Radiological Physics and Technology最新文献_第8页

Simplified assessment for chemical exchanged saturation transfer (CEST) imaging: local offset frequency and CEST effect. 化学交换饱和转移（CEST）成像的简化评估：局部偏移频率和CEST效应。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-10-28 DOI: 10.1007/s12194-023-00752-z

Daiki Chiba, Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Hiroaki Hayashi, Akihiro Haga

{"title":"Simplified assessment for chemical exchanged saturation transfer (CEST) imaging: local offset frequency and CEST effect.","authors":"Daiki Chiba, Yuki Kanazawa, Tosiaki Miyati, Masafumi Harada, Mitsuharu Miyoshi, Hiroaki Hayashi, Akihiro Haga","doi":"10.1007/s12194-023-00752-z","DOIUrl":"10.1007/s12194-023-00752-z","url":null,"abstract":"The aim of this study is to develop a novel phantom for the evaluation of clinical CEST imaging settings, e.g., B0 and B1 field inhomogeneities, CEST contrast, and post-processing. We made a phantom composed of two slice sections: a grid section for local offset frequency evaluation and a sample section for CEST effect evaluation using different concentrations of an egg white albumin solution. On a 3 Tesla MR scanner, a phantom study was performed using CEST imaging; the mean B1 amplitudes were set at 1.2 and 1.9 µT, and CEST images with and without B0 corrections were acquired. Next, region of interest (ROI) analysis was performed for each slice. Then, CEST images with and without B0 corrections were compared at each B1 amplitude. The B0 corrected Z-spectrums at each local region in the grid section showed a shifting of the curve bottom to 0 ppm. Z-spectrum at B1 = 1.9 µT showed a broader curve shape than that at 1.2 µT. Moreover, MTRasym values at 3.5 ppm for each albumin sample at B1 = 1.9 µT were about two times higher than those at 1.2 µT. Our phantom enabled us to evaluate and optimize B0 inhomogeneity and the CEST effect at the B1 amplitude.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66784465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of mega-voltage CT scan parameters on offline adaptive radiation therapy. 巨电压 CT 扫描参数对离线自适应放射治疗的影响。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-09 DOI: 10.1007/s12194-023-00773-8

Kento Hoshida, Ayumu Ohishi, Asumi Mizoguchi, Sunao Ohkura, Hidemichi Kawata

{"title":"The effects of mega-voltage CT scan parameters on offline adaptive radiation therapy.","authors":"Kento Hoshida, Ayumu Ohishi, Asumi Mizoguchi, Sunao Ohkura, Hidemichi Kawata","doi":"10.1007/s12194-023-00773-8","DOIUrl":"10.1007/s12194-023-00773-8","url":null,"abstract":"TomoTherapy involves image-guided radiation therapy (IGRT) using Mega-voltage CT (MVCT) for each treatment session. The acquired MVCT images can be utilized for the retrospective assessment of dose distribution. The TomoTherapy provides 18 distinct imaging conditions that can be selected based on a combination of algorithms, acquisition pitch, and slice interval. We investigated the accuracy of dose calculation and deformable image registration (DIR) depending on MVCT scan parameters and their effects on adaptive radiation therapy (ART). We acquired image values for density calibration tables (IVDTs) under 18 different MVCT conditions and compared them. The planning CT (pCT) was performed using a thoracic phantom, and an esophageal intensity-modulated radiation therapy (IMRT) plan was created. MVCT images of the thoracic phantom were acquired under each of the 18 conditions, and dose recalculation was performed. DIR was performed on the MVCT images acquired under each condition. The accuracy of DIR, depending on the MVCT scan parameters, was compared using the mean distance to agreement (MDA) and Dice similarity coefficient (DSC). The dose distribution calculated on the MVCT images was deformed using deformed vector fields (DVF). No significant differences were observed in the results of the 18 IVDTs. The esophageal IMRT plan also showed a small dose difference. Regarding verifying the DIR accuracy, the MDA increased, and the DSC decreased as the acquisition pitch and slice interval increased. The difference between the dose distributions after dose mapping was comparable to that before DIR. The MVCT scan parameters had little effect on ART.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning-based PET image denoising and reconstruction: a review. 基于深度学习的 PET 图像去噪与重建：综述。

IF 1.7

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-06 DOI: 10.1007/s12194-024-00780-3

Fumio Hashimoto, Yuya Onishi, Kibo Ote, Hideaki Tashima, Andrew J Reader, Taiga Yamaya

引用次数: 0

Study on the radiofrequency transparency of partial-ring oval-shaped prototype PET inserts in a 3 T clinical MRI system. 在3T临床MRI系统中部分环形椭圆形原型PET插入物的射频透明性研究。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-10-24 DOI: 10.1007/s12194-023-00747-w

Md Shahadat Hossain Akram, Craig S Levin, Fumihiko Nishikido, Sodai Takyu, Takayuki Obata, Taiga Yamaya

{"title":"Study on the radiofrequency transparency of partial-ring oval-shaped prototype PET inserts in a 3 T clinical MRI system.","authors":"Md Shahadat Hossain Akram, Craig S Levin, Fumihiko Nishikido, Sodai Takyu, Takayuki Obata, Taiga Yamaya","doi":"10.1007/s12194-023-00747-w","DOIUrl":"10.1007/s12194-023-00747-w","url":null,"abstract":"The purpose of this study is to evaluate the RF field responses of partial-ring RF-shielded oval-shaped positron emission tomography (PET) inserts that are used in combination with an MRI body RF coil. Partial-ring PET insert is particularly suitable for interventional investigation (e.g., trimodal PET/MRI/ultrasound imaging) and intraoperative (e.g., robotic surgery) PET/MRI studies. In this study, we used electrically floating Faraday RF shield cages to construct different partial-ring configurations of oval and cylindrical PET inserts and performed experiments on the RF field, spin echo and gradient echo images for a homogeneous phantom in a 3 T clinical MRI system. For each geometry, partial-ring configurations were studied by removing an opposing pair or a single shield cage from different positions of the PET ring. Compared to the MRI-only case, reduction in mean RF homogeneity, flip angle, and SNR for the detector opening in the first and third quadrants was approximately 13%, 15%, and 43%, respectively, whereas the values were 8%, 23%, and 48%, respectively, for the detector openings in the second and fourth quadrants. The RF field distribution also varied for different partial-ring configurations. It can be concluded that the field penetration was high for the detector openings in the first and third quadrants of both the inserts.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49692947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and evaluation of an integrated liver nodule diagnostic method by combining the liver segment division and lesion localization/classification models for enhanced focal liver lesion detection. 通过结合肝段划分和病变定位/分类模型，开发和评估用于增强局灶性肝病变检测的综合性肝结节诊断方法。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-11-02 DOI: 10.1007/s12194-023-00753-y

Tomomi Takenaga, Shouhei Hanaoka, Yukihiro Nomura, Takahiro Nakao, Hisaichi Shibata, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Osamu Abe

{"title":"Development and evaluation of an integrated liver nodule diagnostic method by combining the liver segment division and lesion localization/classification models for enhanced focal liver lesion detection.","authors":"Tomomi Takenaga, Shouhei Hanaoka, Yukihiro Nomura, Takahiro Nakao, Hisaichi Shibata, Soichiro Miki, Takeharu Yoshikawa, Naoto Hayashi, Osamu Abe","doi":"10.1007/s12194-023-00753-y","DOIUrl":"10.1007/s12194-023-00753-y","url":null,"abstract":"The purpose of the study was to develop a liver nodule diagnostic method that accurately localizes and classifies focal liver lesions and identifies the specific liver segments in which they reside by integrating a liver segment division algorithm using a four-dimensional (4D) fully convolutional residual network (FC-ResNet) with a localization and classification model. We retrospectively collected data and divided 106 gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance examinations into Case-sets 1, 2, and 3. A liver segment division algorithm was developed using a 4D FC-ResNet and trained with semi-automatically created silver-standard annotations; performance was evaluated using manually created gold-standard annotations by calculating the Dice scores for each liver segment. The performance of the liver nodule diagnostic method was assessed by comparing the results with those of the original radiology reports. The mean Dice score between the output of the liver segment division model and the gold standard was 0.643 for Case-set 2 (normal liver contours) and 0.534 for Case-set 1 (deformed liver contours). Among the 64 lesions in Case-set 3, the diagnostic method localized 37 lesions, classified 33 lesions, and identified the liver segments for 30 lesions. A total of 28 lesions were true positives, matching the original radiology reports. The liver nodule diagnostic method, which integrates a liver segment division algorithm with a lesion localization and classification model, exhibits great potential for localizing and classifying focal liver lesions and identifying the liver segments in which they reside. Further improvements and validation using larger sample sizes will enhance its performance and clinical applicability.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of deep learning reconstruction on diffusion-weighted imaging quality and apparent diffusion coefficient using an ice-water phantom. 利用冰水模型评估深度学习重建对扩散加权成像质量和表观扩散系数的影响。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-12-28 DOI: 10.1007/s12194-023-00765-8

Tatsuya Hayashi, Shinya Kojima, Toshimune Ito, Norio Hayashi, Hiroshi Kondo, Asako Yamamoto, Hiroshi Oba

{"title":"Evaluation of deep learning reconstruction on diffusion-weighted imaging quality and apparent diffusion coefficient using an ice-water phantom.","authors":"Tatsuya Hayashi, Shinya Kojima, Toshimune Ito, Norio Hayashi, Hiroshi Kondo, Asako Yamamoto, Hiroshi Oba","doi":"10.1007/s12194-023-00765-8","DOIUrl":"10.1007/s12194-023-00765-8","url":null,"abstract":"This study assessed the influence of deep learning reconstruction (DLR) on the quality of diffusion-weighted images (DWI) and apparent diffusion coefficient (ADC) using an ice-water phantom. An ice-water phantom with known diffusion properties (true ADC = 1.1 × 10-3 mm2/s at 0 °C) was imaged at various b-values (0, 1000, 2000, and 4000 s/mm2) using a 3 T magnetic resonance imaging scanner with slice thicknesses of 1.5 and 3.0 mm. All DWIs were reconstructed with or without DLR. ADC maps were generated using combinations of b-values 0 and 1000, 0 and 2000, and 0 and 4000 s/mm2. Based on the quantitative imaging biomarker alliance profile, the signal-to-noise ratio (SNRs) in DWIs was calculated, and the accuracy, precision, and within-subject parameter variance (wCV) of the ADCs were evaluated. DLR improved the SNR in DWIs with b-values ranging from 0 to 2000s/mm2; however, its effectiveness was diminished at 4000 s/mm2. There was no noticeable difference in the ADCs of images generated with or without implementing DLR. For a slice thickness of 1.5 mm and combined b-values of 0 and 4000 s/mm2, the ADC values were 0.97 × 10-3and 0.98 × 10-3mm2/s with and without DLR, respectively, both being lower than the true ADC value. Furthermore, DLR enhanced the precision and wCV of the ADC measurements. DLR can enhance the SNR, repeatability, and precision of ADC measurements; however, it does not improve their accuracies.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validating computer applications for calculating spatial resolution and noise property in CT using simulated images with known properties. 利用已知属性的模拟图像验证计算 CT 空间分辨率和噪声属性的计算机应用程序。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-01-10 DOI: 10.1007/s12194-023-00771-w

Takeshi Inoue, Katsuhiro Ichikawa, Takanori Hara, Kazuya Ohashi, Kazuhiro Sato, Hiroki Kawashima

{"title":"Validating computer applications for calculating spatial resolution and noise property in CT using simulated images with known properties.","authors":"Takeshi Inoue, Katsuhiro Ichikawa, Takanori Hara, Kazuya Ohashi, Kazuhiro Sato, Hiroki Kawashima","doi":"10.1007/s12194-023-00771-w","DOIUrl":"10.1007/s12194-023-00771-w","url":null,"abstract":"The purpose of this study was to evaluate, using simulated images with known property values, how accurately some computer applications for calculating modulation transfer function (MTF), task transfer function (TTF), or noise power spectrum (NPS) in computed tomography (CT) based on widely known techniques produce their results. Specifically, they were three applications applicable to the wire method for MTF calculation, two applications corresponding to the circular edge (CE) and linear edge (LE) methods for TTF, and one application using a two-dimensional Fourier transform for NPS, which are collectively integrated with the software 'CTmeasure' provided by the Japanese Society of CT Technology. Images for the calculation with radial symmetry were generated based on a roll-off type filter function. The accuracy of each application was evaluated by comparing the calculated property with the true one. The calculated MTFs for the wire method accurately matched the true ones with percentage errors of smaller than 1.0%. In contrast, the CE and LE methods presented relatively large errors of up to 50% at high frequencies, whereas the NPS's errors were up to 30%. A closer investigation revealed, however, that these errors were attributable not to the applications but to the insufficiencies in the measurement techniques commonly employed. By improving the measurement conditions to minimize the effects of the insufficiencies, the errors notably decreased, whichvalidated the calculation techniques in the applications we used.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139404735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task-based assessment of resolution properties of CT images with a new index using deep convolutional neural network. 使用深度卷积神经网络使用新指数对CT图像的分辨率特性进行基于任务的评估。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-11-06 DOI: 10.1007/s12194-023-00751-0

Aiko Hayashi, Ryohei Fukui, Shogo Kamioka, Kazushi Yokomachi, Chikako Fujioka, Eiji Nishimaru, Masao Kiguchi, Junji Shiraishi

{"title":"Task-based assessment of resolution properties of CT images with a new index using deep convolutional neural network.","authors":"Aiko Hayashi, Ryohei Fukui, Shogo Kamioka, Kazushi Yokomachi, Chikako Fujioka, Eiji Nishimaru, Masao Kiguchi, Junji Shiraishi","doi":"10.1007/s12194-023-00751-0","DOIUrl":"10.1007/s12194-023-00751-0","url":null,"abstract":"In this study, we propose a method for obtaining a new index to evaluate the resolution properties of computed tomography (CT) images in a task-based manner. This method applies a deep convolutional neural network (DCNN) machine learning system trained on CT images with known modulation transfer function (MTF) values to output an index representing the resolution properties of the input CT image [i.e., the resolution property index (RPI)]. Sample CT images were obtained for training and testing of the DCNN by scanning the American Radiological Society phantom. Subsequently, the images were reconstructed using a filtered back projection algorithm with different reconstruction kernels. The circular edge method was used to measure the MTF values, which were used as teacher information for the DCNN. The resolution properties of the sample CT images used to train the DCNN were created by intentionally varying the field of view (FOV). Four FOV settings were considered. The results of adapting this method to the filtered back projection (FBP) and hybrid iterative reconstruction (h-IR) images indicated highly correlated values with the MTF10% in both cases. Furthermore, we demonstrated that the RPIs could be estimated in the same manner under the same imaging conditions and reconstruction kernels, even for other CT systems, where the DCNN was trained on CT systems produced by the same manufacturer. In conclusion, the RPI, which is a new index that represents the resolution property using the proposed method, can be used to evaluate the resolution of a CT system in a task-based manner.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71487242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directional vector visualization of scattered rays in mobile c-arm fluoroscopy. 移动式 C 臂透视中散射射线的定向矢量可视化。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI: 10.1007/s12194-024-00779-w

Kyoko Hizukuri, Toshioh Fujibuchi, Hiroyuki Arakawa

{"title":"Directional vector visualization of scattered rays in mobile c-arm fluoroscopy.","authors":"Kyoko Hizukuri, Toshioh Fujibuchi, Hiroyuki Arakawa","doi":"10.1007/s12194-024-00779-w","DOIUrl":"10.1007/s12194-024-00779-w","url":null,"abstract":"Previous radiation protection-measure studies for medical staff who perform X-ray fluoroscopy have employed simulations to investigate the use of protective plates and their shielding effectiveness. Incorporating directional information enables users to gain a clearer understanding of how to position protective plates effectively. Therefore, in this study, we propose the visualization of the directional vectors of scattered rays. X-ray fluoroscopy was performed; the particle and heavy-ion transport code system was used in Monte Carlo simulations to reproduce the behavior of scattered rays in an X-ray room by reproducing a C-arm X-ray fluoroscopy system. Using the calculated results of the scattered-ray behavior, the vectors of photons scattered from the phantom were visualized in three dimensions. A model of the physician was placed on the directional vectors and dose distribution maps to confirm the direction of the scattered rays toward the physician when the protective plate was in place. Simulation accuracy was confirmed by measuring the ambient dose equivalent and comparing the measured and calculated values (agreed within 10%). The directional vectors of the scattered rays radiated outward from the phantom, confirming a large amount of backscatter radiation. The use of a protective plate between the patient and the physician's head part increased the shielding effect, thereby enhancing radiation protection for the physicians compared to cases without the protective plate. The use of directional vectors and the surrounding dose-equivalent distribution of this method can elucidate the appropriate use of radiation protection plates.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139693201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold nanoparticles conjugated with epidermal growth factor and gadolinium for precision delivery of contrast agents in magnetic resonance imaging. 与表皮生长因子和钆结合的金纳米颗粒在磁共振成像中用于造影剂的精确递送。

IF 1.6

Radiological Physics and Technology Pub Date : 2024-03-01 Epub Date: 2023-11-22 DOI: 10.1007/s12194-023-00761-y

Suélio M Queiroz, Thaís S Veriato, Leandro Raniero, Maiara L Castilho

{"title":"Gold nanoparticles conjugated with epidermal growth factor and gadolinium for precision delivery of contrast agents in magnetic resonance imaging.","authors":"Suélio M Queiroz, Thaís S Veriato, Leandro Raniero, Maiara L Castilho","doi":"10.1007/s12194-023-00761-y","DOIUrl":"10.1007/s12194-023-00761-y","url":null,"abstract":"The utilization of contrast agents in magnetic resonance imaging (MRI) has become increasingly important in clinical diagnosis. However, the low diagnostic specificity of this technique is a limiting factor for the early detection of tumors. To develop a new contrast agent with a specific target for early stage tumors, we present the synthesis and characterization of a nanocontrast composed of gold nanoparticles (AuNPs), gadopentetic acid (Gd-DTPA), and epidermal growth factor (EGF). Carbodiimide-based chemistry was utilized to modify Gd-DTPA for functionalization with AuNPs. This resulted in the formation of the Au@Gd-EGF nanocontrast. The relaxation rate (1/T1) of the nanocontrast was analyzed using MRI, and cytotoxicity was determined based on cell viability and mitochondrial activity in a human breast adenocarcinoma cell line. Fourier-transform infrared spectroscopy analysis confirmed the effectiveness of carbodiimide in the formation of the Gd-DTPA-cysteamine complex in the presence of bands at 930, 1042, 1232, 1588, and 1716 cm-1. The complexes exhibited good interactions with the AuNPs. However, the signal intensity of the Au@Gd-EGF nanocontrast was lower than that of the commercial contrast agent because the r1/r2 relaxivities of the Gd-DTPA-based contrast agents were lower than those of the gadoversetamide-based molecules. The Au@Gd-EGF nanocontrast agent exhibited good biocompatibility, low cytotoxicity, and high signal intensity in MRI with active targeted delivery, suggesting significant potential for future applications in the early diagnosis of tumors.","PeriodicalId":46252,"journal":{"name":"Radiological Physics and Technology","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138292044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0