The role of epigenetics in respiratory health in urban populations in low and middle-income countries.

IF 1.1 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Nicole M Robertson, Alex Kayongo, Trishul Siddharthan, Suzanne L Pollard, Jose Gomez Villalobos, Christine Ladd-Acosta, Bruce Kirenga, William Checkley
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引用次数: 2

Abstract

As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

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表观遗传学在低收入和中等收入国家城市人口呼吸健康中的作用。
随着低收入和中等收入国家城市化程度的提高,城市人口将越来越多地面临非传染性疾病的一系列环境风险因素。城市环境中不适当的生活条件可能影响调节基因表达的机制,从而导致非传染性呼吸系统疾病的发展。我们通过MEDLINE、PubMed、EMBASE和Google Scholar搜索表观遗传学、慢性呼吸系统疾病(CRDs)、肺部发育、慢性阻塞性气道疾病和哮喘等术语,对文献进行了系统回顾,以评估在低收入国家观察到的呼吸系统健康和表观遗传因素与城市环境暴露之间的关系。共纳入文献2835篇,其中48篇纳入本综述。我们发现,早期发育过程中的环境因素与表观遗传效应有关,而表观遗传效应可能与较高的crd风险相关。组蛋白去乙酰化酶(HDAC)和组蛋白乙酰转移酶基因家族基因表达的表观遗传失调可能与贫民窟居民的肺部健康有关。呼吸相关环境暴露影响HDAC功能和脱氧核糖核酸甲基化,是CRD发生的重要危险因素。需要更多的表观遗传学研究来提高我们对环境暴露与非传染性呼吸系统疾病之间关系的理解。
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来源期刊
Global Health Epidemiology and Genomics
Global Health Epidemiology and Genomics PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
1.40
自引率
0.00%
发文量
10
审稿时长
20 weeks
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