Global Health Epidemiology and Genomics最新文献_第9页

Developing a novel risk prediction model for severe malarial anemia. 建立一种新的严重疟疾性贫血风险预测模型。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-09-11 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.8

E B Brickley, E Kabyemela, J D Kurtis, M Fried, A M Wood, P E Duffy

{"title":"Developing a novel risk prediction model for severe malarial anemia.","authors":"E B Brickley, E Kabyemela, J D Kurtis, M Fried, A M Wood, P E Duffy","doi":"10.1017/gheg.2017.8","DOIUrl":"10.1017/gheg.2017.8","url":null,"abstract":"As a pilot study to investigate whether personalized medicine approaches could have value for the reduction of malaria-related mortality in young children, we evaluated questionnaire and biomarker data collected from the Mother Offspring Malaria Study Project birth cohort (Muheza, Tanzania, 2002-2006) at the time of delivery as potential prognostic markers for pediatric severe malarial anemia. Severe malarial anemia, defined here as a Plasmodium falciparum infection accompanied by hemoglobin levels below 50 g/L, is a key manifestation of life-threatening malaria in high transmission regions. For this study sample, a prediction model incorporating cord blood levels of interleukin-1β provided the strongest discrimination of severe malarial anemia risk with a C-index of 0.77 (95% CI 0.70-0.84), whereas a pragmatic model based on sex, gravidity, transmission season at delivery, and bed net possession yielded a more modest C-index of 0.63 (95% CI 0.54-0.71). Although additional studies, ideally incorporating larger sample sizes and higher event per predictor ratios, are needed to externally validate these prediction models, the findings provide proof of concept that risk score-based screening programs could be developed to avert severe malaria cases in early childhood.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e14"},"PeriodicalIF":1.1,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between sleep difficulties as well as duration and hypertension: is BMI a mediator? 睡眠困难和持续时间与高血压之间的关系:BMI是一个中介吗?

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-08-29 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.10

R M Carrillo-Larco, A Bernabe-Ortiz, K A Sacksteder, F Diez-Canseco, M K Cárdenas, R H Gilman, J J Miranda

{"title":"Association between sleep difficulties as well as duration and hypertension: is BMI a mediator?","authors":"R M Carrillo-Larco, A Bernabe-Ortiz, K A Sacksteder, F Diez-Canseco, M K Cárdenas, R H Gilman, J J Miranda","doi":"10.1017/gheg.2017.10","DOIUrl":"https://doi.org/10.1017/gheg.2017.10","url":null,"abstract":"Sleep difficulties and short sleep duration have been associated with hypertension. Though body mass index (BMI) may be a mediator variable, the mediation effect has not been defined. We aimed to assess the association between sleep duration and sleep difficulties with hypertension, to determine if BMI is a mediator variable, and to quantify the mediation effect. We conducted a mediation analysis and calculated prevalence ratios with 95% confidence intervals. The exposure variables were sleep duration and sleep difficulties, and the outcome was hypertension. Sleep difficulties were statistically significantly associated with a 43% higher prevalence of hypertension in multivariable analyses; results were not statistically significant for sleep duration. In these analyses, and in sex-specific subgroup analyses, we found no strong evidence that BMI mediated the association between sleep indices and risk of hypertension. Our findings suggest that BMI does not appear to mediate the association between sleep patterns and hypertension. These results highlight the need to further study the mechanisms underlying the relationship between sleep patterns and cardiovascular risk factors.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e12"},"PeriodicalIF":1.9,"publicationDate":"2017-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.10","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016. 加强非洲人类遗传学研究:2016年5月在达喀尔举行的非洲人类遗传学学会第9次会议报告。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-08-04 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.3

R Ndiaye Diallo, M Gadji, B J Hennig, M V Guèye, A Gaye, J P D Diop, M Sylla Niang, P Lopez Sall, P M Guèye, A Dem, O Faye, A Dieye, A Cisse, M Sembene, S Ka, N Diop, S M Williams, E Matovu, R S Ramesar, A Wonkam, M Newport, C Rotimi, M Ramsay

{"title":"Strengthening human genetics research in Africa: report of the 9th meeting of the African Society of Human Genetics in Dakar in May 2016.","authors":"R Ndiaye Diallo, M Gadji, B J Hennig, M V Guèye, A Gaye, J P D Diop, M Sylla Niang, P Lopez Sall, P M Guèye, A Dem, O Faye, A Dieye, A Cisse, M Sembene, S Ka, N Diop, S M Williams, E Matovu, R S Ramesar, A Wonkam, M Newport, C Rotimi, M Ramsay","doi":"10.1017/gheg.2017.3","DOIUrl":"https://doi.org/10.1017/gheg.2017.3","url":null,"abstract":"The 9th meeting of the African Society of Human Genetics, in partnership with the Senegalese Cancer Research and Study Group and the Human Heredity and Health in Africa (H3Africa) Consortium, was held in Dakar, Senegal. The theme was Strengthening Human Genetics Research in Africa. The 210 delegates came from 21 African countries and from France, Switzerland, UK, UAE, Canada and the USA. The goal was to highlight genetic and genomic science across the African continent with the ultimate goal of improving the health of Africans and those across the globe, and to promote the careers of young African scientists in the field. A session on the sustainability of genomic research in Africa brought to light innovative and practical approaches to supporting research in resource-limited settings and the importance of promoting genetics in academic, research funding, governmental and private sectors. This meeting led to the formation of the Senegalese Society for Human Genetics.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e10"},"PeriodicalIF":1.9,"publicationDate":"2017-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The long road to elimination: malaria mortality in a South African population cohort over 21 years. 消除疟疾的漫长道路:21年来南非人口队列中的疟疾死亡率。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-07-25 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.7

P Byass, M A Collinson, C Kabudula, F X Gómez-Olivé, R G Wagner, S Ngobeni, B Silaule, P Mee, M Coetzee, W Twine, S M Tollman, K Kahn

{"title":"The long road to elimination: malaria mortality in a South African population cohort over 21 years.","authors":"P Byass, M A Collinson, C Kabudula, F X Gómez-Olivé, R G Wagner, S Ngobeni, B Silaule, P Mee, M Coetzee, W Twine, S M Tollman, K Kahn","doi":"10.1017/gheg.2017.7","DOIUrl":"https://doi.org/10.1017/gheg.2017.7","url":null,"abstract":"Background: Malaria elimination is on global agendas following successful transmission reductions. Nevertheless moving from low to zero transmission is challenging. South Africa has an elimination target of 2018, which may or may not be realised in its hypoendemic areas.Methods: The Agincourt Health and Demographic Surveillance System has monitored population health in north-eastern South Africa since 1992. Malaria deaths were analysed against individual factors, socioeconomic status, labour migration and weather over a 21-year period, eliciting trends over time and associations with covariates.Results: Of 13 251 registered deaths over 1.58 million person-years, 1.2% were attributed to malaria. Malaria mortality rates increased from 1992 to 2013, while mean daily maximum temperature rose by 1.5 °C. Travel to endemic Mozambique became easier, and malaria mortality increased in higher socioeconomic groups. Overall, malaria mortality was significantly associated with age, socioeconomic status, labour migration and employment, yearly rainfall and higher rainfall/temperature shortly before death.Conclusions: Malaria persists as a small but important cause of death in this semi-rural South African population. Detailed longitudinal population data were crucial for these analyses. The findings highlight practical political, socioeconomic and environmental difficulties that may also be encountered elsewhere in moving from low-transmission scenarios to malaria elimination.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e11"},"PeriodicalIF":1.9,"publicationDate":"2017-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2017.7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35687825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Infectious disease research and the gender gap. 传染病研究和性别差距。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-06-08 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.2

J Sommerfeld, L Manderson, B Ramirez, J A Guth, J C Reeder

{"title":"Infectious disease research and the gender gap.","authors":"J Sommerfeld, L Manderson, B Ramirez, J A Guth, J C Reeder","doi":"10.1017/gheg.2017.2","DOIUrl":"10.1017/gheg.2017.2","url":null,"abstract":"Historically, women have been less likely to be supported through higher degree training programmes, and they continue to hold more junior positions in science. This paper reviews the current gender research and gender capacity-building efforts led by the UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR). Created more than 40 years ago as the only United Nations-based Special Programme dedicated to research and research capacity building on infectious diseases, TDR has a longstanding track record both in supporting research into gender-specific questions and in research capacity strengthening among women scientists. We provide an overview of these approaches, then describe a recent pilot programme on Women in Science, designed to understand and remedy the gender gaps in health research. The programme focused on Africa, but it is hoped that the replication of such schemes in TDR and other international funding agencies will lead to more attention being given to women in infectious diseases research in other continents. This article may not be reprinted or reused in any way in order to promote any commercial products or services.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e9"},"PeriodicalIF":1.1,"publicationDate":"2017-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The time is now - a call to action for gender equality in global health leadership. 现在是时候了——呼吁在全球卫生领导中采取行动，实现性别平等。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-05-24 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.1

R Dhatt, K Thompson, D Lichtenstein, K Ronsin, K Wilkins

引用次数: 6

Embedding gender equality into institutional strategy. 将性别平等纳入制度战略。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-05-15 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.5

S Ahmed

引用次数: 3

Complementary and alternative medicine use by diabetes patients in Kerala, India. 印度喀拉拉邦糖尿病患者使用补充和替代药物。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-05-15 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.6

N Vishnu, G K Mini, K R Thankappan

引用次数: 35

Antimicrobial resistance in human populations: challenges and opportunities. 人群中的抗菌素耐药性：挑战与机遇。

IF 1.1

Global Health Epidemiology and Genomics Pub Date : 2017-05-10 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2017.4

S Allcock, E H Young, M Holmes, D Gurdasani, G Dougan, M S Sandhu, L Solomon, M E Török

引用次数: 0

Mentoring for early-career women in health research: the HIGHER Women Consortium approach. 指导从事卫生研究的早期职业妇女:高等妇女联合会方法。

IF 1.9

Global Health Epidemiology and Genomics Pub Date : 2017-03-06 eCollection Date: 2017-01-01 DOI: 10.1017/gheg.2016.20

S K Kwedi Nolna, P E Essama Mekongo, R G F Leke

{"title":"Mentoring for early-career women in health research: the HIGHER Women Consortium approach.","authors":"S K Kwedi Nolna, P E Essama Mekongo, R G F Leke","doi":"10.1017/gheg.2016.20","DOIUrl":"https://doi.org/10.1017/gheg.2016.20","url":null,"abstract":"Attracting and retaining women in health research is crucial as it will maximize creativity and innovation as well as increase gender competency and expertise in the field. To help address the gender gap in the research for health field in Cameroon, some women research scientists formed the Higher Institute for Growth in HEalth Research for Women (HIGHER Women) consortium to support and encourage the growth of women research scientists through a training institute with a Mentor-Protégé Program (MPP). The consortium set up a MPP aiming at providing professional guidance to facilitate protégés' growth and emergence in health research. The consortium has conducted two workshops aiming at increasing the early-career women's skills needed to launch their career and focusing on proposal writing with the aim of producing a fundable project. Since 2015, the consortium has brought together approximately 100 women comprising of 80 protégés. The most significant outcome is in the protégés' feedback from their annual evaluations. The protégés are now more likely to submit abstracts and attend international conferences. Some grants have been obtained as a result of the working relationship with mentors. The HIGHER women consortium works to develop a pipeline of women leaders in health research by fostering growth and leadership culture through their MPP.","PeriodicalId":44052,"journal":{"name":"Global Health Epidemiology and Genomics","volume":" ","pages":"e3"},"PeriodicalIF":1.9,"publicationDate":"2017-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1017/gheg.2016.20","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36193212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6