Paulo de Carvalho Contu, Daniel de Carvalho Damin, Camila Leal Guimarães, Beatriz Padoin Camilo, Jordy Guimarães Costa, Rafaella Aléssio Naibo, Beatriz Lima Silveira, Marina Ferreira da Luz
{"title":"Colorectal Cancer Arising in a Diverticulum: Report of an Unusual Presentation.","authors":"Paulo de Carvalho Contu, Daniel de Carvalho Damin, Camila Leal Guimarães, Beatriz Padoin Camilo, Jordy Guimarães Costa, Rafaella Aléssio Naibo, Beatriz Lima Silveira, Marina Ferreira da Luz","doi":"10.1155/crgm/4631169","DOIUrl":"10.1155/crgm/4631169","url":null,"abstract":"<p><p>The coexistence of diverticulitis and colorectal cancer is rare but clinically significant. We present an unusual case of an elderly patient with recurrent acute diverticulitis, colonic obstruction due to a sigmoid stenosis, in which an adenocarcinoma originated within a diverticulum. This presentation is particularly challenging because the extramural growth pattern within the wall of the pseudodiverticulum, which lacks the muscularis propria layer, facilitates early transmural spread without a significant intraluminal mucosal mass, leading to an advanced diagnosis more frequently. This case underscores the need for high clinical vigilance and specialized radiologic review in patients with complex diverticular disease and unexplained stenosis.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"4631169"},"PeriodicalIF":0.6,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edwin Mendoza, Alan Jurado, Virali Gulla, Gian Rodriguez Franco, Osvaldo Padilla, Sherif Elhanafi, Luis Chozet, Tamis Bright
{"title":"Vanished Without a Trace: A Middle-Aged Man With Vanishing Bile Duct Syndrome-A Case Report.","authors":"Edwin Mendoza, Alan Jurado, Virali Gulla, Gian Rodriguez Franco, Osvaldo Padilla, Sherif Elhanafi, Luis Chozet, Tamis Bright","doi":"10.1155/crgm/4371217","DOIUrl":"10.1155/crgm/4371217","url":null,"abstract":"<p><p>Vanishing bile duct syndrome, VBDS, is a rare disease that is poorly understood and is a term used to loosely describe a group of disorders associated with the progressive destruction of intrahepatic ducts. This syndrome ultimately leads to cholestasis. There are many potential etiologies for this disease including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), autoimmune diseases, medications, genetic abnormalities, infectious causes, or neoplastic disorders. The diagnosis consists of both clinical and histological findings found via liver biopsy. We present a rare case of VBDS in a 41-year-old male likely attributed to multiple herbal supplements in the setting of severe hyperlipidemia. This case highlights the importance of recognizing supplement-related liver injury and unusual metabolic associations.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"4371217"},"PeriodicalIF":0.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Migration of a Nasopharyngeal Airway Into the Gastrointestinal Tract During Endoscopic Retrograde Cholangiopancreatography: A Rare Complication in Obstructive Jaundice Management.","authors":"Xu Yan, Zhiqiang Zhou, Ailin Luo, Xue Zhang, Yilin Zhao","doi":"10.1155/crgm/2476267","DOIUrl":"10.1155/crgm/2476267","url":null,"abstract":"<p><strong>Background: </strong>Obstructive jaundice often requires endoscopic retrograde cholangiopancreatography (ERCP) for diagnosis and management. Airway management during sedation in ERCP poses unique challenges, though device-related complications are rarely reported.</p><p><strong>Case presentation: </strong>A 35-year-old male with obstructive jaundice due to distal common bile duct stenosis underwent ERCP under sedation with propofol and oxycodone. A 16Fr silicone nasopharyngeal airway (NPA) was inserted due to mild upper airway obstruction. During the prolonged procedure (185 min), the NPA migrated unnoticed into the stomach, where it was discovered upon endoscope withdrawal and successfully retrieved using rat-tooth forceps.</p><p><strong>Intervention: </strong>The NPA was removed without mucosal injury, and a biliary metal stent was deployed uneventfully.</p><p><strong>Outcome: </strong>The patient recovered without gastrointestinal or pulmonary complications, with normalized bilirubin levels at 1-month follow-up.</p><p><strong>Conclusion: </strong>This first reported case of NPA migration into the gastrointestinal tract during ERCP highlights the need for improved fixation, monitoring, and awareness of airway devices during prolonged endoscopic procedures.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"2476267"},"PeriodicalIF":0.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148362908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lavender Otom, Priyanka Panwar, Gerald Odong, Peter Chacha Magabe, Christopher Opio, Saleem Abdulkarim
{"title":"Recurrent Upper Gastrointestinal Bleeding due to Gastric Arteriovenous Malformation.","authors":"Lavender Otom, Priyanka Panwar, Gerald Odong, Peter Chacha Magabe, Christopher Opio, Saleem Abdulkarim","doi":"10.1155/crgm/4276818","DOIUrl":"10.1155/crgm/4276818","url":null,"abstract":"<p><p>We present the case of a 45-year-old male with repeated episodes of upper gastrointestinal bleeding due to a gastric arteriovenous malformation (AVM). The case underscores the diagnostic challenges, multidisciplinary decision-making, and management considerations associated with gastrointestinal vascular malformations. Given the rarity of gastric AVMs and their potential for serious complications, this report highlights the importance of an integrated approach to diagnosis and treatment, including advanced imaging and endovascular interventions.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"4276818"},"PeriodicalIF":0.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Superior Mesenteric Artery Syndrome After Previous Nuss Procedure: A Case Report of Anatomical Realignment With Unintended Consequences.","authors":"Pin Wen Wang, Chun-Hsiang Wang, Hui-Ting Hsu, Yi-Wei Chou","doi":"10.1155/crgm/2887106","DOIUrl":"10.1155/crgm/2887106","url":null,"abstract":"<p><strong>Background: </strong>Superior mesenteric artery (SMA) syndrome is a rare condition resulting from compression of the third segment of the duodenum. The condition is associated with a reduction of the aortomesenteric angle and distance between the SMA and the abdominal aorta, often due to weight loss or anatomical changes. The Nuss procedure, a minimally invasive corrective procedure for pectus excavatum, may inadvertently alter this anatomy.</p><p><strong>Case presentation: </strong>We report a case of a 22-year-old male with a history of pectus excavatum who presented with two weeks of abdominal pain and vomiting. Abdominal A CT scan and esophagogastroduodenoscopy examinations were performed, revealing duodenal compression with a narrowed aortomesenteric distance of 6 mm, which is consistent with SMA syndrome. The patient then underwent laparoscopic duodenojejunostomy anastomosis bypass after failed conservative management with complete symptom resolution.</p><p><strong>Conclusion: </strong>Clinicians should be aware of the potential development of SMA syndrome in patients following the Nuss procedure. Monitoring nutritional status and prompt evaluation of gastrointestinal symptoms are essential to early diagnosis and intervention.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"2887106"},"PeriodicalIF":0.6,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"McKittrick-Wheelock Syndrome Caused by Giant Tubulovillous Adenomas With Malignant Transformation: A Case Report.","authors":"Marko Kalezic, Emilija Krsmanovic, Srdjan Marinkovic, Miljan Milanovic, Djordje Miladinovic, Branka Filipovic, Predrag Savic, Dusan Popovic","doi":"10.1155/crgm/1802324","DOIUrl":"10.1155/crgm/1802324","url":null,"abstract":"<p><p>Giant villous adenomas of the colon are a rare cause of chronic secretory diarrhea. These lesions can produce excessive mucus, fluid, and electrolyte loss, leading to life-threatening hypokalemia, hyponatremia, and acute kidney injury. Chronic secretory diarrhea with electrolyte imbalance and possible acute kidney injury caused by secretory giant tubulovillous adenomas constitutes McKittrick-Wheelock syndrome, a rare condition described in 257 patients worldwide. We report two cases of McKittrick-Wheelock syndrome caused by giant tubulovillous adenomas of the rectum and rectosigmoid junction with malignant transformation. The first case, a 72-year-old female, presented with profound electrolyte depletion and acute renal failure, managed in the intensive care unit with supportive therapy. The second case, a 73-year-old male, had chronic diarrheal syndrome and marked electrolyte depletion due to three giant colonic tubulovillous adenomas with malignant transformation. After rehydration and electrolyte replacement, both patients underwent surgical resection with low anterior rectal resection and protective loop ileostomy. The male patient required reoperation with total proctocolectomy due to coloanal anastomotic dehiscence. Postoperative courses were uneventful, and both patients were discharged with normalized laboratory values and scheduled for regular follow-up. McKittrick-Wheelock syndrome should be suspected in patients with chronic diarrhea and electrolyte disturbances. Prompt endoscopic evaluation allows accurate diagnosis, and timely fluid and electrolyte replacement combined with surgical resection of the secretory lesion is essential for effective treatment and prevention of serious complications.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"1802324"},"PeriodicalIF":0.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148319878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Delayed-Onset Hepatocellular Liver Injury Associated With Nitrofurantoin and Herbal Supplement Use: A Case Report With Multiple Potential Exposures.","authors":"Edwin Mendoza, Manas Pustake, Jeffrey Annabi, Joshua Torres, Joanna Mendez, Lakshmi Kattamuri, Benjamin Williams, Abhizith Deoker","doi":"10.1155/crgm/1187155","DOIUrl":"10.1155/crgm/1187155","url":null,"abstract":"<p><p>Nitrofurantoin, a first-line antibiotic, works effectively for treating uncomplicated urinary tract infections, but it can cause severe liver damage. In the setting of concurrent supplement use, distinguishing what caused liver damage is challenging. A 57-year-old woman who had nonalcoholic fatty liver disease developed sudden jaundice after finishing her short nitrofurantoin treatment while consuming a commercial weight-loss supplement. The laboratory results demonstrated a significant liver cell damage pattern with autoimmune test results positive while liver biopsy showed nonspecific inflammation that supported drug-induced liver injury over drug-induced autoimmune such as hepatitis. The patient received intravenous N-acetylcysteine emergently after removing all suspected hepatotoxic substances from her treatment plan. N-acetylcysteine was administered empirically due to concern for progression, although its role in nonacetaminophen DILI remains uncertain. The case demonstrates that clinicians should evaluate for polysubstance-induced liver damage when patients present with multiple possible liver-damaging substances.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"1187155"},"PeriodicalIF":0.6,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13282457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to \"<i>Clostridium difficile</i> Peritonitis Complicated by Splenic Rupture and Pelvic Abscess Formation in a Patient Previously on Continuous Ambulatory Peritoneal Dialysis\".","authors":"","doi":"10.1155/crgm/9815752","DOIUrl":"https://doi.org/10.1155/crgm/9815752","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1155/crgm/7775218.].</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"9815752"},"PeriodicalIF":0.6,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13273389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148279150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zachary Vinton, Carter Schulz, William McGuire, Safina Hafeez, Sarah Malik
{"title":"Beyond the Surface: Duodenal-Type Follicular Lymphoma Diagnosed Despite Normal-Appearing Duodenal Mucosa and Absence of Focal Duodenal FDG Uptake.","authors":"Zachary Vinton, Carter Schulz, William McGuire, Safina Hafeez, Sarah Malik","doi":"10.1155/crgm/1030883","DOIUrl":"10.1155/crgm/1030883","url":null,"abstract":"<p><p>Duodenal-type follicular lymphoma (DTFL) is an uncommon and often indolent extranodal lymphoma that may be difficult to recognize when characteristic endoscopic or imaging findings are absent. We report a 60-year-old man evaluated for progressive fatigue, epigastric pain, and iron deficiency whose esophagogastroduodenoscopy showed normal-appearing duodenal mucosa. Random duodenal biopsies revealed follicular lymphoma with morphology and immunophenotype consistent with follicular lymphoma, duodenal type, in the absence of systemic follicular lymphoma. Staging positron emission tomography/computed tomography (PET/CT) showed no focal duodenal fluorodeoxyglucose uptake but demonstrated equivocal low-level uptake in mildly prominent mesenteric lymph nodes. Given unclear staging and persistent gastrointestinal symptoms affecting quality of life, the patient was treated with rituximab monotherapy. Follow-up PET/CT findings were consistent with complete metabolic response, and repeat duodenal biopsies showed no residual lymphoma. This case highlights the diagnostic value of random duodenal biopsy in unexplained iron deficiency and emphasizes the staging complexity of DTFL when PET/CT findings are equivocal.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"1030883"},"PeriodicalIF":0.6,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13270414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148273305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An Unusual Case of Pancreatic Ductal Adenocarcinoma With Synchronous Rectal Metastasis in a Younger Female.","authors":"Olanrewaju Adeniran, Farirai Marwizi, Abdullahi Sulaiman, Nolan Holley, Omotomilola Fadipe, Budoor Alqinai, Ayowumi Adekolu, Joshua Kirkpatrick, Ethan M Cohen, Joseph Simmons, Mohamed Zitun, Asad Pervez","doi":"10.1155/crgm/9940087","DOIUrl":"10.1155/crgm/9940087","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer (PC) remains one of the leading causes of cancer mortality in the United States. There has been a concerning trend in recent years where younger females are experiencing a faster annual percentage increase than their male counterparts (2.36% vs. 0.62%). Metastasis of pancreatic ductal adenocarcinoma (PDAC) to the rectum is uncommon, and synchronous rectal metastasis occurs even less frequently.</p><p><strong>Case presentation: </strong>We describe a case of a 49-year-old woman with Stage IV PDAC with synchronous rectal metastases. The hallmark of her symptoms was hematochezia and epigastric pain, initially misdiagnosed as gastritis. However, the patient returned with new laboratory and imaging findings of the synchronous pancreatic tail and rectal masses confirmed by histology. Immunohistochemistry was crucial in distinguishing a primary PC from a rectal primary. The patient continues to undergo chemotherapy 14 months after presentation.</p><p><strong>Conclusion: </strong>This represents the first documented case in the United States and the sixth reported case of synchronous rectal metastasis from PDAC. It highlights the increasing incidence and the demographic shift of PC among young women in the United States, which needs further investigation. The case adds to our knowledge of the unusual metastatic pattern of PDAC and the need for a multidisciplinary approach, including the role of immunohistochemistry in distinguishing between the primary etiology of malignancy to establish an accurate diagnosis, instituting an appropriate treatment plan, and preventing unwanted treatment and surgeries.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2026 ","pages":"9940087"},"PeriodicalIF":0.6,"publicationDate":"2026-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13266272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148266481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}