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Possible mechanisms and simulation modeling of FLASH radiotherapy. FLASH 放射治疗的可能机制和模拟模型。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-01-06 DOI: 10.1007/s12194-023-00770-x
Yuta Shiraishi, Yusuke Matsuya, Hisanori Fukunaga
{"title":"Possible mechanisms and simulation modeling of FLASH radiotherapy.","authors":"Yuta Shiraishi, Yusuke Matsuya, Hisanori Fukunaga","doi":"10.1007/s12194-023-00770-x","DOIUrl":"10.1007/s12194-023-00770-x","url":null,"abstract":"<p><p>FLASH radiotherapy (FLASH-RT) has great potential to improve patient outcomes. It delivers radiation doses at an ultra-high dose rate (UHDR: ≥ 40 Gy/s) in a single instant or a few pulses. Much higher irradiation doses can be administered to tumors with FLASH-RT than with conventional dose rate (0.01-0.40 Gy/s) radiotherapy. UHDR irradiation can suppress toxicity in normal tissues while sustaining antitumor efficiency, which is referred to as the FLASH effect. However, the mechanisms underlying the effects of the FLASH remain unclear. To clarify these mechanisms, the development of simulation models that can contribute to treatment planning for FLASH-RT is still underway. Previous studies indicated that transient oxygen depletion or augmented reactions between secondary reactive species produced by irradiation may be involved in this process. To discuss the possible mechanisms of the FLASH effect and its clinical potential, we summarized the physicochemical, chemical, and biological perspectives as well as the development of simulation modeling for FLASH-RT.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139111277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of an open project rectangular collimator for use with intraoral dental X-ray unit. 开发用于口内牙科 X 射线装置的开放式矩形准直器。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI: 10.1007/s12194-023-00772-9
Marina C Poletto, Eduardo Thomazi, Janete E Zorzi, Thiago O Gamba, Cláudio A Perottoni
{"title":"Development of an open project rectangular collimator for use with intraoral dental X-ray unit.","authors":"Marina C Poletto, Eduardo Thomazi, Janete E Zorzi, Thiago O Gamba, Cláudio A Perottoni","doi":"10.1007/s12194-023-00772-9","DOIUrl":"10.1007/s12194-023-00772-9","url":null,"abstract":"<p><p>In this work, an open beam-limiting device, consisting of a rectangular collimator to be coupled to an intraoral dental X-ray device, was made using recycled lead sheets as a radiation-absorbing element. The collimator was designed for 3D printing, and using Spektr 3.0 software, the number of lead sheets needed to absorb excess radiation was calculated. The rectangular collimator reduced the radiation dose to patients by 65% when using four layers of recycled lead sheets (saturating with a 70% reduction in radiation dose at the limit of eight or more sheets of lead). The rectangular collimator does not negatively impact the quality of the radiological image, is available as an open design for 3D printing, and can be built with materials that are easily accessible to the dentist, facilitating its use in clinical practice and reducing the patient's exposure to ionizing radiation.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography. 评估脑灌注单光子发射计算机断层扫描中头部支架的衰减校正方法。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-09 DOI: 10.1007/s12194-024-00778-x
Masahiro Nakashima, Yuta Yamazaki
{"title":"Evaluation of attenuation correction method for head holder in brain perfusion single-photon emission computed tomography.","authors":"Masahiro Nakashima, Yuta Yamazaki","doi":"10.1007/s12194-024-00778-x","DOIUrl":"10.1007/s12194-024-00778-x","url":null,"abstract":"<p><p>Head holder attenuation affects brain perfusion single-photon emission computed tomography (SPECT) image quality. Here, we proposed a head holder-attenuation correction (AC) method using attenuation coefficient maps calculated by Chang's method from CT images. Then, we evaluated the effectiveness of the head holder-AC method by numerical phantom and clinical cerebral perfusion SPECT studies. In the numerical phantom, the posterior counts were 10.7% lower than the anterior counts without head holder-AC method. However, by performing head holder-AC, the posterior count recovered by approximately 6.8%, approaching the true value. In the clinical study, the normalized count ratio was significantly increased by performing the head holder-AC method in the posterior-middle cerebral artery, posterior cerebral artery and cerebellum regions. There were no significant increases in other regions. The head holder-AC method can correct the counts attenuated by the head holder.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving the depiction of small intracranial vessels in head computed tomography angiography: a comparative analysis of deep learning reconstruction and hybrid iterative reconstruction. 改善头部计算机断层扫描血管造影术中颅内小血管的描绘：深度学习重建和混合迭代重建的比较分析。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-10-28 DOI: 10.1007/s12194-023-00749-8
Makoto Ozaki, Shota Ichikawa, Masaaki Fukunaga, Hiroyuki Yamamoto
{"title":"Improving the depiction of small intracranial vessels in head computed tomography angiography: a comparative analysis of deep learning reconstruction and hybrid iterative reconstruction.","authors":"Makoto Ozaki, Shota Ichikawa, Masaaki Fukunaga, Hiroyuki Yamamoto","doi":"10.1007/s12194-023-00749-8","DOIUrl":"10.1007/s12194-023-00749-8","url":null,"abstract":"<p><p>This study aimed to evaluate the ability of deep learning reconstruction (DLR) compared to that of hybrid iterative reconstruction (IR) to depict small vessels on computed tomography (CT). DLR and two types of hybrid IRs were used for image reconstruction. The target vessels were the basilar artery (BA), superior cerebellar artery (SCA), anterior inferior cerebellar artery (AICA), and posterior inferior cerebellar artery (PICA). The peak value, ΔCT values defined as the difference between the peak value and background, and full width at half maximum (FWHM), were obtained from the profile curves. In all target vessels, the peak and ΔCT values of DLR were significantly higher than those of the two types of hybrid IR (p < 0.001). Compared to that associated with hybrid IR, the FWHM of DLR was significantly lower in the SCA (p < 0.001), AICA (p < 0.001), and PICA (p < 0.001). In conclusion, DLR has the potential to improve visualization of small vessels.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A practical method to simulate realistic reduced-exposure CT images by the addition of computationally generated noise. 一种实用的方法来模拟真实的减少暴露的CT图像，通过添加计算产生的噪声。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-11-13 DOI: 10.1007/s12194-023-00755-w
Nicholas Mark Gibson, Amy Lee, Martin Bencsik
{"title":"A practical method to simulate realistic reduced-exposure CT images by the addition of computationally generated noise.","authors":"Nicholas Mark Gibson, Amy Lee, Martin Bencsik","doi":"10.1007/s12194-023-00755-w","DOIUrl":"10.1007/s12194-023-00755-w","url":null,"abstract":"<p><p>Computed tomography (CT) scanning protocols should be optimized to minimize the radiation dose necessary for imaging. The addition of computationally generated noise to the CT images facilitates dose reduction. The objective of this study was to develop a noise addition method that reproduces the complexity of the noise texture present in clinical images with directionality that varies over images according to the underlying anatomy, requiring only Digital Imaging and Communications in Medicine (DICOM) images as input data and commonly available phantoms for calibration. The developed method is based on the estimation of projection data by forward projection from images, the addition of Poisson noise, and the reconstruction of new images. The method was validated by applying it to images acquired from cylindrical and thoracic phantoms using source images with exposures up to 49 mAs and target images between 39 and 5 mAs. 2D noise spectra were derived for regions of interest in the generated low-dose images and compared with those from the scanner-acquired low-dose images. The root mean square difference between the standard deviations of noise was 4%, except for very low exposures in peripheral regions of the cylindrical phantom. The noise spectra from the corresponding regions of interest exhibited remarkable agreement, indicating that the complex nature of the noise was reproduced. A practical method for adding noise to CT images was presented, and the magnitudes of noise and spectral content were validated. This method may be used to optimize CT imaging.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89719972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Verification of image quality improvement of low-count bone scintigraphy using deep learning. 利用深度学习验证低计数骨闪烁成像的图像质量改进。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-10 DOI: 10.1007/s12194-023-00776-5
Taisuke Murata, Takuma Hashimoto, Masahisa Onoguchi, Takayuki Shibutani, Takashi Iimori, Koichi Sawada, Tetsuro Umezawa, Yoshitada Masuda, Takashi Uno
{"title":"Verification of image quality improvement of low-count bone scintigraphy using deep learning.","authors":"Taisuke Murata, Takuma Hashimoto, Masahisa Onoguchi, Takayuki Shibutani, Takashi Iimori, Koichi Sawada, Tetsuro Umezawa, Yoshitada Masuda, Takashi Uno","doi":"10.1007/s12194-023-00776-5","DOIUrl":"10.1007/s12194-023-00776-5","url":null,"abstract":"<p><p>To improve image quality for low-count bone scintigraphy using deep learning and evaluate their clinical applicability. Six hundred patients (training, 500; validation, 50; evaluation, 50) were included in this study. Low-count original images (75%, 50%, 25%, 10%, and 5% counts) were generated from reference images (100% counts) using Poisson resampling. Output (DL-filtered) images were obtained after training with U-Net using reference images as teacher data. Gaussian-filtered images were generated for comparison. Peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) to the reference image were calculated to determine image quality. Artificial neural network (ANN) value, bone scan index (BSI), and number of hotspots (Hs) were computed using BONENAVI analysis to assess diagnostic performance. Accuracy of bone metastasis detection and area under the curve (AUC) were calculated. PSNR and SSIM for DL-filtered images were highest in all count percentages. BONENAVI analysis values for DL-filtered images did not differ significantly, regardless of the presence or absence of bone metastases. BONENAVI analysis values for original and Gaussian-filtered images differed significantly at ≦25% counts in patients without bone metastases. In patients with bone metastases, BSI and Hs for original and Gaussian-filtered images differed significantly at ≦10% counts, whereas ANN values did not. The accuracy of bone metastasis detection was highest for DL-filtered images in all count percentages; the AUC did not differ significantly. The deep learning method improved image quality and bone metastasis detection accuracy for low-count bone scintigraphy, suggesting its clinical applicability.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139713234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology. 放射技术、医学物理和放射学领域的临床前磁共振成像和光谱学。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1007/s12194-024-00785-y
Shigeyoshi Saito, Junpei Ueda
{"title":"Preclinical magnetic resonance imaging and spectroscopy in the fields of radiological technology, medical physics, and radiology.","authors":"Shigeyoshi Saito, Junpei Ueda","doi":"10.1007/s12194-024-00785-y","DOIUrl":"10.1007/s12194-024-00785-y","url":null,"abstract":"<p><p>Magnetic resonance imaging (MRI) is an indispensable diagnostic imaging technique used in the clinical setting. MRI is advantageous over X-ray and computed tomography (CT), because the contrast provided depends on differences in the density of various organ tissues. In addition to MRI systems in hospitals, more than 100 systems are used for research purposes in Japan in various fields, including basic scientific research, molecular and clinical investigations, and life science research, such as drug discovery, veterinary medicine, and food testing. For many years, additional preclinical imaging studies have been conducted in basic research in the fields of radiation technology, medical physics, and radiology. The preclinical MRI research includes studies using small-bore and whole-body MRI systems. In this review, we focus on the animal study using small-bore MRI systems as \"preclinical MRI\". The preclinical MRI can be used to elucidate the pathophysiology of diseases and for translational research. This review will provide an overview of previous preclinical MRI studies such as brain, heart, and liver disease assessments. Also, we provide an overview of the utility of preclinical MRI studies in radiological physics and technology.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10901953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
John Roderick Cameron (1922-2005): Scientist, teacher, mentor, inventor, and philanthropist extraordinaire. 约翰-罗德里克-卡梅隆（1922-2005 年）：杰出的科学家、教师、导师、发明家和慈善家。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-12 DOI: 10.1007/s12194-023-00775-6
Kwan Hoong Ng, Kunio Doi
{"title":"John Roderick Cameron (1922-2005): Scientist, teacher, mentor, inventor, and philanthropist extraordinaire.","authors":"Kwan Hoong Ng, Kunio Doi","doi":"10.1007/s12194-023-00775-6","DOIUrl":"10.1007/s12194-023-00775-6","url":null,"abstract":"","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139724464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of gadolinium concentration and cell oxygen levels on radiobiological characteristics of gadolinium neutron capture therapy technique in brain tumor treatment. 钆浓度和细胞氧水平对钆中子俘获治疗脑肿瘤技术放射生物学特性的影响。
IF 1.6
Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-11-21 DOI: 10.1007/s12194-023-00758-7
Reza Shamsabadi, Hamid Reza Baghani
{"title":"Impact of gadolinium concentration and cell oxygen levels on radiobiological characteristics of gadolinium neutron capture therapy technique in brain tumor treatment.","authors":"Reza Shamsabadi, Hamid Reza Baghani","doi":"10.1007/s12194-023-00758-7","DOIUrl":"10.1007/s12194-023-00758-7","url":null,"abstract":"<p><p>Neutron capture therapy (NCT) with various concentrations of gadolinium (<sup>157</sup>Gd) is one of the treatment modalities for glioblastoma (GBM) tumors. Current study aims to evaluate how variations of <sup>157</sup>Gd concentration and cell oxygen levels can affect the relative biological effectiveness (RBE) of gadolinium neutron capture therapy (GdNCT) technique through a hybrid Monte Carlo (MC) simulation approach. At first, Snyder phantom including a spherical tumor was simulated by Geant4 MC code and relevant energy electron spectra to different <sup>157</sup>Gd concentrations including 100, 250, 500, and 1000 ppm were calculated following the neutron irradiation of simulated phantom. Scored energy electron spectra were then imported to Monte Carlo damage simulation (MCDS) code to estimate RBE values (both RBE<sub>SSB</sub> and RBE<sub>DSB</sub>) at different gadolinium concentrations and oxygen levels from 10 to 100%. The results indicate that variations of <sup>157</sup>Gd can affect the energy spectrum of released secondary electrons including Auger electrons. Variation of gadolinium concentration from 100 to 1000 ppm in tumor region can change RBE<sub>SSB</sub> and RBE<sub>DSB</sub> values by about 0.1% and 0.5%, respectively. Besides, maximum variations of 4.3% and 2% were calculated for RBE<sub>DSB</sub> and RBE<sub>SSB</sub> when cell oxygen level changed from 10 to 100%. From the results, variations of considered gadolinium and oxygen concentrations during GdNCT can influence RBE values. Nevertheless, due to the not remarkable changes in the intensity of Auger electrons, a slight difference in RBE values would be expected at various <sup>157</sup>Gd concentrations, although considerable RBE changes were calculated relevant to the oxygen alternations inside tumor tissue.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy. 肺立体定向放射治疗靶体积内定义不确定度的探讨。
IF 1.6
Radiological Physics and Technology Pub Date : 2023-12-01 Epub Date: 2023-09-15 DOI: 10.1007/s12194-023-00737-y
Daiki Nakanishi, Masataka Oita, Jun-Ichi Fukunaga, Taka-Aki Hirose, Tadamasa Yoshitake, Motoharu Sasaki
{"title":"Investigation of uncertainty in internal target volume definition for lung stereotactic body radiotherapy.","authors":"Daiki Nakanishi, Masataka Oita, Jun-Ichi Fukunaga, Taka-Aki Hirose, Tadamasa Yoshitake, Motoharu Sasaki","doi":"10.1007/s12194-023-00737-y","DOIUrl":"10.1007/s12194-023-00737-y","url":null,"abstract":"<p><p>This study evaluated the validity of internal target volumes (ITVs) defined by three- (3DCT) and four-dimensional computed tomography (4DCT), and subsequently compared them with actual movements during treatment. Five patients with upper lobe lung tumors were treated with stereotactic body radiotherapy (SBRT) at 48 Gy in four fractions. Planning 3DCT images were acquired with peak-exhale and peak-inhale breath-holds, and 4DCT images were acquired in the cine mode under free breathing. Cine images were acquired using an electronic portal imaging device during irradiation. Tumor coverage was evaluated based on the manner in which the peak-to-peak breathing amplitude on the planning CT covered the range of tumor motion (± 3 SD) during irradiation in the left-right, anteroposterior, and cranio-caudal (CC) directions. The mean tumor coverage of the 4DCT-based ITV was better than that of the 3DCT-based ITV in the CC direction. The internal margin should be considered when setting the irradiation field for 4DCT. The proposed 4DCT-based ITV can be used as an efficient approach in free-breathing SBRT for upper-lobe tumors of the lung because its coverage is superior to that of 3DCT.</p>","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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