Indian Journal of Nuclear Medicine最新文献

{"title":"Impact of Teleradiology on Oncological Interpretation of PET-CT Scans.","authors":"Arjun Kalyanpur, Neetika Mathur","doi":"10.4103/ijnm.ijnm_31_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_31_24","url":null,"abstract":"<p><strong>Background: </strong>Cancer is a prime cause of death globally and accounted for about 10 million deaths in 2020. The accurate determination of the extent of disease is crucial for treatment conceptualization and planning. The aim of the present study was to assess the role of teleradiology in the oncological interpretation of positron emission tomography-computed tomography (PET-CT) scans.</p><p><strong>Materials and methods: </strong>In this retrospective study, a total of 1137 PET-CT scans of a cohort of 1057 patients from hospitals in India, the US and Nepal were uploaded to the teleradiology cloud server and interpreted by board certified radiologists empanelled by a teleradiology service provider.</p><p><strong>Results: </strong>The telehealth model proposed in the study was seen to provide timely and quality reporting of all PET- CT studies with a mean turnaround time of 20.06 h 95% confidence interval (19.35-20.78).</p><p><strong>Conclusion: </strong>The early-stage diagnosis of cancer before it has progressed or metastasized is crucial for the immediate treatment conceptualization and plan and improves the prognosis for long-term survival of the patient. Teleradiology is an important tool in the field of oncology, providing rapid and accurate interpretation of imaging findings, essential for appropriate treatment planning.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"436-440"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Muscular NK/T Cell Lymphoma: A Rare Presentation of Post-Transplant Lymphoproliferative Disorders.","authors":"Srishti Srivastava, Parag Jilhare, Aftab Hasan Nazar, Manish Ora, Sanjay Gambhir","doi":"10.4103/ijnm.ijnm_108_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_108_24","url":null,"abstract":"<p><p>Posttransplant lymphoproliferative disorders (PTLDs) represent a spectrum of malignancies occurring in transplant recipients under immunosuppression, often linked with Epstein-Barr Virus infection. PTLD has a varied presentation, and isolated muscular involvement is infrequent. Here, we present the case of a 47-year-old female renal transplant recipient presenting with acute left knee joint swelling, initially suggestive of an infective or inflammatory etiology. Biopsy revealed high-grade non-Hodgkin lymphoma of natural killer/T-cell lymphoma. F-18 Fluorodeoxyglucose positron emission tomography-computed tomography scan revealed metabolically active soft tissue mass lesions isolated to thigh muscles. The patient was on a modified chemotherapy regimen tailored to accommodate renal function. This case underscores the necessity for heightened vigilance in diagnosing PTLD, particularly considering its atypical presentations.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"457-459"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Pattern of Brain Metabolism in Drug-naive versus Refractory OCD using [18F]-FDG PET/MRI Brain.","authors":"Shailesh Jha, Amarnath Jena, Prerana Rana, Achal Bhagat","doi":"10.4103/ijnm.ijnm_112_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_112_24","url":null,"abstract":"<p><p>Obsessive-compulsive disorder is among the most extensively researched mental health disorder. Various metabolic neuroimaging research findings are consistent but still nonconclusive. The major limitation is a homogeneous sample. There are research findings which have established the impact of treatment in changing brain metabolism. Therefore, it is important to highlight differential metabolic changes with respect to treatment staging and its outcome. It will also help to individualized neuromodulation protocol based on differential metabolic findings. This study highlights the distinct differential fluorodeoxyglucose metabolic changes among two distinct cases: drug-naïve and treatment-refractory.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"449-453"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Time of Diagnostic and Posttherapeutic Iodine-131 Whole-body Scan in Post-Operative Pediatric and Young Adult Differentiated Thyroid Cancer Patients.","authors":"Praveen Kumar, Chandrasekhar Bal, Nishikant Avinash Damle","doi":"10.4103/ijnm.ijnm_133_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_133_24","url":null,"abstract":"<p><strong>Purpose of the study: </strong>The 2015 American Thyroid Association pediatric differentiated thyroid cancer (DTC) guidelines recommend posttherapy whole body scan (PTS) 4-7 days after (Iodine-131) I-131 activity administration. There is no recommendation of timing of performing a diagnostic whole-body scan (Dx-WBS). However, this 4-7 day time frame for PTS lacks a solid basis and is essentially arbitrary. This is especially crucial as it has the potential to significantly impact patient management. Our primary goal in this study was to establish the optimal timing for both Dx-WBS and PTS in pediatric and young adult patients with DTC.</p><p><strong>Methods: </strong>The DTC patients aged ≤21 years underwent serial whole-body scan (WBS) at 24 h, 48 h, and/or 72 h or more after the administration of diagnostic and therapeutic activities of I-131. The utility of Dx-WBS and PTS was assessed based on the identification of new lesions that could potentially influence the prescribed therapeutic activity of I-131. The optimal timing for acquiring Dx-WBS and PTS was determined based on when the first lesion appeared in the I-131 WBS.</p><p><strong>Results: </strong>Ninety-five patients (27 males and 68 females) with an average age of 17.9 ± 3 years received a 74 MBq I-131 for Dx-WBS. Ten patients (10.5%) showed no uptake in Dx-WBS, thus, no I-131 therapy was given. The remaining 85 patients received a therapeutic activity of 1.11-5.55 GBq I-131 based on the extent of their disease. The serial Dx-WBS or PTS showed no additional lesions in patients with thyroid remnants. However, additional nodes were detected in 2/32 patients in the ≥48 h Dx-WBS, and 1/32 patients in the known nodal disease patients, which were not clinically relevant. Importantly, 72 h PTS picked up pulmonary metastases in 17.6% (3 out of 17) of patients, which were missed in serial Dx-WBS. However, >72 h PTS did not have additional value.</p><p><strong>Conclusion: </strong>I-131 Dx-WBS is best to be performed at 48 h, and PTS at 72 h in pediatric and young adult patients with DTC.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"428-435"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Primary Aldosteronism with Negative ⁶⁸Ga-Pentixafor PET/CT and Positive FDG-PET/CT in a Left Adrenal Adenoma.","authors":"Aamir Nazar, Gaurav Malhotra, Sandip Basu","doi":"10.4103/ijnm.ijnm_150_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_150_24","url":null,"abstract":"<p><p>A 65-year-old male with systemic hypertension, progressively rising aldosterone levels, low plasma renin activity, contrast Magnetic resonance imaging (MRI) described left adrenal lesion isointense to liver parenchyma on T2-weighted images and other features suggestive of left adrenal incidentaloma underwent ⁶⁸Ga-Pentixafor Positron emission tomography-computed tomography (PET/CT), which unexpectedly did not show tracer uptake in the known left adrenal adenoma. However, the said nodule showed significant focal tracer uptake on F-18 Fluorodeoxyglucose (FDG)-PET/CT that was done within 2 weeks of ⁶⁸Ga-Pentixafor PET/CT study. This unusual finding, which has hitherto been unreported in known patients of primary aldosteronism needs further exploration to determine its clinical significance.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"472-474"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SSTR Expressing Mediastinal Ectopic Thyroid: A Rarity Unveiled.","authors":"Yogita Khandelwal, Nishikant Avinash Damle, Mohit Kumar Joshi, Aruna Nambiranjan, Surabhi Jain, Rajinder Parshad","doi":"10.4103/ijnm.ijnm_88_24","DOIUrl":"https://doi.org/10.4103/ijnm.ijnm_88_24","url":null,"abstract":"<p><p>Rarely, ectopic thyroid tissue can coexist with an eutopic thyroid. Technetium pertechnetate scan is peculiar for thyroid tissue uptake. However, DOTANOC uptake in mediastinal ectopic thyroid has been rarely reported. We present a unique case of an ectopic mediastinal thyroid mass that did not show any uptake on a pertechnetate scan and showed significantly increased uptake on ⁶⁸Ga-DOTANOC positron emission tomography-computed tomography with an eutopic cervical thyroid with normal pertechnetate and physiological mild DOTANOC uptake.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 6","pages":"469-471"},"PeriodicalIF":0.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]FDG- PET/CT in Diagnosis, Staging, and Management of Patients with Langerhans Cell Histiocytosis.","authors":"V M Vimala Priyadharshini, Indirani Muthukrishnan, Dinesh Kumar Gauthaman, Shelley Simon","doi":"10.4103/ijnm.ijnm_46_24","DOIUrl":"10.4103/ijnm.ijnm_46_24","url":null,"abstract":"<p><strong>Background: </strong>Langerhans cell histiocytosis (LCH), a rare hematological disorder, presents significant diagnostic challenges due to its varied clinical manifestations. This study aims to analyse the use of F-18 fluoro-deoxy-glucose positron emission tomography computed tomography (F-18 FDG PET/CT) in diagnosis, staging, and management of LCH.</p><p><strong>Materials and methods: </strong>Fifty-nine patients with LCH were included, who underwent a total of ninety-three F-18 FDG PET/CT scans (including follow-up scans in 19 patients). The sites of abnormal FDG uptake were assessed and the maximum standardized uptake value was measured in all the scans.</p><p><strong>Results: </strong>Twenty-five patients (42.4%) had single system LCH (SS-LCH) and 34 patients (57.6%) had multisystem involvement LCH, 49/59. The most common sites of LCH involvement were bones (49/59, 83.1%) and lymph nodes (39/59, 44.9%). 12/59 patients (20.3%) had unifocal SS-LCH bone lesions, mostly in skull. The other common sites involved were lungs, liver, spleen, marrow, skin, and soft tissues. Less commonly involved sites included pancreas (2 cases), occipital lobe (1 case), and bowel (1 case). PET/CT was used in response assessment in 19 patients and helped in initiation of second line chemotherapy in cases of disease progression (2 cases) and relapse (2 cases). Seven cases with clinical suspicion were diagnosed as LCH based on lesion characteristics and FDG uptake, which were later biopsy proven.</p><p><strong>Conclusion: </strong>F-18 FDG PET/CT revealed morphological and metabolic characteristics of LCH lesions, aiding in accurate diagnosis, assessment of disease burden, and prognostication, thereby can be used as a comprehensive imaging tool in management of LCH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"341-346"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Manuscript Preparation: Are We Becoming Dependent on Machines?","authors":"Himel Mondal","doi":"10.4103/ijnm.ijnm_130_24","DOIUrl":"10.4103/ijnm.ijnm_130_24","url":null,"abstract":"","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"415-416"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Focal Lesions on Overall and Progression-free Survival in Multiple Myeloma.","authors":"Tugcan Alp Kirkizlar, Onur Kirkizlar, Selin Soyluoglu, Elif Gulsum Umit, Funda Ustun, Ahmet Muzaffer Demir","doi":"10.4103/ijnm.ijnm_131_24","DOIUrl":"10.4103/ijnm.ijnm_131_24","url":null,"abstract":"<p><strong>Purpose: </strong>In this study, we aimed to reveal the incidence of ≥3 focal lesions (FLs) and analyze overall survival (OS) and progression-free survival (PFS) according to the number of FLs, as well as to identify mortality and PFS risk factors, in our newly diagnosed multiple myeloma (NDMM) patients.</p><p><strong>Materials and methods: </strong>A total of 89 NDMM patients who underwent ¹⁸F-FDG positron emission tomography/computerized tomography (PET/CT) imaging were included in the study.</p><p><strong>Results: </strong>While 57.3% of the patients had ≥3 FLs, 20.2% had no FL. The median OS and PFS were 55 and 43 months, respectively. The median survival time was 49 months for patients with ≥3 FLs and 101 months for patients with <3 FLs, with a statistically significant difference (<i>P</i> = 0.049). The median PFS was 34 months in patients with ≥3 FLs and 67 months in patients with <3 FLs; this difference was also statistically significant (<i>P</i> = 0.026). The difference in median survival was statistically significant, based on whether autologous stem cell transplantation (ASCT) was performed and the number of FLs (≥3 or <3) (<i>P</i> = 0.011). In the multivariate regression analysis, ≥3 FLs was not a predictor of mortality but was a risk factor for PFS.</p><p><strong>Conclusion: </strong>In our study, we observed significantly worse OS and PFS in patients with ≥3 FLs at diagnosis, and it is noteworthy that the OS was worse in those patients who did not undergo ASCT. ¹⁸F-FDG PET/CT is a feasible imaging technique for the prediction of prognosis in the initial evaluation of NDMM, and we believe that consolidation with ASCT as a modifiable factor, especially in patients with ≥3 FLs, will lead to a more favorable prognosis.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"353-359"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-induced Activated White Adipose Tissue on FDG PET-CT.","authors":"Ashique Rehman, Tejasvini Singhal, Parneet Singh, Girish Kumar Parida, Kanhaiyalal Agrawal, P Sai Sradha Patro, T Kishan Subudhi, Sunita Gupta","doi":"10.4103/ijnm.ijnm_94_24","DOIUrl":"10.4103/ijnm.ijnm_94_24","url":null,"abstract":"<p><p>White adipose tissue (WAT) generally has negligible glucose utilization and thus, shows no or insignificant Fluorine-18 fluoro D-glucose (FDG) uptake. However, corticosteroids can cause altered biodistribution of FDG with increased uptake in WAT. We hereby describe a case of immune complex-mediated glomerulonephritis showing diffusely increased FDG uptake in WAT secondary to high-dose corticosteroid therapy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"39 5","pages":"409-410"},"PeriodicalIF":0.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}