Medical Bulletin of Sisli Etfal Hospital最新文献

{"title":"Measles Seroprevalence and Associated Factors among Adult Individuals in the City Center of Şanlıurfa Province.","authors":"Ahmet Gunduzalp, Burcu Beyazgu, Feyyaz Barlas","doi":"10.14744/SEMB.2025.88655","DOIUrl":"https://doi.org/10.14744/SEMB.2025.88655","url":null,"abstract":"<p><strong>Objectives: </strong>The aim is to determine measles seroprevalence in adult individuals in Şanlıurfa city center and to evaluate related factors.</p><p><strong>Methods: </strong>The research is of a cross-sectional type. The research was carried out in Şanlıurfa city center between March 2023 and April 2023. The population of the study consisted of individuals over the age of 18 who applied to the Family Health Centers (FHC) in the city center of Şanlıurfa. A 30-cluster sampling method was used to determine the FHCs where the study would be conducted. In this study, the number of people to be included in each cluster was determined as 7, and the total sample size was 210. Thirty FHCs were randomly selected from a total of 80 ASMs in 3 central districts in Şanlıurfa, proportional to the number of units. Blood was drawn from the participants by the researcher. The blood samples were then sent by a private hospital to a private laboratory for testing.</p><p><strong>Results: </strong>A total of 210 adults were included in the study. Fifty-one percent of the participants were women. The measles seropositivity rate of the adults participating in the study was 87.6%, and the measles seronegativity rate was 8.6%. When the participants were examined according to age groups, it was found that the measles seropositivity level was lowest in the 18-21 age group, at 52.63%. In the created logistic regression model, measles seropositivity status in adults: being 33 years or younger reduces it 10 times.</p><p><strong>Conclusion: </strong>This study showed that measles seropositivity in the adult population in Şanlıurfa city center was 87.6%. This suggests the need to reconsider the administration of an extra-dose measles vaccine using the catch-up vaccination method for individuals aged 18-21 and then 22-25, the most susceptible age group in this study.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"53-61"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Neutrophil/Lymphocyte Ratio and the Progression and Clinical Features of Alzheimer's Disease.","authors":"Hatice Omercikoglu Ozden, Fatma Seyda Ustuner, Merve Bikem Ucar, Fatma Nazli Durmaz Celik","doi":"10.14744/SEMB.2026.67764","DOIUrl":"https://doi.org/10.14744/SEMB.2026.67764","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR), a peripheral inflammatory marker, and both baseline clinical features and short-term cognitive progression in patients with Alzheimer's disease (AD). Specifically, we sought to determine whether NLR is associated with disease stage, cognitive performance, vascular comorbidities, and 12-month cognitive decline assessed by the Mini-Mental State Examination (MMSE).</p><p><strong>Methods: </strong>We conducted a retrospective observational study including 100 adults diagnosed with mild, moderate, or severe AD who were followed for at least 12 months at a tertiary memory clinic. Demographic characteristics, clinical data, and serial MMSE scores (baseline, 6 months, and 12 months) were extracted from medical records. Complete blood counts from the same time points were used to calculate NLR. Descriptive statistics summarized clinical variables. Correlations between NLR and MMSE scores were analyzed using Pearson and Spearman methods. Group comparisons across disease stage, sex, and vascular comorbidity were performed using t-tests or ANOVA as appropriate. Statistical significance was defined as p<0.05.</p><p><strong>Results: </strong>The mean age of the cohort was 72.5±9.9 years, and 62% were women. Baseline disease severity was distributed as mild (28%), moderate (26%), and severe (46%). Mean baseline NLR was 2.41±1.17, increasing to 2.87±1.47 at 6 months and 3.75±3.54 at 12 months. Baseline NLR was significantly higher in patients with vascular comorbidities (p=0.008) but did not differ across AD severity categories. Higher baseline NLR was modestly associated with lower baseline MMSE scores (r=-0.24, p=0.021). Unexpectedly, higher baseline NLR correlated with a smaller decline in MMSE over 12 months (r=0.36, p=0.005). Patients with low NLR showed greater cognitive deterioration (-3.72±3.97 points) than those with high NLR (-1.38±4.38 points; p=0.037).</p><p><strong>Conclusion: </strong>NLR was associated with worse cognitive performance at diagnosis and increased gradually over 12 months in AD patients, supporting its role as a marker of systemic inflammation. However, the counterintuitive finding that higher baseline NLR was linked to slower short-term cognitive decline highlights the complexity of inflammatory mechanisms in established AD. These results suggest that while NLR reflects clinically relevant inflammatory status, it should not be used as a standalone predictor of disease progression but rather as part of a broader multimodal biomarker framework.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"24-29"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Risk Factors Influencing Recurrence Rates Following Open Excision of Wrist Ganglion Cysts: A Retrospective Cohort Study'.","authors":"Kishankumar Mahida, Snehal Rajendra Jagtap","doi":"10.14744/SEMB.2026.47897","DOIUrl":"https://doi.org/10.14744/SEMB.2026.47897","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"130-131"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Postoperative Cognitive Dysfunction and Its Risk Factors in Elderly Patients Undergoing Elective Non-Cardiac Surgery: A Prospective Observational Study.","authors":"Arzu Ceren Yigit, Tugba Yucel Yenice, Mustafa Altinay, Ayse Surhan Cinar, Leyla Turkoglu Kilinc","doi":"10.14744/SEMB.2025.47700","DOIUrl":"https://doi.org/10.14744/SEMB.2025.47700","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the incidence, course, and potential risk factors of postoperative cognitive dysfunction (POCD) in elderly patients undergoing elective non-cardiac surgery.</p><p><strong>Methods: </strong>A prospective observational study was conducted on 35 patients aged 60 years and older who underwent elective non-cardiac surgery under general or regional anesthesia. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) test preoperatively, at 24 hours, and on postoperative day 30. Demographic characteristics, comorbidities, perioperative events, and anesthesia-related factors were recorded.</p><p><strong>Results: </strong>The mean preoperative MoCA score was 20.9±3.2, which decreased significantly to 18.0±2.6 at 24 hours (p<0.001) and improved to 22.7±2.7 by postoperative day 30 (p<0.001). The incidence of cognitive dysfunction (MoCA <21) was 42.9% preoperatively, 85.7% at 24 hours, and 20.0% at day 30. No significant associations were found between POCD and comorbidities, anesthesia type, intraoperative hypotension, bleeding, transfusion, or narcotic use (p>0.05). However, preoperative cognitive performance was lower among patients with lower education levels, and postoperative day-30 scores were significantly lower among smokers (p=0.043).</p><p><strong>Conclusion: </strong>POCD was common in the early postoperative period but largely resolved by day 30. Smoking and low educational level were associated with poorer cognitive outcomes. Larger multicenter studies are needed to further clarify risk factors and long-term neurocognitive trajectories in elderly surgical patients.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"43-52"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Systemic Steroid Use on the Success of Core Decompression in Non-Traumatic Early-Stage Femoral Head Osteonecrosis.","authors":"Gokhan Pehlivanoglu, Osman Cimen, Alper Koksal","doi":"10.14744/SEMB.2025.04207","DOIUrl":"https://doi.org/10.14744/SEMB.2025.04207","url":null,"abstract":"<p><strong>Objectives: </strong>Systemic corticosteroid use is a well-established risk factor for non-traumatic osteonecrosis of the femoral head (ONFH). However, its impact on the clinical outcomes of joint-preserving procedures, such as core decompression (CD), remains uncertain. This study aimed to evaluate whether systemic steroid exposure influences the success of CD in patients with early-stage ONFH.</p><p><strong>Methods: </strong>This retrospective cohort study included 49 hips from 41 patients with Ficat stage IIa ONFH who underwent isolated CD between 2013 and 2021. Patients were stratified into two groups according to systemic corticosteroid use within one year prior to diagnosis. Demographic and radiologic data, including modified Kerboul angle and stage, were collected. Treatment success was defined as the absence of femoral head collapse or conversion to total hip arthroplasty at the final radiologic follow-up. Outcomes were compared between steroid users and non-users using t-tests, Mann-Whitney U, chi-square, and Fisher's exact tests, as appropriate.</p><p><strong>Results: </strong>Overall, treatment success was achieved in 63.3% of hips. The success rate was 70.4% in steroid users and 54.5% in non-users, but this difference was not statistically significant (p=0.372). Baseline radiologic parameters, including modified Kerboul angle and stage, did not differ significantly. Sex distribution differed significantly (p=0.003), while age, follow-up duration, and bilaterality were comparable.</p><p><strong>Conclusion: </strong>Systemic corticosteroid use was not significantly associated with worse radiologic outcomes following CD in early-stage ONFH. These findings support CD as a viable joint-preserving treatment in appropriately selected patients, irrespective of prior steroid exposure.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"79-84"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Reply.","authors":"Uğur Temel, Bülent Arslan, Mehmet Oğuzhan Özyurtkan","doi":"10.14744/SEMB.2026.58259","DOIUrl":"https://doi.org/10.14744/SEMB.2026.58259","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"135"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of Surgical Branch Residents on Anatomy Education and Its Importance.","authors":"Zekiye Karaca Bozdag, Ayla Kurkcuoglu, Didem Daymaz Yılmaz, Nazire Kılıç Safak, Buse Naz Candır Gurses","doi":"10.14744/SEMB.2026.52822","DOIUrl":"https://doi.org/10.14744/SEMB.2026.52822","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the pre-graduation anatomy training of residents from multiple surgical specialties and to assess their views and needs concerning anatomy during their surgical residency training.</p><p><strong>Methods: </strong>Following the acquisition of the requisite institutional approvals, a questionnaire prepared using the Google Survey platform was circulated online among physicians at various stages of surgical residency training. This multicenter study included participants from multiple hospitals across different cities in Türkiye. Questions about participants' demographic characteristics and experiences with anatomy training during both their undergraduate and specialist training were asked. All responses were analyzed statistically.</p><p><strong>Results: </strong>A total of 143 surgical residents participated in the study. Of the participants, 31.5% were female and 68.5% were male, and the mean age was 28±2.8 years. Of the residents, 67.1% had taken anatomy courses in the first two semesters of medical school, and 67.7% stated that they found their medical education inadequate for surgical residency. During their undergraduate education, 97.2% of the participants received face-to-face anatomy practice training, 47.6% received training with cadavers and plastic models. In addition, those who were trained with cadavers were more supportive of anatomy integration (p=0.031). It was also noteworthy that senior residents (defined as those with ≥2 years of residency training) considered anatomy integration into surgical residency training more necessary (p=0.006).</p><p><strong>Conclusion: </strong>This study highlights the critical role of anatomy knowledge in surgical training and emphasizes its importance in the effective integration of education during surgical residency training.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"9-15"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Bedside Ultrasonography in Neonatal Central Venous Access Applications.","authors":"Adil Umut Zubarioglu, Ali Bulbul, Hasan Sinan Uslu","doi":"10.14744/SEMB.2025.04206","DOIUrl":"https://doi.org/10.14744/SEMB.2025.04206","url":null,"abstract":"<p><p>Vascular access in critically ill neonates is crucial for management and is often challenging. Neonatal venous access must allow for the administration of all necessary medications and diagnostic tests. For these purposes, the catheter must be centrally located. Therefore, determining the correct location of the tip of central venous access devices is crucial, and traditionally, this assessment has relied on thoracoabdominal radiography. However, this method has limitations; it is an indirect method that uses radiological landmarks, is postprocedural, can only be used for tip location, and has long-term risks because of ionizing radiation. Current guidelines recommend that the imaging method used in central venous access procedures be real-time, intraprocedural, rapid, accurate, easy to use, noninvasive, reproducible, and inexpensive. Bedside ultrasonography, which possesses all these features, is considered the ideal imaging method. Ultrasonography is used with various catheter types for selecting the appropriate vein for catheterization, during needle insertion, for advancing the catheter in the correct direction, for catheter tip navigation, for determining catheter tip position, for monitoring puncture-site-related complications, and for identifying and monitoring late complications. The goal of this review was to examine the advantages and feasibility of using bedside ultrasonography in central venous catheter insertion procedures, especially in the newborn period.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"1-8"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Surgery for First Episode PSP: Is It Overtreatment?","authors":"Serkan Uysal","doi":"10.14744/SEMB.2026.95695","DOIUrl":"https://doi.org/10.14744/SEMB.2026.95695","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"133-134"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Reply.","authors":"Mehmet Kostek, Mehmet Uludağ","doi":"10.14744/SEMB.2026.98048","DOIUrl":"https://doi.org/10.14744/SEMB.2026.98048","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"138-139"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}