Indian Journal of Nuclear Medicine最新文献

{"title":"[18F]FDG- PET/CT in Diagnosis, Staging, and Management of Patients with Langerhans Cell Histiocytosis.","authors":"V M Vimala Priyadharshini, Indirani Muthukrishnan, Dinesh Kumar Gauthaman, Shelley Simon","doi":"10.4103/ijnm.ijnm_46_24","DOIUrl":"10.4103/ijnm.ijnm_46_24","url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis (LCH), a rare hematological disorder, presents significant diagnostic challenges due to its varied clinical manifestations. This study aims to analyse the use of F-18 fluoro-deoxy-glucose positron emission tomography computed tomography (F-18 FDG PET/CT) in diagnosis, staging, and management of LCH.</p><p><strong>Materials and methods: </strong>Fifty-nine patients with LCH were included, who underwent a total of ninety-three F-18 FDG PET/CT scans (including follow-up scans in 19 patients). The sites of abnormal FDG uptake were assessed and the maximum standardized uptake value was measured in all the scans.</p><p><strong>Results: </strong>Twenty-five patients (42.4%) had single system LCH (SS-LCH) and 34 patients (57.6%) had multisystem involvement LCH, 49/59. The most common sites of LCH involvement were bones (49/59, 83.1%) and lymph nodes (39/59, 44.9%). 12/59 patients (20.3%) had unifocal SS-LCH bone lesions, mostly in skull. The other common sites involved were lungs, liver, spleen, marrow, skin, and soft tissues. Less commonly involved sites included pancreas (2 cases), occipital lobe (1 case), and bowel (1 case). PET/CT was used in response assessment in 19 patients and helped in initiation of second line chemotherapy in cases of disease progression (2 cases) and relapse (2 cases). Seven cases with clinical suspicion were diagnosed as LCH based on lesion characteristics and FDG uptake, which were later biopsy proven.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT revealed morphological and metabolic characteristics of LCH lesions, aiding in accurate diagnosis, assessment of disease burden, and prognostication, thereby can be used as a comprehensive imaging tool in management of LCH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"341-346"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG PET Scan in Cutaneous Rosai-Dorfman-Destombes Disease.","authors":"Shrikant Vasantrao Solav, Chakor Vora, Rajlaxmi Jagtap, Shailendra Savale, Ishtiyaq Shaikh, Aman Solav","doi":"10.4103/ijnm.ijnm_121_24","DOIUrl":"10.4103/ijnm.ijnm_121_24","url":null,"abstract":"<p><p>Rosai-Dorfman-Destombes (RDD) disease is also called as sinus histiocytosis and is characterized by enlarged lymph nodes and previously called as non-Langerhans cell histiocytosis. Based on pathologic, molecular, and genetic features, RDD disease has been classified into sporadic noncutaneous (classical nodal, extranodal, neoplasia associated, and autoimmune associated), familial (H syndrome, autoimmune lymphoproliferative syndrome related, and familial NOS), and cutaneous subtypes. Cutaneous RDD disease is not associated with lymphadenopathy or visceral organ involvement. The disease is usually localized and has relatively better long-term prognosis. Presented here is a case of indurated plaque-like skin lesions over the abdomen. ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography scan revealed FDG avid cutaneous-subcutaneous soft-tissue lesions. Histology confirmed the diagnosis of cutaneous RDD disease.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"396-398"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-induced Activated White Adipose Tissue on FDG PET-CT.","authors":"Ashique Rehman, Tejasvini Singhal, Parneet Singh, Girish Kumar Parida, Kanhaiyalal Agrawal, P Sai Sradha Patro, T Kishan Subudhi, Sunita Gupta","doi":"10.4103/ijnm.ijnm_94_24","DOIUrl":"10.4103/ijnm.ijnm_94_24","url":null,"abstract":"<p><p>White adipose tissue (WAT) generally has negligible glucose utilization and thus, shows no or insignificant Fluorine-18 fluoro D-glucose (FDG) uptake. However, corticosteroids can cause altered biodistribution of FDG with increased uptake in WAT. We hereby describe a case of immune complex-mediated glomerulonephritis showing diffusely increased FDG uptake in WAT secondary to high-dose corticosteroid therapy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"409-410"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Focal Lesions on Overall and Progression-free Survival in Multiple Myeloma.","authors":"Tugcan Alp Kirkizlar, Onur Kirkizlar, Selin Soyluoglu, Elif Gulsum Umit, Funda Ustun, Ahmet Muzaffer Demir","doi":"10.4103/ijnm.ijnm_131_24","DOIUrl":"10.4103/ijnm.ijnm_131_24","url":null,"abstract":"<p><strong>Purpose: </strong>In this study, we aimed to reveal the incidence of ≥3 focal lesions (FLs) and analyze overall survival (OS) and progression-free survival (PFS) according to the number of FLs, as well as to identify mortality and PFS risk factors, in our newly diagnosed multiple myeloma (NDMM) patients.</p><p><strong>Materials and methods: </strong>A total of 89 NDMM patients who underwent ¹⁸F-FDG positron emission tomography/computerized tomography (PET/CT) imaging were included in the study.</p><p><strong>Results: </strong>While 57.3% of the patients had ≥3 FLs, 20.2% had no FL. The median OS and PFS were 55 and 43 months, respectively. The median survival time was 49 months for patients with ≥3 FLs and 101 months for patients with <3 FLs, with a statistically significant difference (<i>P</i> = 0.049). The median PFS was 34 months in patients with ≥3 FLs and 67 months in patients with <3 FLs; this difference was also statistically significant (<i>P</i> = 0.026). The difference in median survival was statistically significant, based on whether autologous stem cell transplantation (ASCT) was performed and the number of FLs (≥3 or <3) (<i>P</i> = 0.011). In the multivariate regression analysis, ≥3 FLs was not a predictor of mortality but was a risk factor for PFS.</p><p><strong>Conclusion: </strong>In our study, we observed significantly worse OS and PFS in patients with ≥3 FLs at diagnosis, and it is noteworthy that the OS was worse in those patients who did not undergo ASCT. ¹⁸F-FDG PET/CT is a feasible imaging technique for the prediction of prognosis in the initial evaluation of NDMM, and we believe that consolidation with ASCT as a modifiable factor, especially in patients with ≥3 FLs, will lead to a more favorable prognosis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"353-359"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Appearance on Radioiodine Scintigraphy Due to Achalasia Cardia - A Potential Diagnostic Pitfall.","authors":"Kunal Ramesh Chandekar, Nishikant Avinash Damle, Chandrasekhar Bal","doi":"10.4103/ijnm.ijnm_87_24","DOIUrl":"10.4103/ijnm.ijnm_87_24","url":null,"abstract":"<p><p>We present the case of a 36-year-old woman with papillary thyroid cancer (PTC) who had undergone thyroidectomy and nodal dissection. In addition to thyroid remnant and nodal metastases, initial postoperative radioiodine (RAI) diagnostic whole-body scintigraphy showed abnormal diffusely increased linear band-like uptake in the thorax corresponding to the esophageal contour, raising suspicion of lower esophageal obstruction. Retrospective inquiry revealed a history of long-standing, progressive dysphagia. Findings of computed tomography, barium swallow study, and esophageal manometry were consistent with achalasia cardia. She underwent high-dose RAI therapy for PTC and laparoscopic cardio-myotomy for achalasia cardia. This case report aims to familiarize nuclear medicine physicians with the appearance of achalasia cardia on RAI scintigraphy, which may mask surrounding lymph nodal or vertebral metastases. Such a finding when encountered should also prompt further work-up and appropriate management.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"406-408"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Manuscript Preparation: Are We Becoming Dependent on Machines?","authors":"Himel Mondal","doi":"10.4103/ijnm.ijnm_130_24","DOIUrl":"10.4103/ijnm.ijnm_130_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"415-416"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Report on the \"Brics International Forum on Nuclear Medicine\" June 19-21, 2024, Saint Petersburg, Russia.","authors":"Maroor Raghavan Ambikalmajan Pillai, Prabhu Ethiraj","doi":"10.4103/ijnm.ijnm_100_24","DOIUrl":"10.4103/ijnm.ijnm_100_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"418-420"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Usefulness of FDG PET-CT in the Routine Staging of Gastric Cancer: A Retrospective Analysis from the Lead Cancer Center, Pakistan.","authors":"Jamshed Ali, Sara Baloch, Iftikhar Qayum, Amer Rehman Farooqui, Kashif Sajjad, Zubair Shabbir Khanzada","doi":"10.4103/ijnm.ijnm_69_24","DOIUrl":"10.4103/ijnm.ijnm_69_24","url":null,"abstract":"<p><strong>Background: </strong>Accurate staging of tumors is paramount in the management of cancer patients. Current noninvasive modalities like computed tomography (CT) and fluorodeoxyglucose positron emission tomography (FDG PET) scan offer viable approaches to stage the disease; however, the role of FDG PET-CT in gastric cancer remains unclear, in comparison to esophageal and gastroesophageal junction cancers, where they have proven usefulness.</p><p><strong>Aim: </strong>The primary outcome was to assess the usefulness of FDG PET-CT in staging gastric cancer in our population. The secondary outcome was to compare the positive yield of PET-CT with staging laparoscopy and avidity of FDG PET-CT scan in gastric cancer.</p><p><strong>Materials and methods: </strong>In our institution, FDG PET-CT is routinely used in staging gastric cancer, where CT scan does not show metastases. We did a retrospective analysis of data of gastric cancer patients, who were not known to have metastatic disease, who underwent pretreatment staging workup at our institute between January 2018 and December 2022. Tumor and lymph node (LN) avidity and their association with Lauren classification was assessed. Multivariate regression analysis for factors associated with metastases on FDG PET-CT scan with tumor size, nodal status, and node avidity was also assessed. Data were analyzed using SPSS version 26 for descriptive and comparative statistics; multivariate regression analysis was performed to identify factors affecting the diagnosis of metastases on PET-CT. <i>P</i> =0.05 was considered statistically significant.</p><p><strong>Results: </strong>Tumor avidity was shown in 181 (89.16%) patients, and LN avidity in 80 (39.4%) patients. This was independent of the Lauren classification. In addition, previously unidentified metastases were highlighted in 16 (8%) patients. Multivariate regression analysis for factors associated with metastases on FDG PET-CT scan showed a significant association with tumor size (<i>P</i> < 0.001), nodal status (<i>P</i> = 0.005), and node avidity (<i>P</i> = 0.024).</p><p><strong>Conclusions: </strong>FDG PET-CT scan can identify an additional 8% of previously unidentified metastases, thereby playing a useful role in the staging workup of advanced gastric cancer patients. Approximately 90% of gastric cancers and 40% of LNs were PET avid in our population.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"347-352"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of Cross-sectional and Correlative Imaging in Differentiated Thyroid Carcinoma with Unusual Presentation of Adrenal Metastases - Case Series and Review of Literature.","authors":"Piyush Aggarwal, Venkata Subramanian Krishnaraju, Ashwani Sood, Yamini Mathur, Anish Bhattacharya, Bhagwant Rai Mittal","doi":"10.4103/ijnm.ijnm_76_24","DOIUrl":"10.4103/ijnm.ijnm_76_24","url":null,"abstract":"<p><p>Differentiated thyroid carcinoma (DTC) metastasizing to the adrenal glands is very infrequent. We present three cases of DTC with adrenal metastasis in their follow-up, in which two were from follicular thyroid carcinoma and one from papillary thyroid carcinoma along with review of literature to emphasize the role of cross-sectional and correlative imaging in DTC with adrenal metastasis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"399-405"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> Study to Compare Stability and Homogeneity of Various Routinely Used Meals for Gastric Emptying Scintigraphy (GES) for Solids and Validating Radiolabeled Idli (Savory Cake) as an Improved Alternate Vegetarian Meal.","authors":"Prathamesh Rajai, Natasha Singh, Divya Shivdasani, Melwika Pereira","doi":"10.4103/ijnm.ijnm_132_23","DOIUrl":"10.4103/ijnm.ijnm_132_23","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of the study was to compare the stability and homogeneity of various routinely used meals for gastric emptying scintigraphy (GES) for solids and to validate an improved vegetarian well uniformly radiolabeled solid meal for GES, which is easily fully consumed by patients in view of their common symptoms in such indications and in keeping with Indian food culture.</p><p><strong>Materials and methods: </strong>Following various types of solid meal preparations were labeled with 3 mCi of 99 mTc sulfur colloid (SC), and image of each meal was acquired on General Electric (GE) Infinia Hawkeye 4 camera: (1) Meal of 4 slice bread + 20 g butter with calorific value ≈ 356 kcal. (2) 4 slice bread + 30 g jam with calorific value ≈ 332 kcal. (3) 4 slice bread + 70 ml of milk with calorific value ≈ 243 kcal. (4) 150 g of sagu (sabudana) +5 ml refined vegetable oil + 10 g peanuts (sagu khichdi) with calorific value ≈ 324 kcal. (5) 4 idli + 2 tablespoon green chutney with calorific value ≈ 280 kcal. (6) 70 g wheat + 50 ml water + 5 ml refined vegetable oil with calorific value ≈ 237 kcal. (7) Meal of 75 g of idli mix + 80 ml water + 10 g butter with calorific value ≈ 310 kcal. All radiolabeled meals were subjected to the radiolabeled stability test procedure to calculate labeling efficiency which was compared.</p><p><strong>Results: </strong>Idli meal prepared with radiotracer added to the batter mixture itself, with a calorific value ≈ 310 kcal showed the highest uniform Tc99 m SC distribution in comparison to all other meal preparations.</p><p><strong>Conclusions: </strong>Radiolabeled idli (savory cake) prepared with radiotracer added to the batter mixture itself, appears to be an ideal vegetarian meal in comparison to all other meal preparations for gastric emptying scintigraphy studies, especially among patients with specific dietary restrictions.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"335-340"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}