Case Reports in Hematology最新文献_第9页

IF 0.7

Case Reports in Hematology Pub Date : 2022-03-30 DOI: 10.1155/2022/1840589

Stamatios Chrysochoou, A. Kreft, Eberhard Schneider

引用次数: 1

Double-Expressor Appendiceal Burkitt's Lymphoma: A Case Report and Literature Review 双表达阑尾伯基特淋巴瘤1例报告及文献复习

IF 0.7

Case Reports in Hematology Pub Date : 2022-03-25 DOI: 10.1155/2022/6795699

Osama N. Dukmak, Hamzeh M. I. Abugharbieh, Mohammad Emar, Iman Khamayseh, Salem M. Tos, Rafiq Salhab

{"title":"Double-Expressor Appendiceal Burkitt's Lymphoma: A Case Report and Literature Review","authors":"Osama N. Dukmak, Hamzeh M. I. Abugharbieh, Mohammad Emar, Iman Khamayseh, Salem M. Tos, Rafiq Salhab","doi":"10.1155/2022/6795699","DOIUrl":"https://doi.org/10.1155/2022/6795699","url":null,"abstract":"Background Appendiceal lymphoma is a very rare entity accounting for 0.015% of all gastrointestinal lymphoma cases. Acute appendicitis is the most common presentation of primary appendix neoplasms. Burkitt's lymphoma presenting as an acute appendicitis is a rare entity with around 21% of the cases presenting as a lower iliac fossa mass. Case Presentation. A 23-year-old male was admitted to the surgical ward as a case of acute appendicitis with localized tenderness in the right iliac fossa, positive rebound tenderness, a positive Rovsing's sign, and ultrasound findings of suspected complicated appendicitis. Appendectomy was performed. Histopathological examination of the appendectomy specimen revealed a double-expressor non-Hodgkin diffuse large cell lymphoma with Burkitt's-like morphology. He was sent for chemotherapy treatment. Conclusion Only 34 cases of Burkitt's lymphoma have been reported to present as acute appendicitis. Histological examination following appendectomy for an apparent appendicitis is essential. Furthermore, complete blood count and a computed tomography scan aid the diagnosis of lymphoma. Double-expressor lymphoma has been shown to have poor outcomes. Therefore, prompt and aggressive treatment is vital.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"40 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80411975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Acquired Hemophilia A in a Patient with Exposure to COVID-19 COVID-19暴露患者发生获得性血友病A例

IF 0.7

Case Reports in Hematology Pub Date : 2022-03-22 DOI: 10.1155/2022/9494249

Jorge D. Guerra, Jasmine Gowarty, Jordan Buess, James Mason, K. Halka

引用次数: 11

An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement 罕见多发性骨髓瘤伴轻链型肾病继发于未累及骨髓的非常大浆细胞瘤1例

IF 0.7

Case Reports in Hematology Pub Date : 2022-02-21 DOI: 10.1155/2022/7531142

Justin Komisarof, J. Lipof, Joseph DiTursi, A. Chowdhry, Hae Yoon Grace Choung, W. Burack, L. Constine, F. Passero

引用次数: 0

Relapse of NPM1-Mutated AML with Extramedullary Manifestation 17 Years after Allogeneic Hematopoietic Stem Cell Transplantation. 异基因造血干细胞移植后17年npm1突变AML伴髓外表现复发

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/3317936

Jan Braune, Kathrin Rieger, Olga Blau, Ulrich Keller, Lars Bullinger, Jan Krönke

引用次数: 0

A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis. 联合免疫抑制治疗合并潜在结核的获得性血友病A的快速和令人满意的结果。

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/2271228

G A C Gamakaranage, C Kulathilake, P G N Nadeeshani, K H B P Fernandopulle, C S Moonesinghe, D Gunawardena, R S Gamage, N Perera, J Indrakumar

{"title":"A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis.","authors":"G A C Gamakaranage, C Kulathilake, P G N Nadeeshani, K H B P Fernandopulle, C S Moonesinghe, D Gunawardena, R S Gamage, N Perera, J Indrakumar","doi":"10.1155/2022/2271228","DOIUrl":"https://doi.org/10.1155/2022/2271228","url":null,"abstract":"Acquired haemophilia A (AHA) is a rare disorder with an incidence of 1.5 cases per million per year in the United Kingdom. The incidence could be underestimated due to difficulty in diagnosis and also due to the fact that people with low titre inhibitor levels are asymptomatic. It is usually a disease affecting elderly but a disease peak in the younger population is known. The common underlying diseases are autoimmune disorders, malignancies, infections, and drugs. However, approximately 50% of the cases do not have a specific aetiology and about 10% will not have bleeding manifestations. Therefore, an isolated prolongation of APTT should be evaluated, especially prior to any haemostatic challenges. We report a case of a middle-aged man who presented with bleeding due to AHA associated with high inhibitory titres and active pulmonary tuberculosis. He was treated with both antituberculous and combined-aggressive immunosuppressive therapy which resulted in satisfactory disease remission.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"2271228"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10365048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature. 甲氨蝶呤相关淋巴细胞增生性疾病在银屑病患者:1例报告和文献复习。

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/7178065

Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes

{"title":"Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature.","authors":"Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes","doi":"10.1155/2022/7178065","DOIUrl":"https://doi.org/10.1155/2022/7178065","url":null,"abstract":"Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"7178065"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PD-1 Checkpoint Blockade in Patients for Acute Myeloid Leukemia after HSCT Relapse Resulted in Severe GVHD and sHLH. 急性髓系白血病HSCT复发后PD-1检查点阻断导致严重GVHD和sHLH

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/1705905

Zhi Zhuo Du, Mi Zhou, Jing Ling, Lan Cao, Lingjun Kong, Shengqin Cheng, Peifang Xiao, Shaoyan Hu

引用次数: 2

Ibrutinib Plus R-ICE Induces Remission in Blastoid Variant Mantle Cell Lymphoma with CNS Relapse. 伊鲁替尼加R-ICE诱导伴有中枢神经系统复发的囊胚变异性套细胞淋巴瘤缓解。

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/1930546

Timothy S Oh, Madelyn Burkart, Amir Behdad, Hatice Savas, Reem Karmali

{"title":"Ibrutinib Plus R-ICE Induces Remission in Blastoid Variant Mantle Cell Lymphoma with CNS Relapse.","authors":"Timothy S Oh, Madelyn Burkart, Amir Behdad, Hatice Savas, Reem Karmali","doi":"10.1155/2022/1930546","DOIUrl":"https://doi.org/10.1155/2022/1930546","url":null,"abstract":"Mantle cell lymphoma (MCL) is an aggressive, difficult to treat subtype of lymphoma, resulting in relapses and poor outcomes. Novel agents such as Bruton tyrosine kinase (BTK) inhibitors have been studied in the treatment of relapsed/refractory (R/R) MCL. BTK inhibitor ibrutinib, in particular, has demonstrated improvement in survival outcomes of R/R MCL. Despite these advancements, many cases of MCL, including the more aggressive blastoid and pleomorphic variants, will undergo disease progression leading to poor survival outcomes. Blastoid variant MCL is associated with an increased risk of central nervous system (CNS) involvement, causing high mortality rates. In this case report, we discuss a patient with a diagnosis of blastoid MCL with CNS relapse who achieved a complete response (CR) after receiving standard rituximab plus ifosfamide-carboplatin-etoposide (R-ICE) salvage chemotherapy with the addition of ibrutinib. The patient subsequently underwent autologous stem cell transplantation (autoSCT) and maintained CR with ibrutinib maintenance.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"1930546"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9259440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bone Marrow Infiltration in Rosai-Dorfman Disease. Rosai-Dorfman病的骨髓浸润。

IF 0.7

Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/3420311

Fatima Zahra Rahali, Fatima Taher, Houda Nassih, Sanae Sayagh

{"title":"Bone Marrow Infiltration in Rosai-Dorfman Disease.","authors":"Fatima Zahra Rahali, Fatima Taher, Houda Nassih, Sanae Sayagh","doi":"10.1155/2022/3420311","DOIUrl":"https://doi.org/10.1155/2022/3420311","url":null,"abstract":"Rosai-Dorfman disease (RDD) is a rare and benign nonLangerhans cell histiocytosis. RDD commonly affects children and young adults typically presenting with massive, painless, and bilateral cervical lymphadenopathy. Extranodal involvement is present in about 40% of cases, and bone marrow infiltration is rare and unusual. RDD prognosis is usually good, however, involvement of bone marrow is associated with poor prognosis. We report a case of RDD with bone marrow involvement occurring in a 5-year-old female. She was admitted for asthenia, gingival bleeding, and diffuse bone pain without fever. Physical examination showed pallor, petechiae over the abdomen, painless and bilateral cervical lymphadenopathy, and several bony nodules, without splenomegaly or hepatomegaly. Cell blood count revealed microcytic hypochromic anemia with thrombocytopenia. Bone marrow aspiration showed infiltration by large histiocytes with hypochromatic nuclei and abundant vacuolated cytoplasm without emperipolesis. Biopsies of bone marrow, lymph node, and bone revealed immunohistochemical features of RDD: the histiocytes were positive for CD68 and S100 protein, but negative for CD1a. The patient initially received symptomatic treatment. One week after admission, she died of septic shock before the final establishment of RDD diagnosis. This case report highlights that bone marrow involvement in RDD is rare and associated with poor prognosis. We also aim to emphasize the obligation of bone marrow exploration in patients with RDD and presenting cytopenias in order to make an early diagnosis of bone marrow infiltration.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"3420311"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10495589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0