Indian Journal of Nuclear Medicine最新文献

{"title":"18-F FDG PET/CT in a Case of Recurrent Pericardial Effusion Diagnosed as Cardiac Sarcoma.","authors":"Anurag Jain, Abhishek Mahato, Prerna Guleria, Madan Gopal Vishnoi, Bushra Asima, Awadhesh Tiwari","doi":"10.4103/ijnm.ijnm_29_23","DOIUrl":"10.4103/ijnm.ijnm_29_23","url":null,"abstract":"<p><p>Recurrent pericardial effusion poses a diagnostic challenge, especially in young patients. We present a case of a 22-year-old female who experienced recurrent pericardial effusion and cardiac tamponade. Despite initial treatment with anti-tubercular drugs and prednisolone, the patient had a relapse of symptoms, necessitating further investigation. Imaging studies revealed massive pericardial effusion with septations, suggestive of constrictive pericarditis with impending cardiac tamponade. To establish a definitive diagnosis, the patient underwent an FDG PET-CT scan after adhering to a specific dietary regimen. The scan revealed an ill-defined mediastinal mass with high metabolic activity, along with a gross pericardial effusion showing metabolic activity in the periphery and septations. Subsequent biopsy of the mediastinal mass confirmed a diagnosis of high-grade sarcoma.Primary malignant cardiac tumors are rare, and their prognosis is generally poor due to limited treatment options. While echocardiography and MRI are commonly used imaging techniques, FDG PET-CT is not routinely employed for evaluating cardiac tumors. However, in this case, FDG PET-CT played a crucial role in identifying the mediastinal mass and confirming the diagnosis.Early detection and accurate diagnosis of cardiac tumors are vital for initiating appropriate treatment strategies. Further studies are needed to explore the utility of FDG PET-CT in the evaluation of cardiac tumors, especially in cases of recurrent pericardial effusion.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 2","pages":"144-145"},"PeriodicalIF":0.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series Depicting PSMA Expression in Nonmalignant Lesions.","authors":"Suchismita Ghosh, Archi Agrawal, Sayak Choudhury, Nilendu C Purandare, Venkatesh Rangarajan","doi":"10.4103/ijnm.ijnm_113_23","DOIUrl":"10.4103/ijnm.ijnm_113_23","url":null,"abstract":"<p><p>Prostate-specific membrane antigen (PSMA) is a widely accepted and used tracer in staging and biochemical recurrences of prostate cancer. PSMA is extensively expressed in normal prostatic epithelial cells and prostate cancer cells, with some amount of expression also in nonprostatic cells. False-positive PSMA uptake in nonmalignant lesions creates ambiguity in disease detection. In such cases, histopathological correlation and radiological follow-up assist in clinical decision-making. In this case series, we illustrate a few cases where PSMA uptake was incidentally found in some of the commonly occurring benign conditions.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 2","pages":"129-134"},"PeriodicalIF":0.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Approaches in Nuclear Medicine for Reproductive Health Assessment: Hysterosalpingography in Radiology versus hysterosalpingoscintigraphy.","authors":"Bushra Asima, Anurag Jain, Jayanta Kumar Biswas, Abhishek Mahato, Madan Gopal Vishnoi, Awadhesh Tiwari","doi":"10.4103/ijnm.ijnm_98_23","DOIUrl":"10.4103/ijnm.ijnm_98_23","url":null,"abstract":"<p><strong>Background: </strong>Infertility is a significant aspect of reproductive health and evaluating degree of tubal pathology is essential for determining appropriate management plans.</p><p><strong>Aims and objectives: </strong>To assess the role of hysterosalpingoscintigraphy (HSSG) as a tubal patency test in nuclear medicine and compare it with hysterosalpingography (HSG) in radiology in infertile women and study pain perception in both tests as well.</p><p><strong>Materials and methods: </strong>A prospective study was conducted on 50 infertility patients undergoing infertility evaluation at a tertiary care hospital. Both HSG and HSSG procedures were performed during proliferative phase of menstrual cycle.</p><p><strong>Results: </strong>Our study demonstrated the potential of HSSG as a tool for evaluating tubal patency in infertility workup. It showed good accuracy in detecting tubal patency compared to HSG.</p><p><strong>Conclusion: </strong>HSG is a radiological procedure valued for its ability to provide detailed anatomical information of uterus and patency of fallopian tubes. In contrast, HSSG provides dynamic information on the functional aspects of the reproductive system using nuclear medicine techniques. Both HSG and HSSG are vital tools in the diagnostic armamentarium for assessing female reproductive health, offering complementary information that aids in comprehensive patient management.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 2","pages":"115-119"},"PeriodicalIF":0.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141581190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Case of Primary Leiomyosarcoma of Bone - Findings on 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.","authors":"Pramit Kumar, Parneet Singh, Girish Kumar Parida, Tejasvini Singhal, Pavithra Ayyanar, R Pavithra, Kanhaiyalal Agrawal","doi":"10.4103/ijnm.ijnm_85_23","DOIUrl":"10.4103/ijnm.ijnm_85_23","url":null,"abstract":"<p><p>Primary leiomyosarcoma of bone (PLB) is a rare tumor, constituting <0.7% of all primary bone malignancies. It is clinically aggressive with heterogeneous presentation and a dismal prognosis. The most common presentation is pain with swelling and pathological fracture at times. Limited literature is available on PLB and only about 150 cases have been reported to date with only a few case reports defining the utility of 18F-fluorodeoxyglucose (18-F FDG) positron emission tomography/computed tomography (PET-CT) in its management. We hereby present a case of primary leiomyosarcoma of the right distal femur and the role of FDG-PET-CT in its management.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"52-54"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standardization and Clinical Use of a Single-vial Formulation of Technetium-99m-Trodat Using Autoclave Method.","authors":"Riptee Thakur, Chandana Nagaraj, Raman Kumar Joshi, Jitender Saini, Ravi Yadav, Pardeep Kumar","doi":"10.4103/ijnm.ijnm_104_23","DOIUrl":"10.4103/ijnm.ijnm_104_23","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra. SPECT imaging using technetium-99m [^99mTc] labeled trodat is the choice of imaging to differentiate PD from its other forms like drug-induced PD.</p><p><strong>Aims and objectives: </strong>The main objective of our study was to prepare in-house sterile formulation of [^99mTc]Tc-trodat and use in clinics.</p><p><strong>Materials and methods: </strong>The labeling of trodat was standardized using glucoheptonate sodium salt (GHA), stannous chloride dihydrate (in 0.05 N HCl), and ethylenediaminetetraacetic acid (Na-EDTA). The preparation was mixed and autoclaved at 15 psi for 15 min. The standardised formulation was stored at 4°C, -20°C and -80°C and labeling with ^99mTc was tested for up to 6 days. The radiochemical purity, chemical impurities, and endotoxin levels were tested. The frozen formulation was tested in swiss mice (n = 3) for biodistribution studies at 4 h. Around 18 ± 2 mCi was injected intravenously in each patient (n = 5) and the image was acquired at 4 h post-injection.</p><p><strong>Results: </strong>The radiochemical purity of the preparation was 98.3 ± 1.4% with a retention time of 16.8 ± 1.5 min as compared to 4.0 ± 0.5 min for free ^99mTc. Animal distribution showed highest uptake in liver and dual excretion via hepatobiliary and renal system. [^99mTc]Tc-trodat imaging was able to differentiate both caudate and putamen.</p><p><strong>Conclusions: </strong>In-house frozen preparation was advantageous, as it has decreased the chance of manual error as compared to daily make up formulations and economical as compared to commercially available kits.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"18-23"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Artifacts Encountered during Routine Studies on Positron Emission Tomography-Computed Tomography and Gamma Camera.","authors":"Prathamesh Rajai, Natasha Singh, Divya Shivdasani, Melvika Pereira","doi":"10.4103/ijnm.ijnm_105_23","DOIUrl":"10.4103/ijnm.ijnm_105_23","url":null,"abstract":"<p><p>Artifacts in nuclear medicine imaging are not uncommon. We are aware of some of these, for which we follow necessary protocols to avoid them. However, there are some unusual and unavoidable artifacts that we come across in daily imaging, which may be of concern and need to be detected and corrected on time. Hence, sharing a few such unusual artifacts we encountered while performing routine studies on positron emission tomography-computed tomography and gamma cameras, evaluating the cause and possible precautions.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"43-46"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Message from the Editor-in-Chief.","authors":"C S Bal","doi":"10.4103/ijnm.ijnm_37_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_37_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"1"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Frequency of Type 2 Deiodinase Thr92Ala Polymorphism (rs225014) in ¹³¹I-treated Differentiated Thyroid Cancer Patients Undertaking L-thyroxine (L-T4) Suppression Therapy.","authors":"Smita Gawandi, Kumarasamy Jothivel, Savita Kulkarni","doi":"10.4103/ijnm.ijnm_120_23","DOIUrl":"10.4103/ijnm.ijnm_120_23","url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 deiodinase (DIO2) enzyme plays a vital role in peripheral T4 to T3 conversion and in the negative feedback regulation of pituitary thyroid-stimulating hormone (TSH) secretion. Thr92Ala polymorphism (rs225014) is a common single-nucleotide polymorphism (SNP) that lowers DIO2 activity and is associated with diverse physiological disorders. Differentiated thyroid cancer (DTC) patients are given L-T4 therapy after total thyroidectomy and ¹³¹I treatment to suppress TSH levels.</p><p><strong>Aim: </strong>The aim of the study was to determine the frequency of rs225014 in DTC patients and to investigate its effect on the thyroid function tests (TFTs) and L-T4 dose required to suppress TSH levels.</p><p><strong>Materials and methods: </strong>The study included a DTC patient group and a control group. TFTs were estimated by RIA/IRMA kits. Genomic DNA of all the subjects was screened for rs225014 SNP by polymerase chain reaction.</p><p><strong>Results: </strong>The frequency of Thr/Thr (wild type), Thr/Ala (heterozygous mutant), and Ala/Ala (homozygous mutant) genotypes in the DTC patients' group was 0.21, 0.52, and 0.27, respectively. T3 levels and T3/T4 ratio were significantly low in the Ala/Ala genotype in the DTC group indicating impaired DIO2 activity. L-T4 dose requirement to suppress TSH levels in the DTC patients harboring rs225014 SNP was not statistically different from the wild-type genotype.</p><p><strong>Conclusion: </strong>The SNP rs225014 was observed to be associated with T3 and T3/T4 ratio but not with the L-T4 dose in DTC harboring SNP suggesting the presence of a compensatory pathway to overcome DIO2 impairment. However, it is essential to study the genetic makeup of DTC patients showing reduced response to TSH suppression to enable quicker decision-making in the implementation of personalized L-T4 dose to prevent any adverse effects.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"24-28"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Bilateral Hot Forearm Sign\": Ingeminating the Pattern of Physiological Uptake of ¹⁸F-Fludeoxyglucose.","authors":"Srinivas Ananth Kumar, Bhagwant Rai Mittal, Tanigassalam Sindhu, Rajender Kumar","doi":"10.4103/ijnm.ijnm_145_23","DOIUrl":"10.4103/ijnm.ijnm_145_23","url":null,"abstract":"<p><p>Exertion and exercise increase glucose metabolism within the skeletal muscles causing increased fludeoxyglucose (FDG) uptake on ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT). Here, we present findings of ¹⁸F-FDG PET/CT in a patient with acute viral hepatitis A-induced liver failure with multiple foci of pyoderma and incessant itching resulting in increased FDG uptake in the muscles of the bilateral forearm, producing the \"bilateral hot forearm sign.\"</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"61-62"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Leiomyosarcoma of Suprahepatic Inferior Vena Cava with Metastases.","authors":"Anitha Mandava, Veeraiah Koppula, Meghana Kandati, Arvind Kumar Reddy, Zakir Ali Abubacker","doi":"10.4103/ijnm.ijnm_130_23","DOIUrl":"10.4103/ijnm.ijnm_130_23","url":null,"abstract":"<p><p>A 67-year-old female presented with shortness of breath, weight loss, abdomen, and back pain for 2 months. Ultrasound of the abdomen revealed multiple focal liver lesions. ¹⁸F-Fluorodeoxyglucose whole-body positron emission tomography/computed tomography revealed a hypermetabolic lesion in the suprahepatic inferior vena cava extending into the right atrium. Multiple hypermetabolic lesions were seen in liver, bones, and abdominal lymph nodes, suggestive of metastases. Histopathology and immunohistochemistry of the lesions revealed it to be metastatic leiomyosarcoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 1","pages":"63-65"},"PeriodicalIF":0.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141181098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}