Medical Bulletin of Sisli Etfal Hospital最新文献

{"title":"A Novel Marker in Hypogonadal Hypogonadism: Apelin.","authors":"Alperen Akansel Caglar, Engin Sebin, Emine Kartal Baykan, Ayse Carlıoglu","doi":"10.14744/SEMB.2025.92160","DOIUrl":"https://doi.org/10.14744/SEMB.2025.92160","url":null,"abstract":"<p><strong>Objectives: </strong>Apelin is a recently identified adipokine with pleiotropic actions in cardiovascular regulation, metabolic homeostasis, bone remodeling, and reproductive physiology. Through binding to the apelin receptor (APJ), apelin has been shown to influence gonadotropin-releasing hormone (GnRH) secretion, which is essential for the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Given its potential role in the hypothalamic-pituitary-gonadal (HPG) axis, alterations in circulating apelin may contribute to hypogonadotropic hypogonadism (HH). This study aimed to investigate whether serum apelin concentrations are altered in patients with HH and to evaluate its potential relevance as a complementary biomarker in the diagnostic approach to HH.</p><p><strong>Methods: </strong>A total of 60 participants were enrolled: 30 newly diagnosed HH patients (untreated for at least one year, with no comorbid chronic diseases) and 30 age- and body mass index (BMI)-matched healthy controls. Individuals with BMI<20 or BMI>30 were excluded to minimize confounding metabolic influences on apelin secretion. Following overnight fasting, venous blood samples were obtained for complete biochemical and hormonal profiles. Serum apelin levels were measured using a validated human ELISA kit (SunRed Biotechnology, China; intra- and inter-assay coefficients of variation<10%). Statistical analysis was performed using SPSS 17.0.</p><p><strong>Results: </strong>Apelin concentrations were significantly lower in HH patients compared with healthy controls (median 35.2ng/L vs. 63.3ng/L, p=0.046). ROC analysis yielded an area under the curve (AUC) of 0.65, with a sensitivity of 76% and a specificity of 64%.</p><p><strong>Conclusion: </strong>These findings demonstrate reduced circulating apelin concentrations in HH, supporting the hypothesis of its involvement in GnRH regulation and the pathogenesis of hypogonadism. Although its diagnostic accuracy is modest, apelin may complement traditional hormonal markers. Further multicenter studies and mechanistic research are required to validate these observations.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"36-42"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Cosmetic Lengthening Complication Causing Precice Stryde Nail Failure: A Case Report.","authors":"Muharrem Kanar, Enver Ipek, Suleyman Cakirturk","doi":"10.14744/SEMB.2025.20586","DOIUrl":"https://doi.org/10.14744/SEMB.2025.20586","url":null,"abstract":"<p><p>Limb-lengthening surgeries have been described for medical and cosmetic treatment. Innovative surgical procedures and various instrumentation techniques have been developed with advancing technology. Remote-controlled intramedullary lengthening nail systems (RCILNS) are frequently used in limb-lengthening surgery. In the literature, few surgical complications have been reported in limb-lengthening surgery. Here, we present a case of an unexpected complication caused by a filling material previously applied for gluteal augmentation in a patient who underwent cosmetic limb-lengthening surgery.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"120-123"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Liver Steatosis and Liver Fibrosis in Patients with Type 1 Diabetes Mellitus Using Non-invasive Scores.","authors":"Zulal Istemihan, Fatih Bektas, Ali Emre Bardak, Cansu Kiziltas, Gamze Kemec, Ziya Imanov, Ibrahim Volkan Senkal, Kanan Nuriyev, Aynura Rustamzade, Sezen Genc Ulucecen, Hulya Hacisahinogullari, Kubilay Karsidag, Bilger Cavus, Aslı Cifcibası Ormeci, Filiz Akyuz, Kadir Demir, Fatih Besisik, Sabahattin Kaymakoglu","doi":"10.14744/SEMB.2026.57777","DOIUrl":"https://doi.org/10.14744/SEMB.2026.57777","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and clinically significant fibrosis (CSF) in patients with type 1 diabetes mellitus (T1DM), as well as the factors affecting them, using non-invasive tests based on blood and imaging methods.</p><p><strong>Methods: </strong>Adult T1DM patients who were followed up in the diabetes mellitus outpatient clinic at a tertiary university hospital and who did not have other causes of liver disease were prospectively investigated. MASLD and CSF were evaluated using non-invasive scores based on biochemical tests and FibroScan®. MASLD was defined as a FibroScan® CAP score ≥275 dB/m, and CSF was defined as F≥8 kPa in the absence of any other chronic liver disease or secondary cause of hepatic steatosis in T1DM patients.</p><p><strong>Results: </strong>The prevalence of MASLD and CSF was 12.9% and 5%, respectively. BMI, fasting blood glucose, and waist and hip circumference were significantly higher in patients with MASLD (p<0.05). The rates of hypertension and dyslipidemia were also higher in patients with MASLD (p=0.026 and p=0.012, respectively). According to Pearson's correlation test, LSM was most strongly correlated with Agile 4 (p<0.001, r=0.922) and Agile 3+ scores (p<0.001, r=0.685). CAP was most strongly correlated with the fatty liver index (p<0.001, r=0.514) and the hepatic steatosis index (p<0.001, r=0.404).</p><p><strong>Conclusion: </strong>Components of metabolic syndrome are important risk factors for MASLD in patients with T1DM. There is currently no consensus on screening and diagnostic pathways for MASLD in T1DM, and further research is needed in this area.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"112-119"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interscalene Block versus Posterior Suprascapular Block for Postoperative Analgesia on Arthroscopic Shoulder Surgery: Randomized, Controlled, Prospective Study.","authors":"Sinem Ozler, Leyla Kilinc, Gamze Dilara Demir, Tugba Yucel, Pinar Sayin, Ayse Surhan Cinar","doi":"10.14744/SEMB.2026.65391","DOIUrl":"https://doi.org/10.14744/SEMB.2026.65391","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the effects of interscalene block and posterior suprascapular nerve block on postoperative analgesia in the first 24 hours after unilateral arthroscopic shoulder surgery.</p><p><strong>Methods: </strong>Ninety-eight adult patients aged between 18 and 65 years, with ASA (American Society of Anesthesiologists) physical status I-II, undergoing elective arthroscopic shoulder surgery were included in this prospective, randomized controlled study. All patients were randomized into two groups: the interscalene block group (Group ISB, n=48) and the suprascapular block group (Group SSB, n=50). Both groups received 10 mL of 0.5% bupivacaine. The duration of analgesia, total opioid consumption, complications, and Visual Analog Scale (VAS) scores were recorded at postoperative 0, 1, 4, 6, 12, and 24 hours.</p><p><strong>Results: </strong>Statistical data were analyzed in 87 patients after 7 patients from Group SSNB and 4 patients from Group ISB were excluded from the study. There was no significant difference between the two groups in analgesia duration, total opioid consumption, and patient satisfaction. While VAS values at 0 hours (p<0.01), 1 hour (p<0.05), 4 hours (p<0.01), and 6 hours (p<0.01) were lower in Group ISB, the VAS value at the 12th hour was similar between Group SSB and Group ISB (p>0.05). However, the VAS value at the 24th hour was lower in Group SSB (p<0.01). The complication rate was higher in Group ISB (p<0.01).</p><p><strong>Conclusion: </strong>It was concluded that ultrasound-guided posterior SSB for postoperative pain after arthroscopic shoulder surgery is not equivalent to ISB, especially in the early postoperative period, but it is an effective alternative technique with fewer side effects.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"85-92"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatty Liver and Pancreatic Steatosis in Patients with Chronic Hepatitis B and C and Wilson's Disease.","authors":"Mehmet Aksoy, Feyza Gelebek, Kemal Ozan Lule, Nezihe Otay Lule, Abdullah Emre Yildirim, Sezgin Barutcu","doi":"10.14744/SEMB.2025.79735","DOIUrl":"https://doi.org/10.14744/SEMB.2025.79735","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to determine the presence of fatty liver and pancreatic steatosis in individuals diagnosed with Chronic Hepatitis B (CHB), Chronic Hepatitis C (CHC), and Wilson's Disease (WD) and to evaluate the relationship between the presence of fatty liver and pancreatic steatosis and laboratory parameters.</p><p><strong>Methods: </strong>Forty-eight CHB, fifty-six CHC, and thirty-five WD patients were included in the study. Pancreatic steatosis was measured by three methods: steatosis according to the mean pancreas value, steatosis according to the pancreas/spleen difference value, and steatosis according to the pancreas/spleen density ratio. Hepatic steatosis was measured by noncontrast CT using multi-site attenuation sampling and the Liver Attenuation Index (LAI); steatosis was graded according to predefined LAI cut-offs. Fatty liver and pancreatic steatosis were graded as Grade 1, 2, or 3. Certain laboratory parameters of the patients were also retrospectively reviewed.</p><p><strong>Results: </strong>In 69.1% of all patients, grade 1 fatty liver disease was present. Pancreatic steatosis was absent in 50.3% of patients according to the mean pancreas value, 63.3% according to the pancreas/spleen difference, and 61.9% according to the pancreas/spleen density ratio. Fatty liver disease was positively correlated with high Erythrocyte Sedimentation Rate (ESR) (r=0.255, p=0.002) and Alanine Transaminase (ALT) (r=0.180, p=0.034). ESR (p=0.025) and urea level (p=0.024) were found to be significantly higher in the group with steatosis according to the mean pancreas value. According to the group with steatosis based on the pancreas/spleen density ratio, globulin level was significantly higher (p=0.038). The rates of steatosis according to the pancreas mean value (p=0.003) and the pancreas/spleen density ratio (p=0.039) were significantly more advanced in CHC patients compared with the other patient groups. There was no statistically significant difference between the stage of fatty liver and the stage of fatty pancreas (p>0.05).</p><p><strong>Conclusion: </strong>Although fatty liver and pancreatic steatosis are considered similar pathologies, our findings suggest that these two conditions should not be considered interchangeable. Further studies with larger samples may be useful to better demonstrate the correlation between the two conditions and the investigated parameters.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"62-70"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracoscopic Bronchovascular (Double) Sleeve Lobectomy to Correct Intraoperative Vascular Injury: A Case Report.","authors":"Volkan Erdogu, Melike Ulker, Merve Ekinci Fidan, Ali Cevat Kutluk, Muzaffer Metin","doi":"10.14744/SEMB.2026.71463","DOIUrl":"https://doi.org/10.14744/SEMB.2026.71463","url":null,"abstract":"<p><p>Double sleeve lobectomy, involving both bronchial and vascular reconstruction, is a complex but lung-sparing alternative to pneumonectomy for centrally located tumors. While traditionally performed via thoracotomy, its application through video-assisted thoracoscopic surgery (VATS) remains limited. We report the first known case of a double sleeve lobectomy in Türkiye performed via a VATS approach in a 58-year-old female with a centrally located left upper lobe pleomorphic carcinoma involving both the pulmonary artery and bronchus. This case demonstrates the technical feasibility of VATS double-sleeve lobectomy when performed by experienced surgeons and shows that a mistake made during pulmonary artery division does not necessarily result in pneumonectomy.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"124-129"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Mediastinal Staging in NSCLC Among Thoracic Surgeons: A Survey Study From Türkiye.","authors":"Melike Ulker, Volkan Erdogu, Ali Cevat Kutluk, Muzaffer Metin","doi":"10.14744/SEMB.2025.04903","DOIUrl":"https://doi.org/10.14744/SEMB.2025.04903","url":null,"abstract":"<p><strong>Objectives: </strong>Mediastinal lymph node staging is a critical step in the treatment algorithm for non-small cell lung cancer (NSCLC). Current guidelines define the patient groups in which invasive or minimally invasive mediastinal lymph node sampling is required during preoperative staging. This study aimed to determine the extent to which thoracic surgeons actively practicing in Türkiye adhere to these guideline recommendations and to assess the concordance between their daily clinical practices and these recommendations.</p><p><strong>Methods: </strong>A guideline-based survey, including nine case scenarios, was emailed to 417 thoracic surgeons registered with the Turkish Thoracic Surgery Association. The survey collected data on participants' demographic characteristics, institutional profiles, and approaches to each clinical scenario. Responses were analyzed for concordance with guideline recommendations.</p><p><strong>Results: </strong>The survey response rate was 29.2% (n=122). A total of 48.3% of the participants possessed an academic title, and 77.8% were employed at training and research or university hospitals. In scenarios involving a radiologically positive, single, non-bulky N2 lymph node, 85.2% of respondents indicated that invasive mediastinal staging was required by guidelines. In contrast, among patients without radiologic evidence of N2 disease, the proportion of surgeons recommending mediastinal staging was 19.7% for squamous cell carcinoma >3 cm in size and 36.9% for adenocarcinoma. For centrally located tumors, 59% of participants recommended staging. Notably, there was substantial variation in opinions regarding the necessity of invasive sampling for suspicious aortopulmonary window lymph nodes.</p><p><strong>Conclusion: </strong>Thoracic surgeons in Türkiye generally exhibit approaches to mediastinal staging that align with guideline recommendations; however, variations exist in certain subgroups. Standardization is particularly needed in the definition of central tumors, the approach to sampling aortopulmonary lymph node stations, and staging strategies based on histologic tumor type. These findings highlight the importance of educational and awareness initiatives aimed at improving the integration of guideline recommendations into clinical practice.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"71-78"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Kostek et al.: Deciding on Fine Needle Aspiration Biopsy in Thyroid Incidentalomas in FDG-PET/CT: Should Ultrasonographic Evaluation or FDG Uptake Be in the Foreground?","authors":"Betul Vatankulu, Sait Sager","doi":"10.14744/SEMB.2026.53486","DOIUrl":"https://doi.org/10.14744/SEMB.2026.53486","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"136-137"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's Reply.","authors":"Barıs Acar, Ahmet Senel, Ahmet Sinan Kalyenci, Saltuk Bugra Tekin, Onur Gunday","doi":"10.14744/SEMB.2026.02058","DOIUrl":"https://doi.org/10.14744/SEMB.2026.02058","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"132"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Turkish Version of the Quality of Recovery-15 Questionnaire.","authors":"Kaan Sunter, Kadir Yagiz Turker, Can Ates, Mehmet Ali Koc, Yusuf Sevim, Cemal Ensari, Onur Ilkay Dincer, Ismail Cem Eray, Burak Yavuz, Timucin Erol, Siyar Ersoz, Burak Kutlu, Mehmet Ayhan Kuzu","doi":"10.14744/SEMB.2026.70933","DOIUrl":"https://doi.org/10.14744/SEMB.2026.70933","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to perform a cross-cultural adaptation and psychometric evaluation of the Quality of Recovery-15 (QoR-15) questionnaire in Türkiye.</p><p><strong>Methods: </strong>The QoR-15 was translated into Turkish through a rigorous process involving independent translations, consensus, forward-backward translation, and review. The questionnaire was administered to patients undergoing major abdominal surgery preoperatively and on postoperative days 1, 7, and 30. Reliability was assessed using Cronbach's α, McDonald's Omega, and the inter-item correlation coefficient. Construct validity was evaluated using confirmatory factor analysis (CFA), and responsiveness was analyzed using Cohen's effect size and the standardized response mean (SRM).</p><p><strong>Results: </strong>A total of 510 patients participated in the study; 335 (65.69%) were <65 years old, and 279 (54.71%) were male. The Turkish version of QoR-15 (QoR-15T) demonstrated good internal consistency, with Cronbach's α values of 0.896 and 0.888 for preoperative and postoperative administrations, respectively, and McDonald's Omega coefficients of 0.894 and 0.878. Confirmatory factor analysis confirmed the two-factor (two-dimensional) structure of the QoR-15T. The comparative fit indices for Models 1 and 2 were 0.970 and 0.991, respectively. QoR-15T showed responsiveness to changes in health status, with Cohen's effect size (1.22) and the standardized response mean (1.18) indicating its ability to detect clinically important changes.</p><p><strong>Conclusion: </strong>The QoR-15T is a reliable, valid, and responsive questionnaire for assessing the quality of recovery in patients undergoing major abdominal surgery. Its ability to capture patients' perspectives and multidimensional aspects of recovery makes it a valuable tool for clinical and research purposes.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 1","pages":"93-102"},"PeriodicalIF":0.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147692737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}