Journal of Kidney Cancer and VHL最新文献

{"title":"When Effective Therapies Collide: Aorto-Esophageal Fistula After Thoracic Radiotherapy and Anti-VEGF TKI in a Long-Survivor with mRCC.","authors":"Simone Rota, Valentina Guadalupi, Camilla Damonte, Tommaso Cascella, Edoardo Borsotti, Giuseppe Procopio","doi":"10.15586/jkc.v13i2.448","DOIUrl":"https://doi.org/10.15586/jkc.v13i2.448","url":null,"abstract":"<p><p>Advances in systemic therapies have improved survival in metastatic renal cell carcinoma (mRCC), leading to a growing population of long-term survivors who may receive both radiotherapy (RT) and tyrosine kinase inhibitors (TKIs) during their disease course. Both treatments induce vascular and mucosal toxicity, and their biological effects may overlap, increasing the risk of rare but life-threatening complications such as aorto-esophageal fistula (AEF). Herein, we present the case of a 47-year-old man with mRCC treated with nephrectomy and repeated pulmonary metastasectomies, followed by sunitinib, mediastinal stereotactic body radiotherapy (SBRT), and later cabozantinib for hepatic progression. Five years after thoracic RT and shortly after initiating cabozantinib, the patient developed massive hematemesis due to an AEF. Management included thoracic endovascular aortic repair (TEVAR), esophageal stenting, and prolonged antimicrobial therapy. Despite initial stabilization, recurrent fistulization and infections led to progressive deterioration and death 7 months later. This case underscores the catastrophic potential of RT-TKI interaction in long-term survivor patients. Sequential exposure can transform subclinical vascular injury into fatal outcomes. Risk stratification, nonconcurrent scheduling of RT and anti-VEGF therapy, and vigilant long-term monitoring are essential. Integration of multidisciplinary and palliative approaches is necessary to balance treatment efficacy with safety.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 2","pages":"1-7"},"PeriodicalIF":1.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147784986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Margin Length Predict Recurrence After Partial Nephrectomy, or Is Presence Alone Sufficient?","authors":"Ural Oğuz, Mehmet Giray Sönmez, Birgül Tok, Pembe Oltulu, Şenol Adanur, Rabia Demirtaş, Mehmet Salih Boğa, Tangül Pınarcı, Gizem Teoman, Sevdegül Aydın Mungan, İlke Onur Kazaz, Gökhan Sönmez, Hülya Akgün, Ertürk Altun, İbrahim Göksoy, Erhan Demirelli, Ercan Öğreden, Doğan Sabri Tok, Salih Al, Eren Baş, Erol Eğrioğlu, Mutlu Ateş, Selçuk Güven","doi":"10.15586/jkc.v13i1.421","DOIUrl":"https://doi.org/10.15586/jkc.v13i1.421","url":null,"abstract":"<p><p>To evaluate whether the length of positive surgical margin carries a risk for recurrence, data of patients that underwent partial nephrectomy (PN) from six centers were evaluated. Fifty-three patints with positive surgical margins (PSMs) (the PSM group) and 438 patients with negative surgical margin (the NSM group) were included in the present study. Pathologic reevaluations were performed, and surgical margins were measured in micrometers. The number of positive margin areas, and the length of the maximum and total positive margins were evaluated. Data were analyzed using SPSS 27 package program. A p-value less than 0.001 was considered statistically significant. Local recurrence occured in 16.98% of patients in the PSM group and 4.24% of patients in the NSM group. (p<0.001). Patients with PSM were at fourfold increased risk for recurrence. Age, gender, tumor location, tumor side and size, and fuhrman grade were not associated with local recurrence of the tumor (p>0.01). However, positive surgical margin was an important risk factor for local recurrence (p<0.01). No relationship was found between positive margin length and local recurrence (p=0.044). Logistic regression analysis did not identify any parameters associated with local recurrence. The presence of a PSM was significantly associated with an increased risk of local recurrence following PN. The number of positive margin foci and total or maximum length of margin involvement were not associated with recurrence. These findings suggest that it is the presence of PSM, rather than its extent, that may be the primary factor influencing oncological risk.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 1","pages":"27-32"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric Neuroendocrine Tumor Presenting Atypically in von Hippel-Lindau Disease: A Case Report.","authors":"Jiawei Chang, Qiong Zhang, Zhihui Liu, Yinmiao Bai, Hongchen Ji, Hong-Mei Zhang","doi":"10.15586/jkc.v13i1.420","DOIUrl":"https://doi.org/10.15586/jkc.v13i1.420","url":null,"abstract":"<p><p>von Hippel-Lindau (VHL) disease, an autosomal dominant inherited disorder resulting from mutations in the VHL gene, is known to be associated with the development of neuroendocrine tumors (NET) in various organs, including the adrenal gland, pancreas, and paraganglion. However, the development of gastric NET (gNET) in VHL disease has not been reported. Limited studies have suggested that clear cell change is a distinctive feature of VHL-associated tumors. Herein, we first report a case of a patient with VHL syndrome who presented with a gNET showing clear cell change, an unusual morphological characteristic of gNET, and harbored a pathogenic germline VHL mutation (c.351 G>T). The patient underwent surgical treatment for retinal hemangioblastoma, gNET, and renal cell carcinoma, in addition to receiving endocrine therapy and antiangiogenic drugs. The patient survived for 17 years. Our case highlights the possibility of VHL-associated NET development in uncommon locations. Further studies are required to elucidate the correlation between VHL mutation sites and the clinical manifestation of the disease.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 1","pages":"21-26"},"PeriodicalIF":1.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Nephrectomy of Renal Cell Carcinoma in Horseshoe Kidney with Assistance of Intraoperative Retrograde Pyelogram: A Case Report and Literature Review.","authors":"Omar Wai-Kiu Tsui, Sunny Shek-Long Tsang, Henry Hong-Yin Lie, Thomas Ting-Fung Wong, Wilson Pui-Long Hung, Simon Hoi-Lung Wong, Terence Chun-Ting Lai, Chiu-Fung Tsang, Ada Tsui-Lin Ng","doi":"10.15586/jkc.v13i1.449","DOIUrl":"10.15586/jkc.v13i1.449","url":null,"abstract":"<p><p>Horseshoe kidney (HSK), characterized by the fusion of two kidneys forming a U-shape, presents intricate challenges in renal anatomy and poses a unique landscape for the development of renal cell carcinoma (RCC). This abstract delves into the case of a 74-year-old male with HSK who also developed RCC, where the employment of intraoperative retrograde pyelogram (RP) played a pivotal role in enhancing surgical precision. The patient's complex tumor was successfully resected through meticulous identification and dissection. A comprehensive literature review reveals the significance of laparoscopic and robotic surgeries in treating RCC within HSKs, with 3D-reconstruction aiding in surgical planning. While advancements in imaging technologies have improved surgical outcomes, the underexplored utility of intraoperative RP stands out. RP provided real-time insights into the renal pelvis anatomy, guiding the surgical team in navigating intricate structures and ensuring optimal reconstruction post-tumor excision. The discussion underscores the challenges posed by RCC in HSKs, importance of preoperative 3D-reconstruction and angiography in surgical planning, and the critical role of intraoperative RP in mapping renal pelvis anatomy. Unlike conventional imaging methods, RP offers dynamic visualization of the renal drainage system, safeguarding against inadvertent closures and enhancing surgical precision. The successful utilization of RP in this case not only facilitated safe tumor resection but also highlighted its potential in managing unclear renal structures. In conclusion, the integration of intraoperative RP in surgical interventions for RCC within HSKs proves instrumental in enhancing surgical precision and navigating complex anatomical variations. By emphasizing the importance of real-time imaging guidance, surgeons can optimize treatment outcomes for individuals with RCC in the challenging context of HSK anomalies.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 1","pages":"12-20"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147595384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Renal Fibrosarcoma with Massive Tumor Size and Inferior Vena Cava Extension Mimicking Renal Cell Carcinoma: A Rare Case Report.","authors":"Kapil Rathore, Ketan Mehra, Manoj Yadav, Devashish Kaushal, Deepti Joshi, Kumar Madhavan, Nikita Shrivastava, Chandana","doi":"10.15586/jkc.v13i1.430","DOIUrl":"10.15586/jkc.v13i1.430","url":null,"abstract":"<p><p>Primary renal fibrosarcoma is an exceedingly rare malignant mesenchymal tumor that accounts for only 1-3% of adult renal malignancies, often mistaken for sarcomatoid renal cell carcinoma (RCC) or leiomyosarcoma due to overlapping morphology. Thus, accurate disease diagnosis is crucial for its management. We report a case of a 49-year-old female, a chronic smoker, who presented with right flank pain and progressive abdominal swelling. Clinical examination revealed a firm mass in the right abdomen, and contrast-enhanced computed tomography demonstrated a large exophytic right renal mass with areas of necrosis, infiltration of the psoas muscle, and extension of tumor thrombus into the inferior vena cava (IVC). The patient underwent right radical nephrectomy with IVC thrombectomy, and a 20 × 15 cm irregular renal mass with 2 cm IVC thrombus was excised intraoperatively. Histopathology revealed a high-grade spindle cell neoplasm with interlacing fascicles and herringbone patterns, brisk mitoses (10-12 mitotic figures per 10HPF), and 20% necrosis. Immunohistochemistry showed diffuse vimentin positivity with negative staining for epithelial, myogenic, neural, and renal lineage markers, confirming the diagnosis of high-grade primary renal fibrosarcoma. This case is notable for being the largest renal fibrosarcoma reported to date, with rare IVC extension, features typically associated with advanced RCC rather than fibrosarcoma. Despite aggressive pathology, no metastases were identified, and the patient remained recurrence-free at 6 months postoperatively, with chemotherapy reserved for recurrence or metastasis. This report emphasizes the diagnostic challenges, surgical complexity, and clinical significance of primary renal fibrosarcoma and highlights the importance of including it in the differential diagnosis of large renal masses with vascular involvement.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 1","pages":"6-11"},"PeriodicalIF":1.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12808933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rosy Cells with a Rocky Core: Low-Grade Oncocytic Tumor with Osseous Metaplasia.","authors":"Joseph Stenberg, Justin Tse, Emily Volpicelli","doi":"10.15586/jkc.v13i1.439","DOIUrl":"10.15586/jkc.v13i1.439","url":null,"abstract":"<p><p>Osseous metaplasia is rarely reported in renal neoplasms and is predominantly associated with a favorable prognosis. Low-grade oncocytic tumor (LOT) represents a novel diagnostic classification of renal neoplasms that exhibit overlapping features of oncocytomas and chromophobe renal cell carcinoma. To the best of our knowledge, there are two definitive cases of low-grade oncocytic tumors with osseous metaplasia in the English literature. We present the third case of a 52-year-old female diagnosed with a low-grade oncocytic tumor exhibiting osseous metaplasia.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"13 1","pages":"1-5"},"PeriodicalIF":1.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Minimally Invasive Surgery: Robotic Adrenalectomy for Pheochromocytoma-Efficacy, Safety, and Cost-Effectiveness in Focus.","authors":"Danilo Coco, Silvana Leanza","doi":"10.15586/jkc.v12i4.389","DOIUrl":"10.15586/jkc.v12i4.389","url":null,"abstract":"<p><p>Pheochromocytoma, a rare neuroendocrine tumor of the adrenal glands, drives excessive catecholamine production, precipitating hypertension, cardiovascular crises, and systemic symptoms. Laparoscopic adrenalectomy has long been the surgical gold standard, but robotic adrenalectomy is increasingly recognized as a precise, minimally invasive alternative with potential advantages in recovery and operative precision. This narrative review critically evaluates the efficacy, safety, and cost-effectiveness of robotic adrenalectomy for pheochromocytoma, synthesizing evidence from clinical studies to compare perioperative outcomes, complications, and economic impacts against laparoscopic approaches. While robotic techniques demonstrate promising short-term results, including reduced blood loss and shorter hospital stays, the analysis identifies gaps in long-term outcome data and potential publication bias favoring newer technologies. This review underscores the necessity for rigorous prospective studies to validate these findings and refine patient selection criteria. By contextualizing robotic adrenalectomy within the evolving landscape of minimally invasive surgery, this work aims to guide clinical practice, optimize resource allocation, and improve patient-centered care.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"12 4","pages":"46-51"},"PeriodicalIF":1.9,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12631137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zinc as a Dual-Condition Inhibitor of HIF-1α/VEGF-α-Mediated Angiogenesis in Clear Cell Renal Carcinoma.","authors":"Guilherme Oliveira Carlos, Beatriz Miquilino Neto, Luiz Felipe S Teixeira, Amanda Sena de Sousa, Monica Beatriz Mathor, Maria Helena Bellini Marumo","doi":"10.15586/jkc.v12i4.429","DOIUrl":"10.15586/jkc.v12i4.429","url":null,"abstract":"<p><p>Clear cell renal cell carcinoma (ccRCC) is marked by aberrant hypoxia-driven signaling and enhanced angiogenesis mediated by hypoxia-inducible factor 1-alpha (HIF-1α) and vascular endothelial growth factor alpha (VEGF-α). Zinc (Zn), an essential trace element with emerging anticancer potential, was evaluated for its ability to modulate angiogenesis in von Hippel-Lindau (VHL)-deficient 786-0 cells under normoxic and hypoxic conditions. Using quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence, we observed that Zn treatment reduced HIF-1α expression and VEGF-α secretion across both oxygenation states. Notably, Zn inhibited the hypoxia-induced nuclear accumulation of HIF-1α and attenuated paracrine endothelial activation, as shown by reduced human umbilical vein endothelial cell (HUVEC) viability in conditioned media assays. These effects likely involve transcriptional repression, enhanced proteasomal degradation of HIF-1α, and interference with VEGF-α-dependent signaling. Overall, our findings suggest that zinc may function as a multifunctional modulator of tumor angiogenesis and holds potential as an adjuvant in antiangiogenic strategies, particularly under hypoxic conditions.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"12 4","pages":"35-45"},"PeriodicalIF":1.9,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12599116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imaging Characteristics of Pediatric Renal Cell Carcinoma and Wilms Tumor and Its Impact on Their Management and Outcomes-A Case Report and Review of Literature.","authors":"Anand Chetan Shah, Prasanth Srinivasan, Shalini Shree Krishnamurthy, Shirley Sunder Singh, Venkatraman Radhakrishnan, Anand Raja","doi":"10.15586/jkc.v12i4.388","DOIUrl":"10.15586/jkc.v12i4.388","url":null,"abstract":"<p><p>Renal cell carcinoma (RCC) in children is rare, comprising only 1.4-6.3% of pediatric renal tumors. Differentiating RCC from Wilms tumor, the most common pediatric renal tumor is crucial due to differing management and prognosis. Imaging characteristics, such as the presence of calcifications and cystic components, guided the decision to perform surgery without pretreatment biopsy, reducing the risk of needle tract seeding. Translocation-associated RCC is the most common subtype in children, and surgical resection remains the cornerstone of treatment. Long-term follow-up is essential due to the potential for late recurrences. We are reporting the details of a 4-year-old boy, who presented with a 15-day history of fever and abdominal distension, accompanied by a ballotable mass in the right lumbar region. Imaging studies, including a CT scan, revealed a large complex cystic mass in the right kidney, consistent with Bosniak category IV, and enlarged paraaortic nodes. Further evaluation with an FDG-PET scan confirmed the uptake only in the right kidney. The child underwent a right radical nephrectomy with retroperitoneal lymph node dissection. Histopathology revealed translocation-associated RCC features, characterized by slender papillae, psammoma bodies, necrosis, and uniform epithelial cells with hyperchromatic nuclei. Immunohistochemistry showed positivity for markers including TEF3, keratin, and vimentin, with a KI-67 proliferation index of 10-20%. The final stage was pT2aN0, and the patient had an uneventful recovery, with no recurrence at 36 months of follow-up.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"12 4","pages":"30-34"},"PeriodicalIF":1.9,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12591865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145483306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Composition May Be a Novel Presurgical Risk Factor for Acute Kidney Injury among Clear Cell Renal Cell Cancer Patients Undergoing Radical Nephrectomy.","authors":"Linnea T Olsson, Alejandro Sanchez, Marina Mourtzakis, A Ari Hakimi, Paul Russo, Edgar A Jaimes, Patrick T Bradshaw, Helena Furberg","doi":"10.15586/jkc.v12i4.423","DOIUrl":"10.15586/jkc.v12i4.423","url":null,"abstract":"<p><p>Patients with renal cell carcinoma (RCC) undergoing nephrectomy are at risk for acute kidney injury (AKI). Prior studies have focused predominantly on nonmodifiable surgical AKI risk factors. We conducted the first investigation of body composition features and AKI to identify factors that could improve presurgical risk stratification and be targeted in future interventions. We analyzed data from 1199 patients with stages I-III, clear cell RCC undergoing radical (RN) or partial nephrectomy (PN) from 2000 to 2020. AKI was defined as a serum creatinine (sCr) increase by 0.3 mg/dL within 48 h or a 1.5-fold increase in sCr within 7 days. Preoperative computed tomography (CT) scans were segmented to determine quantities and radiodensities of adipose tissue and skeletal muscle using Automatica software. Multivariable generalized linear models estimated 7-day risk differences (RD) and 95% confidence intervals (CI) within surgical subgroups. AKI was more frequent among patients undergoing RN (66%) than PN (26%). For RN, only higher visceral adipose tissue (VAT) quantity was significantly associated with greater AKI risk (RD per 40-unit increase 5.2 [95% CI: 1.3, 9.2]). We initially detected a similar association in PN, but after multivariable adjustment for all body composition features, associations were attenuated and became nonsignificant. Associations between presurgical body composition and AKI risk vary by surgery type. Higher VAT quantity increased AKI risk only among RN patients. If confirmed, CT-derived VAT quantity may be a novel presurgical imaging characteristic that could be used to inform treatment selection or modified to decrease postoperative AKI risk in RN patients.</p>","PeriodicalId":44291,"journal":{"name":"Journal of Kidney Cancer and VHL","volume":"12 4","pages":"19-29"},"PeriodicalIF":1.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12542082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145356340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}