术前进行和未进行肾肿块活检的肾癌患者行肾切除术后肿瘤预后的比较。

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.14744/SEMB.2024.37980
Serhat Yentur, Ibrahim Ogulcan Canitez, Muhammet Murat Dincer, Mustafa Zafer Temiz, Aykut Colakerol, Yigit Can Filtekin, Sergen Sahin, Sule Ozsoy, Ismail Engin Kandirali
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引用次数: 0

摘要

目的:本研究的目的是检查经皮肾肿块活检的安全性,并比较在肾切除术前进行肾活检和未进行活检的患者的肿瘤预后。方法:我们评估了2017年1月至2021年1月期间因肾癌接受肾切除术的145例患者。根据预处理经皮肾肿块活检,我们将患者分为活检(-)组和活检(+)组。我们对所有组的肿瘤放射学和组织学特征进行了比较分析。我们还对两组部分肾切除术的手术切缘结果进行了比较。此外,我们还分析了各组患者的总生存期(OS)、无复发生存期(RFS)、无转移生存期(MFS)和无病生存期(DFS)。结果:145例符合纳入标准的患者中,我们分析了119例。平均年龄56.75±11.71岁,肿瘤直径53.77±23.99 mm。平均手术时间176.87±56.46分钟,平均随访25.67±14.27个月(8 ~ 60个月)。活检(-)和活检(+)的肾部分切除率分别为35.41%和43.47%,活检(-)和活检(+)的左肾肿瘤分别为46/96和16/23。囊性和外生性肿瘤组间差异有统计学意义(p=0.01和p=0.03)。在随访期间,发生16例死亡。平均总生存期(OS)为51.38±2.26个月。我们分别注意到4例和7例患者局部复发和转移进展,所有病例均有肺转移。RFS、MFS和DFS时间平均分别为57.94±1.00、54.75±1.67和53.83±1.75个月。活检(+)组显示乳头状和憎色RCC亚型的患病率较高。两组间病理参数和手术结果具有可比性。OS、RFS、MFS、DFS时间差异无统计学意义(p < 0.05)。结论:根据我们的发现,经皮肾肿块活检是一种安全的手术。它可以帮助诊断评估疑似肾肿块和减轻任何不利影响的肿瘤预后。我们认为疑似肾癌的患者可以安全、成功地进行常规经皮肾肿块活检。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparison of Oncologic Outcomes after Nephrectomy in Kidney Cancer Patients with and without Preoperative Renal Mass Biopsy.

Objectives: The objective of this study is to examine the safety of percutaneous renal mass biopsy and compare the oncological outcomes between patients who had a renal biopsy prior to nephrectomy procedures and those who did not have a biopsy.

Methods: We evaluated a total of 145 patients who underwent nephrectomy for renal cancer between January 2017 and January 2021. Based on the pretreatment percutaneous renal mass biopsy, we categorized the patients into two groups: the biopsy (-) group and the biopsy (+) group. We performed a comparative analysis of the radiologic and histological characteristics of the tumors in all the groups. We also conducted an examination of the surgical margin outcomes in cases of partial nephrectomy between the two groups. In addition, we did an analysis of the overall survival (OS), recurrence-free survival (RFS), metastasis-free survival (MFS), and disease-free survival (DFS) between each group.

Results: Out of 145 patients meeting inclusion criteria, we analyzed 119 cases. The mean age and tumor diameter were 56.75±11.71 years and 53.77±23.99 mm, respectively. Operative time averaged 176.87±56.46 minutes, with a mean follow-up of 25.67±14.27 months (range: 8-60 months). Partial nephrectomy rates were 35.41% (biopsy (-)) and 43.47% (biopsy (+)), with left kidney tumors in 46/96 (biopsy (-)) and 16/23 (biopsy (+)) cases, respectively. Cystic and exophytic tumors varied significantly between groups (p=0.01 and p=0.03). During follow-up, 16 deaths occurred. Mean overall survival (OS) was 51.38±2.26 months. We noted local recurrence and metastatic progression in 4 and 7 patients, respectively, with lung metastases in all cases. RFS, MFS and DFS times averaged 57.94±1.00, 54.75±1.67, and 53.83±1.75 months, respectively. The biopsy (+) group showed a higher prevalence of papillary and chromophobe RCC subtypes. Pathological parameters and surgical outcomes were comparable between groups. OS, RFS, MFS, and DFS times did not significantly differ (p>0.05).

Conclusion: According to our findings, a percutaneous renal mass biopsy is a safe procedure. It can aid in the diagnostic evaluation of suspected renal masses and mitigate any adverse effects on oncological outcomes. Our opinion is that patients with suspected renal cancer can safely and successfully use routine percutaneous renal mass biopsy.

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Medical Bulletin of Sisli Etfal Hospital
Medical Bulletin of Sisli Etfal Hospital MEDICINE, GENERAL & INTERNAL-
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