Case Reports in Gastrointestinal Medicine最新文献

{"title":"Peutz-Jeghers Syndrome in a Young Ethiopian Male: A Case Report.","authors":"Abate Bane Shewaye, Kaleb Assefa Berhane","doi":"10.1155/crgm/3667487","DOIUrl":"https://doi.org/10.1155/crgm/3667487","url":null,"abstract":"<p><p>Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by hamartomatous polyps in the gastrointestinal (GI) tract, pigmented mucocutaneous lesions, and an increased risk of cancer. We report a case of a 22-year-old male from Ethiopia who presented with recurrent abdominal pain and a history of surgery for bowel obstruction. Endoscopic evaluation revealed multiple polyps in the stomach, ileum, and colon, which were confirmed histopathologically as hamartomatous polyps. Mucocutaneous pigmentation and family history of GI symptoms and maternal breast cancer led to the diagnosis of PJS, despite the unavailability of genetic testing. The patient underwent therapeutic polypectomy and was advised on cancer surveillance. This case highlights the importance of recognizing and managing PJS in resource-limited settings, emphasizing the need for early diagnosis and vigilant surveillance to prevent complications, especially when genetic testing may not be readily available.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"3667487"},"PeriodicalIF":0.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Ileitis and Partial Small Bowel Obstruction Secondary to Mesh Erosion After Totally Extraperitoneal Inguinal Hernia Repair.","authors":"Pranesh de Silva, Joseph Do Woong Choi, Craig Lynch, Stephen Pillinger, Saurabh Gupta, Praveen Ravindran","doi":"10.1155/crgm/3047912","DOIUrl":"10.1155/crgm/3047912","url":null,"abstract":"<p><p>The objectives were to highlight that: (1) mesh erosion related partial small bowel obstruction after laparoscopic totally extraperitoneal (TEP) inguinal hernia repair (IHR) as an uncommon complication can clinically and radiologically mimic ileocolic Crohn's disease in young adults; and (2) implore clinicians to consider a broad set of differential diagnosis and prompt involvement of other subspecialties, especially if preliminary investigations and treatment yield minimal results. The authors report a 34-year-old male who presented with computed tomography (CT) findings of ileitis, which was initially investigated for Crohns' disease. Due to persisting abdominal pain and negative initial investigations, he underwent a laparotomy demonstrating secondary mesh migration with erosion into distal ileum requiring bowel resection, 2.5 years after an uneventful laparoscopic right TEP IHR. The patient made an uneventful postoperative recovery and at 6 weeks follow-up, he had resolution of abdominal pains, and normal bowel function.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"3047912"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Bleeding Unmasking Gastric Metastases From a Primary Breast Malignancy: A Case Report.","authors":"Thilini Delungahawatta, Richard Hum, Stephanie M Woo, Rashmi Samdani, Mark J Real","doi":"10.1155/crgm/2763114","DOIUrl":"https://doi.org/10.1155/crgm/2763114","url":null,"abstract":"<p><p>Metastases to the gastrointestinal tract from primary breast malignancies are rare. Acute gastrointestinal bleeding in patients with history of breast cancer, however, should raise clinical suspicion and warrant further investigation for metastatic disease involving the gastrointestinal tract. We report a case of a 74-year-old female with metastatic breast cancer and provoked thromboembolic events on anticoagulation, who was found to have poorly cohesive gastric carcinoma with immunohistochemistry consistent with primary breast malignancy, after presenting with new-onset melena. Use of anticoagulation may have exacerbated bleeding prompting endoscopic examination. Biopsy and histologic assessment are needed for definitive diagnosis and timely management.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"2763114"},"PeriodicalIF":0.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celiac Crisis: A Rare Medical Emergency Case Report in Adult Celiac Disease.","authors":"Mais Musleh, Amani AlMokbel","doi":"10.1155/crgm/6259846","DOIUrl":"https://doi.org/10.1155/crgm/6259846","url":null,"abstract":"<p><p>Celiac crisis (CC) is a rare but potentially life-threatening complication of celiac disease (CD), characterized by severe diarrhea, electrolyte imbalances, and metabolic disturbances. We report the case of a 32-year-old pregnant woman presented significant dehydration, weight loss, and steatorrheic stools. Diagnosis was confirmed by duodenal biopsy, with rapid improvement following a gluten-free diet (GFD) and corticosteroids. The diagnosis of CC was established based on the acute clinical presentation and rapid improvement following a GFD and corticosteroid therapy. This case highlights the importance of early recognition and prompt management of CC, particularly in undiagnosed or untreated CD, to prevent severe maternal and fetal complications.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6259846"},"PeriodicalIF":0.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Mesenteric Cyst in a Young Adult Mimicking Refractory Ascites: A Diagnostic and Surgical Challenge-A Case Report.","authors":"Abate Bane Shewaye, Kaleb Assefa Berhane, Amanuel Getu Gebresilassie, Amsalework Daniel Fanta, Megersa Regassa, Fekadu Ayalew, Eyerusalem Fekede, Biruk Demisse Ayalew","doi":"10.1155/crgm/7405161","DOIUrl":"https://doi.org/10.1155/crgm/7405161","url":null,"abstract":"<p><p>Mesenteric cysts are rare benign intra-abdominal tumors that are usually asymptomatic and diagnosed incidentally while being investigated for other conditions or their complications. Surgical excision remains the primary treatment option. Here we present the case of a 30-year-old male with progressive abdominal distension, initially misdiagnosed with liver disease and refractory ascites, leading to inappropriate diuretic therapy. Subsequent imaging revealed a giant mesenteric cyst, which was successfully managed with complete surgical excision.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"7405161"},"PeriodicalIF":0.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Challenges in Autoimmune Hepatitis Management: A Successful Outcome With Intravenous Immune Globulin (IVIg).","authors":"Amirali Mashhadiagha, Parnian Khalili, Maryam Ataollahi, Fereshteh Karbasian, Ali Arman, Bita Geramizadeh","doi":"10.1155/crgm/4446896","DOIUrl":"https://doi.org/10.1155/crgm/4446896","url":null,"abstract":"<p><p><b>Background:</b> Several autoimmune diseases, such as autoimmune hepatitis (AIH), can arise or become decompensated following COVID-19 infection or vaccination; however, there is a lack of data regarding the management of concurrent COVID-19 infection and autoimmune diseases. <b>Case Summary:</b> In this paper, we present a case of a 9-year-old boy with yellowish discoloration of the skin and sclera, abnormal liver function test, followed by positive qRT-PCR for SARS-CoV-2 and progressive bicytopenia. After a lack of response to corticosteroids, intravenous immune globulin (IVIg) was administrated and a decline in liver enzymes, total bilirubin, and direct bilirubin was observed. <b>Result and Discussion:</b> This case illustrates how IVIg significantly improved the AIH symptoms in the patient with positive qRT-PCR for the SARS-CoV-2 test. We hope our report encourages further research on therapeutic approaches for AIH concomitant with COVID-19.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"4446896"},"PeriodicalIF":0.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gallstone Ileus in a 25-Year-Old Female With Cyclin-Dependent Kinase-Like 5 Deficiency Disorder: A Case Report.","authors":"Hikaru Onoda, Mami Kuroda, Ryo Takeguchi, Ryosuke Tanaka, Daisuke Ishii, Hisayuki Miyagi, Masatoshi Hirasawa, Satoru Takahashi","doi":"10.1155/crgm/4901433","DOIUrl":"10.1155/crgm/4901433","url":null,"abstract":"<p><p>Gallstone ileus is an uncommon complication of cholelithiasis and the delayed diagnosis may be associated with increased risk of mortality. When gallstones block the cystic duct, they can lead to cholecystitis. If a fistula forms between the inflamed gallbladder and the adjacent intestine, the gallstones may pass into the intestinal tract and cause obstruction in the intestine. We report a case of 25-year-old female with developmental and epileptic encephalopathy who was intraoperatively diagnosed with gallstone ileus during surgery for small bowel obstruction of unknown origin. The patient had potential risk factors enhancing the formation of cholesterol gallstones, including long-term use of phenobarbital, vagus nerve injury in open gastrostomy and laparoscopic fundoplication, and tube feeding; however, the patient's gallstone had been undiagnosed for a long time. Computed tomography of the abdomen showed small bowel obstruction and pneumobilia. The presence of pneumobilia in a patient without a surgical history of the biliary system should raise suspicion of a bilioenteric fistula. The awareness of this complication of cholelithiasis is important to make an early diagnosis and to initiate the appropriate treatment.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"4901433"},"PeriodicalIF":0.6,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Tract Perineuriomas and Benign Fibroblastic Polyps: Case Report and Comprehensive Systematic Review.","authors":"Ahmad F Alenezi, Haitham Jahrami, Yonca Kanber, Talat Bessissow","doi":"10.1155/crgm/1636142","DOIUrl":"https://doi.org/10.1155/crgm/1636142","url":null,"abstract":"<p><p><b>Background:</b> Perineurioma is a rare benign peripheral nerve sheath tumor that can arise in various body locations. In the gastrointestinal (GI) tract, perineuriomas are uncommon and have only been reported in case reports and case series. In addition, a new classification suggests reclassifying benign fibroblastic polyps as perineurioma when they show positive markers of perineurial differentiation. <b>Objective:</b> This study aims to enhance understanding of GI tract perineuriomas by presenting a new case and conducting a systematic literature review. <b>Methods:</b> We described a new case of colonic perineurioma and systematically reviewed all case reports and case series on GI perineuriomas and benign fibroblastic polyps with perineurial markers. We searched ScienceDirect, PubMed/MEDLINE, and Web of Science up to May 2024. <b>Results:</b> A total of 148 cases were analyzed, and most of the cases were published in the last decade (2014-2024). The majority were females (59.46%), with a mean age of 51 years (standard deviation [SD] ±14.87). Most GI perineuriomas (87.5%) were in the distal colon, predominantly in the sigmoid/rectosigmoid (56%) and rectum (14%). Outside the colon, the stomach was the most affected site (7 of 10 cases), with fewer cases in the small intestine and esophagus. The two most commonly performed stains were for epithelial membrane antigen (EMA) and glucose transporter 1 (GLUT-1), at 75% and 56% of cases, respectively. Noncolonic perineuriomas were generally larger and more symptomatic than colonic ones. Submucosal polyps were more likely symptomatic than mucosal polyps. <b>Conclusion:</b> Perineurioma in the GI tract is a rare benign polyp mainly identified in the distal colon. Its rarity and limited follow-up data restrict our understanding of recurrence rates. We recommend reporting uncommon polyp locations, detailing polyp morphologies, and using at least two markers for classification.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"1636142"},"PeriodicalIF":0.6,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reexamining Multisystem Desmoid Tumors Linked to Gardner's Syndrome: A Clinical Case.","authors":"Haijia Zhang, Yongjie Wu, Xiushan Dong, Jie An","doi":"10.1155/crgm/6882566","DOIUrl":"https://doi.org/10.1155/crgm/6882566","url":null,"abstract":"<p><p>A variation of familial adenomatous polyposis (FAP), known as Gardner's syndrome (GS), can manifest as extraintestinal tumors, such as desmoid tumors (DTs). A key part in the diagnosing process is played by the clinician. Because DT frequently occurs before intestinal polyposis develops, doctors can identify the underlying illness early by looking for DT's telltale signs. Nevertheless, in this instance, the patient's failure to recognize the illness promptly following the excision of the tumor in the abdomen wall caused a delay in the diagnosis and impacted the disease's course.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6882566"},"PeriodicalIF":0.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11991836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Treatment of a Spontaneously Ruptured Echinococcus Cyst of the Spleen and Its Complications.","authors":"Sévérine De Bruijn, Annick De Weerdt, Glenn Broeckx, Maarten Spinhoven, Rudi De Paep, Dominique Robert, Niels Komen, Philippe G Jorens","doi":"10.1155/crgm/6657981","DOIUrl":"10.1155/crgm/6657981","url":null,"abstract":"<p><p><b>Introduction:</b> Cystic echinococcosis, also known as hydatid cyst, is a parasitic infection of mammals that can affect any organ. Although the diagnosis of primary splenic echinococcosis is challenging, especially in nonendemic areas, it can be life-saving because an anaphylactic shock may occur when the cyst ruptures. Recommendations regarding optimal treatment options after rupture are scarce, and the overall prognosis remains poor. <b>Case Presentation:</b> A patient with a spontaneous rupture of an isolated splenic hydatid cyst was treated with splenectomy and peritoneal lavage with a hypertonic salt solution. The patient survived despite rapidly progressive hypernatremia, which was treated with conventional therapy along with continuous venovenous hemofiltration with gradient sodium replacement. <b>Discussion:</b> When the decision is made to treat a patient with a spontaneously ruptured splenic echinococcus cyst, splenectomy is the only surgical option. Hypernatremia is a complication to be expected when hypertonic saline is used to rinse the splenic and abdominal cavities. <b>Conclusion:</b> This case highlights the importance of prompt surgical intervention and the management of hypernatremia in patients with ruptured splenic hydatid cysts.</p>","PeriodicalId":45645,"journal":{"name":"Case Reports in Gastrointestinal Medicine","volume":"2025 ","pages":"6657981"},"PeriodicalIF":0.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11867722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}