Global Health Epidemiology and Genomics最新文献_第5页

The Nigerian Bioinformatics and Genomics Network (NBGN): a collaborative platform to advance bioinformatics and genomics in Nigeria. 尼日利亚生物信息学和基因组学网络（NBGN）：推动尼日利亚生物信息学和基因组学发展的合作平台。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2020-07-15 eCollection Date: 2020-01-01 DOI: 10.1017/gheg.2020.3

Segun Fatumo, ThankGod E Ebenezer, Chinwe Ekenna, Itunuoluwa Isewon, Umar Ahmad, Charles Adetunji, Elijah Kolawole Oladipo, Marion Adebiyi, Ezekiel Adebiyi, Oyekanmi Nashiru

{"title":"The Nigerian Bioinformatics and Genomics Network (NBGN): a collaborative platform to advance bioinformatics and genomics in Nigeria.","authors":"Segun Fatumo, ThankGod E Ebenezer, Chinwe Ekenna, Itunuoluwa Isewon, Umar Ahmad, Charles Adetunji, Elijah Kolawole Oladipo, Marion Adebiyi, Ezekiel Adebiyi, Oyekanmi Nashiru","doi":"10.1017/gheg.2020.3","DOIUrl":"10.1017/gheg.2020.3","url":null,"abstract":"Africa plays a central importance role in the human origins, and disease susceptibility, agriculture and biodiversity conservation. Nigeria as the most populous and most diverse country in Africa, owing to its 250 ethnic groups and over 500 different native languages is imperative to any global genomic initiative. The newly inaugurated Nigerian Bioinformatics and Genomics Network (NBGN) becomes necessary to facilitate research collaborative activities and foster opportunities for skills' development amongst Nigerian bioinformatics and genomics investigators. NBGN aims to advance and sustain the fields of genomics and bioinformatics in Nigeria by serving as a vehicle to foster collaboration, provision of new opportunities for interactions between various interdisciplinary subfields of genomics, computational biology and bioinformatics as this will provide opportunities for early career researchers. To provide the foundation for sustainable collaborations, the network organises conferences, workshops, trainings and create opportunities for collaborative research studies and internships, recognise excellence, openly share information and create opportunities for more Nigerians to develop the necessary skills to exceed in genomics and bioinformatics. NBGN currently has attracted more than 650 members around the world. Research collaborations between Nigeria, Africa and the West will grow and all stakeholders, including funding partners, African scientists, researchers across the globe, physicians and patients will be the eventual winners. The exponential membership growth and diversity of research interests of NBGN just within weeks of its establishment and the unanticipated attendance of its activities suggest the significant importance of the network to bioinformatics and genomics research in Nigeria.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"5 ","pages":"e3"},"PeriodicalIF":1.9,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7372179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38221021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health impact of the Anthropocene: the complex relationship between gut microbiota, epigenetics, and human health, using obesity as an example. 人类世对健康的影响:肠道微生物群、表观遗传学和人类健康之间的复杂关系，以肥胖为例。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2020-04-20 eCollection Date: 2020-01-01 DOI: 10.1017/gheg.2020.2

Cecilie Torp Austvoll, Valentina Gallo, Doreen Montag

{"title":"Health impact of the Anthropocene: the complex relationship between gut microbiota, epigenetics, and human health, using obesity as an example.","authors":"Cecilie Torp Austvoll, Valentina Gallo, Doreen Montag","doi":"10.1017/gheg.2020.2","DOIUrl":"10.1017/gheg.2020.2","url":null,"abstract":"The growing prevalence of obesity worldwide poses a public health challenge in the current geological epoch, the Anthropocene. Global changes caused by urbanisation, loss of biodiversity, industrialisation, and land-use are happening alongside microbiota dysbiosis and increasing obesity prevalence. How alterations of the gut microbiota are associated with obesity and the epigenetic mechanism mediating this and other health outcome associations are in the process of being unveiled. Epigenetics is emerging as a key mechanism mediating the interaction between human body and the environment in producing disease. Evidence suggests that the gut microbiota plays a role in obesity as it contributes to different mechanisms, such as metabolism, body weight and composition, inflammatory responses, insulin signalling, and energy extraction from food. Consistently, obese people tend to have a different epigenetic profile compared to non-obese. However, evidence is usually scattered and there is a growing need for a structured framework to conceptualise this complexity and to help shaping complex solutions. In this paper, we propose a framework to analyse the observed associations between the alterations of microbiota and health outcomes and the role of epigenetic mechanisms underlying them using obesity as an example, in the current context of global changes within the Anthropocene.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"5 ","pages":"e2"},"PeriodicalIF":1.9,"publicationDate":"2020-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2020.2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37896815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Tobacco smoking as a risk factor for tuberculous pleural effusion: a case-control study. 吸烟是结核性胸腔积液的危险因素:一项病例对照研究。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2020-02-12 DOI: 10.1017/gheg.2020.1

Pavit Tewatia, Rajeev Mohan Kaushik, Reshma Kaushik, Sanjeev Kumar

{"title":"Tobacco smoking as a risk factor for tuberculous pleural effusion: a case-control study.","authors":"Pavit Tewatia, Rajeev Mohan Kaushik, Reshma Kaushik, Sanjeev Kumar","doi":"10.1017/gheg.2020.1","DOIUrl":"https://doi.org/10.1017/gheg.2020.1","url":null,"abstract":"This study assessed the tobacco smoking-associated risk for tuberculous pleural effusion (TPE) in India. Ninety-two patients with TPE and 184 controls were randomly selected and assessed regarding their tobacco-smoking status and type, quantity and duration of tobacco used. Odds ratios (ORs) for the association of smoking cigarette, beedi and cigarette or beedi with TPE were 19.22 (p < 0.0001), 2.89 (p = 0.0006) and 4.57 (p < 0.0001) respectively. ORs for developing TPE increased with an increase in beedi/cigarette consumption, duration and pack years of smoking (p < 0.001 each). TPE was significantly associated with confounding risk factors viz., regular alcohol use (OR = 1.89, p = 0.019), history of contact with tuberculosis (TB) patient (OR = 8.07, p < 0.0001), past history of TB (OR = 22.31, p < 0.0001), family history of TB (OR = 9.05, p = 0.0002) and underweight (OR = 3.73, p = 0.0009). Smoking (OR = 3.07, p < 0.001), regular alcohol use (OR = 2.10, p = 0.018), history of contact with TB patient (OR = 4.01, p = 0.040), family history of TB (OR = 10.80, p = 0.001) and underweight (OR = 5.04, p < 0.001) were independently associated with TPE. Thus, both cigarette- and beedi-smoking have a significant association with TPE. The risk for TPE in tobacco smokers is dose- and duration-dependent.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"5 ","pages":"e1"},"PeriodicalIF":1.9,"publicationDate":"2020-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2020.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37743716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

The role of epigenetics in respiratory health in urban populations in low and middle-income countries. 表观遗传学在低收入和中等收入国家城市人口呼吸健康中的作用。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-11-26 DOI: 10.1017/gheg.2019.7

Nicole M Robertson, Alex Kayongo, Trishul Siddharthan, Suzanne L Pollard, Jose Gomez Villalobos, Christine Ladd-Acosta, Bruce Kirenga, William Checkley

{"title":"The role of epigenetics in respiratory health in urban populations in low and middle-income countries.","authors":"Nicole M Robertson, Alex Kayongo, Trishul Siddharthan, Suzanne L Pollard, Jose Gomez Villalobos, Christine Ladd-Acosta, Bruce Kirenga, William Checkley","doi":"10.1017/gheg.2019.7","DOIUrl":"https://doi.org/10.1017/gheg.2019.7","url":null,"abstract":"As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"4 ","pages":"e8"},"PeriodicalIF":1.9,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2019.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37635307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A model for point of care testing for non-communicable disease diagnosis in resource-limited countries 资源有限国家非传染性疾病诊断的护理点检测模型

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-09-11 DOI: 10.1017/gheg.2019.6

Stuart Malcolm, J. Cadet, Lindsay Crompton, V. DeGennaro

{"title":"A model for point of care testing for non-communicable disease diagnosis in resource-limited countries","authors":"Stuart Malcolm, J. Cadet, Lindsay Crompton, V. DeGennaro","doi":"10.1017/gheg.2019.6","DOIUrl":"https://doi.org/10.1017/gheg.2019.6","url":null,"abstract":"Non-communicable disease diagnosis frequently relies on biochemical measurements but laboratory infrastructure in low-income settings is often insufficient and distances to clinics may be vast. We present a model for point of care (POC) epidemiology as used in our study of chronic disease in the Haiti Health Study, in rural and urban Haiti. Point of care testing (POCT) of creatinine, cholesterol, and hemoglobin A1c as well as physical measurements of weight, height, and waist circumference allowed for diagnosis of diabetes, chronic kidney disease, dyslipidemias, and obesity. Methods and troubleshooting techniques for the data collection of this study are presented. We discuss our method of community-health worker (CHW) training, community engagement, study design, and field data collection. We also discuss the machines used and our quality control across CHWs and across geographical regions. Pitfalls tended to include equipment malfunction, transportation issues, and cultural differences. May this paper provide information for those attempting to perform similar diagnostic and screening studies using POCT in resource poor settings.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"4 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2019-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2019.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41466512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

You have to be twice as good and work twice as hard: a mixed-methods study of perceptions of sexual harassment, assault and women's leadership among female faculty at a research university in the USA 你必须加倍优秀，加倍努力:一项针对美国一所研究型大学女教师对性骚扰、性侵犯和女性领导力认知的混合方法研究

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-09-05 DOI: 10.1017/gheg.2019.5

Dabney P. Evans, J. Sales, K. Krause, C. del Rio

{"title":"You have to be twice as good and work twice as hard: a mixed-methods study of perceptions of sexual harassment, assault and women's leadership among female faculty at a research university in the USA","authors":"Dabney P. Evans, J. Sales, K. Krause, C. del Rio","doi":"10.1017/gheg.2019.5","DOIUrl":"https://doi.org/10.1017/gheg.2019.5","url":null,"abstract":"Introduction The purpose of this study was to examine the perceptions of institutional policies and practices for the prevention of and response to gender inequities as experienced by female faculty working in the health sciences at a US research university. Methods Data from the institution's Faculty Campus Climate Survey (n = 260 female faculty) were coupled with qualitative interviews (n = 14) of females in leadership positions, exploring campus climate, and institutional policies and practices aimed at advancing women. Results Two-thirds (59%) of the female faculty respondents indicated witnessing sexual harassment and 28% reported experiencing sexual harassment. Several organizational themes emerged to address this problem: culture, including cultural change, transparency, and accountability. Conclusions The findings reveal the ways in which university culture mimics the larger societal context. At the same time, the distinct culture of higher education processes for recruitment, career advancement – specifically tenure and promotion – are identified as important factors that require modifications in support of reductions in gender inequalities.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2019.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45567058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’ “过去十年中希腊北部丙型肝炎病毒基因型的分布：描述性分析和临床相关性”

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-09-02 DOI: 10.1017/gheg.2019.4

G. Gioula, E. Sinakos, E. Gigi, I. Goulis, T. Vasiliadis, F. Minti, E. Akriviadis

{"title":"‘Distribution of Hepatitis C Virus genotypes in northern Greece in the last decade: descriptive analysis and clinical correlations’","authors":"G. Gioula, E. Sinakos, E. Gigi, I. Goulis, T. Vasiliadis, F. Minti, E. Akriviadis","doi":"10.1017/gheg.2019.4","DOIUrl":"https://doi.org/10.1017/gheg.2019.4","url":null,"abstract":"Hepatitis C virus (HCV) represents a major public health problem, while the identification of a HCV genotype is clinically very important for therapy prescription. The aim of the present study was to determine the HCV genotype distribution patients from northern Greece with HCV RNA positive viral load and to identify whether there is a shift in this distribution, during 2009–2017. The study was performed on 915 HCV positive patients and according to the results, genotype 3 was the most prevalent genotype (Ν = 395, 43.2%) followed by genotype 1 (Ν = 361, 39.5%). Regarding the gender of the patients, genotype 1 was mostly detected in women. Moreover, genotype 1 was associated with higher viral loads, while genotype 3 was most frequently detected in patients with a history of intravenous drug use. In conclusion, our results show that genotype 3 is the most prevalent genotype in Greece during the last decade as opposed to older epidemiological studies, likely due to intravenous drug use becoming the major source of infection.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2019.4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44825880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka. 情绪化进食与抑郁症状之间的关系:斯里兰卡一项基于人群的双胞胎研究

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-05-08 eCollection Date: 2019-01-01 DOI: 10.1017/gheg.2019.3

Moritz P Herle, Carol Kan, Kaushalya Jayaweera, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Milana Smolkina, Athula Sumathipala, Clare Llewellyn, Khalida Ismail, Matthew Hotopf, Janet Treasure, Frühling Rijsdijk

{"title":"The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka.","authors":"Moritz P Herle, Carol Kan, Kaushalya Jayaweera, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Milana Smolkina, Athula Sumathipala, Clare Llewellyn, Khalida Ismail, Matthew Hotopf, Janet Treasure, Frühling Rijsdijk","doi":"10.1017/gheg.2019.3","DOIUrl":"https://doi.org/10.1017/gheg.2019.3","url":null,"abstract":"This study investigated the genetic and environmental contributions to emotional overeating (EOE) and depressive symptoms, and their covariation, in a Sri-Lankan population, using genetic model-fitting analysis. In total, 3957 twins and singletons in the Colombo Twin and Singleton Study-Phase 2 rated their EOE behaviour and depressive symptoms, which were significantly associated (men: r = 0.11, 95% confidence interval (CI) 0.06-0.16, women: r = 0.12, 95% CI 0.07-0.16). Non-shared environmental factors explained the majority of variance in men (EOE e2 = 87%, 95% CI 78-95%; depressive symptoms e2 = 72%, 95% CI 61-83%) and women (EOE e2 = 76%, 95% CI 68-83%; depressive symptoms e2 = 64%, 95% CI 55-74%). Genetic factors were more important for EOE in women (h2 = 21%, 95% CI 4-32%) than men (h2 = 9%, 95% CI 0-20%). Shared-environmental factors were more important for depressive symptoms in men (c2 = 25%, 95% CI 10-36%) than women (c2 = 9%, 95% CI 0-35%). Non-shared environmental factors explained the overlap between depressive symptoms and EOE in women but not in men. Results differed from high-income populations, highlighting the need for behavioural genetic research in global populations.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"4 ","pages":"e4"},"PeriodicalIF":1.9,"publicationDate":"2019-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2019.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37255938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Non-alcoholic fatty liver disease in Africa: a hidden danger. 非洲的非酒精性脂肪肝：隐藏的危险。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2019-04-12 eCollection Date: 2019-01-01 DOI: 10.1017/gheg.2019.2

Imran M Paruk, Fraser J Pirie, Ayesha A Motala

{"title":"Non-alcoholic fatty liver disease in Africa: a hidden danger.","authors":"Imran M Paruk, Fraser J Pirie, Ayesha A Motala","doi":"10.1017/gheg.2019.2","DOIUrl":"10.1017/gheg.2019.2","url":null,"abstract":"There is a dearth of data on the burden and spectrum of non-alcoholic fatty liver disease (NAFLD) in African populations. The limited available information suggests that the prevalence of NAFLD in the general population is lowest for the Africa region. However, this is likely to be an underestimate and also does not take into consideration the long-term impact of rising rates of obesity, type-2 diabetes mellitus (T2DM) and high human immunodeficiency virus infection burden in Africa. A racial disparity in the prevalence of NAFLD has been observed in some studies but remains unexplained. There is an absence of data from population-based studies in Africa and this highlights the need for such studies, to reliably define the health service needs for this region. Screening for NAFLD at a population-based level using ultrasound is perhaps the ideal method for resource-poor settings because of its relative cost-effectiveness. What is required as a priority from Africa, are well-designed epidemiologic studies that screen for NAFLD in the general population as well as high-risk groups such as patients with T2DM or obesity.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"4 ","pages":"e3"},"PeriodicalIF":1.1,"publicationDate":"2019-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37181915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lifestyle intervention programme for Indian women with history of gestational diabetes mellitus. 有妊娠期糖尿病史的印度妇女的生活方式干预方案。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2019-03-11 eCollection Date: 2019-01-01 DOI: 10.1017/gheg.2018.18

Deksha Kapoor, Yashdeep Gupta, Ankush Desai, Devarsetty Praveen, Rohina Joshi, Roya Rozati, Neerja Bhatla, Dorairaj Prabhakaran, Prasuna Reddy, Anushka Patel, Nikhil Tandon

{"title":"Lifestyle intervention programme for Indian women with history of gestational diabetes mellitus.","authors":"Deksha Kapoor, Yashdeep Gupta, Ankush Desai, Devarsetty Praveen, Rohina Joshi, Roya Rozati, Neerja Bhatla, Dorairaj Prabhakaran, Prasuna Reddy, Anushka Patel, Nikhil Tandon","doi":"10.1017/gheg.2018.18","DOIUrl":"https://doi.org/10.1017/gheg.2018.18","url":null,"abstract":"Aim: To evaluate the feasibility and potential effectiveness of a lifestyle intervention (diet and physical activity) among women with history of gestational diabetes mellitus (GDM), delivered by trained facilitators.Methods: Fifty-six normoglycaemic or prediabetic women with prior GDM were recruited at mean of 17 months postpartum. Socio-demographic, medical and anthropometric data were collected. Six sessions on lifestyle modification were delivered in groups (total four groups, with 12-15 women in each group). Pre and post intervention (6 months) weight, body mass index (BMI), waist circumference, 75 g oral glucose tolerance test, blood pressure (BP) and lipid parameters were compared.Results: The intervention was feasible, with 80% of women attending four or more sessions. Post-intervention analyses showed a significant mean reduction of 1.8 kg in weight, 0.6 kg/m2 in BMI and 2 cm in waist circumference. There was also a significant drop of 0.3 mmol/L in fasting plasma glucose, 0.9 mmol/L in 2 h post glucose load value of plasma glucose, 3.6 mmHg in systolic BP, and 0.15 mmol/L in triglyceride levels. Changes in total cholesterol, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol and diastolic BP were non-significant.Conclusions: This study showed feasibility of the lifestyle intervention delivered in group sessions to women with prior gestational diabetes.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"4 ","pages":"e1"},"PeriodicalIF":1.9,"publicationDate":"2019-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2018.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37072303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9