Indian Journal of Nuclear Medicine最新文献

{"title":"[18F]FDG- PET/CT Imaging Spectrum of the Most Prevalent Adrenal Lesions.","authors":"Man Mohan Singh, Pravin Suresh Pareek, Lavish Kakkar, Priyamedha Bose Thakur, Satyawati Deswal","doi":"10.4103/ijnm.ijnm_63_24","DOIUrl":"10.4103/ijnm.ijnm_63_24","url":null,"abstract":"<p><p>Detection of adrenal lesions either incidentally, or in symptomatic cases and/or during staging/restaging of oncological cases, it is very crucial to know the adrenal lesion is benign or malignant. Fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) helps in this comprehensive evaluating process. Here, we present the most frequently facing adrenal lesions in routine oncological PET/CT scans. The aim of this presentation is to know the FDG uptake spectrum of various adrenal lesions on PET/CT scan so that increase the diagnostic accuracy and spectrum of differential diagnosis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"370-375"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Atlas of Gallium-68-fibroblast Activation Protein Inhibitor (FAPI) in Oncology and Nononcology Imaging.","authors":"Shrikant Vasantrao Solav, Rajlaxmi Rangrao Jagtap, Shailendra V Savale","doi":"10.4103/ijnm.ijnm_70_24","DOIUrl":"10.4103/ijnm.ijnm_70_24","url":null,"abstract":"<p><p>Fibroblast activation protein (FAP) is a quinoline-based membrane bound glycoprotein enzyme. It is not expressed in normal adult tissue except for the myometrium and sometimes in pancreas. The expression increases in inflammation and in cancer-associated fibroblasts. Gallium 68-FAP inhibitor (FAPI) is known to localize in various neoplasms by the virtue of their property of cancer-associated fibroblast activity. Fibroblasts are also known to be associated in inflammatory and infectious condition such as cholecystitis, pyelonephritis, and tuberculosis. Immunoglobulin G4 related disease (IgG4RD) is characterized by infiltration of various tissues with IgG4-rich lymphoplasmacytic fibrotic tissue and has been reported to express cancer-associated fibroblast. The time-tested molecule for cancer imaging F18-fluorode-oxyglucose requires 4-6 h of fasting state. Ga68-FAPI does not require fasting. This pictorial essay illustrates various entities, cancerous as well as noncancerous using Ga68-FAPI positron emission tomography computed tomography (PET CT) imaging.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"360-369"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Autonomously Functioning Thyroid Nodule: An Unusual Imaging Finding.","authors":"Tejasvini Singhal, Kanhaiyalal Agrawal, Tara Prasad Tripathy, Girish Kumar Parida","doi":"10.4103/ijnm.ijnm_40_24","DOIUrl":"10.4103/ijnm.ijnm_40_24","url":null,"abstract":"<p><p>A 48-year-old female, a known case of ulcerative colitis, on routine workup, was incidentally detected to have biochemical hyperthyroidism. ^99mTc pertechnetate thyroid scintigraphy performed for the evaluation of hyperthyroidism revealed two foci of increased tracer uptake in the right thyroid lobe with suppressed uptake in the rest of the thyroid gland consistent with dual autonomously functioning thyroid nodules.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"393-395"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT in Nuclear Medicine - Expanding Possibilities and Navigating Challenges: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.4103/ijnm.ijnm_72_24","DOIUrl":"10.4103/ijnm.ijnm_72_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"417"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG- PET/CT in Staging and Restaging of Fetal Type Adenocarcinoma of the Lung: A Case Report and a Review of the Literature.","authors":"Pietro Bellini, Francesco Dondi, Gian Luca Viganò, Francesco Bertagna","doi":"10.4103/ijnm.ijnm_113_24","DOIUrl":"10.4103/ijnm.ijnm_113_24","url":null,"abstract":"<p><p>Fetal type adenocarcinoma (FTA) is a rare malignant tumor of the lung that histologically resembles an embryonic lung. Due to its rarity, no studies had investigated the possible role of the ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) in the initial assessment and/or in the restaging of the disease yet. We present a case of a male patient with tongue carcinoma and incidental findings of well-differentiated FTA at [¹⁸F]FDG PET/CT. The patient was treated by specific therapy and also performed a subsequent [¹⁸F]FDG PET/CT scan that showed a significant reduction of the uptake on lung lesion. This case highlights the potential role and usefulness of PET imaging for staging and posttherapeutic restaging of well-differentiated FTA. The review of the available literature underlined the rarity of the disease since only seven reports were present. Anyway, a possible role of the [¹⁸F]FDG PET/CT in the staging of FTA is conceivable.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"376-380"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884344/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of [18F]FDG- PET/CT in Initial Staging and Management of Patients with Esophageal Carcinoma: A Tertiary Care Center Experience.","authors":"Sankari Kommi, Ramya Priya Rallapeta, Bala Venkat Subramanian, Lakshmi Amancharla Yadagiri, Narendra Hulikal, C Chandramaliteeswaran, Rukmangada Nandyala, Tekchand Kalawat","doi":"10.4103/ijnm.ijnm_118_23","DOIUrl":"10.4103/ijnm.ijnm_118_23","url":null,"abstract":"<p><strong>Aim of the study: </strong>This study aims to study the utility of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) findings in the initial staging and management of patients with esophageal carcinoma.</p><p><strong>Materials and methods: </strong>In this prospective study, we evaluated 74 patients with a mean age of 59.4 ± 11.6 with a range of 35-86 years. Comparison between the mean and standard deviation of SUV_max of primary tumor between two histopathological groups, squamous cell carcinoma (SCC) and adenocarcinoma (AC) was done using unpaired Student's <i>t</i>-test. The mean of SUV_max of primary tumor in relation to localized tumor to nodal to distant metastases was assessed by ANOVA test. <i>P</i> <0.05 was considered statistically significant. The extent of agreement between findings of contrast-enhanced computed tomography (CECT) chest and abdomen and ¹⁸F-FDG PET/CT was done using Cohen's kappa coefficient (κ).</p><p><strong>Results: </strong>Among total <i>n</i> = 74 (42 males and 32 females with mean age 59.4 ± 11.4; range 35-86 years) patients, SCC was seen in 78.4% and AC in 21.6% of patients. There is a progressively increased SUV_max value of primary tumor with nodal and distant metastases. ¹⁸F-FDG PET/CT showed disease of Stage I-II in 12.1%, Stage III in 20.2%, Stage IVA in 25.6%, and Stage IVB in 41.8% patients. There is agreement between ¹⁸F-FDG PET/CT and CECT chest and abdomen in the evaluation of regional lymph nodes (37.8% vs. 36.4%; κ - 0.96), nonregional lymph nodes (24.3% vs. 20.2%; κ -0.74), and distant organ involvement (21.6% vs. 17.5%; κ -0.82). In addition, ¹⁸F-FDG PET/CT found synchronous malignancies in 4.0% of patients.</p><p><strong>Conclusion: </strong>¹⁸F-FDG PET/CT metabolic parameters help in identifying metastatic involvement in morphologically equivocal and clinically suspicious lesions in carcinoma esophagus patients. Being a whole-body imaging modality, ¹⁸F-FDG PET/CT has inbuilt advantage to detect occult, distant metastases, and synchronous malignancies for effective staging and improving plan of clinical management.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"329-334"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Onsite Regeneration of Crystal Data in a 3/8\" Foresight Detector Using a Digital Workflow.","authors":"Sarika Sharma Prashar, Ajay Kumar, Ashwani Sood, Bhagwant Rai Mittal","doi":"10.4103/ijnm.ijnm_81_24","DOIUrl":"10.4103/ijnm.ijnm_81_24","url":null,"abstract":"<p><p>Generally after the accreditation of the gamma camera, its unfailing optimal operation is guaranteed with established departmental preventive maintenance schedules. However, it is not easy to always religiously follow the same maintenance routines. Therefore, instead of preventive maintenance schedule, a reactive maintenance schedule was adopted in our department for a short span of time. In our center, the humidity level in the gamma camera room was recorded to be 90%, which was much higher than the recommended value of 50%-60%. This was due to the inundated water in the gamma camera room due to an accidental breakage of fire-extinguishing water pipeline, adjacent to the room. Postaccident, higher values of nonuniformity (both intrinsic and extrinsic uniformity) were observed. The reactive maintenance was undertaken by medical physicist and field engineer to record and confirm the crystal hydration in the detector and to restore the system for the clinical studies. The digital workflow program successfully rectified the problem of crystal hydration. It is highly recommended to perform timely reactive action which may prevent the permanent damage to the systems.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"411-414"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serendipitous Detection of Hepatocellular Carcinoma in a Patient Undergoing Staging for Prostate Cancer.","authors":"Yash Jain, Nilendu Purandare, Archi Agrawal, Sneha Shah, Ameya Puranik, Vishesha Vipul Adhvaryu, Swapnil Rane, Venkatesh Rangarajan","doi":"10.4103/ijnm.ijnm_50_24","DOIUrl":"10.4103/ijnm.ijnm_50_24","url":null,"abstract":"<p><p>Isolated liver metastasis from prostate cancer is exceedingly rare. Prostate-specific membrane antigen-positron emission tomography/computed tomography has become the one-stop shop imaging in prostate cancer, but the uptake is a relatively nonspecific tracer and its expression can be seen in a plethora of nonprostatic solid tumors. We report one such example of an oligometastatic prostate cancer who presented with an isolated liver lesion which turned out to be an incidental hepatocellular carcinoma, thus representing a potentially unique diagnostic challenge.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"385-388"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Presentation of Thyroid Storm Postradioiodine Ablation: Case Report and Review of Literature.","authors":"Yogita Khandelwal, Preeti Vijay Namjoshi, Nishikant Avinash Damle, Jeepalem Sai Moulika, Bela Jain, Manasvini Bhatt, Yashdeep Gupta, Viveka Jyotsna","doi":"10.4103/ijnm.ijnm_54_24","DOIUrl":"10.4103/ijnm.ijnm_54_24","url":null,"abstract":"<p><p>Thyroid storm is an acute life-threatening complication of hyperthyroidism that presents with multisystem involvement. It can be precipitated by radioiodine therapy in high-risk patients. It has become less frequent, as current therapeutic approaches (antithyroid drugs and beta blockers) prevent the impact of thyroid hormones on the cardiovascular and central nervous systems. Hence, there is a concern that this rare clinical entity is misdiagnosed and inadequately managed leading to fatal outcomes. We report an elderly female with thyrotoxicosis who presented 4 weeks postradioiodine ablation with thyroid storm emphasizing the challenges in prompt diagnosis and future prevention of this rare clinical entity.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"381-384"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral Radiculoplexopathy Caused by Direct Perineural Spread of Carcinoma Prostate Diagnosed in Ga-68 PSMA PET/CT.","authors":"Mages Saravanen, Indirani Muthukrishnan, Dinesh Kumar Gauthaman, Shelley Simon","doi":"10.4103/ijnm.ijnm_44_24","DOIUrl":"10.4103/ijnm.ijnm_44_24","url":null,"abstract":"<p><p>Certain abdominal and pelvic malignancies present with sensory, motor or autonomic symptoms suggestive of nerve root involvement. Perineural spread of tumor is an emerging explanation of such presentations. This could be seen in carcinoma prostate. In this case report, we present one such case of carcinoma prostate with local recurrence and perineural spread of tumor causing unilateral sacral plexopathy. The patient presented with persistently elevated serum prostate-specific antigen and symptoms of lower backache and paraesthesia in the back of the thigh. On evaluation with Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (Ga-68 PSMA PET/CT), perineural spread of recurrent lesion to S2-S4 nerve roots was identified. The patient received radiotherapy for local recurrence and improved symptomatically and is under follow-up. Carcinoma prostate patients presenting with neurological symptoms should be carefully evaluated to rule out perineural spread of tumor. Ga-68 PSMA PET/CT has proven to be a useful modality in diagnosing such cases.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"389-392"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}