrothrombocytes, and thrombocytopenia. This report presents a unique case of a 33-year-old pregnant woman diagnosed with MHA and discusses the diagnostic challenges and management strategies. Case Presentation: A 33-year-old pregnant woman, 17 weeks into her pregnancy, presented with a history of persistent thrombocytopenia. She had previously been diagnosed with immune thrombocytopenia (ITP) and treated with steroids, intravenous immunoglobulin (IVIG), and thrombopoietin receptor agonists (TPO-RA). Her platelet counts had been between 35,000 and 50,000/μL. Upon referral to the hematology clinic, her platelet count was critically low at 15,000/μL, but the mean platelet volume (MPV) remained within normal limits. Despite her low platelet count, her coagulation profile was normal, and physical examination showed no pathological findings. Diagnostic Assessment: The patient's blood smear revealed giant platelets and Döhle-like inclusions in the granulocytes. Genetic testing confirmed a heterozygous mutation in the MYH9 gene, leading to the diagnosis of MHA. Therapeutic Intervention: Due to the risks associated with thrombocytopenia in pregnancy, her prenatal care included routine platelet monitoring and a normal bleeding time assessment. The patient underwent a cesarean delivery under general anesthesia, which resulted in the birth of a healthy baby boy. Conclusion: The case highlights the importance of accurate diagnosis and careful monitoring in managing pregnancy in patients with MHA. A multidisciplinary approach involving obstetricians and hematologists is crucial for optimizing maternal and neonatal outcomes.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"4997232"},"PeriodicalIF":0.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Odyssey: Primary CNS Lymphoma (Lymphoma Cerebri) Presenting as Rapidly Progressive Dementia. 诊断过程：原发性中枢神经系统淋巴瘤（脑淋巴瘤）表现为快速进行性痴呆。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI: 10.1155/crh/8819799

Yuanli Lei, Aqsa Asharf, Jessica Amos, Mohamad Khawandanah, Anand Annan, James Battiste, Michel Torbey, Taha Al-Juhaishi, Nidhiben Anadani

引用次数: 0

Successful Hemostasis With Platelet Transfusion and Tranexamic Acid, and Inhibitor Elimination With Cyclosporine, in Steroid-Resistant Acquired Coagulation Factor V Deficiency Caused by Antibiotic Readministration. 再给药引起的类固醇耐药获得性凝血因子V缺乏的血小板输注和氨甲环酸成功止血，以及环孢素消除抑制剂。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI: 10.1155/crh/1402790

Kazuto Togitani, Moe Yamamoto, Soichiro Tanaka, Rei Aono, Yoshiki Uemura

{"title":"Successful Hemostasis With Platelet Transfusion and Tranexamic Acid, and Inhibitor Elimination With Cyclosporine, in Steroid-Resistant Acquired Coagulation Factor V Deficiency Caused by Antibiotic Readministration.","authors":"Kazuto Togitani, Moe Yamamoto, Soichiro Tanaka, Rei Aono, Yoshiki Uemura","doi":"10.1155/crh/1402790","DOIUrl":"10.1155/crh/1402790","url":null,"abstract":"Acquired factor V deficiency (AFVD) is a rare coagulation abnormality associated with infectious diseases, antibiotics, surgery, autoimmune diseases, and malignancy, which causality is difficult to prove. Here, we report a case of a 90-year-old woman who developed melena following antibiotic treatment for pneumonia. She had been on cefepime for bacterial pneumonia for 2 months to 2 weeks prior to her arrival in the emergency room. Upon presentation, she had severe anemia (Hb: 6.7 g/dL) and prolonged PT (74.3 s) and activated partial thromboplastin time (APTT) (161.9 s). Coagulation studies revealed incomplete correction of the APTT in a 1:1 mixing study with normal pooled plasma, factor V activity of 0%, and a factor V inhibitor titer of 13 Bethesda units, confirming the diagnosis of AFVD. Since the antibiotics were not recognized as the cause, the coagulation abnormality worsened after their readministration. The melena subsequently improved with platelet transfusion and administration of tranexamic acid, while prednisolone-resistant coagulation abnormalities improved with cyclosporine A (CsA) treatment. This case shows the importance of avoiding suspected drugs and the effectiveness of CsA as a second-line treatment of AFVD.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"1402790"},"PeriodicalIF":0.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Rare Hemoglobinopathies: Hematologic Characterization of Double Heterozygous Hb D and Hb E With Beta-Thalassemia-A Case Report. 揭示罕见的血红蛋白病：双杂合Hb D和Hb E与β -地中海贫血- a病例报告的血液学特征。

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Case Reports in Hematology Pub Date : 2025-07-06 eCollection Date: 2025-01-01 DOI: 10.1155/crh/8375604

Aiman Mahmood Minhas, Hadia Eiman, Javed Iqbal, Ayisha Imran, A S Chughtai

{"title":"Unveiling Rare Hemoglobinopathies: Hematologic Characterization of Double Heterozygous Hb D and Hb E With Beta-Thalassemia-A Case Report.","authors":"Aiman Mahmood Minhas, Hadia Eiman, Javed Iqbal, Ayisha Imran, A S Chughtai","doi":"10.1155/crh/8375604","DOIUrl":"10.1155/crh/8375604","url":null,"abstract":"Background: Hemoglobinopathies are genetic disorders of hemoglobin, with over 700 variants. Common types include beta-thalassemia, Hb S, Hb E, Hb D, and Hb C, and their prevalence is increasing, especially in developing regions of sub-Saharan Africa and Asia. Pakistan, located in the \"thalassemia belt,\" has a high rate of these disorders, with beta-thalassemia being the most common. Genetic combinations, including compound heterozygosity, can lead to unpredictable and severe clinical outcomes. Understanding such rare presentations can aid in more accurate diagnosis, better management strategies, and a deeper insight into the genetic diversity of hemoglobinopathies. It also emphasizes the importance of genetic screening in populations with high hemoglobinopathy prevalence, such as Pakistan, to improve patient outcomes. Case Presentation: A one-year-old girl from consanguineous parents in Multan presented with fatigue, feeding difficulties, and severe growth retardation. She had a history of severe anemia requiring a transfusion at 6 months. Examination revealed pallor and mild hepatosplenomegaly. Hemoglobin analysis showed severe anemia (Hb 5.3 g/dL) and a dimorphic blood picture, with electrophoresis indicating compound heterozygosity for Hb D and Hb E, predominated by Hb D. Her father was a compound heterozygote for Hb E and beta-thalassemia. However, the mother was heterozygous for Hb D. Genetic profiling was not completed due to resource limitations, but the family was counseled on consanguinity risks. Conclusion: Given the rising prevalence of uncommon severe hemoglobinopathies in Pakistan and existing resource limitations, targeted screening in high-risk districts and enhanced patient counseling are essential to mitigate the disease burden and improve diagnostic and management strategies.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"8375604"},"PeriodicalIF":0.7,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Central Nervous System Presentation of Early T-Cell Precursor Acute Lymphoblastic Leukemia/Lymphoma: A Rare Case of Exclusive Brain Involvement. 早期t细胞前体急性淋巴母细胞白血病/淋巴瘤的分离中枢神经系统表现：一个罕见的脑部受累病例。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI: 10.1155/crh/7634316

Violet O Swart, Behyar Zoghi

{"title":"Isolated Central Nervous System Presentation of Early T-Cell Precursor Acute Lymphoblastic Leukemia/Lymphoma: A Rare Case of Exclusive Brain Involvement.","authors":"Violet O Swart, Behyar Zoghi","doi":"10.1155/crh/7634316","DOIUrl":"10.1155/crh/7634316","url":null,"abstract":"Early T-cell precursor acute lymphoblastic leukemia/lymphoma (ETP-ALL/LBL) is a high-risk and biologically distinct subset of T-cell acute lymphoblastic leukemia, typically characterized by leukemic involvement of bone marrow, peripheral blood, and mediastinal structures. Central nervous system (CNS) involvement is typically a secondary manifestation [1, 2, 3]. We report a rare case of isolated CNS presentation of ETP-ALL/LBL in a 73-year-old woman who presented with progressive neurological symptoms. Imaging revealed a large right frontal extra-axial mass. Systemic evaluation, including peripheral blood flow cytometry and CT imaging of chest, abdomen, and pelvis, showed no evidence ofsystemic disease. Surgical resection and subsequent histopathology confirmed the diagnosis of ETP-ALL/LBL. A bone marrow biopsy was deffered to the patient's preference and rapid clinical deterioration. This case underscores the diagnostic and therapeutic challenges of CNS-restricted leukemic presentations and highlights the need for early recognition and CNS-directed diagnostic evaluation.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"7634316"},"PeriodicalIF":0.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144609874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three Challenges in an Infant: Neuroblastoma Mimicking Infantile Hepatic Hemangioma, With Chylothorax and Rosettes in Pleural Fluid. 婴儿的三个挑战：神经母细胞瘤模拟婴儿肝血管瘤，胸膜液中有乳糜胸和莲座。

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Case Reports in Hematology Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI: 10.1155/crh/9948246

Samin Alavi, Mitra Khalili, Maryam Kazemi Aghdam, Alireza Zamani, Tahereh Madani

引用次数: 0

Cytokine Release Syndrome Induced by Pembrolizumab for Metastatic Anal Melanoma. Pembrolizumab治疗转移性肛门黑色素瘤诱导的细胞因子释放综合征。

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Case Reports in Hematology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.1155/crh/5444075

Erica Martel, Shijia Li, Mayssaa Hoteit, Zubin Bham

引用次数: 0

Successful Treatment of Anemia With Ringed Sideroblasts Induced by Antidepressants Through Vitamin B6 Supplementation and Discontinuation of Antidepressants. 通过补充维生素B6和停用抗抑郁药物成功治疗抗抑郁药物诱导的环状铁母细胞贫血。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.1155/crh/7046013

Sanshiro Nakao, Chiaki Nakaseko, Chikako Ohwada, Keisuke Kirito, Asuka Shibamiya, Akane Tanaka, Reiko Watanabe, Naomi Shimizu

引用次数: 0

Severe Thrombocytopenia Secondary to Babesiosis: A Case Report. 巴贝斯虫病继发严重血小板减少1例。

IF 0.7

Case Reports in Hematology Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.1155/crh/9918329

Vidyasagar R Cirra, Sharath Kommu, Michael Husak, Christopher Osterbauer

{"title":"Severe Thrombocytopenia Secondary to Babesiosis: A Case Report.","authors":"Vidyasagar R Cirra, Sharath Kommu, Michael Husak, Christopher Osterbauer","doi":"10.1155/crh/9918329","DOIUrl":"10.1155/crh/9918329","url":null,"abstract":"A 76-year-old man with a history of atrial fibrillation treated with warfarin, renal calculi with a history of lithotripsy, hypertension, anxiety, and diabetes mellitus with recent tick exposure presented with abdominal pain, fatigue, nausea, and fever with chills. Workup revealed thrombocytopenia and hemolysis. Due to the likelihood of immune thrombocytopenia (ITP) secondary to a viral etiology, the patient was initially started on steroids. The patient subsequently tested positive for babesiosis on peripheral smear and polymerase chain reaction. A peripheral smear showed giant platelets and was positive for immunoglobulin M platelet antibodies. Other etiologies of thrombocytopenia were excluded. The patient was diagnosed with ITP secondary to babesiosis. Antibiotics were initiated to treat babesiosis. The platelet count was nonresponsive to steroids and gradually improved following intravenous immunoglobulin administration and continued antibiotic treatment. This rare case highlights the importance of considering ITP secondary to babesiosis as the etiology of severe thrombocytopenia in babesiosis, as appropriate recognition and early treatment of babesiosis and ITP can prevent serious complications.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2025 ","pages":"9918329"},"PeriodicalIF":0.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144592625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0