Indian Journal of Nuclear Medicine最新文献

{"title":"Rare Pituitary Metastasis from Adenocarcinoma of Right Lung in ¹⁸F FDG PET/CT.","authors":"Srijani Mandal, T Kishan Subudhi, Santosh C Kannur, Girish Kumar Parida, Manoj Kumar Nayak, P Sai Sradha Patro, Kanhaiyalal Agrawal","doi":"10.4103/ijnm.ijnm_25_25","DOIUrl":"10.4103/ijnm.ijnm_25_25","url":null,"abstract":"<p><p>Lung cancer is the leading cause of cancer and cancer-related deaths, and India ranks the fourth highest country. Lung cancer is a highly aggressive malignancy with a tendency for rapid progression, making early detection and prompt treatment essential for improving patient outcomes. Lung cancer can spread locally into surrounding tissue as well as travel through lymphatics to other parts of the body, most often to bone, brain, liver, and adrenal glands. Metastasis to pituitary and pineal glands is extremely rare. The differential diagnosis for pituitary metastasis could be pituitary adenoma where lesion usually lies at the anterior aspect of pituitary fossa, whereas metastasis is seen at the posterior aspect. There is a paucity of published literature, with only a few cases reported of pituitary and pineal gland metastasis. Hence, to add to the literature, we present a case of pituitary metastasis in an older woman with lung cancer.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"178-180"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of SPECT/CT in Non-Traumatic Osteonecrosis: Revisited with New Insights from a Prospective Diagnostic Study.","authors":"Mangu Srinivas Bharadwaj, Vir Singh Negi, Deepak Barathi, Madhusudhanan Ponnusamy","doi":"10.4103/ijnm.ijnm_13_25","DOIUrl":"10.4103/ijnm.ijnm_13_25","url":null,"abstract":"<p><strong>Objectives: </strong>Bone scintigraphy is a sensitive imaging method to evaluate patients with suspected osteonecrosis. We assessed the diagnostic performance of combined bone single-photon emission computed tomography/computed tomography (SPECT/CT) (CBS) in patients with known rheumatic disease or other connective tissue disorders and clinical suspicion of osteonecrosis compared to magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This prospective diagnostic accuracy study included 70 patients with clinical suspicion of osteonecrosis in any bone who underwent a planar triple-phase bone scan along with a regional SPECT/CT (CBS) and regional MRI. MRI was considered the standard for diagnosing the sensitivity, specificity, predictive values, and accuracy of CBS. Cohen's kappa statistic of the agreement was also calculated.</p><p><strong>Results: </strong>The distribution of the patients based on the joint regions suspected to have osteonecrosis is as follows: 21 hip, 43 knee, and six ankle. MRI detected osteonecrosis in 30/70 patients. CBS had a sensitivity of 100% (30/70 were detected) and a specificity of 97% (2/40 were false positive). Overall, there was good agreement between the two scans regarding the diagnosis of osteonecrosis (Cohen's kappa statistic = 0.94). In addition to the suspected sites, CBS detected osteonecrosis in 19 additional asymptomatic sites in 13 patients.</p><p><strong>Conclusion: </strong>The study has demonstrated that CBS, which includes whole-body imaging and SPECT/CT, is highly sensitive in detecting osteonecrosis with accuracy comparable to regional MRI. Its inherent whole-body imaging technique enabled the detection of multifocal osteonecrosis. It can be used as an early investigating modality after routine plain radiography to establish the diagnosis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"127-135"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of ¹⁸F-FDG-avid Renomegaly as the Initial Presentation of Acute Lymphoblastic Leukemia.","authors":"Vineet Mishra, Prakash Singh, Shiwangi Yadav","doi":"10.4103/ijnm.ijnm_122_24","DOIUrl":"10.4103/ijnm.ijnm_122_24","url":null,"abstract":"<p><p>Acute lymphoblastic leukaemia (ALL) is a prevalent cause of paediatric leukaemia. Patients with ALL typically exhibit symptoms such as fever, bleeding, weight loss, and bone pain. Blood investigations results predominantly show anaemia and pancytopenia with blast cells in the peripheral smear. While ALL primarily affects the bone marrow, it can also impact nearly every organ. There have been previous reports of extramedullary involvement of multiple organs in cases of ALL. This case represents a rare occurrence of ¹⁸F-fluorodeoxyglucose (FDG) avid symmetrically enlarged kidneys as initial presentation of ALL.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"170-171"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Tc-99m MDP Activities in Multifocal Atypical Ossifying Fibromyxoid Tumor.","authors":"Hui Ming, Yuanhao Chen, Xun Sun, Hui Yu","doi":"10.4103/ijnm.ijnm_28_25","DOIUrl":"10.4103/ijnm.ijnm_28_25","url":null,"abstract":"<p><p>This case demonstrates extraosseous technetium-99m methylene diphosphonate (Tc-99m MDP) accumulation from an atypical ossifying fibromyxoid tumor (OFMT). A 63-year-old man presented with a 10-year history of a gradually enlarging, painless back mass. Physical examination revealed multiple hard, nontender subcutaneous nodules without signs of inflammation or pigmentation. Computed tomography scan of the back showed calcified masses. Whole-body bone scintigraphy revealed areas of increased Tc-99m MDP uptake in subcutaneous regions, suggesting extraosseous uptake. Histopathological examination of the back mass confirmed the diagnosis of atypical OFMT.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"181-182"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of 1,3,4,6-Tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose Triflate) Precursor for the Production of [¹⁸F] FDG.","authors":"K S Ali Muhammad, Jaise Mariya George, Raviteja Nanabala, Anitta Antony, K Anees Muhammed, Dilshad Kottuparamban, Junais Pokkat, P K Arun, Shinooj Maniyoth Kuni, Vishnunath Pazhakkal, Thomas George, Maroor Raghavan Ambikalamajan Pillai","doi":"10.4103/ijnm.ijnm_102_24","DOIUrl":"10.4103/ijnm.ijnm_102_24","url":null,"abstract":"<p><strong>Purpose of the study: </strong>1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (mannose triflate), the precursor used for the synthesis of [¹⁸F] Fluorodeoxyglucose ([¹⁸F] FDG) is imported from a few commercial suppliers abroad. As part of self-reliance, a reliable synthesis and characterization of mannose triflate has been developed, details of which are reported in this paper.</p><p><strong>Materials and methods: </strong>Synthesis of 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β-D-mannopyranose (Mannose triflate) carried by Triflation of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose with Tf2O-pyridine under argon atmosphere for 6 h. Synthesized mannose triflate is used for the production of [¹⁸F] FDG using siemens explora FDG-4-automated module.</p><p><strong>Results: </strong>Starting from 2.6 g of 1,3,4,6-Tetra-O-acetyl-β-D-mannopyranose, mannose triflate was synthesized with an overall yield of ~ 3.0 g (~80%). The synthesis was systematically scaled up to 52 g based on the experience from the initial small size batches. The characterization of the product was done by Infra Red, Nuclear Magnetic Resonance and Mass spectroscopy. The precursor was used in the manufacture of [¹⁸F] FDG using Siemens Explora synthesis module. Radiochemical yields of 55% ± 2% (decay uncorrected), radiochemical purity >96% were obtained which is comparable with the imported precursor. All the quality control parameters were within the limits as per pharmacopoeia when the in-house synthesized mannose triflate was used.</p><p><strong>Conclusion: </strong>A large-scale preparation of mannose triflate is now carried out to satisfy the growing needs for FDG in positron emission tomography centers and hospitals.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"146-151"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Utility of FDG PET-CT in Metastatic Recurrent Extra Skeletal Renal Osteosarcoma.","authors":"John Pathak, Dikhra Khan, Shamim Ahmed Shamim, Sambit Sagar, Sameer Rastogi","doi":"10.4103/ijnm.ijnm_83_22","DOIUrl":"10.4103/ijnm.ijnm_83_22","url":null,"abstract":"<p><p>Metastatic renal osteosarcoma is a rare entity. We report a case of a 52-year-old male postright nephrectomy status presented to us with metastatic renal osteosarcoma. 18-fluorine- fluorodeoxyglucose (¹⁸F-FDG) avid lesions were seen in the right renal bed with extension to adjacent hepatic parenchyma. The patient exhibited a favorable response to 6 cycles of carboplatin and doxorubicin with no FDG avid lesions in the postchemotherapy follow-up scan. On 6-month follow-up scan, scan findings reveal a recurrent lesion at the renal bed region infiltrating psoas muscle and liver metastatic lesion. This case highlights the use of ¹⁸F-FDG positron emission tomography/computed tomography in metastatic recurrent extraskeletal osteosarcoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"166-167"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Brain Tumor Treatment through Nanotechnology and Proton Therapy Using Laser-driven Accelerators through GEANT4 Simulation.","authors":"Mehdi Kavehnia, Hossein Sadeghi, Seyede Nasrin Hosseinimotlagh","doi":"10.4103/ijnm.ijnm_167_24","DOIUrl":"10.4103/ijnm.ijnm_167_24","url":null,"abstract":"<p><strong>Background: </strong>Another approach to improve the dose conformity is to use charged particles like protons instead of the conventional X- and γ-rays. Protons exhibit a specific depth-dose distribution which allows to achieve a more targeted dose deposition and a significant sparing of healthy tissue behind the tumor. In particular, proton therapy has, therefore, become a routinely prescribed treatment for tumors located close to sensitive structures. Moreover, the track structure and energy transfer of protons is different from those of photons which can provide advantages in terms of biological effectiveness. Furthermore, the application of nanotechnology in radiotherapy also offers interesting approaches to improve the therapeutic index.</p><p><strong>Methods: </strong>Therefore, in this work, we first introduce the water phantom and simultaneously inject high-energy protons into it through a pencil beam and 50 nm nanoparticles (NPs) with different concentrations and investigate the increase in the absorbed dose. Then, we present a more realistic model of brain tumor and study the increase in the absorbed dose in the activated tumor in two cases with and without the injection of gold, silver, and platinum NPs into the brain phantom. The simulation software used in this article is GEANT4.</p><p><strong>Results: </strong>As can be seen from this work, the absorbed dose with the injection of NPs at an energy of 150 MeV is, in order, from highest to lowest, related to platinum, gold, silver, and finally water without the injection of NPs, and this is due to the fact that the number of secondary electrons produced by platinum is more than gold, gold is more than silver and silver is more than water (Pt>Au>Ag>W).</p><p><strong>Conclusion: </strong>This work shows that the optimum energy deposited in the Bragg curve at the end of the brain tumor is 110 MeV.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"136-145"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nuclear Medicine Facility in Northeastern Part of India, at Silchar - Genesis and Glimpses on Difficulties in Extending Patient Care.","authors":"Ramamoorthy Ravichandran, Tarani Mondal, Ravi Kannan","doi":"10.4103/ijnm.ijnm_41_25","DOIUrl":"10.4103/ijnm.ijnm_41_25","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"185-187"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Banana-like Appearance of Rib Fibrous Dysplasia in Bone Scintigraphy and Single-Photon Emission Computed Tomography (SPECT).","authors":"Nor Hasniza Abdul Halim, Idris Ibrahim, Nadia Mohamed Tarmizi, Mohd Hazeman Zakaria","doi":"10.4103/ijnm.ijnm_141_24","DOIUrl":"10.4103/ijnm.ijnm_141_24","url":null,"abstract":"<p><p>The patient, a 37-year-old male, initially presented with per rectal bleed. Colonoscopy revealed a circumferential lesion within the lower rectum, along with a few satellite lesions. At that time, we performed a biopsy, but the histopathological examination revealed consistent solitary rectal ulcer syndrome. Subsequent bone scan revealed increased radiotracer uptake at the left 6^th rib, resulting in a \"banana-like appearance\" and a ground glass appearance on the corresponding single-photon emission computed tomography (SPECT), in keeping with fibrous dysplasia. Given his asymptomatic state, the patient received reassurance and surveillance regarding his benign bone lesion.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"172-173"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallium-68-Pentixafor PET/CT for Subtyping Diagnosis of Primary Aldosteronism: A Pictorial Essay.","authors":"Sunny J Gandhi, Nikitha P Kunder, Sachin Gupta, Rushikesh Kute","doi":"10.4103/ijnm.ijnm_151_24","DOIUrl":"10.4103/ijnm.ijnm_151_24","url":null,"abstract":"<p><p>Primary aldosteronism (PA) is one of the prevalent causes of secondary hypertension, characterized by the autonomous hypersecretion of aldosterone and concurrent renin inhibition. Clinical and biochemical remission rates for patients with PA achieved through surgery are far higher compared to those achieved through drug treatment; hence, subtyping PA is crucial for identifying patients who will benefit most from surgery. Computed tomography (CT) scan with adrenal protocol and adrenal venous sampling (AVS) is used conventionally for PA subtype classification. CT scans, being structural imaging, cannot provide functional information, while AVS is an invasive, technically challenging method with a limited success rate and a high risk of complications. The C-X-C chemokine receptor type 4 (CXCR4) is overexpressed in aldosterone-producing tissue but is almost negligibly expressed in nonfunctional adenoma. The positron emission tomography tracer 68Ga-pentixafor, a specific ligand for CXCR4, can detect aldosterone-producing adenoma noninvasively, which can guide surgical treatment. The image series below demonstrates the utility and patterns of findings on Ga-68-pentixafor for subtyping PA.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 3","pages":"161-165"},"PeriodicalIF":0.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}