Journal of Kidney Cancer and VHL最新文献_第3页

VHL-dependence of EHHADH Expression in a Human Renal Cell Carcinoma Cell Line. 人类肾细胞癌细胞系中 EHHADH 表达的 VHL 依赖性

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2024-01-29 eCollection Date: 2024-01-01 DOI: 10.15586/jkcvhl.v11i1.322

Julia Felicitas Pilz, Marinella Klein, Elke Neumann-Haefelin, Athina Ganner

{"title":"VHL-dependence of EHHADH Expression in a Human Renal Cell Carcinoma Cell Line.","authors":"Julia Felicitas Pilz, Marinella Klein, Elke Neumann-Haefelin, Athina Ganner","doi":"10.15586/jkcvhl.v11i1.322","DOIUrl":"https://doi.org/10.15586/jkcvhl.v11i1.322","url":null,"abstract":"The von Hippel-Lindau tumor suppressor gene (VHL) is mutated in up to 90% of clear cell renal cell carcinoma (ccRCC) cases, thus playing a key role in ccRCC pathogenesis. ccRCC can be classified as a metabolic disease in which alterations in fatty acid metabolism facilitate cancer cell proliferation. Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase (EHHADH) is an enzyme involved in peroxisomal fatty acid degradation. It is primarily expressed in renal proximal tubule cells, presumably the origin of ccRCC. Although EHHADH is still a relatively unexplored gene, it is known to be differentially expressed in several tumors. In this study, analysis of several databases revealed that EHHADH expression is downregulated in ccRCC samples compared to healthy kidney samples. Moreover, cell culture experiments were performed to investigate the relationship between EHHADH and VHL at the gene and protein level. qPCR and Western blot analyses using the human ccRCC cell line RCC4 revealed that EHHADH is expressed in a VHL-dependent manner. RCC4 cells reconstituted with VHL show significantly higher EHHADH mRNA and protein levels than VHL-deficient RCC4 control cells. These results indicate that the downregulation of EHHADH in ccRCC reported may be due to the loss of VHL function. This study is the first to molecularly characterize EHHADH, a key enzyme in peroxisomal ß-oxidation, in relation to VHL, suggesting a potential pathogenic interaction that is worthy of further investigation.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"11 1","pages":"12-18"},"PeriodicalIF":1.6,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10834178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Site of Metachronous Metastases from Renal Cell Carcinoma 肾细胞癌转移的罕见部位

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2024-01-05 DOI: 10.15586/jkcvhl.v11i1.282

Anand Raja, Madhuri Nutakki, Kanchana Murhekar, Shirley Sundersingh

引用次数: 0

Robotic Radical Nephrectomy with Vena Cava Thrombus Extraction (RRN-VCTE) for Renal Cell Carcinoma 机器人根治性肾切除术与腔静脉血栓抽取术（RRN-VCTE）治疗肾细胞癌

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2024-01-05 DOI: 10.15586/jkcvhl.v11i1.288

D. Coco, S. Leanza

{"title":"Robotic Radical Nephrectomy with Vena Cava Thrombus Extraction (RRN-VCTE) for Renal Cell Carcinoma","authors":"D. Coco, S. Leanza","doi":"10.15586/jkcvhl.v11i1.288","DOIUrl":"https://doi.org/10.15586/jkcvhl.v11i1.288","url":null,"abstract":"Renal cell carcinoma (RCC) with vena cava tumor thrombus is a challenging condition, which requires complex surgical management. Robotic radical nephrectomy with vena cava thrombus extraction (RRN-VCTE) has emerged as a promising and minimally invasive technique. This meta-analysis aims to review the surgical technique and outcomes of RRN-VCTE in patients with RCC and vena cava tumor thrombus. A comprehensive literature search was conducted using databases, including PubMed, Embase, and Cochrane Library. Studies published in English till October 2021 were included. Keywords used for the search included “robotic radical nephrectomy,” “vena cava tumor thrombus,” “surgical technique,” and “outcomes.” Studies that reported on patient outcomes and surgical techniques of RRN-VCTE were included. Statistical analysis was performed to assess the pooled outcomes. The meta-analysis included 16 studies comprising 298 patients who underwent RRN-VCTE. The majority of patients were males (62.4%) with a median age of 58.9 years. The median tumor size was 7.2 cm, and 93.9% of patients had level 3 or 4 vena cava thrombus. The mean operating time was 328 min, with a range of 248–423 min. Blood loss ranged from 100 to 1500 mL. The overall complication rate was 26.5%, with no reported deaths. The average hospital stay was 9.5 days. The 2-year and and 5-year survival rates were 77.5 and 53.1%, respectively. RRN-VCTE is a promising and minimally invasive surgical technique for RCC with vena cava tumor thrombus, whch is associated with low complication rates and acceptable oncological outcomes. Further research is needed to confirm the long-term survival rates and compare RRN-VCTE outcomes with conventional surgical techniques. Nonetheless, RRN-VCTE appears to be a valuable option for patients with RCC and vena cava tumor thrombus.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"45 46","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139382506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative Embolization during Inferior Vena Cava Tumor Thrombectomy for Renal Cell Carcinoma. 下腔静脉肿瘤血栓切除术治疗肾细胞癌时的术中栓塞。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-12-30 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.299

Samantha A Roberts, Divyaam Satija, Henry Gold, Mina S Makary, Jing G Wang, Eric A Singer, Tasha Posid, Nahush A Mokadam, Shawn Dason

{"title":"Intraoperative Embolization during Inferior Vena Cava Tumor Thrombectomy for Renal Cell Carcinoma.","authors":"Samantha A Roberts, Divyaam Satija, Henry Gold, Mina S Makary, Jing G Wang, Eric A Singer, Tasha Posid, Nahush A Mokadam, Shawn Dason","doi":"10.15586/jkcvhl.v10i4.299","DOIUrl":"10.15586/jkcvhl.v10i4.299","url":null,"abstract":"Intraoperative tumor thrombus embolization is a potentially lethal complication during inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC). Intraoperative embolization is uncommonly encountered because IVC thrombectomy surgical technique is focused on avoiding this complication. Nonetheless, early recognition of embolization is essential so that emergent management can be instituted. When available, cardiopulmonary bypass (CPB) and embolectomy should be considered the gold standard for the management of intraoperative embolization. Several novel endovascular techniques are also available for selective use. We present the case of a 71-year-old female with a right renal mass and level II (retrohepatic) IVC tumor thrombus. During cytoreductive nephrectomy and IVC thrombectomy, tumor embolization was diagnosed during a period of hypotension based on transesophageal echocardiographic finding of new thrombus within the right atrium. This prompted sternotomy, CPB, and pulmonary artery embolectomy. The patient survived this embolization event and has a complete response to systemic therapy 9 months postoperatively. This case serves as the framework for a discussion on management considerations surrounding intraoperative embolization during IVC thrombectomy.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 4","pages":"43-49"},"PeriodicalIF":1.6,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10764280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139098916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preserving Renal Function without Compromising Oncological Outcomes: A Comparative Study of Partial and Total Nephrectomies in T3 Stage Renal Cell Carcinoma. 保留肾功能而不影响肿瘤结果：T3期肾细胞癌部分和全部肾切除术的比较研究》（A Comparative Study of Partial and Total Nephrectomies in T3 Stage Renal Cell Carcinoma）。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.290

Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Areez Shafqat, Belal Nedal Sabbah, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Salman Bin Ofisan, Mohammed Alghamdi, Nasser Albogami, Abdullah Al-Khayal

{"title":"Preserving Renal Function without Compromising Oncological Outcomes: A Comparative Study of Partial and Total Nephrectomies in T3 Stage Renal Cell Carcinoma.","authors":"Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Areez Shafqat, Belal Nedal Sabbah, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Salman Bin Ofisan, Mohammed Alghamdi, Nasser Albogami, Abdullah Al-Khayal","doi":"10.15586/jkcvhl.v10i4.290","DOIUrl":"10.15586/jkcvhl.v10i4.290","url":null,"abstract":"The utility of partial nephrectomy (PN) in locally advanced, stage T3 renal cell carcinoma (RCC) is controversial. This retrospective study aimed to review the oncological and functional outcomes of patients with T3a RCC who underwent PN. We included all patients with pT3a stage RCC undergoing either open, laparoscopic, or robotic PN at our center between January 2015 and 2023. A Wilcoxon rank sum test was utilized to compare nephrectomy types (radical nephrectomy [RN] vs PN). Survival analysis was conducted using Kaplan-Meier plots and a log-rank test. P-value < 0.05 indicated statistical significance. There were no significant differences in demographic characteristics between the RN and PN groups, except age (53.0 vs 6.5, respectively; P = 0.012) and body mass index (28.7 vs 34.3, respectively; P = 0.020). Furthermore, there were also no significant differences in the rates of local recurrence (P = 0.597), metastatic progression (P = 0.129), and chemotherapy use (P = 0.367) between nephrectomy types. Patient survival did not differ significantly based on the type of nephrectomy (log-rank P-value = 0.852). Together, our findings indicated that PN and RN yield near-equivalent oncological outcomes in terms of local recurrence, metastasis, and overall survival rates among pT3a RCC patients during a nearly 3-year follow-up period.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 4","pages":"28-32"},"PeriodicalIF":1.6,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Papillary Renal Cell Carcinoma: Demographics, Survival Analysis, Racial Disparities, and Genomic Landscape. 乳头状肾细胞癌：人口统计学、生存分析、种族差异和基因组图谱。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-12-26 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.294

Asad Ullah, Abdul Qahar Khan Yasinzai, Naema Daino, Bisma Tareen, Zulfiqar Haider Jogezai, Haleema Sadia, Nimra Jamil, Girahnaz Baloch, Adil Karim, Kaleemullah Badini, Agha Wali, Abdul Waheed, Marjan Khan, Bina Asif, Kaleemullah Kakar, Saleh Heneidi, Feroze Sidhwa, Nabin R Karki

{"title":"Papillary Renal Cell Carcinoma: Demographics, Survival Analysis, Racial Disparities, and Genomic Landscape.","authors":"Asad Ullah, Abdul Qahar Khan Yasinzai, Naema Daino, Bisma Tareen, Zulfiqar Haider Jogezai, Haleema Sadia, Nimra Jamil, Girahnaz Baloch, Adil Karim, Kaleemullah Badini, Agha Wali, Abdul Waheed, Marjan Khan, Bina Asif, Kaleemullah Kakar, Saleh Heneidi, Feroze Sidhwa, Nabin R Karki","doi":"10.15586/jkcvhl.v10i4.294","DOIUrl":"10.15586/jkcvhl.v10i4.294","url":null,"abstract":"Papillary renal cell carcinoma (PRCC) is the second most common histological subtype of renal cell cancer. This research aims to present a large database study highlighting the demographic, clinical, and pathological factors, racial disparities, prognosis, and survival of PRCC. The clinical and demographic data were extracted from the Surveillance, Epidemiology, and End Results (SEER) database, and molecular data was cured from the Catalogue Of Somatic Mutations in Cancer (COSMIC) database. PRCC had a median age of diagnosis at 64 years, with a higher incidence in men (77%), and Whites (68%). 70.3% of cases were Grades I-IV (13, 53, 31, and 3%, respectively). In patients with known data, 85% were localized to the kidney, and 84% of cases were 7 cm in size. No metastasis occurred in 97% of the known data. The most common treatment offered was surgical resection (9%). The 5-year overall survival was 79%, with patients undergoing surgery having a 90.6% 5-year survival. Multivariable analysis revealed age > 60 years, Black race, poor histologic differentiation, distant metastases, and tumor size > 10 cm as independent risk factors for mortality. The most common mutations identified from the COSMIC database were MET, KMT2D, KMT2C, ARID1A, and SPEN. PRCC affects male individuals in the sixth decade of life. Increased age, Black race, distant metastases, and tumors > 10 cm are associated with a worse prognosis. Surgical resection offers a favorable survival outcome. Next-generation sequencing (NGS) could identify potentially targetable alterations and future personalized therapeutic approaches.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 4","pages":"33-42"},"PeriodicalIF":1.6,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10755762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139075417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of the Patients Aged Less than 40 Years Operated for a Renal Mass 因肾脏肿块接受手术的 40 岁以下患者的特征

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-12-21 DOI: 10.15586/jkcvhl.v10i4.287

Abdullah Ilktac, Bayram Doğan, C. Ersoz, G. Çoban, S. Kalkan

{"title":"Characteristics of the Patients Aged Less than 40 Years Operated for a Renal Mass","authors":"Abdullah Ilktac, Bayram Doğan, C. Ersoz, G. Çoban, S. Kalkan","doi":"10.15586/jkcvhl.v10i4.287","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i4.287","url":null,"abstract":"The incidence of renal cell cancer (RCC) is low in individuals aged less than 40 years; however several studies have shown this increasing trend over the years. Hereditary syndromes are associated with RCC and are more frequently observed in early-onset cases. In this study, we investigated the characteristics of the patients, aged less than 40 years, who were operated for a renal mass with the suspicion of RCC. We analyzed patients aged <40 years who underwent partial or radical nephrectomy between January 2012 and December 2022. A total of 618 patients underwent partial or radical nephrectomy and 60 (9.7%) patients were aged <40 years. A total of 62 renal masses were resected. The median age of the patients was 34 (31.75–38) years. RCC was detected in 50 (80.6%) lesions, while 12 (19.4%) lesions were benign. The most commonly observed benign tumors were oncocytoma and multicystic nephroma. Low-stage RCC (stage 1) was detected in 78% of patients. Recurrence was observed in two patients and both had von Hippel–Landau gene mutation. During follow-up, two patients were found to have lung metastasis, while another patient had bone metastasis. Three patients died during the follow-up period. Disease free survival rate was 89.58% and cancer specific survival rate was 93.88%. The incidences of kidney cancer in young adults are increasing; therefore, early discovery and the diagnosis are important. Further research is required to gain a better understanding.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"90 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Renal Malignancies in Saudi Arabia: Insights from a Tertiary Care Center Study. 探索沙特阿拉伯的肾脏恶性肿瘤：来自三级医疗中心研究的启示。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-12-18 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.289

Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Belal Nedal Sabbah, Areez Shafqat, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Fisal Tariq Aldokhel, Salman Bin Ofisan, Saud Abdullah Alawad

{"title":"Exploring Renal Malignancies in Saudi Arabia: Insights from a Tertiary Care Center Study.","authors":"Ahmed Alasker, Turki Rashed Alnafisah, Mohammad Alghafees, Belal Nedal Sabbah, Areez Shafqat, Abdullah Alhaider, Abdulrahman Alsayyari, Naif Althonayan, Mohammed AlOtaibi, Fisal Tariq Aldokhel, Salman Bin Ofisan, Saud Abdullah Alawad","doi":"10.15586/jkcvhl.v10i4.289","DOIUrl":"https://doi.org/10.15586/jkcvhl.v10i4.289","url":null,"abstract":"This retrospective study aims to describe the characteristics of renal cell carcinoma (RCC) in Saudi Arabia, in terms of epidemiology, clinical presentation, tumor subtype, Fuhrman grade, tumor size and stage, and overall survival. A total of 431 adult patients with a histopathological diagnosis of RCC between 2015 and 2023 were included in the analysis. Most patients (72.4%) had clear cell tumors, followed by chromophobe (15.1%) and papillary (12.5%) subtypes. In males, papillary RCC (85.2%) was more common compared to clear cell (59.8%) and chromophobe (67.7%) subtypes. Significant differences were observed in median body mass index (BMI) across tumor subtypes, and papillary tumor patients exhibited the highest incidence of hematuria (33.3%) compared to other subtypes. The Fuhrman grade also varied significantly among RCC types. Survival times were found to be lower for patients with papillary tumors. No significant difference was observed based on patients' nationality. This study can inform clinical decision-making on patient prognosis and management as well as public health efforts aimed at reducing the alarming rise of RCC incidence.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 4","pages":"13-19"},"PeriodicalIF":1.6,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10739328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcomatoid Carcinoma Metastasis to the Colon from a Small Renal Mass: Case Report with Review of Literature. 肾小肿块向结肠转移的肉瘤样癌：病例报告并文献复习。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-10-31 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.297

Shailesh Patidar, Arun Ramdas Menon, Shirley Sundersingh, Ramakrishnan Ayloor Seshadri, Anand Raja

引用次数: 0

Advancing Treatment Frontiers: Radiofrequency Ablation for Small Renal Mass-Intermediate-Term Results. 推进治疗前沿：小肾脏肿块射频消融中期结果。

IF 1.6

Journal of Kidney Cancer and VHL Pub Date : 2023-10-04 eCollection Date: 2023-01-01 DOI: 10.15586/jkcvhl.v10i4.303

Rohit Kumar Singh, Manav Gideon, Rohan Rajendran, Georgie Mathew, Kannan Nair

{"title":"Advancing Treatment Frontiers: Radiofrequency Ablation for Small Renal Mass-Intermediate-Term Results.","authors":"Rohit Kumar Singh, Manav Gideon, Rohan Rajendran, Georgie Mathew, Kannan Nair","doi":"10.15586/jkcvhl.v10i4.303","DOIUrl":"10.15586/jkcvhl.v10i4.303","url":null,"abstract":"Our study aims to discern the immediate and intermediate-term oncological outcomes of the patients with small renal mass and who were surgically unfit or were having a bilateral tumor and underwent radiofrequency ablation (RFA) of the mass. We retrospectively and prospectively analyzed the status of the patients who were diagnosed to have small renal masses and were biopsy-proven renal cell carcinoma (RCC) cases, who underwent RFA at our institute from the year 2013 to 2022. Patients were followed-up for 3 years. Data regarding complications were analyzed for all patients who underwent renal RFA along with the 3-year recurrence-free survival (RFS) rate. A total of 28 patients were eligible for the study based on our inclusion and exclusion criteria. Their renal function was recorded. They underwent RFA and were followed-up for a period of 3 years for RFS. Four patients out of the total had immediate complications, out of which two developed a hematoma. Three-year-follow-ups showed six recurrences, overall having 78.6% RFS. Post-procedural renal function was stable as documented by Estimated glomerular filtration rate. Oncological results of RFA in patients with small renal masses who are surgically unfit are associated with a low risk of immediate and intermediate-term deterioration of renal function.","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"10 4","pages":"1-6"},"PeriodicalIF":1.6,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10560514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0