Deepanksha Datta, Prateek Bisht, Y T Yogananda, Rajesh Kumar
{"title":"在印度北部的一项回顾性队列研究中，PET/CT显示胆囊内18F - FDG的生理摄取。","authors":"Deepanksha Datta, Prateek Bisht, Y T Yogananda, Rajesh Kumar","doi":"10.4103/ijnm.ijnm_31_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong><sup>18</sup>F fluoro 2-deoxy-D-glucose (FDG) uptake in positron emission tomography/computed tomography (PET/CT) scans is commonly observed in the brain, myocardium, liver, intestines, and excretory pathways such as kidneys and the urinary bladder. This study examines the incidence and contributing factors for physiological FDG accumulation in the gallbladder (GB) lumen, in the absence of clinical history or anatomical abnormalities.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted at a North Indian tertiary care hospital on patients who underwent <sup>18</sup>F FDG PET/CT between January and August 2024. The study group included individuals with GB intraluminal FDG uptake exceeding blood pool levels without anatomical changes, while the control group comprised patients without GB uptake. Comparisons were made based on body mass index, fasting blood sugar, FDG dose, time-to-scan interval, and SUVmax (standardized uptake value). Mann-Whitney <i>U</i>-test was employed for statistical analysis.</p><p><strong>Results: </strong>Among 632 screened patients, 82 (13%) exhibited GB FDG uptake, whereas 149 were randomly selected for the control group. The study group showed significantly higher fasting blood sugar (101 [24] vs. 93 [18] mg/dl, <i>P</i> = 0.007), FDG dose (6.8 [2.5] vs. 6 [2.3] mCi, <i>P</i> < 0.001), and longer time to scan (82 [54] vs. 78 [38] min, <i>P</i> = 0.02). The median SUVmax for GB uptake was 2.1 (0.93) g/ml.</p><p><strong>Conclusion: </strong>Physiological GB FDG uptake occurs in about 13% of patients. Increased fasting blood sugar, higher FDG dose, and prolonged scan intervals elevate the likelihood of GB uptake.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"218-221"},"PeriodicalIF":0.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503175/pdf/","citationCount":"0","resultStr":"{\"title\":\"Physiological Intraluminal Uptake of <sup>18</sup>F FDG in Gallbladder on PET/CT - A Retrospective Cohort study in North India.\",\"authors\":\"Deepanksha Datta, Prateek Bisht, Y T Yogananda, Rajesh Kumar\",\"doi\":\"10.4103/ijnm.ijnm_31_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong><sup>18</sup>F fluoro 2-deoxy-D-glucose (FDG) uptake in positron emission tomography/computed tomography (PET/CT) scans is commonly observed in the brain, myocardium, liver, intestines, and excretory pathways such as kidneys and the urinary bladder. This study examines the incidence and contributing factors for physiological FDG accumulation in the gallbladder (GB) lumen, in the absence of clinical history or anatomical abnormalities.</p><p><strong>Materials and methods: </strong>This retrospective study was conducted at a North Indian tertiary care hospital on patients who underwent <sup>18</sup>F FDG PET/CT between January and August 2024. The study group included individuals with GB intraluminal FDG uptake exceeding blood pool levels without anatomical changes, while the control group comprised patients without GB uptake. Comparisons were made based on body mass index, fasting blood sugar, FDG dose, time-to-scan interval, and SUVmax (standardized uptake value). Mann-Whitney <i>U</i>-test was employed for statistical analysis.</p><p><strong>Results: </strong>Among 632 screened patients, 82 (13%) exhibited GB FDG uptake, whereas 149 were randomly selected for the control group. The study group showed significantly higher fasting blood sugar (101 [24] vs. 93 [18] mg/dl, <i>P</i> = 0.007), FDG dose (6.8 [2.5] vs. 6 [2.3] mCi, <i>P</i> < 0.001), and longer time to scan (82 [54] vs. 78 [38] min, <i>P</i> = 0.02). The median SUVmax for GB uptake was 2.1 (0.93) g/ml.</p><p><strong>Conclusion: </strong>Physiological GB FDG uptake occurs in about 13% of patients. Increased fasting blood sugar, higher FDG dose, and prolonged scan intervals elevate the likelihood of GB uptake.</p>\",\"PeriodicalId\":45830,\"journal\":{\"name\":\"Indian Journal of Nuclear Medicine\",\"volume\":\"40 4\",\"pages\":\"218-221\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503175/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Nuclear Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ijnm.ijnm_31_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnm.ijnm_31_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
引用次数: 0
摘要
目的：在正电子发射断层扫描/计算机断层扫描（PET/CT）中，通常在脑、心肌、肝脏、肠道和排泄途径（如肾脏和膀胱）中观察到18F氟2-脱氧-d -葡萄糖（FDG）摄取。本研究在没有临床病史或解剖异常的情况下，探讨了FDG在胆囊（GB）腔内的生理性蓄积的发生率和影响因素。材料和方法：本回顾性研究在北印度一家三级医院进行，研究对象为2024年1月至8月期间接受18F FDG PET/CT检查的患者。研究组包括GB腔内FDG摄取超过血池水平且无解剖改变的个体，而对照组包括没有GB摄取的患者。根据体重指数、空腹血糖、FDG剂量、扫描时间间隔和SUVmax（标准化摄取值）进行比较。采用Mann-Whitney u检验进行统计分析。结果：在632例筛查患者中，82例（13%）表现出GB FDG摄取，而对照组随机选择149例。研究组的空腹血糖（101[24]比93 [18]mg/dl， P = 0.007）、FDG剂量（6.8[2.5]比6 [2.3]mCi, P < 0.001）和扫描时间（82[54]比78 [38]min， P = 0.02）显著升高。GB摄取的中位SUVmax为2.1 (0.93)g/ml。结论：约13%的患者发生GB FDG生理性摄取。空腹血糖升高，FDG剂量增加，扫描间隔延长，会增加摄取GB的可能性。
Physiological Intraluminal Uptake of 18F FDG in Gallbladder on PET/CT - A Retrospective Cohort study in North India.
Purpose: 18F fluoro 2-deoxy-D-glucose (FDG) uptake in positron emission tomography/computed tomography (PET/CT) scans is commonly observed in the brain, myocardium, liver, intestines, and excretory pathways such as kidneys and the urinary bladder. This study examines the incidence and contributing factors for physiological FDG accumulation in the gallbladder (GB) lumen, in the absence of clinical history or anatomical abnormalities.
Materials and methods: This retrospective study was conducted at a North Indian tertiary care hospital on patients who underwent 18F FDG PET/CT between January and August 2024. The study group included individuals with GB intraluminal FDG uptake exceeding blood pool levels without anatomical changes, while the control group comprised patients without GB uptake. Comparisons were made based on body mass index, fasting blood sugar, FDG dose, time-to-scan interval, and SUVmax (standardized uptake value). Mann-Whitney U-test was employed for statistical analysis.
Results: Among 632 screened patients, 82 (13%) exhibited GB FDG uptake, whereas 149 were randomly selected for the control group. The study group showed significantly higher fasting blood sugar (101 [24] vs. 93 [18] mg/dl, P = 0.007), FDG dose (6.8 [2.5] vs. 6 [2.3] mCi, P < 0.001), and longer time to scan (82 [54] vs. 78 [38] min, P = 0.02). The median SUVmax for GB uptake was 2.1 (0.93) g/ml.
Conclusion: Physiological GB FDG uptake occurs in about 13% of patients. Increased fasting blood sugar, higher FDG dose, and prolonged scan intervals elevate the likelihood of GB uptake.
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