全肠外营养对早产儿血浆铝水平的影响。

IF 1 Q3 MEDICINE, GENERAL & INTERNAL
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI:10.14744/SEMB.2024.27837
Semra Bahar Akin, Ali Bulbul, Umut Zubarioglu, Mesut Dursun
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引用次数: 0

摘要

目的:铝在体内蓄积,扰乱智力发育,影响骨矿物质结构,引起肝脏胆汁淤积。目的探讨早产儿肠外营养与铝的传播。方法:本研究设计为单中心前瞻性研究。在怀孕周≤32克和/或1500克以下的45名婴儿被纳入研究。在所有婴儿出生时采集脐带血样本。第14天的血铝含量与脐带血铝含量比较。结果:患者脐带血铝水平评估为3.35±1.73 g/L (18-9.7 g/L),第14天报告的水平为4.79±3.54 (1.6-18.6 g/L)。铝水平升高1.44±3.86 (0.28-2.60)f/L,差异有统计学意义(p=0.021)。铝含量的增加与使用速尿的天数高度相关(p=0.012)。经肠外喂养超过10天的患者血清铝水平升高明显较高。但没有统计学上的显著差异。当检查肠外溶液的含量时,发现在前7天给予的钙和镁水平与第14天的血清铝水平之间存在重要的正相关(p=0.044和p=0.008)。结论:经肠外营养喂养的早产儿血清铝水平升高具有统计学意义。长时间的肠外营养与血清铝水平的增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Total Parenteral Nutrition on Plasma Aluminum Levels in Premature.

Objectives: Aluminum accumulates in the body, disrupts mental development, affects bone mineral structure and causes cholestasis in the liver. Aimed to investigate parenteral nutrition and aluminum transmission in preterm infants.

Methods: Our study was designed as a single-center prospective study. And 45 babies were included during pregnancy weeks ≤32 and/or under 1500 grams. Cord blood samples were taken at birth from all infants. And blood levels of aluminum on the 14th day compared with cord blood levels of aluminum.

Results: Aluminum levels evaluated from patients' cord blood were 3.35±1.73 g/L (18-9.7 g/L), while levels reported on day 14 were 4.79±3.54 (1.6-18.6 g/L). Aluminum levels increased by 1.44±3.86 (0.28-2.60) f/L, which was statistically significant (p=0.021). The increase in aluminum levels was highly associated with number of days that furosemide was administered (p=0.012). The increase in serum aluminum levels of patients receiving parenteral feeding for more than 10 days was found to be significantly higher. But there was no statistically significant difference. When the contents of parenteral solutions were examined, it was discovered that there was an important positive correlation between calcium and magnesium levels administered in the first seven days and serum aluminum levels on the fourteenth day (p=0.044 and p=0.008, respectively).

Conclusion: The increase in serum aluminum levels in preterm infants fed parenteral nutrition was found to be statistically significant. Longer parenteral nutrition was associated with a greater increase in serum aluminum levels.

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Medical Bulletin of Sisli Etfal Hospital
Medical Bulletin of Sisli Etfal Hospital MEDICINE, GENERAL & INTERNAL-
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