Indian Journal of Nuclear Medicine最新文献

{"title":"Incidental Adrenal Histoplasmosis Revealed by FAPI PET-CT in an Immunocompetent Patient.","authors":"Sairam Doppalapudi, Ashish Mohite, Rumaanah Khan, Karuna Luthra","doi":"10.4103/ijnm.ijnm_143_24","DOIUrl":"10.4103/ijnm.ijnm_143_24","url":null,"abstract":"<p><p>A 77-year-old male presented with pyrexia of unknown origin. Chest computed tomography (CT) showed adrenal lesions, a suspicion of neoplasia was raised, and Fluorodeoxyglucose Positron Emission Tomography (FDG PET-CT) was recommended. Since the patient had uncontrolled diabetes (Fasting Blood Sugar - 326 mg/dL), FDG-PET was not feasible. The patient, therefore, underwent Ga68-Fibroblast Activating Protein Inhibitor - 46 PET-CT (FAPI PET-CT). Scan showed high-grade Fibroblast Activating Protein (FAP) expression in bilateral enlarged adrenals. Findings appeared atypical for malignancy and the possibility of chronic inflammatory/infectious condition was raised. Biopsy proved adrenal histoplasmosis (AH). Although FDG avidity in AH is known and previously reported, this is best to our knowledge the first literature documentation of FAP expression in AH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"49-50"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpectedly Low FDG and FAPI Uptake in Mucosal Melanoma: Case Report with Literature Review.","authors":"Nimmagadda Ajit, Prathyusha Bikkina, Zakir Ali Abubacker, C B Virupakshappa, S Lm Chandrasekhar Rao, Koyye Ravindranath Tagore, Suseela Kodandapani","doi":"10.4103/ijnm.ijnm_123_24","DOIUrl":"10.4103/ijnm.ijnm_123_24","url":null,"abstract":"<p><p>Mucosal melanomas (MMs) represent a rare subset of melanomas arising from melanocytes in noncutaneous sites such as mucosal membranes of the head-and-neck, gastrointestinal, and genitourinary tracts. Unlike cutaneous melanomas, MMs often present late due to their occult nature, leading to a poor prognosis. Fluorine-18 fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is widely utilized for staging and monitoring melanomas, leveraging their characteristic high FDG avidity. Recently, fibroblast activation protein inhibitor (FAPI)-based PET/CT imaging has become a popular modality in the evaluation of various cancers. Here, we present a case of MM where FDG avidity was notably absent and mild FAPI avidity, despite the lesion's typical anatomical location and clinical suspicion. This case highlights an uncommon scenario within the literature and underscores the variability in radiotracer uptake observed in MMs, challenging conventional imaging expectations and potentially impacting clinical management decisions.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"32-35"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Finding of Acute Appendicitis on FDG PET/CT in Breast Carcinoma.","authors":"Bela Jain, Yogita Khandelwal, Nishikant Avinash Damle, Madhavi Tripathi, Chandrasekhar Bal","doi":"10.4103/ijnm.ijnm_68_24","DOIUrl":"10.4103/ijnm.ijnm_68_24","url":null,"abstract":"<p><p>The interpretation of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans can be confounded by incidental findings, as illustrated in this case of a 47-year-old woman with a history of breast carcinoma. Following neoadjuvant chemotherapy and mastectomy, she underwent FDG PET/CT for disease evaluation, revealing unexpected hypermetabolic activity in the right iliac fossa corresponding to acute appendicitis. Thus, FDG PET/CT has the potential to uncover treatable conditions beyond cancer and imaging findings need clinical correlation.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"42-43"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult Langerhans Cell Histiocytosis: Solitary and Multisystemic Involvement Detected on FDG PET-CT Scan.","authors":"Aishwarya Wagle, Melvika Pereira, Natasha Singh, Divya Shivdasani, Lokesh Kumar, Janpreet Singh, Sreelakshmi Sujith","doi":"10.4103/ijnm.ijnm_97_24","DOIUrl":"10.4103/ijnm.ijnm_97_24","url":null,"abstract":"<p><p>Langerhans Cell Histiocytosis (LCH) is a rare neoplasm of the hematopoietic system, characterized by the clonal proliferation of Langerhans cells and it is more common in children. We present two interesting adult cases of LCH, diagnosed with the help of FDG PET-CT imaging which is often challenging to diagnose due to its rarity and nonspecific clinical presentation.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"44-46"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tiger-man Appearance in a Case of DLBCL.","authors":"A R Vishnu, Nishikant Avinash Damle, Sameer Bakhshi, Deepam Pushpam","doi":"10.4103/ijnm.ijnm_129_24","DOIUrl":"10.4103/ijnm.ijnm_129_24","url":null,"abstract":"<p><p>Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (PC-EBV-DLBCL) is a rare and aggressive neoplasm with a poorer prognosis than other cutaneous lymphoma. Here, we present the ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) scan findings of a 39-year-old male with erythematous ulcerative nodules, which showed a gamut of cutaneous lesions consistent with EBV-associated PC-DLBCL. We highlight the utility of ¹⁸F-FDG PET/CT in evaluating the extent of disease, involvement of extranodal sites, and response to treatment in PC-EBV-DLBCL.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"40-41"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimmune Encephalitis Pattern on PET-MRI in a Patient with Amyotrophic Lateral Sclerosis.","authors":"Sandesh Voosala, M Sandhya, P S Mathuranath, Rohan R Mahale","doi":"10.4103/ijnm.ijnm_9_24","DOIUrl":"10.4103/ijnm.ijnm_9_24","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a progressive primary motor neuron disorder whose etiology is a subject of debate even today. Interplay between multiple genetic and environmental factors and co-existent/antecedent infection, inflammation, and malignancy have all been hypothesized as potentially causative for this disease. Owing to its hybrid diagnostic capability, fluorodeoxyglucose positron emission tomography-magnetic resonance imaging is highly valuable in detecting varied autoimmune encephalitis patterns, one of which we report in a patient with ALS providing insight into autoimmunity as a potential etiology in the pathogenesis of this disease.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"22-25"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pitfall We Should Be Aware of on Bone Scintigraphy.","authors":"Majdouline Bel Lakhdar, Ouafae Boumaaza, Ayat Mouaden, Imad Ghfir, Hasnae Guerrouj","doi":"10.4103/ijnm.ijnm_73_24","DOIUrl":"10.4103/ijnm.ijnm_73_24","url":null,"abstract":"<p><p>Nuclear medicine imaging frequently encounters injection artifacts. Although inadvertent intra-arterial injection is infrequent, it may pose diagnostic difficulties in pathological contexts. We present a case study of a woman with breast cancer and increased bone uptake in her right forearm and hand on bone scintigraphy. The pitfall was corrected by her clinical background and three-phase bone scintigraphy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"26-27"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case.","authors":"Ghasemali Divband, Raheleh Hedayati, Hamidreza Amini, Leila Hassanzadeh","doi":"10.4103/ijnm.ijnm_79_24","DOIUrl":"10.4103/ijnm.ijnm_79_24","url":null,"abstract":"<p><p>A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR₂, and FAP identified biomarkers for personalized therapy. This led to the choice of [177Lu]Lu-FAPI-2286. After the first cycle, the patient reported pain relief, but subsequent imaging revealed rapid brain metastasis. This case highlights the importance of personalized medicine and molecular imaging in treating advanced melanoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"28-31"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of 6-Fluoro-18F-l-3,4-DOPA MR-PET in Clinical Workup in Movement Disorders Cases: An Exploratory Study in a Tertiary Care Neuropsychiatric Setup.","authors":"Keerti Sitani, Sandhya Mangalore, Manoj Kumar Verma, Pardeep Kumar, Pawan Bairwa Btech, Venkatesh Murthy Konappa Agrahara Shama","doi":"10.4103/ijnm.ijnm_151_23","DOIUrl":"10.4103/ijnm.ijnm_151_23","url":null,"abstract":"<p><strong>Introduction: </strong>6-Fluoro-18F-l-3,4-dihydroxyphenylalanine (18F-DOPA) is primarily used to differentiate nondopamine deficient symptomatic subjects from Parkinsonian disorders and various etiologies from one another, which otherwise can be challenging. The current study aimed to determine (18F)-DOPA positron emission tomography (PET) patterns in Idiopathic Parkinson's disease (IPD), nondopamine deficient symptomatic (NDDS) and other movement disorders.</p><p><strong>Materials and methods: </strong>Sixty patients referred from neuropsychiatric outpatient department were retrospectively analyzed who underwent (18F)-DOPA magnetic resonance (MR)-PET scans. Out of 60 subjects, 36 were diagnosed with IPD, 5 were cases of other movement disorders, and 19 were normal on PET imaging (NDDS). To evaluate and quantify the tracer uptake from the PET scans, a region of interest (ROI) was drawn on the least radiotracer uptake region, and subsequently, on bilateral occipital cortex, caudate (head, body, tail), putamen (anterior, posterior), periaqueductal gray matter and red nucleus using structural MR images (MRI) for better delineation of anatomical regions. Tracer uptake ratios from each selected region were generated as SUV_max of ROI/occipital. The statistical analysis was performed using SPSS 29.0 version.</p><p><strong>Results: </strong>The posterior putamen showed a significant difference between IPD and other patients with an SUV cutoff of 1.69 and 100% specificity and 99.2% accuracy for normal controls. Whereas, we observed an SUV cutoff of 1.75 and an accuracy and specificity of 100% in patients with other movement disorders. The absolute values from the caudate nucleus were demonstrating a statistical significance between other movement disorders compared to normal controls with a cutoff of 1.69 and an accuracy of 81.2%. The ratio of posterior putamen/occipital ratio was significant between IPD and normal controls, with a cutoff of 3.89 and an accuracy of 95.6%. Right caudate to occipital ratio (RCOR) was significant for differentiating between other movement disorders and normal controls with a cutoff of 3.01 and an accuracy of 95.6%. One novel finding was that occipital lobe uptake was significantly reduced in patients with IPD compared to other movement disorders.</p><p><strong>Conclusion: </strong>The findings from the current study demonstrated that hybrid imaging using 18F-DOPA PET/MRI could efficiently differentiate between various causes of Parkinson's disease with diagnostic accuracy and necessary cut-offs.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"10-15"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Invasive Lobular Carcinoma of the Breast Presenting with Gastric and Uterine Metastases Demonstrated on F-18 FDG PET CT.","authors":"Pramukh Kulkarni, Gayana Shankaramurthy, Vivek Belathur, B S Ravindra","doi":"10.4103/ijnm.ijnm_105_24","DOIUrl":"10.4103/ijnm.ijnm_105_24","url":null,"abstract":"<p><p>Invasive lobular carcinoma (ILC) of the breast is distinct among breast cancer subtypes due to its unique metastatic patterns, including the involvement of the liver, genital tract, and gastrointestinal tract. As ILC often exhibits low-grade fluorodeoxyglucose (FDG) avidity, the role of fluorine-18 FDG (F-18 FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this subtype remains under re-explored. This case report highlights a rare presentation of ILC of the right breast with concurrent gastric and uterine metastases detected on F-18 FDG PET/CT, emphasizing its diagnostic utility.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"36-39"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}