Indian Journal of Nuclear Medicine最新文献

{"title":"Integrating Metabolic Imaging with Metabolic Intervention - Unfolding the Mystery of Rare Isolated Pulmonary IgG4-related Disease Masquerading as Lung Tumor.","authors":"Priyank Rajput, Karan Kalra, Sameer Taywade, Gopal Durgeshwar, Siddarth Sahu, Rajesh Kumar, Aasma Nalwa, Iyer Hariharan","doi":"10.4103/ijnm.ijnm_50_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_50_25","url":null,"abstract":"<p><p>IgG4-related disease (IgG4-RD) is a systemic autoimmune fibroinflammatory condition in which IgG4-positive plasma cell infiltration occurs in various organs. Diagnosing IgG4-RD when it presents as a lung mass can be challenging, as its clinical and radiological characteristics resemble those of lung cancer, and its presentation is also not diagnostic. This case presents an elderly male, a former smoker, with a lung mass, initially suspected to be lung carcinoma due to heterogeneous enhancement and spiculated margins on Contrast enhanced computed tomography (CECT). The diagnosis remained uncertain post-computed tomography (CT)-guided biopsy. FFlurodeoxyglucose Positron Emission Tomography- Computed Tomography (FDG PET-CT) revealed a metabolically active lung mass with mediastinal lymphadenopathy. Metabolic PET-CT-guided biopsy confirmed IgG4-RD with IgG4-positive plasma cells. This prevented unnecessary invasive procedures and ensured timely and appropriate treatment. The patient showed symptomatic improvement with steroid therapy. This unique case emphasizes the importance of combining metabolic imaging with metabolic intervention to accurately detect rare, isolated pulmonary IgG4-RD, which can clinically and radiologically mimic lung carcinoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"249-251"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Intraluminal Uptake of ¹⁸F FDG in Gallbladder on PET/CT - A Retrospective Cohort study in North India.","authors":"Deepanksha Datta, Prateek Bisht, Y T Yogananda, Rajesh Kumar","doi":"10.4103/ijnm.ijnm_31_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_31_25","url":null,"abstract":"<p><strong>Purpose: </strong>¹⁸F fluoro 2-deoxy-D-glucose (FDG) uptake in positron emission tomography/computed tomography (PET/CT) scans is commonly observed in the brain, myocardium, liver, intestines, and excretory pathways such as kidneys and the urinary bladder. This study examines the incidence and contributing factors for physiological FDG accumulation in the gallbladder (GB) lumen, in the absence of clinical history or anatomical abnormalities.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted at a North Indian tertiary care hospital on patients who underwent ¹⁸F FDG PET/CT between January and August 2024. The study group included individuals with GB intraluminal FDG uptake exceeding blood pool levels without anatomical changes, while the control group comprised patients without GB uptake. Comparisons were made based on body mass index, fasting blood sugar, FDG dose, time-to-scan interval, and SUVmax (standardized uptake value). Mann-Whitney <i>U</i>-test was employed for statistical analysis.</p><p><strong>Results: </strong>Among 632 screened patients, 82 (13%) exhibited GB FDG uptake, whereas 149 were randomly selected for the control group. The study group showed significantly higher fasting blood sugar (101 [24] vs. 93 [18] mg/dl, <i>P</i> = 0.007), FDG dose (6.8 [2.5] vs. 6 [2.3] mCi, <i>P</i> < 0.001), and longer time to scan (82 [54] vs. 78 [38] min, <i>P</i> = 0.02). The median SUVmax for GB uptake was 2.1 (0.93) g/ml.</p><p><strong>Conclusion: </strong>Physiological GB FDG uptake occurs in about 13% of patients. Increased fasting blood sugar, higher FDG dose, and prolonged scan intervals elevate the likelihood of GB uptake.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"218-221"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosai-Dorfman Disease: A Rare Disease with Uncommon 18F-FDG PET CT Findings.","authors":"T Kishan Subudhi, Ashique Rahman, Saitej Reddy, Kanhaiyalal Agrawal, Ashutosh Panigrahi, Girish Kumar Parida","doi":"10.4103/ijnm.ijnm_21_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_21_25","url":null,"abstract":"<p><p>Rosai-Dorfman disease (RDD) also called as sinus histiocytosis with lymphadenopathy is a rare benign histiocytic proliferative disorder of unknown etiology and was first described in 1969 with the incidence of 1 in 200,000. Most commonly present with lymphadenopathy with around 40 percent presented with extranodal involvement such as skin, central nervous system, nasal cavity, and bones. Bone involvement is rare and it is <10% cases of RDD. We present a case of RDD with extranodal involvement such as nasal cavity, cutaneous nodules, paraspinal lesion with intraspinal extension, and uncommon appendicular skeleton involvement (tibia and fibular involvement).</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"261-262"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striking Bilateral Cerebellar Hypermetabolism on ¹⁸F FDG-PET in a Patient of Sudden Onset Gait Ataxia with Absence of Paraneoplastic Antibody and Other Localizing Imaging Indicator.","authors":"Parth Baberwal, Sunita Nitin Sonavane, Sandip Basu","doi":"10.4103/ijnm.ijnm_26_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_26_25","url":null,"abstract":"<p><p>A 69-year-old gentleman presented with complains of giddiness, gait ataxia, vomiting, and slurring of speech with clinical signs pointing to cerebellar etiology. The magnetic resonance imaging brain revealed no significant abnormality. ¹⁸F-fluorodeoxyglucose (¹⁸F FDG) positron emission tomography (PET)/computed tomography showed hyper-metabolism in bilateral cerebellar hemispheres, pons, mid-brain and bilateral medial temporal cortices. Further quantitative NeuroQ analysis of ¹⁸F FDG-PET showed similar findings. Paraneoplastic antibody panel (anti-Hu, anti-Yo, anti-Ri, NMDA, CASPR-2 etc.) was negative. Clinical suspicion and PET imaging correlation led the neurologist to suspicion of inflammatory/autoimmune etiology, and the patient was empirically started on four cycles of plasma exchange therapy and course of steroids, however, no significant clinical response was noted. At post-6 months of ¹⁸F FDG-PET, he expired out of respiratory illness (pneumonia).</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"240-243"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Severe Hypocellular Anemia on Image Quality in Equilibrium Radionuclide Angiocardiography.","authors":"Sulochana Sarswat, Abhinav Singhal, Kalpa Jyoti Das","doi":"10.4103/ijnm.ijnm_11_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_11_25","url":null,"abstract":"<p><p>Equilibrium radionuclide angiocardiography (ERNA) is a highly accurate and well-established nuclear imaging modality for ventricular function evaluation. This technique exploits the binding of technetium-99m, in its reduced form, to intracellular constituents of erythrocytes - referred to as red blood cell (RBC) radiolabeling. Sufficient radiolabeling depends on an adequate number of circulating RBCs to generate optimal signal-to-background ratio and image contrast. Theoretically, a reduction in RBC count may compromise radiolabeling efficiency, culminating in suboptimal image quality. This report elucidates the deleterious effects of hypocellular anemia on ERNA imaging and documents the remarkable improvement in diagnostic image quality following targeted intervention to correct anemia.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"265-266"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Salivary Gland Scintigraphy: Establishing Normative Data through a Healthy Cohort.","authors":"Aryan Kumar, Asem Rangita Chanu, Dikhra Khan, Priyanka Gupta, Bangkim Chandra Khangembam, Chetan Patel, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_23_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_23_25","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective was to establish the normative data of dynamic salivary gland scintigraphy (dSGS). Secondary objectives included comparing salivary gland function across different glands, examining gender differences, and correlations with age.</p><p><strong>Materials and methods: </strong>Twenty-nine consecutive healthy adults (19 females) with a mean age of 46.5 ± 11.9 years underwent dSGS. Scintigraphy images were analyzed visually and quantitatively, generating dynamic salivary scintigrams for each gland. Quantitative indices such as maximum percent uptake (MU%) and excretion fraction (EF%) were calculated. Comparisons between the parotid and submandibular glands, as well as between genders, were performed using the Mann-Whitney <i>U</i>-test or Independent Samples <i>t</i>-test. Spearman's rank correlation was used to analyze the relationship between age and the quantitative indices. Reference values for MU% and EF% were determined using the 5^th percentile and the mean - 1.645 × standard deviation, respectively.</p><p><strong>Results: </strong>On visual analysis, parotid glands showed higher radiotracer uptake than submandibular glands. The dynamic scintigram displayed three distinct phases: accumulation, excretion, and re-accumulation. EF% was significantly higher in parotid than submandibular glands (<i>P</i> < 0.0001). No significant gender differences were found in MU% (<i>P</i> ≥ 0.422), but females had higher EF% in the parotid glands (<i>P</i> = 0.004) and a trend toward higher EF% in submandibular glands (<i>P</i> = 0.058). A weak positive correlation was noted between age and the MU% of the submandibular glands (Spearman's <i>ρ</i> = 0.391, <i>P</i> = 0.036). The reference cutoffs for MU% and EF% were determined to be ≥0.23% and ≥50% for parotid glands and ≥0.18% and ≥32% for submandibular glands, respectively.</p><p><strong>Conclusion: </strong>This study established normative data of dSGS for evaluating salivary gland function. Further research with larger cohorts is recommended to explore age and gender variations and to validate these findings across diverse populations.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"197-203"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Interesting Case of Sister Mary Joseph's Nodule Revealed by ¹⁸F-FDG PET.","authors":"Salah Nabih Oueriagli, Omar Ait Sahel, Yassir Benameur, Abderrahim Doudouh","doi":"10.4103/ijnm.ijnm_34_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_34_25","url":null,"abstract":"<p><p>The Sister Mary Joseph's nodule is a rare umbilical metastatic lesion, occurring in 1%-3% of abdominopelvic adenocarcinomas. It represents the visible tip of the iceberg, and its presence is associated with a poor prognosis. We report the case of a 61-year-old postmenopausal female patient with rectosigmoid adenocarcinoma. An ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET) scan revealed, in addition to a large sigmoid mass, multiple hypermetabolic lumbo-aortic lymphadenopathies, secondary hypermetabolic pulmonary and hepatic nodules, and a large subcutaneous umbilical nodule consistent with a Sister Marie Joseph's nodule. This case supports the systematic use of ¹⁸F-FDG PET in oncologic evaluations involving suspicious umbilical nodules.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"263-264"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Features of Neurosarcoidosis in FDG PET/CT.","authors":"Anjali Prakash, Shagos Gopalan Nair Santhamma, C Ashwini, Sandeep Padmanabhan","doi":"10.4103/ijnm.ijnm_63_25","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_63_25","url":null,"abstract":"<p><p>Sarcoidosis is a systemic noncaseating granulomatous immune-mediated disease with multiorgan involvement. Neurosarcoidosis was historically reported to occur in 5%-10% of all patients with sarcoidosis. Neurosarcoidosis can present with a myriad of clinical symptoms, including cranial neuropathy, myelopathy, and parenchymal involvement. Conventional imaging is often nonspecific and central nervous system biopsy to confirm the diagnosis is infrequently performed. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful modality in the evaluation of neurosarcoidosis, for assessing systemic involvement and identifying biopsiable site. We present the case of neurosarcoidosis with FDG PET/CT detected rare cranial and spinal radiculopathy lesions apart from other systemic findings.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"267-268"},"PeriodicalIF":0.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Metastases to Liver and Spleen form a Seldom Case of Facial Angiosarcoma Demonstrated on Staging FDG PET-CT.","authors":"Sambit Sagar, Dikhra Khan, Rahul Viswanathan, Prateek Kaushik, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_104_22","DOIUrl":"10.4103/ijnm.ijnm_104_22","url":null,"abstract":"<p><p>Angiosarcoma is a rare type of soft-tissue sarcoma, constituting only 1% out of all soft-tissue sarcomas pathologically originating from lymphatic or vascular endothelial cells. Angiosarcomas are reported to be very aggressive with a high incidence of metastases to different sites; therefore, it is very important to determine disease extension and detect local recurrence and/or distant metastases for appropriate management. We report a case of a 55-year-old Indian male who presented with soft-tissue thickening of the left cheek for which biopsy revealed angiosarcoma and was referred for fludeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) to assess the extent of disease highlighting the potential role of FDG PET/CT in rare malignancies like angiosarcomas.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"168-169"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Region-of-interest Selection on Ejection Fraction Calculation in a Septate Gallbladder.","authors":"Anas Al-Zubaidi, Thomas Radle, Maidane Araujo, Rajesh Kumar, Peeyush Bhargava","doi":"10.4103/ijnm.ijnm_136_24","DOIUrl":"10.4103/ijnm.ijnm_136_24","url":null,"abstract":"<p><p>A 62-year-old woman with chronic nausea and epigastric pain underwent hepatobiliary scintigraphy. Gallbladder ejection fraction (GBEF) calculation suggested normal function. However, upon further review, a septate gallbladder was identified. This promoted a re-evaluation of the selected region of interest (ROI). The initial ROI included only the gallbladder fundus, leading to GBEF overestimation. Recalculation with a comprehensive ROI that encompassed both compartments yielded a lower GBEF, consistent with biliary dyskinesia or chronic cholecystitis. This case highlights the importance of ROI selection for accurate assessment of GBEF calculation in anatomical variations such as septate gallbladder and correlating functional studies with anatomical imaging.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"174-175"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}