The Sri Lankan twin registry biobank: South Asia's first twin biobank.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-09-09 eCollection Date: 2020-01-01 DOI:10.1017/gheg.2020.4

Kaushalya Jayaweera, Lakshan Warnakula, Lasith Dissanayake, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Fruhling Rijsdijk, Patricia A Zunszain, Carmine M Pariante, Nick Glozier, Matthew Hotopf, Athula Sumathipala

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引用次数: 2

Abstract

Introduction: Biobanks are a valuable resource for creating advancements in science through cutting-edge omics research. Twin research methods allow us to understand the degree to which genetics and environmental factors contribute to health outcomes.

Methods: The Sri Lankan Twin Registry biobank (SLTR-b) was established in 2015 as part of Colombo Twin and Singleton Follow-up Study. Venous blood and urine were collected from twins and comparative sample of singletons for clinical investigations and biobanking.

Results: The SLTR-b currently houses 3369 DNA and serum samples. Biobank specimens are linked to longitudinal questionnaire data, clinical investigations, anthropometric measurements, and other data.

Discussion: The SLTR-b aims to address gaps in health and genetics research. It will provide opportunities for academic collaborations, local and international, and capacity building of future research leaders in twin and omics research. This paper provides a cohort profile of the SLTR-b and its linked data, and an overview of the strategies used for biobanking.

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斯里兰卡双胞胎登记生物库:南亚第一个双胞胎生物库。

生物银行是通过尖端组学研究创造科学进步的宝贵资源。双胞胎研究方法使我们能够了解遗传和环境因素对健康结果的影响程度。方法:斯里兰卡双胞胎注册生物库(SLTR-b)于2015年建立，作为科伦坡双胞胎和单胞胎随访研究的一部分。采集双胞胎和单胎对照样本静脉血和尿液用于临床调查和生物库。结果:SLTR-b目前保存了3369份DNA和血清样本。生物样本库与纵向问卷调查数据、临床调查、人体测量和其他数据相关联。讨论:SLTR-b旨在解决健康和遗传学研究方面的差距。它将为本地和国际学术合作提供机会，并为双胞胎和组学研究的未来研究领导者提供能力建设。本文提供了SLTR-b的队列概况及其相关数据，并概述了用于生物银行的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.