Case Reports in Hematology最新文献_第8页

A Curious Case of Hemolytic Anemia with Pseudoreticulopenia 溶血性贫血伴假网状白血球减少一例

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Case Reports in Hematology Pub Date : 2022-04-21 DOI: 10.1155/2022/6423143

S. Mayer, N. Srinivasan, J. Nguyen, R. Spilman, D. Scherbak

{"title":"A Curious Case of Hemolytic Anemia with Pseudoreticulopenia","authors":"S. Mayer, N. Srinivasan, J. Nguyen, R. Spilman, D. Scherbak","doi":"10.1155/2022/6423143","DOIUrl":"https://doi.org/10.1155/2022/6423143","url":null,"abstract":"Herein, we present a unique case of a Coombs-negative, steroid-refractory autoimmune hemolytic anemia (AIHA) complicated by pseudoreticulopenia, describe its clinical presentation, histopathologic findings, and management, and review the salient literature. Coombs-negative, steroid-refractory AIHAs represent fewer than 1% of all AIHAs. Diagnosis of the disease is difficult and often delayed due to the pursuit of alternate diagnoses following a negative Coombs test. However, when suspicion remains high for an autoimmune process, the super-Coombs test may be utilized for the diagnosis of AIHA that the traditional Coombs test fails to detect. A majority of cases respond to rituximab as the indicated second-line therapy, but delays in diagnosis and subsequent treatment may increase morbidity. Reticulopenia may be associated with AIHAs secondary to bone marrow dysfunction, but this patient had a normal function marrow confirmed on biopsy. Indeed, reticulopenia in this case was a diagnostic conundrum that further obscured the diagnosis and delayed treatment. Ultimately, reticulopenia was determined to be pseudoreticulopenia secondary to an alteration in the maturation of the erythroid lineage due to an independent, newly diagnosed pernicious anemia. The interaction of these multiple coexisting disease processes is not previously described in the literature. Increased physician awareness of steroid-refractory, Coombs-negative AIHA, and the development of pseudoreticulopenia as a laboratory finding in pernicious anemia may help to improve patient outcomes.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"27 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85391019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis 并发B细胞急性淋巴母细胞淋巴瘤/白血病和单克隆B细胞淋巴细胞增多症:一例广泛分子分析报告

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Case Reports in Hematology Pub Date : 2022-04-21 DOI: 10.1155/2022/1132544

Maryam Mehdipour Dalivand, Parastou Tizro, Julie Partain, A. Aggarwal, J. Lichy, Francisco Mot Ara, V. Nava

引用次数: 0

Splenomegaly in a Patient with a History of Pernicious Anemia; the Potential Therapeutic Effects of B12 Therapy 恶性贫血史患者脾肿大1例B12治疗的潜在疗效

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Case Reports in Hematology Pub Date : 2022-04-11 DOI: 10.1155/2022/2854520

Alexis Lordi, N. Ansari, M. Maroules, Anusha Manjegowda

{"title":"Splenomegaly in a Patient with a History of Pernicious Anemia; the Potential Therapeutic Effects of B12 Therapy","authors":"Alexis Lordi, N. Ansari, M. Maroules, Anusha Manjegowda","doi":"10.1155/2022/2854520","DOIUrl":"https://doi.org/10.1155/2022/2854520","url":null,"abstract":"Splenomegaly is manifested by a variety of etiologies, one of which is macrocytic anemia. Macrocytic anemia has multiple causes in itself that include; folate (Vitamin B9) and Cobalamin (vitamin B12) deficiencies. In this case report, we present a patient with a history of pancytopenia, macrocytic anemia and vitamin B12 deficiency, who underwent a splenectomy. The differential diagnoses for the cause of the patient's splenomegaly included: lymphoma, infiltrative disease, and idiopathic splenomegaly. The pathology report from the splenectomy did not reveal any evidence of lymphoma or infiltrative disease, however, it did mention vascular congestion of the spleen. In theory, vascular congestion, due to extramedullary hematopoiesis in the spleen or sequestration of blood cell lineages, could lead to pancytopenia. In prior visits to the hospital this patient was diagnosed with: splenomegaly, and macrocytic anemia due to pernicious anemia. A splenectomy puts one at increased risk for infection by encapsulated organisms, and is to be avoided if possible. There are few case reports and studies that show vitamin B12 therapy can potentially cause a reversal in the splenomegaly as well as a reversal in the pancytopenia and macrocytic anemia. We hope to show that the least invasive treatment for vitamin B12, vitamin therapy, can be of use and effective.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"32 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80061901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

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Case Reports in Hematology Pub Date : 2022-03-30 DOI: 10.1155/2022/1840589

Stamatios Chrysochoou, A. Kreft, Eberhard Schneider

引用次数: 1

Double-Expressor Appendiceal Burkitt's Lymphoma: A Case Report and Literature Review 双表达阑尾伯基特淋巴瘤1例报告及文献复习

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Case Reports in Hematology Pub Date : 2022-03-25 DOI: 10.1155/2022/6795699

Osama N. Dukmak, Hamzeh M. I. Abugharbieh, Mohammad Emar, Iman Khamayseh, Salem M. Tos, Rafiq Salhab

{"title":"Double-Expressor Appendiceal Burkitt's Lymphoma: A Case Report and Literature Review","authors":"Osama N. Dukmak, Hamzeh M. I. Abugharbieh, Mohammad Emar, Iman Khamayseh, Salem M. Tos, Rafiq Salhab","doi":"10.1155/2022/6795699","DOIUrl":"https://doi.org/10.1155/2022/6795699","url":null,"abstract":"Background Appendiceal lymphoma is a very rare entity accounting for 0.015% of all gastrointestinal lymphoma cases. Acute appendicitis is the most common presentation of primary appendix neoplasms. Burkitt's lymphoma presenting as an acute appendicitis is a rare entity with around 21% of the cases presenting as a lower iliac fossa mass. Case Presentation. A 23-year-old male was admitted to the surgical ward as a case of acute appendicitis with localized tenderness in the right iliac fossa, positive rebound tenderness, a positive Rovsing's sign, and ultrasound findings of suspected complicated appendicitis. Appendectomy was performed. Histopathological examination of the appendectomy specimen revealed a double-expressor non-Hodgkin diffuse large cell lymphoma with Burkitt's-like morphology. He was sent for chemotherapy treatment. Conclusion Only 34 cases of Burkitt's lymphoma have been reported to present as acute appendicitis. Histological examination following appendectomy for an apparent appendicitis is essential. Furthermore, complete blood count and a computed tomography scan aid the diagnosis of lymphoma. Double-expressor lymphoma has been shown to have poor outcomes. Therefore, prompt and aggressive treatment is vital.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"40 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80411975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Acquired Hemophilia A in a Patient with Exposure to COVID-19 COVID-19暴露患者发生获得性血友病A例

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Case Reports in Hematology Pub Date : 2022-03-22 DOI: 10.1155/2022/9494249

Jorge D. Guerra, Jasmine Gowarty, Jordan Buess, James Mason, K. Halka

引用次数: 11

An Unusual Case of Multiple Myeloma with Light-Chain Cast Nephropathy Secondary to a Very Large Plasmacytoma without Bone Marrow Involvement 罕见多发性骨髓瘤伴轻链型肾病继发于未累及骨髓的非常大浆细胞瘤1例

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Case Reports in Hematology Pub Date : 2022-02-21 DOI: 10.1155/2022/7531142

Justin Komisarof, J. Lipof, Joseph DiTursi, A. Chowdhry, Hae Yoon Grace Choung, W. Burack, L. Constine, F. Passero

引用次数: 0

Relapse of NPM1-Mutated AML with Extramedullary Manifestation 17 Years after Allogeneic Hematopoietic Stem Cell Transplantation. 异基因造血干细胞移植后17年npm1突变AML伴髓外表现复发

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/3317936

Jan Braune, Kathrin Rieger, Olga Blau, Ulrich Keller, Lars Bullinger, Jan Krönke

引用次数: 0

A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis. 联合免疫抑制治疗合并潜在结核的获得性血友病A的快速和令人满意的结果。

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/2271228

G A C Gamakaranage, C Kulathilake, P G N Nadeeshani, K H B P Fernandopulle, C S Moonesinghe, D Gunawardena, R S Gamage, N Perera, J Indrakumar

{"title":"A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis.","authors":"G A C Gamakaranage, C Kulathilake, P G N Nadeeshani, K H B P Fernandopulle, C S Moonesinghe, D Gunawardena, R S Gamage, N Perera, J Indrakumar","doi":"10.1155/2022/2271228","DOIUrl":"https://doi.org/10.1155/2022/2271228","url":null,"abstract":"Acquired haemophilia A (AHA) is a rare disorder with an incidence of 1.5 cases per million per year in the United Kingdom. The incidence could be underestimated due to difficulty in diagnosis and also due to the fact that people with low titre inhibitor levels are asymptomatic. It is usually a disease affecting elderly but a disease peak in the younger population is known. The common underlying diseases are autoimmune disorders, malignancies, infections, and drugs. However, approximately 50% of the cases do not have a specific aetiology and about 10% will not have bleeding manifestations. Therefore, an isolated prolongation of APTT should be evaluated, especially prior to any haemostatic challenges. We report a case of a middle-aged man who presented with bleeding due to AHA associated with high inhibitory titres and active pulmonary tuberculosis. He was treated with both antituberculous and combined-aggressive immunosuppressive therapy which resulted in satisfactory disease remission.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"2271228"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9726257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10365048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature. 甲氨蝶呤相关淋巴细胞增生性疾病在银屑病患者:1例报告和文献复习。

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Case Reports in Hematology Pub Date : 2022-01-01 DOI: 10.1155/2022/7178065

Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes

{"title":"Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature.","authors":"Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes","doi":"10.1155/2022/7178065","DOIUrl":"https://doi.org/10.1155/2022/7178065","url":null,"abstract":"Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.","PeriodicalId":46307,"journal":{"name":"Case Reports in Hematology","volume":"2022 ","pages":"7178065"},"PeriodicalIF":0.7,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9078817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10252334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1