Medical Bulletin of Sisli Etfal Hospital最新文献

{"title":"Investigation of Influenza Cases and Risk Factors Associated with Fatality in Türkiye.","authors":"Semanur Kuzi, Fazilet Duygu, Irfan Sencan","doi":"10.14744/SEMB.2024.64614","DOIUrl":"https://doi.org/10.14744/SEMB.2024.64614","url":null,"abstract":"<p><strong>Objectives: </strong>Influenza is an infectious disease that primarily affects the respiratory system. It can cause high morbidity and mortality, especially in people with risk factors. This study aimed to epidemiologically analyze influenza PCR-positive patients in the 2014-2015 influenza season and to identify risk factors associated with disease severity and fatality.</p><p><strong>Methods: </strong>Within the scope of national influenza surveillance program, clinical samples from patients with influenza-like illness (ILI) symptoms are sent to the Turkish Public Health Institution, National Influenza Center for testing, accompanied by case information forms. A retrospective analysis was conducted on the case information forms of patients who tested positive for influenza via PCR during the 2014-2015 influenza season. Demographic data were analyzed, and the presence of risk factors associated with fatality was investigated through further analysis.</p><p><strong>Results: </strong>A total of 1330 patients were included in the study. 684 (51.4%) of the patients were female. The median age was 42.8 years (IQR: 23-61). Among the patients, 154 (11.9%) died. The median age of deceased patients was 60.2 years (IQR: 39.8-75). Being over 65 years old in deceased patients is 3.4 times more likely compared to survived patients [OR=3.4 (95% CI=2.4-4.9)]. Additionally, deceased patients were 4.8 times more likely to have Influenza A (H1N1) compared to survivors [OR=4.8 (95% CI=3.2-7.2)], and the presence of chronic diseases in deceased patients was also 3.4 times higher than in those who survived [OR=3.4 (95% CI=2.3-5.1)].</p><p><strong>Conclusion: </strong>Infection with H1N1, being elderly and presence of chronic diseases were found to be associated with increased fatality. To mitigate morbidity and mortality, it is crucial to vaccinate individuals with chronic diseases and the elderly, educate them about contact precautions, and encourage prompt healthcare seeking when symptoms appear.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"50-58"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enteral Nutrition in Newborns with Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.","authors":"Mehmet Fatih Deveci, Zehra Arslan, Ayse Unal Yuksekgonul, Osman Kosek","doi":"10.14744/SEMB.2025.34356","DOIUrl":"https://doi.org/10.14744/SEMB.2025.34356","url":null,"abstract":"<p><strong>Objectives: </strong>Clinicians are uncertain about the nutrition of patients diagnosed with hypoxic-ischemic encephalopathy due to the risk of necrotizing enterocolitis and feeding intolerance. The nutritional protocols of these patients are still unclear. We aimed to investigate the time of starting nutrition and related conditions in these patients receiving therapeutic hypothermia (TH) treatment.</p><p><strong>Methods: </strong>This retrospective single-center study evaluated patients hospitalized at our unit and receiving TH between January 2022 and June 2023. Those who started nutrition during TH and after TH were defined as the early enteral nutrition (EEN) and late enteral nutrition (LEN) groups, respectively. Analyses were performed between the two groups.</p><p><strong>Results: </strong>Our study evaluated 91 patients, of whom 40 were in the EEN group and 51 were in the LEN group. The reaching birth weight time in the LEN group was delayed (10 [5-22] vs. 7.5 [5-25] days, respectively, p<0.001), the transition time to full enteral nutrition was longer (10 [6-20] vs. 7 [5-18] days, respectively, p<0.001), and the hospitalization time was longer (13 [8-43] vs. 9 [7-35] days, respectively, p<0.001) compared with those of the EEN group.</p><p><strong>Conclusion: </strong>TH is not an obstacle to starting nutrition. Starting nutrition in these patients at an early stage does not increase nutritional complications and shortens their discharge time.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"113-118"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Adverse Neonatal Outcomes and Diastolic Deceleration Area on Fetal MCA Doppler in Patients with Late Fetal Growth Restriction.","authors":"Gulsan Karabay, Zeynep Seyhanli, Betul Tokgoz Cakir, Gizem Aktemur, Serap Topkara Sucu, Nazan Vanli Tonyali, Mevlut Bucak, Recep Taha Agaoglu, Ahmet Arif Filiz, Huseyin Levent Keskin, Umut Karabay, Seda Aydogan, Gulsah Dagdeviren","doi":"10.14744/SEMB.2025.73368","DOIUrl":"https://doi.org/10.14744/SEMB.2025.73368","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the predictive value of the Diastolic Deceleration Area (DDA), a novel Doppler ultrasound parameter, in detecting adverse neonatal outcomes in fetuses with late-onset fetal growth restriction (FGR). While Doppler parameters such as cerebroplacental ratio (CPR), umbilicocerebral ratio (UCR), and cerebralplacentaluterine ratio (CPUR) are commonly used for fetal monitoring, their predictive power varies. Given the importance of cerebral blood flow redistribution in fetal adaptation to hypoxia, we investigated whether DDA could serve as a reliable indicator of fetal distress and adverse perinatal outcomes.</p><p><strong>Methods: </strong>This prospective case-control study was conducted between January 2024 and July 2024, including 90 pregnant women: 45 diagnosed with late-onset FGR and 45 gestational age-matched healthy controls. Doppler ultrasound measurements, including umbilical artery, uterine artery, middle cerebral artery Doppler indices, CPR, UCR, CPUR, and DDA, were performed. The primary outcome was the prediction of adverse neonatal events, such as neonatal intensive care unit (NICU) admission, neonatal sepsis, respiratory distress, low APGAR scores, and low cord blood pH. Receiver Operating Characteristic (ROC) curve analysis was used to determine the predictive ability of the Doppler indices.</p><p><strong>Results: </strong>DDA values were significantly higher in the FGR group compared to controls (p<0.001). At a cut-off value of >7.23, DDA demonstrated 50% sensitivity and 88% specificity, making it the most specific Doppler parameter for predicting adverse neonatal outcomes. In comparison, CPR (cut-off ≤2.11), UCR (cut-off >0.46) and CPUR (cut-off ≤1.36) had higher sensitivity (96%, 96%, 54%) but lower specificity (32%, 31% and 85% respectively).</p><p><strong>Conclusion: </strong>DDA is a promising Doppler parameter for identifying fetuses at risk in late-onset FGR. Its high specificity suggests it could be a valuable supplementary tool alongside traditional Doppler indices for better risk assessment and clinical decision-making. Further studies are needed to validate its role in perinatal care.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"119-126"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Reply.","authors":"Puren Gokbulut, Serife Mehlika Kuskonmaz, Cagatay Emir Onder, Isilay Taskaldiran, Gonul Koc","doi":"10.14744/SEMB.2025.28938","DOIUrl":"https://doi.org/10.14744/SEMB.2025.28938","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"143"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Role of Midkine in Proliferative Diabetic Retinopathy: Implications from Hypoxia-Induced Angiogenesis.","authors":"Ece Ozal, Sadik Altan Ozal, Riza Serttas, Suat Erdogan","doi":"10.14744/SEMB.2025.29964","DOIUrl":"https://doi.org/10.14744/SEMB.2025.29964","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the expression of midkine (MK) in the vitreous of patients with proliferative diabetic retinopathy (PDR) and non-diabetic individuals, elucidating its potential role in the pathogenesis of the disease.</p><p><strong>Methods: </strong>This prospective cross-sectional study included three groups of patients who underwent pars plana vitrectomy (PPV) surgery. The first group (control) consisted of patients who underwent PPV for epiretinal membrane and macular hole and did not have diabetes mellitus (DM). The second group included patients who underwent PPV for vitreous hemorrhage (VH) and tractional retinal detachment (TRD) secondary to PDR without prior anti-VEGF treatment (No preoperative anti-VEGF application: NPa-VEGF). The third group comprised patients who underwent PPV for VH and TRD secondary to PDR and received a preoperative anti-VEGF injection one week before surgery (preoperative anti-VEGF application: Pa-VEGF). Vitreous samples were collected intraoperatively, and the concentrations of MK, interleukin (IL)-6, and IL-8 were measured using specific Enzyme-Linked Immunosorbent Assay (ELISA) kits.</p><p><strong>Results: </strong>The study included a total of 49 eyes from 49 patients undergoing PPV. The concentrations of IL-6 and IL-8 in vitreous samples from the NPa-VEGF group (n=15) and the Pa-VEGF group (n=14) were not significantly different compared to the control group (n=20) (p>0.05). However, the vitreous fluid of patients in the NPa-VEGF group exhibited significantly higher MK concentrations compared to the control group (p<0.007). Similarly, MK concentrations were significantly elevated in the Pa-VEGF group compared to the control group (p<0.046). No significant difference in MK levels was detected between the NPa-VEGF and Pa-VEGF groups (p>0.05).</p><p><strong>Conclusion: </strong>These findings suggest that increased MK expression in the vitreous may be associated with the pathogenesis of PDR. Further studies are warranted to elucidate the precise mechanisms underlying this association and to explore the potential of MK as a therapeutic target for PDR management.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"76-82"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of an Infant with Congenital Focal Hyperinsulinism with No Apparent Lesion During Surgery.","authors":"Ebru Misirli Ozdemir, Teoman Akcay, Arzu Akdag, Cetin Ali Karadag, Mesut Demir, Canan Tanik, Aydilek Dagdeviren Cakir, Ahmet Ucar","doi":"10.14744/SEMB.2024.89021","DOIUrl":"https://doi.org/10.14744/SEMB.2024.89021","url":null,"abstract":"<p><p>Congenital hyperinsulinism (HI) is the leading cause of persistent hypoglycemia in infants and children. Focal pancreatic lesions account for 30-40% of cases with congenital HI. With early diagnosis, these patients can be treated by resection of the lesion, making long-term medical care unnecessary. In this case, a 5-day-old newborn boy presented with convulsion due to severe and persistent hypoglycemia at his hospitalization in neonatal intensive care unit. Laboratory studies revealed very low levels of ketone bodies with inappropriately normal insulin levels during hypoglycemia. The patient was unresponsive to diazoxide treatment. The molecular genetic analysis revealed a heterozygous pathogenic variant in the ABCC8 gene. 18F-DOPA-PET/CT scan showed increased uptake of 18F-DOPA consistent with focal lesion at the tail of the pancreas. A focal pancreatectomy operation was performed when he was three months old. Histopathological evaluation confirmed focal endocrine cell hyperplasia. Hypoglycemia did not recur after the operation. CHI patients with ABCC8 / KCNJ11 mutation are not easy to manage with pharmacotheraphy. In the case of an identifiable focal lesion associated with CHI, surgery is the most preferred option. In focal CHI, as in our case, the lesion may not be visually evident and requires a surgeon experienced in CHI.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"138-141"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciding on Fine Needle Aspiration Biopsy in Thyroid Incidentalomas in FDG-PET/CT: Should Ultrasonographic Evaluation or FDG Uptake Be in the Foreground?","authors":"Mehmet Kostek, Hatice Kostek, Mehmet Taner Unlu, Ozan Caliskan, Yasin Cakir, Zerin Sengul, Ozgul Ekmekcioglu, Mesut Kafi, Alper Ozel, Nurcihan Aygun, Mehmet Uludag","doi":"10.14744/SEMB.2025.49140","DOIUrl":"https://doi.org/10.14744/SEMB.2025.49140","url":null,"abstract":"<p><strong>Objectives: </strong>18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT) is a widespread imaging technique for whole-body scanning. Incidental lesions may be detected in thyroid gland and the importance and management of these lesions are still a matter of debate. The aims of this study were the evaluation of the diagnostic success of ultrasonography and FDG-PET/CT for predicting malignancy and contribution of these techniques for the decision of Fine Needle Aspiration Biopsy (FNAB) in incidental thyroid lesions detected in FDG-PET/CT.</p><p><strong>Methods: </strong>Patients who underwent FDG-PET/CT in Nuclear Medicine Unit in a single institution between January 2018 and December 2022 were screened for thyroid incidentaloma with increased focal FDG uptake. Imaging studies and pathology results of the patients with Focal Thyroid Incidentalomas (FTI) were reviewed retrospectively.</p><p><strong>Results: </strong>A total of 14.003 FDG-PET/CT reports of 8.259 patients were evaluated. In FDG-PET/CT imaging, 495 (6.0%) patients had increased uptake in thyroid gland, 383 (4.6%) patients had focal and 112 (1.4%) patients had diffuse FDG uptake. The rate of malignancy in FTIs was 19.2%. In the ROC curve analysis, regarding the prediction of malignancy in FTIs with FDG uptake, a SUVmax value of 5.5 and above predicts malignancy with a sensitivity of 71.4% and a specificity of 68.6% (AUC:0.718, p=0.018, 95%CI:0.564-0.872). The sensitivity of ACR-TIRADS-5 was 35.7% (95%CI:14.6-61.7) and sensitivity of the combination of SUVmax>5.5 and ACR-TIRADS-5 was 30.0% (95%CI:8.5-60.7).</p><p><strong>Conclusion: </strong>FDG-PET/CT findings can be used for determining malignancy risk and cutoff values such as 5.5 can be threshold for ordering FNAB. In patients with SUVmax less than 5.5, ultrasonographic risk classification criteria should be used for decision-making.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"20-27"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Oncologic Outcomes after Nephrectomy in Kidney Cancer Patients with and without Preoperative Renal Mass Biopsy.","authors":"Serhat Yentur, Ibrahim Ogulcan Canitez, Muhammet Murat Dincer, Mustafa Zafer Temiz, Aykut Colakerol, Yigit Can Filtekin, Sergen Sahin, Sule Ozsoy, Ismail Engin Kandirali","doi":"10.14744/SEMB.2024.37980","DOIUrl":"https://doi.org/10.14744/SEMB.2024.37980","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to examine the safety of percutaneous renal mass biopsy and compare the oncological outcomes between patients who had a renal biopsy prior to nephrectomy procedures and those who did not have a biopsy.</p><p><strong>Methods: </strong>We evaluated a total of 145 patients who underwent nephrectomy for renal cancer between January 2017 and January 2021. Based on the pretreatment percutaneous renal mass biopsy, we categorized the patients into two groups: the biopsy (-) group and the biopsy (+) group. We performed a comparative analysis of the radiologic and histological characteristics of the tumors in all the groups. We also conducted an examination of the surgical margin outcomes in cases of partial nephrectomy between the two groups. In addition, we did an analysis of the overall survival (OS), recurrence-free survival (RFS), metastasis-free survival (MFS), and disease-free survival (DFS) between each group.</p><p><strong>Results: </strong>Out of 145 patients meeting inclusion criteria, we analyzed 119 cases. The mean age and tumor diameter were 56.75±11.71 years and 53.77±23.99 mm, respectively. Operative time averaged 176.87±56.46 minutes, with a mean follow-up of 25.67±14.27 months (range: 8-60 months). Partial nephrectomy rates were 35.41% (biopsy (-)) and 43.47% (biopsy (+)), with left kidney tumors in 46/96 (biopsy (-)) and 16/23 (biopsy (+)) cases, respectively. Cystic and exophytic tumors varied significantly between groups (p=0.01 and p=0.03). During follow-up, 16 deaths occurred. Mean overall survival (OS) was 51.38±2.26 months. We noted local recurrence and metastatic progression in 4 and 7 patients, respectively, with lung metastases in all cases. RFS, MFS and DFS times averaged 57.94±1.00, 54.75±1.67, and 53.83±1.75 months, respectively. The biopsy (+) group showed a higher prevalence of papillary and chromophobe RCC subtypes. Pathological parameters and surgical outcomes were comparable between groups. OS, RFS, MFS, and DFS times did not significantly differ (p>0.05).</p><p><strong>Conclusion: </strong>According to our findings, a percutaneous renal mass biopsy is a safe procedure. It can aid in the diagnostic evaluation of suspected renal masses and mitigate any adverse effects on oncological outcomes. Our opinion is that patients with suspected renal cancer can safely and successfully use routine percutaneous renal mass biopsy.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"8-14"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Smartphone Use on Musculoskeletal Pain Among Healthcare Workers: A Cross-Sectional Study.","authors":"Enes Efe Is, Selda Ciftci Inceoglu, Banu Kuran","doi":"10.14744/SEMB.2025.36518","DOIUrl":"https://doi.org/10.14744/SEMB.2025.36518","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the relationship between smartphone use and musculoskeletal pain among healthcare workers of different occupations. The research sought to examine the connection between smartphone habits and the prevalence and severity of musculoskeletal pain, with a focus on work-related and personal smartphone use, physical activity, temporomandibular dysfunction and neck disability.</p><p><strong>Methods: </strong>The study utilized a cross-sectional survey design conducted via Google Forms targeting healthcare workers affiliated with Sisli Hamidiye Etfal Training and Research Hospital. The survey comprised 99 questions assessing demographic and professional information, health conditions, smartphone addiction, physical activity level, musculoskeletal pain, and pain-related disability.</p><p><strong>Results: </strong>A total of 207 hospital staff members' responses were included in the analysis. Participants with higher smartphone addiction scores exhibited a significantly younger mean age and increased smartphone usage post-pandemic. No significant differences were found in physical activity levels between groups. However, those with higher addiction scores reported more frequent pain in the jaw and elbows, greater neck disability score, and a higher prevalence of temporomandibular dysfunction. The study also revealed a significant association between smartphone addiction and multi-site musculoskeletal pain.</p><p><strong>Conclusion: </strong>The findings indicate that smartphone addiction among healthcare workers is associated with specific patterns of musculoskeletal pain, particularly in the jaw and elbows, and increased neck disability scores. The study highlights the need for targeted interventions to promote healthier smartphone habits and mitigate musculoskeletal pain among healthcare professionals.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"83-88"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144014596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Total Parenteral Nutrition on Plasma Aluminum Levels in Premature.","authors":"Semra Bahar Akin, Ali Bulbul, Umut Zubarioglu, Mesut Dursun","doi":"10.14744/SEMB.2024.27837","DOIUrl":"https://doi.org/10.14744/SEMB.2024.27837","url":null,"abstract":"<p><strong>Objectives: </strong>Aluminum accumulates in the body, disrupts mental development, affects bone mineral structure and causes cholestasis in the liver. Aimed to investigate parenteral nutrition and aluminum transmission in preterm infants.</p><p><strong>Methods: </strong>Our study was designed as a single-center prospective study. And 45 babies were included during pregnancy weeks ≤32 and/or under 1500 grams. Cord blood samples were taken at birth from all infants. And blood levels of aluminum on the 14th day compared with cord blood levels of aluminum.</p><p><strong>Results: </strong>Aluminum levels evaluated from patients' cord blood were 3.35±1.73 g/L (18-9.7 g/L), while levels reported on day 14 were 4.79±3.54 (1.6-18.6 g/L). Aluminum levels increased by 1.44±3.86 (0.28-2.60) f/L, which was statistically significant (p=0.021). The increase in aluminum levels was highly associated with number of days that furosemide was administered (p=0.012). The increase in serum aluminum levels of patients receiving parenteral feeding for more than 10 days was found to be significantly higher. But there was no statistically significant difference. When the contents of parenteral solutions were examined, it was discovered that there was an important positive correlation between calcium and magnesium levels administered in the first seven days and serum aluminum levels on the fourteenth day (p=0.044 and p=0.008, respectively).</p><p><strong>Conclusion: </strong>The increase in serum aluminum levels in preterm infants fed parenteral nutrition was found to be statistically significant. Longer parenteral nutrition was associated with a greater increase in serum aluminum levels.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"106-112"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}