Indian Journal of Nuclear Medicine最新文献

{"title":"Tc-99m Tetrofosmin SPECT-CT as a Guide to Core Needle Biopsy of a Giant Thymoma.","authors":"Mirco Pultrone, Enrico Calandri, Alessio Meli, Alberto Maria Pisacane, Andrea Rognoni, Luca Filippi","doi":"10.4103/ijnm.ijnm_48_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_48_25","url":null,"abstract":"<p><p>Extracardiac images are occasionally revealed on Tc-99m tetrofosmin single photon emission computed tomography-computed tomography (SPECT-CT) imaging due to the known oncotropic properties of the tracer. A large area of inhomogeneous tracer uptake was revealed on SPECT-myocardial perfusion imaging in a 59-year-old male patient referred to our department for suspected coronary artery disease. On subsequent SPECT-CT, the mass was located in the anterior mediastinum, characterized by regular margins not infiltrating the adjacent anatomical structures, and had diameters of 6 cm × 5.2 cm × 10.3 cm. A very high uptake ratio value, equal to 26, strengthened the suspicion of giant thymoma. However, an ultrasound (US)-guided transcutaneous core biopsy was deemed necessary before surgical removal of the lesion due to its extremely large size and the absence of associated paraneoplastic syndromes. In this aspect, the SPECT-CT imaging proved to be very useful in guiding the sampling procedure in an area rich in viable cells, due to the presence of multiple areas of necrosis of various sizes that could have affected the outcome of the US-guided core biopsy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"244-248"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Spread to Breast in a Case of Mucinous Adenocarcinoma Appendix Detected on ¹⁸F-FDG PET-CT scan.","authors":"Aishwarya Wagle, Melvika Pereira, Natasha Singh, Divya Shivdasani, Janpreet Singh, Lokesh Kumar, Sreelakshmi Sujith","doi":"10.4103/ijnm.ijnm_49_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_49_25","url":null,"abstract":"<p><p>Appendiceal adenocarcinomas are rare invasive gastrointestinal neoplasms, with higher propensity to metastasize to lymph nodes and peritoneum, whereas other common sites include liver and lung. Metastases to the breast are exceptionally rare in appendiceal neoplasms, with limited data in literature. We present the case of a recurrent mucinous adenocarcinoma of the appendix with clinically occult breast, skeletal, and nonregional nodal metastases detected on fluorine-18-fluorodeoxyglucose positron emission tomography-computed tomography scan.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"255-257"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Ectopic Mediastinal Parathyroid Adenoma on Myocardial Perfusion Scintigraphy with 99mTc-Tetrofosmin.","authors":"Varvara Valotassiou, Marianna Vlychou, Sotiria Alexiou, Dimitrios Psimadas, George Angelidis, Panagiotis Georgoulias","doi":"10.4103/ijnm.ijnm_40_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_40_25","url":null,"abstract":"<p><p>Parathyroid ectopia may occur in various anatomical regions and is caused by abnormal embryological migration of the parathyroid glands. Ectopic parathyroid adenomas account for 6%-16% of cases of primary hyperparathyroidism. We present the case of a mediastinal ectopic adenoma detected on myocardial perfusion imaging with 99m Technetium (99mTc)-tetrofosmin in a 64-year-old patient. Incidental extracardiac 99mTc-tetrofosmin uptake in mediastinal ectopic parathyroid adenomas has been rarely reported in the literature. Our case is rare as it represents a small proportion of all ectopic parathyroid adenomas.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"252-254"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile Carcinoma Presented with Ilioinguinal Lymphadenopathy, Below-knee Skeletal Metastases, and Peritoneal Superscan on ¹⁸F FDG PET/CT.","authors":"Ahmed Saad Abdlkadir, Ula Al-Rasheed, Dhuha Al-Adhami, Akram Al-Ibraheem","doi":"10.4103/ijnm.ijnm_54_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_54_25","url":null,"abstract":"<p><p>Penile squamous cell carcinoma (PSCC) is an uncommon malignancy in males, often associated with a poor prognosis following metastatic dissemination. We report the case of a 46-year-old male who presented with a rare and extensive metastatic profile of PSCC, as detected by ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography following penectomy. The scan demonstrated extensive hypermetabolic metastatic involvement, including bilateral inguinal and external iliac lymph nodes, multiple lytic osseous metastases, and diffuse peritoneal carcinomatosis, the latter presenting in the form of peritoneal superscan. In addition, skeletal metastases extended below the knees, affecting both tibiae - an atypical metastatic site for PSCC. Despite the aggressive molecular imaging findings, the patient opted against further therapeutic interventions and succumbed to the disease 45 days later at home, highlighting the fulminant and disseminated nature of this malignancy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"258-260"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCR4-targeted Imaging in DLBCL: A Prospective Head-to-head Comparison of ⁶⁸Ga-Pentixafor and ¹⁸F-FDG PET/CT.","authors":"Pradap Palanivelu, Harish Goyal, D Kabilash, Vasanth Madivanane, Prasanth Ganesan, Dhanapathi Halanaik","doi":"10.4103/ijnm.ijnm_78_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_78_25","url":null,"abstract":"<p><strong>Background: </strong>While ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) remains the gold standard for staging diffuse large B-cell lymphoma (DLBCL), it is limited by nonspecific uptake and physiological artifacts. This study explores the potential of the novel C-X-C chemokine receptor type 4 (CXCR4)-targeted tracer ⁶⁸Ga-Pentixafor as a complementary receptor-specific imaging modality.</p><p><strong>Methods: </strong>In this prospective single-center study, 27 treatment-naïve patients with histopathologically confirmed DLBCL underwent ⁶⁸Ga-Pentixafor and ¹⁸F-FDG PET/CT within a 2-week interval. Lesion detection, Lugano staging concordance, and maximum standardized uptake value (SUVmax) were assessed and compared using Cohen's kappa for agreement and paired <i>t</i>-tests for quantitative variables.</p><p><strong>Results: </strong>⁶⁸Ga-Pentixafor PET/CT showed near-perfect agreement with ¹⁸F-FDG PET/CT for extranodal lesion detection (κ =0.926, <i>P</i> < 0.001). For nodal lesions, substantial agreement was observed (κ =0.804, <i>P</i> < 0.0001). Lugano staging results were consistent between both modalities in 92.6% of cases (25/27), with only two instances of discordance. Importantly, ⁶⁸Ga-Pentixafor detected biopsy-confirmed bone marrow involvement in four cases missed by ¹⁸F-FDG. Although ¹⁸F-FDG showed higher SUVmax values for nodal lesions (15.2 ± 7.6 vs. 8.4 ± 4.2; <i>P</i> < 0.001), there was no significant difference in uptake for extranodal sites. Subgroup analysis indicated a nonsignificant trend toward higher CXCR4 expression in the nongerminal center B-cell (non-GCB) subtype compared to the GCB subtype (<i>P</i> = 0.665). Notably, gastrointestinal artifacts associated with metformin use were absent on ⁶⁸Ga-Pentixafor scans.</p><p><strong>Conclusion: </strong>This first-of-its-kind study in a uniform cohort of newly diagnosed DLBCL patients demonstrates that ⁶⁸Ga-Pentixafor PET/CT shows high concordance with ¹⁸F-FDG PET/CT, with superior detection in the bone marrow and reduced physiological background. Its receptor-specific targeting of CXCR4 facilitates accurate disease assessment and provides a noninvasive approach to evaluate therapeutic targets, supporting its potential role in personalized CXCR4-directed theranostic strategies.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"211-217"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Renal Conditions: Role of Imaging Modalities.","authors":"Dikhra Khan, Sambit Sagar, Anushna S Babu, Rakesh Kumar, Sandeep Aggarwala, Vishesh Jain, Devendra Yadav, Prabudh Goel, Devasenathipathy Kandasamy, Manisha Jana","doi":"10.4103/ijnm.ijnm_137_23","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_137_23","url":null,"abstract":"<p><p>This article discusses the role of various imaging modalities in diagnosing and managing surgical renal conditions in pediatric patients. It emphasizes the importance of tailored surgical interventions based on accurate imaging assessments. The cases presented cover a range of conditions, including pelvic-ureteric junction obstruction, vesicoureteric reflux, congenital renal anomalies, and postoperative management. The article underscores the pivotal role of various imaging modalities in diagnosing and managing a spectrum of surgical renal conditions in pediatric patients, providing valuable insights for clinical decision-making.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"227-235"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Gastric Metastasis from Invasive Ductal Carcinoma Breast Mimicking as Metachronous Primary on ¹⁸F-FDG PET/CT.","authors":"Chandra Teja Reddy Singareddy, Chandana Nagaraj, V V Vijaya Lakshmi, Ganesha Vashishta, Renuka Malipatel","doi":"10.4103/ijnm.ijnm_170_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_170_24","url":null,"abstract":"<p><p>The most common metastatic sites from carcinoma breast include the bones, lungs, liver, and brain. Breast cancer metastasizing to the gastrointestinal tract is very rare. This case report is about a compliant woman who was a known treated case of right breast cancer, in whom ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography showed a focal FDG avid mural thickening in the body of stomach 4 years later, for which suspicion of a second primary of gastric origin was raised, considering the rarity of being metastatic. However, histopathology confirmed it as metastasis of breast origin. This case highlights the importance of considering gastric metastasis as a differential diagnosis in patients who present with a gastric lesion and a history of breast cancer.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"236-239"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of ¹⁸F FDG PET/CT in Hemophagocytic Lymphohistiocytosis.","authors":"Piyush Aggarwal, Lakshay Tyagi, Harmandeep Singh, Rajender Kumar, Harpreet Singh, Gaurav Prakash, Ankur Kumar Jindal, Manupdesh Singh Sachdeva, Deepti Suri, Bhagwant Rai Mittal","doi":"10.4103/ijnm.ijnm_5_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_5_25","url":null,"abstract":"<p><strong>Purpose: </strong>Hemophagocytic lymphohistiocytosis (HLH) is a fatal systemic inflammatory syndrome caused by a wide array of causes, which may be detected on ¹⁸F fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F FDG PET/CT). This study explores the utility of ¹⁸F FDG PET/CT in HLH.</p><p><strong>Materials and methods: </strong>Retrospective data of HLH patients referred for whole-body ¹⁸F FDG PET/CT were analyzed for abnormal findings, and quantitative analysis using standardized uptake value (SUV), spleen-to-liver ratio (SLR), and bone-to-liver ratio (BLR) was done and correlated with laboratory parameters, bone marrow (BM) findings, and final diagnosis.</p><p><strong>Results: </strong>Twenty-four patients (median age 22 years [interquartile range 13-34]) were included in the study. The most common cause of HLH was infection (33%), malignancy (29%), and autoimmune disorders (13%), and five patients had primary HLH. ¹⁸F FDG PET/CT was positive in 22/24 patients (92%). Hepatomegaly and splenomegaly were observed in 22 patients (92%) and 16 patients (67%), respectively, with six (25%) showing splenic lesions. Splenic uptake > liver was observed in 62.5% of patients and BM uptake > liver uptake in 50% of patients. There was no significant difference in median BM uptake (SUV_max 4.0 vs. 3.5, <i>P</i> = 0.6) and BLR (1.475 vs. 1.514, <i>P</i> = 0.4) in patients with and without HLH on marrow sampling, but a significant difference was observed in hypercellular vs. normocellular/hypocellular marrow (SUV_max 5.1 vs. 3.2, <i>P</i> = 0.019 and BLR 1.58 vs. 0.82, <i>P</i> = 0.043). A significant positive correlation was observed between splenic and BM uptake (<i>r</i> = 0.501, <i>P</i> = 0.013), BLR and SLR (<i>r</i> = 0.623, <i>P</i> = 0.001), C-reactive protein levels with BLR (<i>r</i> = 0.731, <i>P</i> = 0.001), and SLR (<i>r</i> = 0.594, <i>P</i> = 0.015), respectively. In 11 patients who underwent targeted sampling from most hypermetabolic sites, it helped reach the final diagnosis or eliminate malignant causes.</p><p><strong>Conclusion: </strong>¹⁸F FDG PET/CT has a high diagnostic yield in HLH with the potential to detect its underlying causes and may be considered in the diagnostic algorithm of HLH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"189-196"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference Values for Gallbladder Ejection Fraction in a Healthy Indian Cohort Using Fatty Meal Hepatobiliary Scintigraphy.","authors":"Ashutosh Kumar, Asem Rangita Chanu, Dikhra Khan, Priyanka Gupta, Bangkim Chandra Khangembam, Chetan Patel, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_24_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_24_25","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective was to establish the reference value of gallbladder ejection fraction (GBEF) using a fatty meal-based hepatobiliary scintigraphy protocol tailored to the Indian population. In addition, the study assessed variations in GBEF across different time points and examined potential differences based on gender and age.</p><p><strong>Materials and methods: </strong>This prospective study was conducted from January 2023 to January 2024. Hepatobiliary scintigraphy was performed on healthy individuals aged ≥18 years following a 4-h fasting period. Static images were acquired before and after ingesting a standard fatty meal. The premeal image displaying the highest gallbladder activity concentration and minimal liver activity was selected as the reference premeal image. GBEF was calculated using decay and background-corrected counts from the reference premeal and postmeal images. Statistical analyses included independent sample <i>t</i>-tests to evaluate gender differences, Pearson's correlation to assess relationships between age and GBEF, and repeated measures ANOVA with Bonferroni correction to compare GBEF across different time points. The reference value of GBEF was determined based on the 5^th percentile value at 60 min postmeal ingestion.</p><p><strong>Results: </strong>Twenty-three consecutive healthy individuals (13 females and 10 males) with a mean age of 42 ± 12 years (median: 39 years; range: 23-62 years) participated in the study. The mean GBEF increased progressively over time, with values of 36% ± 20% at 30 min, 50% ± 23% at 45 min, and 55% ± 23% at 60 min, demonstrating statistically significant differences across time points (<i>P</i> < 0.0001). No significant differences in GBEF were observed between males and females at any time point (<i>P</i> ≥ 0.770). In addition, age was not significantly correlated with GBEF at any measured time point (<i>P</i> ≥ 0.820). The reference value of GBEF, determined based on the 5^th percentile at 60 min postmeal ingestion, was established as ≥20%, providing a clinically relevant threshold for assessing gallbladder function.</p><p><strong>Conclusion: </strong>The study established the reference value of GBEF using a standard fatty meal protocol. In addition, using a culturally appropriate, low-cost fatty meal offers a practical alternative to sincalide-based cholescintigraphy, especially where sincalide is scarce or quality control is challenging. This patient-friendly method also shortens imaging sessions, reducing discomfort. These values support diagnostic thresholds in clinical practice.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"204-210"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of ChatGPT for Assisting Patients with Study Preparation and Report Interpretation of Myocardial Viability Scintigraphy: Exploring the Future of AI-driven Patient Comprehension in Nuclear Medicine.","authors":"Malay Mishra, Sameer Taywade, Rajesh Kumar","doi":"10.4103/ijnm.ijnm_76_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_76_25","url":null,"abstract":"<p><strong>Purpose: </strong>India's high-volume healthcare system, including nuclear medicine departments, restricts the quality and frequency of patient-clinician communication. Poor understanding of preparation requirements increases cancellations, image artefacts, and repeat studies. Artificial intelligence (AI) chatbots like chat generative pre-trained transformer (ChatGPT) can be a promising tool to mitigate these challenges. We evaluated the efficiency of ChatGPT to address patients' queries about study instructions and report findings while undergoing nuclear myocardial viability study.</p><p><strong>Subjects and methods: </strong>Six myocardial-viability mock reports were created. OpenAI ChatGPT-4o responses were evaluated for the set of 14-questions regarding patient preparation and 2-questions regarding the reports. All questions and reports were entered as single prompts in separate chats. Each prompt was repeated twice using regenerate-response function. Furthermore, references used to generate responses were analyzed. The responses were then rated based on 5 key parameters: appropriateness, helpfulness, empathy, consistency, and validity of references.</p><p><strong>Results: </strong>Most responses were appropriate and helpful for both preparation (1.5 ± 0.76; 1.64 ± 0.63) and report prompts (1.67 ± 0.49; 2.0). However, empathy and consistency had lower scores in preparations (1.43 ± 0.76; 1.14 ± 0.66) than in report prompts (1.58 ± 0.51; 1.67 ± 0.49). Reference validity remained an issue, as only one response had a valid reference. A hallucinatory response was noted twice. The study demonstrated that none of the prompt responses could have caused harm to the patient under real-life conditions.</p><p><strong>Conclusions: </strong>ChatGPT helps in query resolution in myocardial viability studies. It enhances patient engagement, quality of patient preparation, and comprehension of nuclear medicine reports. However, inconsistent and less empathetic responses mandate supervised use and further refinement before incorporating it into routine practices.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"222-226"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}