Anjali Prakash, Shagos Gopalan Nair Santhamma, C Ashwini, Sandeep Padmanabhan
{"title":"Imaging Features of Neurosarcoidosis in FDG PET/CT.","authors":"Anjali Prakash, Shagos Gopalan Nair Santhamma, C Ashwini, Sandeep Padmanabhan","doi":"10.4103/ijnm.ijnm_63_25","DOIUrl":null,"url":null,"abstract":"<p><p>Sarcoidosis is a systemic noncaseating granulomatous immune-mediated disease with multiorgan involvement. Neurosarcoidosis was historically reported to occur in 5%-10% of all patients with sarcoidosis. Neurosarcoidosis can present with a myriad of clinical symptoms, including cranial neuropathy, myelopathy, and parenchymal involvement. Conventional imaging is often nonspecific and central nervous system biopsy to confirm the diagnosis is infrequently performed. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful modality in the evaluation of neurosarcoidosis, for assessing systemic involvement and identifying biopsiable site. We present the case of neurosarcoidosis with FDG PET/CT detected rare cranial and spinal radiculopathy lesions apart from other systemic findings.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 4","pages":"267-268"},"PeriodicalIF":0.5000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503171/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Nuclear Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ijnm.ijnm_63_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/19 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
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Abstract
Sarcoidosis is a systemic noncaseating granulomatous immune-mediated disease with multiorgan involvement. Neurosarcoidosis was historically reported to occur in 5%-10% of all patients with sarcoidosis. Neurosarcoidosis can present with a myriad of clinical symptoms, including cranial neuropathy, myelopathy, and parenchymal involvement. Conventional imaging is often nonspecific and central nervous system biopsy to confirm the diagnosis is infrequently performed. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) is a useful modality in the evaluation of neurosarcoidosis, for assessing systemic involvement and identifying biopsiable site. We present the case of neurosarcoidosis with FDG PET/CT detected rare cranial and spinal radiculopathy lesions apart from other systemic findings.
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