Indian Journal of Nuclear Medicine最新文献

{"title":"ChatGPT in Nuclear Medicine - Expanding Possibilities and Navigating Challenges: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4103/ijnm.ijnm_72_24","DOIUrl":"10.4103/ijnm.ijnm_72_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"417"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onsite Regeneration of Crystal Data in a 3/8\" Foresight Detector Using a Digital Workflow.","authors":"Sarika Sharma Prashar, Ajay Kumar, Ashwani Sood, Bhagwant Rai Mittal","doi":"10.4103/ijnm.ijnm_81_24","DOIUrl":"10.4103/ijnm.ijnm_81_24","url":null,"abstract":"<p><p>Generally after the accreditation of the gamma camera, its unfailing optimal operation is guaranteed with established departmental preventive maintenance schedules. However, it is not easy to always religiously follow the same maintenance routines. Therefore, instead of preventive maintenance schedule, a reactive maintenance schedule was adopted in our department for a short span of time. In our center, the humidity level in the gamma camera room was recorded to be 90%, which was much higher than the recommended value of 50%-60%. This was due to the inundated water in the gamma camera room due to an accidental breakage of fire-extinguishing water pipeline, adjacent to the room. Postaccident, higher values of nonuniformity (both intrinsic and extrinsic uniformity) were observed. The reactive maintenance was undertaken by medical physicist and field engineer to record and confirm the crystal hydration in the detector and to restore the system for the clinical studies. The digital workflow program successfully rectified the problem of crystal hydration. It is highly recommended to perform timely reactive action which may prevent the permanent damage to the systems.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"411-414"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serendipitous Detection of Hepatocellular Carcinoma in a Patient Undergoing Staging for Prostate Cancer.","authors":"Yash Jain, Nilendu Purandare, Archi Agrawal, Sneha Shah, Ameya Puranik, Vishesha Vipul Adhvaryu, Swapnil Rane, Venkatesh Rangarajan","doi":"10.4103/ijnm.ijnm_50_24","DOIUrl":"10.4103/ijnm.ijnm_50_24","url":null,"abstract":"<p><p>Isolated liver metastasis from prostate cancer is exceedingly rare. Prostate-specific membrane antigen-positron emission tomography/computed tomography has become the one-stop shop imaging in prostate cancer, but the uptake is a relatively nonspecific tracer and its expression can be seen in a plethora of nonprostatic solid tumors. We report one such example of an oligometastatic prostate cancer who presented with an isolated liver lesion which turned out to be an incidental hepatocellular carcinoma, thus representing a potentially unique diagnostic challenge.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"385-388"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of [18F]FDG- PET/CT in Initial Staging and Management of Patients with Esophageal Carcinoma: A Tertiary Care Center Experience.","authors":"Sankari Kommi, Ramya Priya Rallapeta, Bala Venkat Subramanian, Lakshmi Amancharla Yadagiri, Narendra Hulikal, C Chandramaliteeswaran, Rukmangada Nandyala, Tekchand Kalawat","doi":"10.4103/ijnm.ijnm_118_23","DOIUrl":"10.4103/ijnm.ijnm_118_23","url":null,"abstract":"<p><strong>Aim of the study: </strong>This study aims to study the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) findings in the initial staging and management of patients with esophageal carcinoma.</p><p><strong>Materials and methods: </strong>In this prospective study, we evaluated 74 patients with a mean age of 59.4 ± 11.6 with a range of 35-86 years. Comparison between the mean and standard deviation of SUV_max of primary tumor between two histopathological groups, squamous cell carcinoma (SCC) and adenocarcinoma (AC) was done using unpaired Student's <i>t</i>-test. The mean of SUV_max of primary tumor in relation to localized tumor to nodal to distant metastases was assessed by ANOVA test. <i>P</i> <0.05 was considered statistically significant. The extent of agreement between findings of contrast-enhanced computed tomography (CECT) chest and abdomen and ¹⁸F-FDG PET/CT was done using Cohen's kappa coefficient (κ).</p><p><strong>Results: </strong>Among total <i>n</i> = 74 (42 males and 32 females with mean age 59.4 ± 11.4; range 35-86 years) patients, SCC was seen in 78.4% and AC in 21.6% of patients. There is a progressively increased SUV_max value of primary tumor with nodal and distant metastases. ¹⁸F-FDG PET/CT showed disease of Stage I-II in 12.1%, Stage III in 20.2%, Stage IVA in 25.6%, and Stage IVB in 41.8% patients. There is agreement between ¹⁸F-FDG PET/CT and CECT chest and abdomen in the evaluation of regional lymph nodes (37.8% vs. 36.4%; κ - 0.96), nonregional lymph nodes (24.3% vs. 20.2%; κ -0.74), and distant organ involvement (21.6% vs. 17.5%; κ -0.82). In addition, ¹⁸F-FDG PET/CT found synchronous malignancies in 4.0% of patients.</p><p><strong>Conclusion: </strong>¹⁸F-FDG PET/CT metabolic parameters help in identifying metastatic involvement in morphologically equivocal and clinically suspicious lesions in carcinoma esophagus patients. Being a whole-body imaging modality, ¹⁸F-FDG PET/CT has inbuilt advantage to detect occult, distant metastases, and synchronous malignancies for effective staging and improving plan of clinical management.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"329-334"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Presentation of Thyroid Storm Postradioiodine Ablation: Case Report and Review of Literature.","authors":"Yogita Khandelwal, Preeti Vijay Namjoshi, Nishikant Avinash Damle, Jeepalem Sai Moulika, Bela Jain, Manasvini Bhatt, Yashdeep Gupta, Viveka Jyotsna","doi":"10.4103/ijnm.ijnm_54_24","DOIUrl":"10.4103/ijnm.ijnm_54_24","url":null,"abstract":"<p><p>Thyroid storm is an acute life-threatening complication of hyperthyroidism that presents with multisystem involvement. It can be precipitated by radioiodine therapy in high-risk patients. It has become less frequent, as current therapeutic approaches (antithyroid drugs and beta blockers) prevent the impact of thyroid hormones on the cardiovascular and central nervous systems. Hence, there is a concern that this rare clinical entity is misdiagnosed and inadequately managed leading to fatal outcomes. We report an elderly female with thyrotoxicosis who presented 4 weeks postradioiodine ablation with thyroid storm emphasizing the challenges in prompt diagnosis and future prevention of this rare clinical entity.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"381-384"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral Radiculoplexopathy Caused by Direct Perineural Spread of Carcinoma Prostate Diagnosed in Ga-68 PSMA PET/CT.","authors":"Mages Saravanen, Indirani Muthukrishnan, Dinesh Kumar Gauthaman, Shelley Simon","doi":"10.4103/ijnm.ijnm_44_24","DOIUrl":"10.4103/ijnm.ijnm_44_24","url":null,"abstract":"<p><p>Certain abdominal and pelvic malignancies present with sensory, motor or autonomic symptoms suggestive of nerve root involvement. Perineural spread of tumor is an emerging explanation of such presentations. This could be seen in carcinoma prostate. In this case report, we present one such case of carcinoma prostate with local recurrence and perineural spread of tumor causing unilateral sacral plexopathy. The patient presented with persistently elevated serum prostate-specific antigen and symptoms of lower backache and paraesthesia in the back of the thigh. On evaluation with Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-68 PSMA PET/CT), perineural spread of recurrent lesion to S2-S4 nerve roots was identified. The patient received radiotherapy for local recurrence and improved symptomatically and is under follow-up. Carcinoma prostate patients presenting with neurological symptoms should be carefully evaluated to rule out perineural spread of tumor. Ga-68 PSMA PET/CT has proven to be a useful modality in diagnosing such cases.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"389-392"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Performance of the Dose Calibrator Used in Radioactivity Measurement.","authors":"Dinh Xuan Hoang, Truong Dinh Vu, Do Van Dan, Nguyen Thanh Nhan","doi":"10.4103/ijnm.ijnm_51_24","DOIUrl":"10.4103/ijnm.ijnm_51_24","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to evaluate the principal technical characteristics of a well-type gas-filled ionization chamber dose calibrator used in measuring radiopharmaceutical activity, namely accuracy, repeatability, and linearity. Furthermore, this work also explored the correlation between the device's response and the position and volume of the radiopharmaceutical I-131.</p><p><strong>Materials and methods: </strong>Experimental measurements were conducted on the ATOMLAB 500 dose calibrator using NIST traceable Cs-137 source to determine the accuracy and repeatability. For the linearity test, the Tc-99m solution produced at the Dalat Nuclear Research Institute, Vietnam was utilized to examine the performance of the device over a wide measurement range. Effects resulting from different volumes and measuring positions were also determined by experiments and Monte Carlo simulations.</p><p><strong>Results: </strong>Based on acceptance test results, it is revealed that the dose calibrator's characteristics comply with international standards, where the deviations of accuracy, repeatability, and linearity are all lower than 1.0%. The response of the dose calibrator to different measuring positions and volumes was well controlled. To rectify the discrepancy in the response to the changes in solution volume, correction functions were proposed.</p><p><strong>Conclusions: </strong>It is concluded that the dose calibrator is suitable for radioactivity quantification and adheres to standards recommended by international organizations for nuclear medicine activities. The outcome of this work will serve as the foundation for establishing a standard for I-131 radiopharmaceuticals' radioactivity in Vietnam.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 4","pages":"272-278"},"PeriodicalIF":0.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mandatory Requirements for Planning and Commissioning of Medical Cyclotron Facility.","authors":"Rajeev Kumar, Pankaj Tandon, Kamal Deep","doi":"10.4103/ijnm.ijnm_102_23","DOIUrl":"10.4103/ijnm.ijnm_102_23","url":null,"abstract":"<p><p>Over the last 15 years, there has been substantial growth in the installation of medical cyclotrons. This is mainly due to the increased demand for the production of positron emission tomography radiopharmaceuticals. In every country, there is a regulatory body that regulates the uses of medical cyclotron intending to protect occupational workers, the public, and the environment. It regulates the entire stages of such facilities, which mainly controls regulatory activities such as construction, commissioning, operation, and decommissioning. This article primarily highlights the key practices for planning and installation of a medical cyclotron facility (MCF). It also covers the particular aspects that should be considered in the early stages of project planning and provides information for best practices and challenges. If these aspects are properly addressed, then it ensures the safe operation of the MCF. The texts also elaborate on the necessary requirements for effective planning of the MCF, such as layout and space considerations, workload plan and maximum research capacity of the institute and equipment, shielding requirements, water cooling circuit, storage of radioactive components, management of radioactive waste from medical cyclotron and radiochemistry laboratory, construction and commissioning project management, exhaust system and filtration options, plans for staffing and training, and combination of equipment safety systems and building safety systems.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 4","pages":"243-250"},"PeriodicalIF":0.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of [18F]FDG-PET/CT in Evaluation of Tumor Response to Chemoradiation Therapy for Advanced Colorectal Cancer.","authors":"Abhishek Soni, Stuti Chandola, Chandan Jyoti Das, Raju Sharma, Sushmita Pathy, Hemanaga Kumar Bhattacharjee, Sheragaru Hanumanthappa Chandrashekhara, Atul Sharma, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_60_24","DOIUrl":"10.4103/ijnm.ijnm_60_24","url":null,"abstract":"<p><strong>Objectives: </strong>The objective is to evaluate the efficacy of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET) computed tomography (CT) in the evaluation of tumor response to preoperative/palliative chemoradiotherapy (CRT) for advanced colorectal cancer; including metastatic cancer at primary presentation and recurrent cancers with local and/or distant metastasis.</p><p><strong>Materials and methods: </strong>Fifty patients with advanced rectal cancer underwent two point imaging with 18 FDG PET-CT before and after 3 weeks of completion of preoperative/palliative CRT in between 2016 and 2022. Patients with locally recurrent cancer also underwent radical surgery. The assessment consisted of the evaluation of the following metabolic PET parameters: Maximum standardized uptake value (SUV_max), SUV_ratio, metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Response was assessed among the followed patients using RECIST 1.1 criteria.</p><p><strong>Observations and results: </strong>There was a significant decline in the mean post therapy SUV_max and SUV_ratio as compared to baseline (<i>P</i> = 0.0001). Twenty-six out of 50 (52%) patients were classified as responders. A significant decrease in all parameters (SUV_max, SUV_ratio, TLG, and MTV) from baseline was observed in responders of the study when comparing with nonresponders (<i>P</i> < 0.05). Besides SUV_max and SUV_ratio, the mean posttherapy TLG was significantly reduced in responders than nonresponders (<i>P</i> = 0.0065).</p><p><strong>Conclusion: </strong>PET-CT is a useful combined anatomic and functional imaging modality in monitoring tumor response to preoperative/palliative CRT in advanced rectal cancer, whether primary or recurrent, including metastatic cancers at presentation. Posttherapy SUV and TLG in particular are significantly associated with treatment response.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 4","pages":"279-285"},"PeriodicalIF":0.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-efficient HPLC Validation Methodology for the Qualitative Analysis of 68Ga PSMA-11 in Routine Clinical Usage under Isocratic Method.","authors":"Sachin Tayal, Murari Gurjar, Varun Shukla, Manikandan Marappagounder Venkatachalam, Rohit Kumar, Yash Jain","doi":"10.4103/ijnm.ijnm_42_24","DOIUrl":"10.4103/ijnm.ijnm_42_24","url":null,"abstract":"<p><strong>Background: </strong>Prostate-specific membrane antigen (PSMA) has shown to be a promising agent for prostate cancer imaging under PET-CT. With the automation in radiolabeling with 68Ga, using iTG 68Ge/68Ga generator, it has helped introduce various new diagnostic agents and achieve good manufacturing practices (GMP) simultaneously. However, before any radiopharmaceutical is put into clinical usage, it should always be checked for its radiochemical purity and other quality parameters before injecting in the patient. Chromatography techniques such as Gas Chromatography (GC), High-Performance Liquid Chromatography (HPLC), and Thin-Layer Chromatography (TLC) are the most frequently utilized separation technique for purity analysis. A rapid quality control HPLC based methodology was required for radiopharmaceuticals.</p><p><strong>Aim & objective: </strong>In our current setting, we conducted quality control analysis and standardized and validated HPLC method for the routine quality check of 68Ga-PSMA-11.</p><p><strong>Materials and methods: </strong>The QC of 68Ga PSMA-11 was performed under ITLC and HPLC.</p><p><strong>Results: </strong>Linearity, accuracy, precision and specificity were assessed and quantified in accordance with International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use (Q2 (R1) ICH) guidelines, which can be implemented in resource-limited settings to check the quality.</p><p><strong>Conclusion: </strong>The current HPLC based methodology is rapid, with a retention time of 2.24 min, rendering it a favorable analytical standard operating procedure for QC analysis of 68Ga-PSMA-11.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 4","pages":"265-271"},"PeriodicalIF":0.4,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142956521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}