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Molecular imaging findings with 18F-FDG and 68Ga-FAPI PET/CT in a case of chronic polyarthralgia. 慢性多关节痛1例18F-FDG和68Ga-FAPI PET/CT分子影像学表现。
IF 0.5
Indian Journal of Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2025-06-27 DOI: 10.4103/ijnm.ijnm_152_23
Aparna Mahalik, Sivasankar Kanankulam Velliangiri, Sanjana Ballal, Rakesh Kumar
{"title":"Molecular imaging findings with <sup>18</sup>F-FDG and <sup>68</sup>Ga-FAPI PET/CT in a case of chronic polyarthralgia.","authors":"Aparna Mahalik, Sivasankar Kanankulam Velliangiri, Sanjana Ballal, Rakesh Kumar","doi":"10.4103/ijnm.ijnm_152_23","DOIUrl":"10.4103/ijnm.ijnm_152_23","url":null,"abstract":"<p><p>Positron emission tomography (PET) with <sup>18</sup>F-fluorodeoxyglucose for detection of active inflammation is well documented; however, the <i>in vivo</i> visualization of immune-mediated tissue remodeling has not been possible till date. With the recent development of <sup>68</sup>Ga-fibroblast activation protein inhibitors (FAPI), which specifically binds to the activated fibroblasts located around the synovium allowing for the visualization of mesenchymal and stromal activation process <i>in vivo</i>, it is possible to use this modality to use as an objective indicator of disease activity. We observed increased FAPI uptake around all the large joints of the bilateral upper and lower limbs of a chronic polyarthralgia patient. In view of the specificity of FAPI for the activated fibroblasts, the possibility of future therapeutic approach using FAPI must, therefore, be kept in mind.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 2","pages":"113-114"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful Management and Long-term Survival of Malignant Struma Ovarii with Radioactive Iodine Therapy. 放射性碘治疗卵巢恶性肿瘤的成功治疗和长期生存。
IF 0.5
Indian Journal of Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2025-06-27 DOI: 10.4103/ijnm.ijnm_4_25
Nimmagadda Ajit, Zakir Ali Abubacker, Prathyusha Bikkina, C B Virupakshappa
{"title":"Successful Management and Long-term Survival of Malignant Struma Ovarii with Radioactive Iodine Therapy.","authors":"Nimmagadda Ajit, Zakir Ali Abubacker, Prathyusha Bikkina, C B Virupakshappa","doi":"10.4103/ijnm.ijnm_4_25","DOIUrl":"10.4103/ijnm.ijnm_4_25","url":null,"abstract":"<p><p>Struma ovarii (SO) is a rare ovarian teratoma with predominant thyroid tissue. Malignant SO (MSO) occurs in 5%-10% of cases, with papillary and follicular thyroid carcinomas being the most common malignant types. The disease is typically diagnosed in women aged 40-60 years, and management protocols are not well defined due to its rarity. We report the case of a 37-year-old female who initially presented with vague abdominal pain and a complicated right ovarian cyst and who underwent right oophorectomy. Histopathology confirmed SO. Two years later, she experienced a recurrence with elevated cancer antigen 125 levels and a new left adnexal mass. The surgical intervention included total abdominal hysterectomy, with left Salpingo-ophorectomy and laparotomy revealing disseminated disease. A total thyroidectomy showed no malignancy, and the patient required multiple doses of radioactive iodine (RAI). Over 20 years, she received a cumulative dose of 1250 mCi of RAI and remains asymptomatic with stable disease. MSO is a rare tumor that often requires a combination of surgical intervention and RAI therapy for effective management. This case highlights the importance of a multidisciplinary approach, including surgery and RAI, in managing extensive or recurrent MSO, and provides insights into long-term management and outcomes.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 2","pages":"109-112"},"PeriodicalIF":0.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144745448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental Adrenal Histoplasmosis Revealed by FAPI PET-CT in an Immunocompetent Patient. 免疫功能正常患者的FAPI PET-CT显示偶发性肾上腺组织胞浆菌病。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_143_24
Sairam Doppalapudi, Ashish Mohite, Rumaanah Khan, Karuna Luthra
{"title":"Incidental Adrenal Histoplasmosis Revealed by FAPI PET-CT in an Immunocompetent Patient.","authors":"Sairam Doppalapudi, Ashish Mohite, Rumaanah Khan, Karuna Luthra","doi":"10.4103/ijnm.ijnm_143_24","DOIUrl":"10.4103/ijnm.ijnm_143_24","url":null,"abstract":"<p><p>A 77-year-old male presented with pyrexia of unknown origin. Chest computed tomography (CT) showed adrenal lesions, a suspicion of neoplasia was raised, and Fluorodeoxyglucose Positron Emission Tomography (FDG PET-CT) was recommended. Since the patient had uncontrolled diabetes (Fasting Blood Sugar - 326 mg/dL), FDG-PET was not feasible. The patient, therefore, underwent Ga68-Fibroblast Activating Protein Inhibitor - 46 PET-CT (FAPI PET-CT). Scan showed high-grade Fibroblast Activating Protein (FAP) expression in bilateral enlarged adrenals. Findings appeared atypical for malignancy and the possibility of chronic inflammatory/infectious condition was raised. Biopsy proved adrenal histoplasmosis (AH). Although FDG avidity in AH is known and previously reported, this is best to our knowledge the first literature documentation of FAP expression in AH.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"49-50"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unexpectedly Low FDG and FAPI Uptake in Mucosal Melanoma: Case Report with Literature Review. 黏膜黑色素瘤中FDG和FAPI摄取异常低：病例报告并文献复习。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_123_24
Nimmagadda Ajit, Prathyusha Bikkina, Zakir Ali Abubacker, C B Virupakshappa, S Lm Chandrasekhar Rao, Koyye Ravindranath Tagore, Suseela Kodandapani
{"title":"Unexpectedly Low FDG and FAPI Uptake in Mucosal Melanoma: Case Report with Literature Review.","authors":"Nimmagadda Ajit, Prathyusha Bikkina, Zakir Ali Abubacker, C B Virupakshappa, S Lm Chandrasekhar Rao, Koyye Ravindranath Tagore, Suseela Kodandapani","doi":"10.4103/ijnm.ijnm_123_24","DOIUrl":"10.4103/ijnm.ijnm_123_24","url":null,"abstract":"<p><p>Mucosal melanomas (MMs) represent a rare subset of melanomas arising from melanocytes in noncutaneous sites such as mucosal membranes of the head-and-neck, gastrointestinal, and genitourinary tracts. Unlike cutaneous melanomas, MMs often present late due to their occult nature, leading to a poor prognosis. Fluorine-18 fludeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is widely utilized for staging and monitoring melanomas, leveraging their characteristic high FDG avidity. Recently, fibroblast activation protein inhibitor (FAPI)-based PET/CT imaging has become a popular modality in the evaluation of various cancers. Here, we present a case of MM where FDG avidity was notably absent and mild FAPI avidity, despite the lesion's typical anatomical location and clinical suspicion. This case highlights an uncommon scenario within the literature and underscores the variability in radiotracer uptake observed in MMs, challenging conventional imaging expectations and potentially impacting clinical management decisions.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"32-35"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidental Finding of Acute Appendicitis on FDG PET/CT in Breast Carcinoma. 乳腺癌FDG PET/CT急性阑尾炎的偶然发现。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_68_24
Bela Jain, Yogita Khandelwal, Nishikant Avinash Damle, Madhavi Tripathi, Chandrasekhar Bal
{"title":"Incidental Finding of Acute Appendicitis on FDG PET/CT in Breast Carcinoma.","authors":"Bela Jain, Yogita Khandelwal, Nishikant Avinash Damle, Madhavi Tripathi, Chandrasekhar Bal","doi":"10.4103/ijnm.ijnm_68_24","DOIUrl":"10.4103/ijnm.ijnm_68_24","url":null,"abstract":"<p><p>The interpretation of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans can be confounded by incidental findings, as illustrated in this case of a 47-year-old woman with a history of breast carcinoma. Following neoadjuvant chemotherapy and mastectomy, she underwent FDG PET/CT for disease evaluation, revealing unexpected hypermetabolic activity in the right iliac fossa corresponding to acute appendicitis. Thus, FDG PET/CT has the potential to uncover treatable conditions beyond cancer and imaging findings need clinical correlation.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"42-43"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult Langerhans Cell Histiocytosis: Solitary and Multisystemic Involvement Detected on FDG PET-CT Scan. 成人朗格汉斯细胞组织细胞增多症：FDG PET-CT扫描检测到的孤立和多系统累及。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_97_24
Aishwarya Wagle, Melvika Pereira, Natasha Singh, Divya Shivdasani, Lokesh Kumar, Janpreet Singh, Sreelakshmi Sujith
{"title":"Adult Langerhans Cell Histiocytosis: Solitary and Multisystemic Involvement Detected on FDG PET-CT Scan.","authors":"Aishwarya Wagle, Melvika Pereira, Natasha Singh, Divya Shivdasani, Lokesh Kumar, Janpreet Singh, Sreelakshmi Sujith","doi":"10.4103/ijnm.ijnm_97_24","DOIUrl":"10.4103/ijnm.ijnm_97_24","url":null,"abstract":"<p><p>Langerhans Cell Histiocytosis (LCH) is a rare neoplasm of the hematopoietic system, characterized by the clonal proliferation of Langerhans cells and it is more common in children. We present two interesting adult cases of LCH, diagnosed with the help of FDG PET-CT imaging which is often challenging to diagnose due to its rarity and nonspecific clinical presentation.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"44-46"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tiger-man Appearance in a Case of DLBCL. 虎形人在DLBCL中的表现。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_129_24
A R Vishnu, Nishikant Avinash Damle, Sameer Bakhshi, Deepam Pushpam
{"title":"Tiger-man Appearance in a Case of DLBCL.","authors":"A R Vishnu, Nishikant Avinash Damle, Sameer Bakhshi, Deepam Pushpam","doi":"10.4103/ijnm.ijnm_129_24","DOIUrl":"10.4103/ijnm.ijnm_129_24","url":null,"abstract":"<p><p>Primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma (PC-EBV-DLBCL) is a rare and aggressive neoplasm with a poorer prognosis than other cutaneous lymphoma. Here, we present the <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>F-FDG) positron emission tomography/computed tomography (PET/CT) scan findings of a 39-year-old male with erythematous ulcerative nodules, which showed a gamut of cutaneous lesions consistent with EBV-associated PC-DLBCL. We highlight the utility of <sup>18</sup>F-FDG PET/CT in evaluating the extent of disease, involvement of extranodal sites, and response to treatment in PC-EBV-DLBCL.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"40-41"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoimmune Encephalitis Pattern on PET-MRI in a Patient with Amyotrophic Lateral Sclerosis. 肌萎缩性侧索硬化症患者的PET-MRI自身免疫性脑炎模式
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_9_24
Sandesh Voosala, M Sandhya, P S Mathuranath, Rohan R Mahale
{"title":"Autoimmune Encephalitis Pattern on PET-MRI in a Patient with Amyotrophic Lateral Sclerosis.","authors":"Sandesh Voosala, M Sandhya, P S Mathuranath, Rohan R Mahale","doi":"10.4103/ijnm.ijnm_9_24","DOIUrl":"10.4103/ijnm.ijnm_9_24","url":null,"abstract":"<p><p>Amyotrophic lateral sclerosis (ALS) is a progressive primary motor neuron disorder whose etiology is a subject of debate even today. Interplay between multiple genetic and environmental factors and co-existent/antecedent infection, inflammation, and malignancy have all been hypothesized as potentially causative for this disease. Owing to its hybrid diagnostic capability, fluorodeoxyglucose positron emission tomography-magnetic resonance imaging is highly valuable in detecting varied autoimmune encephalitis patterns, one of which we report in a patient with ALS providing insight into autoimmunity as a potential etiology in the pathogenesis of this disease.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"22-25"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Pitfall We Should Be Aware of on Bone Scintigraphy. 在骨显像上我们应该注意的一个陷阱。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_73_24
Majdouline Bel Lakhdar, Ouafae Boumaaza, Ayat Mouaden, Imad Ghfir, Hasnae Guerrouj
{"title":"A Pitfall We Should Be Aware of on Bone Scintigraphy.","authors":"Majdouline Bel Lakhdar, Ouafae Boumaaza, Ayat Mouaden, Imad Ghfir, Hasnae Guerrouj","doi":"10.4103/ijnm.ijnm_73_24","DOIUrl":"10.4103/ijnm.ijnm_73_24","url":null,"abstract":"<p><p>Nuclear medicine imaging frequently encounters injection artifacts. Although inadvertent intra-arterial injection is infrequent, it may pose diagnostic difficulties in pathological contexts. We present a case study of a woman with breast cancer and increased bone uptake in her right forearm and hand on bone scintigraphy. The pitfall was corrected by her clinical background and three-phase bone scintigraphy.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"26-27"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case. 成纤维细胞活化蛋白（FAP）：转移性黑色素瘤微环境的关键调节剂。
IF 0.4
Indian Journal of Nuclear Medicine Pub Date : 2025-01-01 Epub Date: 2025-05-16 DOI: 10.4103/ijnm.ijnm_79_24
Ghasemali Divband, Raheleh Hedayati, Hamidreza Amini, Leila Hassanzadeh
{"title":"Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case.","authors":"Ghasemali Divband, Raheleh Hedayati, Hamidreza Amini, Leila Hassanzadeh","doi":"10.4103/ijnm.ijnm_79_24","DOIUrl":"10.4103/ijnm.ijnm_79_24","url":null,"abstract":"<p><p>A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR<sub>2</sub>, and FAP identified biomarkers for personalized therapy. This led to the choice of [177Lu]Lu-FAPI-2286. After the first cycle, the patient reported pain relief, but subsequent imaging revealed rapid brain metastasis. This case highlights the importance of personalized medicine and molecular imaging in treating advanced melanoma.</p>","PeriodicalId":45830,"journal":{"name":"Indian Journal of Nuclear Medicine","volume":"40 1","pages":"28-31"},"PeriodicalIF":0.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12121835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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