Kalyani队列——印度东部第一个对城市周边环境的健康和疾病参数进行纵向研究的平台。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2017-02-14 eCollection Date: 2017-01-01 DOI:10.1017/gheg.2016.19
S Chatterjee, P P Majumder
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引用次数: 2

摘要

印度西孟加拉邦国家生物医学基因组学研究所于2010年创建了Kalyani队列,其目的是作为一个平台,对健康和疾病相关参数,特别是非传染性疾病的流行病学和基因组学进行前瞻性基础和转化研究。总体目标是评估行为、生物、遗传、社会和环境因素,并获得有效改善健康的必要证据。收集的基线数据包括来自Kalyani和Gayeshpur地区7个市辖区的15727名>14岁的个人。正在收集有关人口统计、目前健康状况、病史和与健康有关的行为的数据。还收集了一部分个体(n = 5132)的血液样本,并对其进行分析,以估计已知的非传染性疾病标志物。从血液样本中提取DNA并储存起来以备将来使用。重要的基线发现包括糖尿病、血脂异常和甲状腺功能减退的高患病率。从自我报告的数据中获得的这些疾病的患病率估计值要低得多,这表明参与者没有意识到自己的健康问题。确定“危险”个体将允许形成亚队列,以便进一步调查非传染性疾病的流行病学和遗传风险因素。本研究创建的资源,包括数据和血液样本,将提供给其他研究人员。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Kalyani cohort - the first platform in Eastern India for longitudinal studies on health and disease parameters in peri-urban setting.

Kalyani cohort - the first platform in Eastern India for longitudinal studies on health and disease parameters in peri-urban setting.

Kalyani cohort - the first platform in Eastern India for longitudinal studies on health and disease parameters in peri-urban setting.

Kalyani cohort - the first platform in Eastern India for longitudinal studies on health and disease parameters in peri-urban setting.

The Kalyani cohort created in 2010 by the National Institute of Biomedical Genomics, West Bengal, India, is designed to serve as a platform for conducting prospective basic and translational studies on epidemiology and genomics of health and disease-related parameters, particularly of non-communicable diseases (NCDs). The overall goal is to assess behavioural, biological, genetic, social and environmental factors and obtain necessary evidence for effective health improvement. Collected baseline data comprise 15727 individuals, >14 years of age from seven municipal wards in the Kalyani and Gayeshpur regions. Data are being collected on demographics, current health status, medical history and health-related behaviours. Blood samples were also collected from a subset of individuals (n = 5132) and analysed for estimation of known markers of NCDs. DNA has been extracted from blood samples and stored for future use. Important baseline findings include a high prevalence of diabetes, dyslipidemias and hypothyroidism. Prevalence estimates for these disorders obtained from self-reported data are significantly lower, indicating that participants are unaware of their health problems. The identification of 'at risk' individuals will allow formation of sub-cohorts for further investigations of epidemiological and genetic risk factors for NCDs. Access to the resource, including data and blood samples, created by this study will be provided to other researchers.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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