J Sommerfeld, L Manderson, B Ramirez, J A Guth, J C Reeder
{"title":"Infectious disease research and the gender gap.","authors":"J Sommerfeld, L Manderson, B Ramirez, J A Guth, J C Reeder","doi":"10.1017/gheg.2017.2","DOIUrl":"10.1017/gheg.2017.2","url":null,"abstract":"<p><p>Historically, women have been less likely to be supported through higher degree training programmes, and they continue to hold more junior positions in science. This paper reviews the current gender research and gender capacity-building efforts led by the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR). Created more than 40 years ago as the only United Nations-based Special Programme dedicated to research and research capacity building on infectious diseases, TDR has a longstanding track record both in supporting research into gender-specific questions and in research capacity strengthening among women scientists. We provide an overview of these approaches, then describe a recent pilot programme on Women in Science, designed to understand and remedy the gender gaps in health research. The programme focused on Africa, but it is hoped that the replication of such schemes in TDR and other international funding agencies will lead to more attention being given to women in infectious diseases research in other continents. This article may not be reprinted or reused in any way in order to promote any commercial products or services.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e9"},"PeriodicalIF":1.1,"publicationDate":"2017-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Dhatt, K Thompson, D Lichtenstein, K Ronsin, K Wilkins
{"title":"The time is now - a call to action for gender equality in global health leadership.","authors":"R Dhatt, K Thompson, D Lichtenstein, K Ronsin, K Wilkins","doi":"10.1017/gheg.2017.1","DOIUrl":"https://doi.org/10.1017/gheg.2017.1","url":null,"abstract":"<p><p>Gender equality is considered paramount to the success of the Sustainable Development Goals and incorporated into global health programming and delivery, but there is great gender disparity within global health leadership and an absence of women at the highest levels of decision making. This perspective piece outlines the current gaps and challenges, highlighting the lack of data and unanswered questions regarding possible solutions, as well as the activity of Women in Global Health and efforts to directly address the inequity and lack of female leaders. We conclude with an agenda and tangible next steps of action for promoting women's leadership in health as a means to promote the global goals of achieving gender equality and catalyzing change.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e7"},"PeriodicalIF":1.9,"publicationDate":"2017-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Embedding gender equality into institutional strategy.","authors":"S Ahmed","doi":"10.1017/gheg.2017.5","DOIUrl":"https://doi.org/10.1017/gheg.2017.5","url":null,"abstract":"<p><p>The SiS (Sex in Science) Programme on the WGC (Wellcome Genome Campus) was established in 2011. Key participants include the Wellcome Trust Sanger Institute, EMB-EBI (EMBL-European Bioinformatics Institute), Open Targets and Elixir. The key objectives are to catalyse cultural change, develop partnerships, communicate activities and champion our women in science work at a national and international level (http://www.sanger.ac.uk/about/sex-science). In this paper, we highlight some of the many initiatives that have taken place since 2013, to address gender inequality at the highest levels; the challenges we have faced and how we have overcome these, and the future direction of travel.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e5"},"PeriodicalIF":1.9,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complementary and alternative medicine use by diabetes patients in Kerala, India.","authors":"N Vishnu, G K Mini, K R Thankappan","doi":"10.1017/gheg.2017.6","DOIUrl":"https://doi.org/10.1017/gheg.2017.6","url":null,"abstract":"<p><p>The study assessed: (1) the prevalence of exclusive use of complementary and alternative medicine (CAM), exclusive use of modern medicine and combined use; (2) the factors associated with exclusive CAM use; and (3) the expenditure for CAM use among type-2 diabetes patients in rural Kerala. We surveyed 400 diabetes patients selected by multi-stage cluster sampling. Exclusive CAM use was reported by 9%, exclusive modern medicine by 61% and combined use by 30%. Patients without any co-morbidity were four times, those having regular income were three times and those who reported regular exercise were three times more likely to use exclusive CAM compared with their counterparts. Expense for medicines was not significantly different for CAM compared with modern medicine both in government and private sector. Patients with any co-morbidity were less likely to use CAM indicating that CAM use was limited to milder cases of diabetes.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e6"},"PeriodicalIF":1.9,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török
{"title":"Antimicrobial resistance in human populations: challenges and opportunities.","authors":"S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török","doi":"10.1017/gheg.2017.4","DOIUrl":"10.1017/gheg.2017.4","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a global public health threat. Emergence of AMR occurs naturally, but can also be selected for by antimicrobial exposure in clinical and veterinary medicine. Despite growing worldwide attention to AMR, there are substantial limitations in our understanding of the burden, distribution and determinants of AMR at the population level. We highlight the importance of population-based approaches to assess the association between antimicrobial use and AMR in humans and animals. Such approaches are needed to improve our understanding of the development and spread of AMR in order to inform strategies for the prevention, detection and management of AMR, and to support the sustainable use of antimicrobials in healthcare.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e4"},"PeriodicalIF":1.1,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mentoring for early-career women in health research: the HIGHER Women Consortium approach.","authors":"S K Kwedi Nolna, P E Essama Mekongo, R G F Leke","doi":"10.1017/gheg.2016.20","DOIUrl":"https://doi.org/10.1017/gheg.2016.20","url":null,"abstract":"<p><p>Attracting and retaining women in health research is crucial as it will maximize creativity and innovation as well as increase gender competency and expertise in the field. To help address the gender gap in the research for health field in Cameroon, some women research scientists formed the Higher Institute for Growth in HEalth Research for Women (HIGHER Women) consortium to support and encourage the growth of women research scientists through a training institute with a Mentor-Protégé Program (MPP). The consortium set up a MPP aiming at providing professional guidance to facilitate protégés' growth and emergence in health research. The consortium has conducted two workshops aiming at increasing the early-career women's skills needed to launch their career and focusing on proposal writing with the aim of producing a fundable project. Since 2015, the consortium has brought together approximately 100 women comprising of 80 protégés. The most significant outcome is in the protégés' feedback from their annual evaluations. The protégés are now more likely to submit abstracts and attend international conferences. Some grants have been obtained as a result of the working relationship with mentors. The HIGHER women consortium works to develop a pipeline of women leaders in health research by fostering growth and leadership culture through their MPP.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e3"},"PeriodicalIF":1.9,"publicationDate":"2017-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Kalyani cohort - the first platform in Eastern India for longitudinal studies on health and disease parameters in peri-urban setting.","authors":"S Chatterjee, P P Majumder","doi":"10.1017/gheg.2016.19","DOIUrl":"https://doi.org/10.1017/gheg.2016.19","url":null,"abstract":"<p><p>The Kalyani cohort created in 2010 by the National Institute of Biomedical Genomics, West Bengal, India, is designed to serve as a platform for conducting prospective basic and translational studies on epidemiology and genomics of health and disease-related parameters, particularly of non-communicable diseases (NCDs). The overall goal is to assess behavioural, biological, genetic, social and environmental factors and obtain necessary evidence for effective health improvement. Collected baseline data comprise 15727 individuals, >14 years of age from seven municipal wards in the Kalyani and Gayeshpur regions. Data are being collected on demographics, current health status, medical history and health-related behaviours. Blood samples were also collected from a subset of individuals (<i>n</i> = 5132) and analysed for estimation of known markers of NCDs. DNA has been extracted from blood samples and stored for future use. Important baseline findings include a high prevalence of diabetes, dyslipidemias and hypothyroidism. Prevalence estimates for these disorders obtained from self-reported data are significantly lower, indicating that participants are unaware of their health problems. The identification of 'at risk' individuals will allow formation of sub-cohorts for further investigations of epidemiological and genetic risk factors for NCDs. Access to the resource, including data and blood samples, created by this study will be provided to other researchers.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e2"},"PeriodicalIF":1.9,"publicationDate":"2017-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K L Mpye, A Matimba, K Dzobo, S Chirikure, A Wonkam, C Dandara
{"title":"Disease burden and the role of pharmacogenomics in African populations.","authors":"K L Mpye, A Matimba, K Dzobo, S Chirikure, A Wonkam, C Dandara","doi":"10.1017/gheg.2016.21","DOIUrl":"https://doi.org/10.1017/gheg.2016.21","url":null,"abstract":"<p><strong>Background: </strong>The burden of communicable and non-communicable diseases in Sub-Saharan Africa poses a challenge in achieving quality healthcare. Although therapeutic drugs have generally improved health, their efficacy differs from individual to individual. Variability in treatment response is mainly because of genetic variants that affect the pharmacokinetics and pharmacodynamics of drugs.</p><p><strong>Method: </strong>The intersection of disease burden and therapeutic intervention is reviewed, and the status of pharmacogenomics knowledge in African populations is explored.</p><p><strong>Results: </strong>The most commonly studied variants with pharmacogenomics relevance are discussed, especially in genes coding for enzymes that affect the response to drugs used for HIV, malaria, sickle cell disease and cardiovascular diseases.</p><p><strong>Conclusions: </strong>The genetically diverse African population is likely to benefit from a pharmacogenomics-based healthcare approach, especially with respect to reduction of drug side effects, and separation of responders and non-responders leading to optimized drug choices and doses for each patient.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e1"},"PeriodicalIF":1.9,"publicationDate":"2017-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.21","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A L Barr, E H Young, L Smeeth, R Newton, J Seeley, K Ripullone, T R Hird, J R M Thornton, M J Nyirenda, S Kapiga, C A Adebamowo, A G Amoah, N Wareham, C N Rotimi, N S Levitt, K Ramaiya, B J Hennig, J C Mbanya, S Tollman, A A Motala, P Kaleebu, M S Sandhu
{"title":"The need for an integrated approach for chronic disease research and care in Africa.","authors":"A L Barr, E H Young, L Smeeth, R Newton, J Seeley, K Ripullone, T R Hird, J R M Thornton, M J Nyirenda, S Kapiga, C A Adebamowo, A G Amoah, N Wareham, C N Rotimi, N S Levitt, K Ramaiya, B J Hennig, J C Mbanya, S Tollman, A A Motala, P Kaleebu, M S Sandhu","doi":"10.1017/gheg.2016.16","DOIUrl":"10.1017/gheg.2016.16","url":null,"abstract":"<p><p>With the changing distribution of infectious diseases, and an increase in the burden of non-communicable diseases, low- and middle-income countries, including those in Africa, will need to expand their health care capacities to effectively respond to these epidemiological transitions. The interrelated risk factors for chronic infectious and non-communicable diseases and the need for long-term disease management, argue for combined strategies to understand their underlying causes and to design strategies for effective prevention and long-term care. Through multidisciplinary research and implementation partnerships, we advocate an integrated approach for research and healthcare for chronic diseases in Africa.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"1 ","pages":"e19"},"PeriodicalIF":1.1,"publicationDate":"2016-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Cuschieri, J Vassallo, N Calleja, N Pace, J Mamo
{"title":"Diabetes, pre-diabetes and their risk factors in Malta: a study profile of national cross-sectional prevalence study.","authors":"S Cuschieri, J Vassallo, N Calleja, N Pace, J Mamo","doi":"10.1017/gheg.2016.18","DOIUrl":"https://doi.org/10.1017/gheg.2016.18","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus constitutes a global epidemic and a major burden on health care systems across the world. Prevention of this disease is essential, and the development of effective prevention strategies requires validated information on the disease burden and the risk factors. Embarking on a nationally representative cross-sectional study is challenging and costly. Few countries undertake this process regularly, if at all.</p><p><strong>Method: </strong>This paper sets out the evidence-based protocol of a recent cross-sectional study that was conducted in Malta. Data collection took place from November 2014 to January 2016.</p><p><strong>Results: </strong>This study presents up-to-date national data on diabetes and its risk factors (such as obesity, smoking, physical activity and alcohol intake) that will soon be publicly available.</p><p><strong>Conclusion: </strong>This protocol was compiled so that the study can be replicated in other countries. The protocol contains step-by-step descriptions of the study design, including details on the population sampling, the permissions required and the validated measurement tools used.</p>","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"1 ","pages":"e21"},"PeriodicalIF":1.9,"publicationDate":"2016-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.18","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}