Global Health Epidemiology and Genomics最新文献_第9页

Novel polymorphisms in TICAM2 and NOD1 associated with tuberculosis progression phenotypes in Ethiopian populations. 埃塞俄比亚人群中与结核病进展表型相关的TICAM2和NOD1新多态性

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2018-01-23 eCollection Date: 2018-01-01 DOI: 10.1017/gheg.2017.17

E Mekonnen, E Bekele, C M Stein

{"title":"Novel polymorphisms in TICAM2 and NOD1 associated with tuberculosis progression phenotypes in Ethiopian populations.","authors":"E Mekonnen, E Bekele, C M Stein","doi":"10.1017/gheg.2017.17","DOIUrl":"10.1017/gheg.2017.17","url":null,"abstract":"Background: Infection by Mycobacterium tuberculosis (Mtb) is a necessary but not sufficient cause for tuberculosis (TB). Although numerous studies suggest human genetic variation may influence TB pathogenesis, there is a conspicuous lack of replication, likely due to imprecise phenotype definition. We aimed to replicate novel findings from a Ugandan cohort in Ethiopian populations.Method: We ascertained TB cases and household controls (n = 292) from three different ethnic groups. Latent Mtb infection was determined using Quantiferon to develop reliable TB progression phenotypes. We sequenced exonic regions of TICAM2 and NOD1.Result: Significant novel associations were observed between two variants in NOD1 and TB: rs751770147 [unadjusted p = 7.28 × 10-5] and chr7:30477156(T), a novel variant, [unadjusted p = 1.04 × 10-4]. Two SNPs in TICAM2 were nominally associated with TB, including rs2288384 [unadjusted p = 0.003]. Haplotype-based association tests supported the SNP-based results.Conclusion: We replicated the association of TICAM2 and NOD1 with TB and identified novel genetic associations with TB in Ethiopian populations.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":"e1"},"PeriodicalIF":1.1,"publicationDate":"2018-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa. 艾滋病毒治疗与甘油三酯升高的概率增加两倍有关：对撒哈拉以南非洲 21 023 人的汇总分析。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2018-01-01 Epub Date: 2018-05-08 DOI: 10.1017/gheg.2018.7

Kenneth Ekoru, Elizabeth H Young, David G Dillon, Deepti Gurdasani, Nathan Stehouwer, Daniel Faurholt-Jepsen, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina A Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Caterina Compostella, Joel A Dave, Carla M Fourie, Henrik Friis, Iolanthe M Kruger, Chris T Longenecker, Dermot P Maher, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Muhammad Sanusi, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Dickman Gareta, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Liam Smeeth, Deenan Pillay, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu

{"title":"HIV treatment is associated with a two-fold higher probability of raised triglycerides: Pooled Analyses in 21 023 individuals in sub-Saharan Africa.","authors":"Kenneth Ekoru, Elizabeth H Young, David G Dillon, Deepti Gurdasani, Nathan Stehouwer, Daniel Faurholt-Jepsen, Naomi S Levitt, Nigel J Crowther, Moffat Nyirenda, Marina A Njelekela, Kaushik Ramaiya, Ousman Nyan, Olanisun O Adewole, Kathryn Anastos, Caterina Compostella, Joel A Dave, Carla M Fourie, Henrik Friis, Iolanthe M Kruger, Chris T Longenecker, Dermot P Maher, Eugene Mutimura, Chiratidzo E Ndhlovu, George Praygod, Eric W Pefura Yone, Mar Pujades-Rodriguez, Nyagosya Range, Mahmoud U Sani, Muhammad Sanusi, Aletta E Schutte, Karen Sliwa, Phyllis C Tien, Este H Vorster, Corinna Walsh, Dickman Gareta, Fredirick Mashili, Eugene Sobngwi, Clement Adebamowo, Anatoli Kamali, Janet Seeley, Liam Smeeth, Deenan Pillay, Ayesha A Motala, Pontiano Kaleebu, Manjinder S Sandhu","doi":"10.1017/gheg.2018.7","DOIUrl":"10.1017/gheg.2018.7","url":null,"abstract":"Background: Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TG) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub-Saharan African (SSA) populations.Methods: Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models.Findings: Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51-2.77, I2=45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies.Interpretation: Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSA.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"3 ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36205100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot. 非洲人群对 Epstein-Barr 病毒抗体反应的全基因组关联研究：一项试验。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-11-27 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.16

N Sallah, T Carstensen, K Wakeham, R Bagni, N Labo, M O Pollard, D Gurdasani, K Ekoru, C Pomilla, E H Young, S Fatumo, G Asiki, A Kamali, M Sandhu, P Kellam, D Whitby, I Barroso, R Newton

{"title":"Whole-genome association study of antibody response to Epstein-Barr virus in an African population: a pilot.","authors":"N Sallah, T Carstensen, K Wakeham, R Bagni, N Labo, M O Pollard, D Gurdasani, K Ekoru, C Pomilla, E H Young, S Fatumo, G Asiki, A Kamali, M Sandhu, P Kellam, D Whitby, I Barroso, R Newton","doi":"10.1017/gheg.2017.16","DOIUrl":"10.1017/gheg.2017.16","url":null,"abstract":"Epstein Barr virus (EBV) infects 95% of the global population and is associated with up to 2% of cancers globally. Immunoglobulin G (IgG) antibody levels to EBV have been shown to be heritable and associated with developing malignancies. We, therefore, performed a pilot genome-wide association analysis of anti-EBV IgG traits in an African population, using a combined approach including array genotyping, whole-genome sequencing and imputation to a panel with African sequence data. In 1562 Ugandans, we identify a variant in human leukocyte antigen (HLA)-DQA1, rs9272371 (p = 2.6 × 10-17) associated with anti-EBV nuclear antigen-1 responses. Trans-ancestry meta-analysis and fine-mapping with European-ancestry individuals suggest the presence of distinct HLA class II variants driving associations in Uganda. In addition, we identify four putative, novel, very rare African-specific loci with preliminary evidence for association with anti-viral capsid antigen IgG responses which will require replication for validation. These findings reinforce the need for the expansion of such studies in African populations with relevant datasets to capture genetic diversity.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":"2 ","pages":"e18"},"PeriodicalIF":1.1,"publicationDate":"2017-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10661052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beta-globin gene haplotypes and selected Malaria-associated variants among black Southern African populations. -珠蛋白基因单倍型和南部非洲黑人人群中选定的疟疾相关变异。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-11-27 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.14

G D Pule, E R Chimusa, K Mnika, K Mhandire, E Kampira, C Dandara, A Wonkam

{"title":"Beta-globin gene haplotypes and selected Malaria-associated variants among black Southern African populations.","authors":"G D Pule, E R Chimusa, K Mnika, K Mhandire, E Kampira, C Dandara, A Wonkam","doi":"10.1017/gheg.2017.14","DOIUrl":"https://doi.org/10.1017/gheg.2017.14","url":null,"abstract":"Partial carrier-resistance to Plasmodium falciparum malaria conferred by the sickle cell (HbS) mutation has resulted in the local amplification and positive selection of sickle cell disease (SCD) in malaria-endemic regions and particularly in sub-Saharan Africa (SSA). The present study investigated the β-globin gene haplotypes, and selected malaria-associated variants among three cohorts of Bantu-speaking individuals from Malawi, Zimbabwe and South Africa compared with reports with data from others SSA populations. The data suggest a south-ward frequency decrease of malaria-associated variants in SSA linked to the evolutionary dynamics of various African populations' genomes through selective pressure of malaria. These selected genomics differences, positive selection of SCD in malaria-endemic regions among 'Bantus' from various part of Africa emphasise the evidence of the dissociation between genetics, anthropology and culture. The present study also showed a relatively prevalent Benin haplotype, which is mostly found in West Africa, among Southern African Blacks and very low Bantu haplotype, which could suggest a major migration route, of Southern Africa Bantu, along the African west coast, post-occurrence of the Sickle cell mutation, which date remain to be fully elucidated.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e17"},"PeriodicalIF":1.9,"publicationDate":"2017-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.14","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Erratum: Antimicrobial resistance in human populations: challenges and opportunities - ERRATUM. 勘误：人类抗菌素耐药性：挑战和机遇-勘误。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-10-27 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.12

S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török

引用次数: 0

Competency of peripheral health workers in detection & management of common syndromic conditions under surveillance, North 24 Parganas, West Bengal, India, 2016: a cross-sectional study. 周边卫生工作者在监测下发现和管理常见综合征的能力，印度西孟加拉邦北24 Parganas, 2016:一项横断面研究。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-10-11 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.13

F Debnath, T Bhatnagar, L Sundaramoorthy, M Ponnaiah

{"title":"Competency of peripheral health workers in detection & management of common syndromic conditions under surveillance, North 24 Parganas, West Bengal, India, 2016: a cross-sectional study.","authors":"F Debnath, T Bhatnagar, L Sundaramoorthy, M Ponnaiah","doi":"10.1017/gheg.2017.13","DOIUrl":"https://doi.org/10.1017/gheg.2017.13","url":null,"abstract":"Background: Competency of peripheral health workers in the detection and management of common syndromic conditions is crucial as they are the first point of contact for the majority of the Indian population.Methods: We measured the competency of auxiliary nurse midwives (ANMs), and factors associated with inadequate competency, in the detection and management of common conditions-diarrhoea, acute respiratory tract infection, fever, malaria-through a cross-sectional study using condition specific validated clinical vignettes and structured questionnaires.Results: Out of 272 selected ANMs, 68% (95% CI 62-74%) were adequately competent. Factors independently associated with inadequate competency were unavailability of essential drugs in preceding month [adjusted odds ratio (AOR) = 1.95; 95% CI 1.1-3.5] and ever trained in integrated management of childhood illness (AOR = 2.4; 95% CI 1.4-4.1).Conclusion: More than two third of the peripheral health workers were adequately competent to detect and manage common conditions. Ensuring uninterrupted drug availability and improved quality in service trainings might facilitate competency levels.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e15"},"PeriodicalIF":1.9,"publicationDate":"2017-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.13","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Developing a novel risk prediction model for severe malarial anemia. 建立一种新的严重疟疾性贫血风险预测模型。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-09-11 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.8

E B Brickley, E Kabyemela, J D Kurtis, M Fried, A M Wood, P E Duffy

{"title":"Developing a novel risk prediction model for severe malarial anemia.","authors":"E B Brickley, E Kabyemela, J D Kurtis, M Fried, A M Wood, P E Duffy","doi":"10.1017/gheg.2017.8","DOIUrl":"10.1017/gheg.2017.8","url":null,"abstract":"As a pilot study to investigate whether personalized medicine approaches could have value for the reduction of malaria-related mortality in young children, we evaluated questionnaire and biomarker data collected from the Mother Offspring Malaria Study Project birth cohort (Muheza, Tanzania, 2002-2006) at the time of delivery as potential prognostic markers for pediatric severe malarial anemia. Severe malarial anemia, defined here as a Plasmodium falciparum infection accompanied by hemoglobin levels below 50 g/L, is a key manifestation of life-threatening malaria in high transmission regions. For this study sample, a prediction model incorporating cord blood levels of interleukin-1β provided the strongest discrimination of severe malarial anemia risk with a C-index of 0.77 (95% CI 0.70-0.84), whereas a pragmatic model based on sex, gravidity, transmission season at delivery, and bed net possession yielded a more modest C-index of 0.63 (95% CI 0.54-0.71). Although additional studies, ideally incorporating larger sample sizes and higher event per predictor ratios, are needed to externally validate these prediction models, the findings provide proof of concept that risk score-based screening programs could be developed to avert severe malaria cases in early childhood.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e14"},"PeriodicalIF":1.1,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sleep difficulties as well as duration and hypertension: is BMI a mediator? 睡眠困难和持续时间与高血压之间的关系:BMI是一个中介吗?

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-08-29 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.10

R M Carrillo-Larco, A Bernabe-Ortiz, K A Sacksteder, F Diez-Canseco, M K Cárdenas, R H Gilman, J J Miranda

{"title":"Association between sleep difficulties as well as duration and hypertension: is BMI a mediator?","authors":"R M Carrillo-Larco, A Bernabe-Ortiz, K A Sacksteder, F Diez-Canseco, M K Cárdenas, R H Gilman, J J Miranda","doi":"10.1017/gheg.2017.10","DOIUrl":"https://doi.org/10.1017/gheg.2017.10","url":null,"abstract":"Sleep difficulties and short sleep duration have been associated with hypertension. Though body mass index (BMI) may be a mediator variable, the mediation effect has not been defined. We aimed to assess the association between sleep duration and sleep difficulties with hypertension, to determine if BMI is a mediator variable, and to quantify the mediation effect. We conducted a mediation analysis and calculated prevalence ratios with 95% confidence intervals. The exposure variables were sleep duration and sleep difficulties, and the outcome was hypertension. Sleep difficulties were statistically significantly associated with a 43% higher prevalence of hypertension in multivariable analyses; results were not statistically significant for sleep duration. In these analyses, and in sex-specific subgroup analyses, we found no strong evidence that BMI mediated the association between sleep indices and risk of hypertension. Our findings suggest that BMI does not appear to mediate the association between sleep patterns and hypertension. These results highlight the need to further study the mechanisms underlying the relationship between sleep patterns and cardiovascular risk factors.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e12"},"PeriodicalIF":1.9,"publicationDate":"2017-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016. 加强非洲人类遗传学研究:2016年5月在达喀尔举行的非洲人类遗传学学会第9次会议报告。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-08-04 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.3

R Ndiaye Diallo, M Gadji, B J Hennig, M V Guèye, A Gaye, J P D Diop, M Sylla Niang, P Lopez Sall, P M Guèye, A Dem, O Faye, A Dieye, A Cisse, M Sembene, S Ka, N Diop, S M Williams, E Matovu, R S Ramesar, A Wonkam, M Newport, C Rotimi, M Ramsay

{"title":"Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016.","authors":"R Ndiaye Diallo, M Gadji, B J Hennig, M V Guèye, A Gaye, J P D Diop, M Sylla Niang, P Lopez Sall, P M Guèye, A Dem, O Faye, A Dieye, A Cisse, M Sembene, S Ka, N Diop, S M Williams, E Matovu, R S Ramesar, A Wonkam, M Newport, C Rotimi, M Ramsay","doi":"10.1017/gheg.2017.3","DOIUrl":"https://doi.org/10.1017/gheg.2017.3","url":null,"abstract":"The 9th meeting of the African Society of Human Genetics, in partnership with the Senegalese Cancer Research and Study Group and the Human Heredity and Health in Africa (H3Africa) Consortium, was held in Dakar, Senegal. The theme was Strengthening Human Genetics Research in Africa. The 210 delegates came from 21 African countries and from France, Switzerland, UK, UAE, Canada and the USA. The goal was to highlight genetic and genomic science across the African continent with the ultimate goal of improving the health of Africans and those across the globe, and to promote the careers of young African scientists in the field. A session on the sustainability of genomic research in Africa brought to light innovative and practical approaches to supporting research in resource-limited settings and the importance of promoting genetics in academic, research funding, governmental and private sectors. This meeting led to the formation of the Senegalese Society for Human Genetics.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e10"},"PeriodicalIF":1.9,"publicationDate":"2017-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The long road to elimination: malaria mortality in a South African population cohort over 21 years. 消除疟疾的漫长道路:21年来南非人口队列中的疟疾死亡率。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-07-25 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.7

P Byass, M A Collinson, C Kabudula, F X Gómez-Olivé, R G Wagner, S Ngobeni, B Silaule, P Mee, M Coetzee, W Twine, S M Tollman, K Kahn

{"title":"The long road to elimination: malaria mortality in a South African population cohort over 21 years.","authors":"P Byass, M A Collinson, C Kabudula, F X Gómez-Olivé, R G Wagner, S Ngobeni, B Silaule, P Mee, M Coetzee, W Twine, S M Tollman, K Kahn","doi":"10.1017/gheg.2017.7","DOIUrl":"https://doi.org/10.1017/gheg.2017.7","url":null,"abstract":"Background: Malaria elimination is on global agendas following successful transmission reductions. Nevertheless moving from low to zero transmission is challenging. South Africa has an elimination target of 2018, which may or may not be realised in its hypoendemic areas.Methods: The Agincourt Health and Demographic Surveillance System has monitored population health in north-eastern South Africa since 1992. Malaria deaths were analysed against individual factors, socioeconomic status, labour migration and weather over a 21-year period, eliciting trends over time and associations with covariates.Results: Of 13 251 registered deaths over 1.58 million person-years, 1.2% were attributed to malaria. Malaria mortality rates increased from 1992 to 2013, while mean daily maximum temperature rose by 1.5 °C. Travel to endemic Mozambique became easier, and malaria mortality increased in higher socioeconomic groups. Overall, malaria mortality was significantly associated with age, socioeconomic status, labour migration and employment, yearly rainfall and higher rainfall/temperature shortly before death.Conclusions: Malaria persists as a small but important cause of death in this semi-rural South African population. Detailed longitudinal population data were crucial for these analyses. The findings highlight practical political, socioeconomic and environmental difficulties that may also be encountered elsewhere in moving from low-transmission scenarios to malaria elimination.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e11"},"PeriodicalIF":1.9,"publicationDate":"2017-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8