Medical Bulletin of Sisli Etfal Hospital最新文献

{"title":"Real-World Outcomes of Fosaprepitant-Containing Prophylaxis in Patients Receiving Highly and Moderately Emetogenic Chemotherapy: A Two-Center Retrospective Study.","authors":"Ozde Melisa Celayir, Taner Korkmaz, Ozlem Sonmez, Alara Ataacar Aydınoglu, Ozlem Er","doi":"10.14744/SEMB.2026.32391","DOIUrl":"https://doi.org/10.14744/SEMB.2026.32391","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy and safety of fosaprepitant-containing antiemetic prophylaxis and associated patient-related risk factors in patients receiving highly emetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC).</p><p><strong>Methods: </strong>Medical records of patients treated between July 2021 and March 2022 at two oncology centers were retrospectively reviewed. A total of 50 adult patients receiving chemotherapy were included in the study. The antiemetic regimen consisted of fosaprepitant, dexamethasone, granisetron, and olanzapine. Demographic data, emetogenic risk classification, Beck Anxiety Inventory (BAI) scores, timing and frequency of nausea and vomiting according to NCI-CTCAE v5.0, the need for rescue antiemetics, and adverse events were evaluated. The primary endpoint was defined as complete response (no vomiting) within 0-120 hours. Statistical analyses were performed using Fisher's exact test.</p><p><strong>Results: </strong>The majority of patients were female (80%) and younger than 65 years (84%). The most frequent diagnoses were breast cancer (38%) and pancreatic-biliary cancers (18%). All patients with comorbidities were in remission. A history of hyperemesis gravidarum was reported in 22% of patients, motion sickness in 18%, and alcohol use in 18%. Based on BAI scores, moderate and severe anxiety were detected in 16% and 2% of patients, respectively. According to the emetogenic risk classification, 82% of patients received HEC and 18% received MEC. Complete vomiting control was achieved in 80% of patients receiving fosaprepitant therapy, whereas 48% experienced no nausea. No statistically significant associations were found between emetogenic risk group, anxiety level, alcohol use, history of hyperemesis gravidarum, or motion sickness and treatment response (p>0.05). Complete response rates were 85.4% in the HEC group and 55.6% in the MEC group (p=0.118). Although the complete response rate was lower in patients with clinically significant anxiety (66.7%) than in those with low anxiety (82.4%), the difference was not statistically significant (p=0.475). Rescue antiemetics were required in 52% of patients. The most common adverse events were fatigue (10%) and dyspepsia (4%).</p><p><strong>Conclusion: </strong>In this real-world study, high rates of vomiting control were observed with fosaprepitant-based antiemetic therapy. The treatment was generally well tolerated. Although not statistically significant, the lower response rates observed in patients receiving MEC regimens and those with high anxiety levels suggest the need for more vigilant monitoring in these patient subgroups.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 3","pages":"360-367"},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes and Comparison of Mucociliary Clearance After Septoplasty and Septorhinoplasty Surgery.","authors":"Nurdan Kose Celebi, Tugba Aslan Dundar, Mert Gurcan","doi":"10.14744/SEMB.2026.38488","DOIUrl":"https://doi.org/10.14744/SEMB.2026.38488","url":null,"abstract":"<p><strong>Objectives: </strong>Nasal mucociliary clearance (MCC) is a physiological mechanism of the upper respiratory tract that removes locally produced deposits, excess secretions, and unwanted inhaled particles. Various pathologies, such as rhinitis, sinusitis, septal deviation, nasal polyposis, and inferior turbinate hypertrophy, are known to reduce the activity of the mucociliary mechanism by causing nasal obstruction. Increased mucus secretion accompanied by impaired ciliary movement prevents the clearance of nasal secretions and predisposes patients to recurrent infections. The aim of this study was to determine how commonly performed nasal surgeries affect mucociliary clearance.</p><p><strong>Methods: </strong>The study included 43 patients who underwent septoplasty and 34 patients who underwent open-technique septorhinoplasty. The two groups were statistically compared in terms of age, sex, smoking status, and MCC scores.</p><p><strong>Results: </strong>Both groups demonstrated a temporary prolongation of MCC in the early postoperative period (first week). At the third month, MCC values improved significantly in the septoplasty group (p<0.05). Improvement was slower in the open-technique septorhinoplasty group, and MCC values remained higher at the third month than in the septoplasty group (p<0.001).</p><p><strong>Conclusion: </strong>Septoplasty has positive effects on the MCC mechanism. Our results suggest that elevation and prolonged operative time may have a negative effect on MCC that persists until the third postoperative month in open-technique septorhinoplasty.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 3","pages":"319-323"},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Gadoxetic Acid-Enhanced MRI as a Diagnostic Tool in Cases of Biliary Atresia: A Two-Case Report.","authors":"Huseyin Ozkurt, Mertcan Avci, Nafiye Urganci","doi":"10.14744/SEMB.2026.52385","DOIUrl":"https://doi.org/10.14744/SEMB.2026.52385","url":null,"abstract":"<p><p>Early diagnosis of biliary atresia (BA) remains challenging, although timely recognition is critical for achieving favorable surgical outcomes. We present two infants in whom gadoxetic acid-enhanced MRI demonstrated imaging findings that supported early suspicion of BA. Two neonates with persistent cholestasis underwent routine laboratory evaluation, targeted ultrasonography, and hepatocyte-specific magnetic resonance imaging using gadoxetic acid. This contrast agent is actively taken up by functioning hepatocytes and is normally excreted into the biliary system during the delayed hepatobiliary phase, allowing functional assessment of bile formation and excretion. MRI findings, particularly biliary excretion on delayed images, were evaluated and correlated with intraoperative cholangiography. In both infants, hepatic parenchymal enhancement after contrast administration was preserved, indicating intact hepatocellular uptake. However, no biliary excretion was observed on delayed hepatobiliary-phase images. Intraoperative cholangiography confirmed biliary atresia in both cases. Although the diagnosis of biliary atresia is traditionally based on clinical findings, laboratory parameters, and ultrasonography, these approaches may remain inconclusive in some patients. Our findings suggest that gadoxetic acid-enhanced MRI, by demonstrating preserved hepatocellular uptake with absent biliary excretion, may serve as a useful adjunctive diagnostic tool and contribute to earlier and more confident identification of biliary atresia.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 3","pages":"412-416"},"PeriodicalIF":1.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149116212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Cause of Ataxia in Patient with Sjogren's Syndrome: Metronidazole Neurotoxicity.","authors":"Bahar Say, Mustafa Gungor, Berfin Kardelen Aydin, Yeliz Pekcelik","doi":"10.14744/SEMB.2025.50146","DOIUrl":"10.14744/SEMB.2025.50146","url":null,"abstract":"<p><p>Cerebellar ataxia associated with metronidazole is rare. Sjögren's syndrome (SS), a chronic autoimmune disease, can also rarely present with neurological symptoms such as cerebellar ataxia. In this report, we aimed to present a 40-year-old female patient diagnosed with SS who developed acute-onset speech disorder and imbalance. The patient's complaints developed shortly, four days, after taking metronidazole for a vaginal infection. Her neurological examination revealed a broad-based gait, explosive speech, and bilateral dysmetria. Routine blood tests, nerve conduction studies, and cerebrospinal fluid analysis were normal. Brain magnetic resonance imaging showed hyperintensity in the dentate nuclei of the cerebellum, consistent with metronidazole-induced neurotoxicity. The patient's symptoms rapidly improved after discontinuation of the drug, and the lesions had completely resolved on imaging one month later. Apart from neuropathy and cerebellar degeneration, which are the most common etiologies of ataxia in Sjögren's syndrome, rare metronidazole-induced neurotoxicity was observed in our patient. Metronidazole-induced neurotoxicity may be a potentially reversible cause of cerebellar symptoms, and its recognition based on typical radiological features is important for drug withdrawal and complete recovery.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"271-274"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Utility of Body Fat and Visceral Fat Measured by Bioimpedance Versus BMI and Waist Circumference in Predicting Elevated Cardiovascular Risk Scores.","authors":"María Gordito Soler, Pedro Juan Tárraga López, Ángel Arturo López González, Irene Coll Campayo, Carla Busquets-Cortés, José Ignacio Ramírez Manent","doi":"10.14744/SEMB.2026.34079","DOIUrl":"10.14744/SEMB.2026.34079","url":null,"abstract":"<p><strong>Objectives: </strong>Obesity is a key modifiable risk factor for cardiovascular disease (CVD), yet the most effective anthropometric index for identifying individuals at elevated cardiovascular risk (CVR) remains debated. Body fat (BF) and visceral fat (VF) measured by bioimpedance may provide greater discriminatory capacity than body mass index (BMI) or waist circumference (WC) when applied to validated CVR scales. To compare the predictive performance of BF and VF with BMI and WC for identifying elevated CVR according to Framingham vascular age, SCORE vascular age, and SCORE2 in a large occupational cohort.</p><p><strong>Methods: </strong>This cross-sectional study included 8,590 Spanish workers (52.2% women) who were evaluated between 2021 and 2023 during routine occupational health assessments. Anthropometric measures included BMI and WC, while BF and VF were obtained through validated bioelectrical impedance analysis. Elevated CVR was defined according to the thresholds of each scale. Predictive capacity was assessed using receiver operating characteristic (ROC) curves and area under the curve (AUC) values with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>In women, VF showed the highest AUC for Framingham vascular age (0.828; 95% CI: 0.808-0.849) and SCORE vascular age (0.779; 95% CI: 0.755-0.804), whereas WC performed slightly better for SCORE2 (0.647; 95% CI: 0.629-0.666). BF achieved moderate accuracy across all scales (AUC: 0.640-0.794), while BMI consistently yielded the lowest values (AUC: 0.607-0.749). In men, BF had the highest AUC for Framingham vascular age (0.799; 95% CI: 0.775-0.823), VF was superior for SCORE vascular age (0.768; 95% CI: 0.749-0.787), and all indices showed lower discrimination for SCORE2 (AUC range: 0.611-0.624).</p><p><strong>Conclusion: </strong>BF and VF measured by bioimpedance demonstrated higher predictive capacity for elevated CVR than BMI or WC in both sexes, although the best-performing index varied by scale and sex. These findings support the inclusion of direct adiposity measurements in occupational health screening to improve the early detection of cardiovascular risk.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"188-199"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinant Factors for The Efficacy of Botulinum Toxin Injections on Lower Limb Function in Cerebral Palsy: Two Year Follow-up Study.","authors":"Julide Oncu Alptekin, Aylin Ayyildiz, Selda Ciftci Inceoglu, Mehmet Ali Talmac, Ihsan Kafadar, Banu Kuran, Kerem Alptekin","doi":"10.14744/SEMB.2026.58815","DOIUrl":"10.14744/SEMB.2026.58815","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the factors predicting the effect of long-term intramuscular botulinum toxin-A (BTX-A) treatment on motor and gait functions in children with spastic cerebral palsy (CP).</p><p><strong>Methods: </strong>Two hundred children diagnosed with CP were treated with BTX-A, with particular attention given to the lower limbs. The children were followed up for over two years. The severity of spasticity was evaluated using the Modified Ashworth Scale. The Gross Motor Function Classification System (GMFCS) and Observational Gait Scale (OGS) were used to assess changes in motor and gait function scores. Outcomes at the end of two years were compared with baseline values.</p><p><strong>Results: </strong>After two years, the severity of spasticity and the GMFCS and OGS scores improved with BTX-A treatment. The most important factors predicting improvement in motor scores after treatment were young age, high baseline OGS scores, independent walking, baseline GMFCS scores, and hemiplegia. The determinant factors for improvement in gait scores were the number of injections and a high baseline GMFCS level.</p><p><strong>Conclusion: </strong>The predictors of the efficacy of BTX-A treatment on gait and motor function were young age, independent ambulatory status, gross motor function level, high baseline gait scores, hemiplegic type of CP, and multiple BTX-A injections.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"200-207"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimicrobial Resistance Profile and Longitudinal Trends of <i>Morganella morganii</i> Clinical Isolates in a University Hospital.","authors":"Elif Seren Tanriverdi, Yusuf Yakupogullari, Irem Yildiz, Baris Otlu","doi":"10.14744/SEMB.2026.60486","DOIUrl":"10.14744/SEMB.2026.60486","url":null,"abstract":"<p><strong>Objectives: </strong><i>Morganella morganii</i> is an opportunistic Gram-negative pathogen increasingly associated with healthcare-associated infections and antimicrobial resistance. However, long-term epidemiological data from Türkiye remain scarce.</p><p><strong>Methods: </strong>This retrospective study analyzed <i>M. morganii</i> isolates obtained between January 2015 and December 2024 at a 1500-bed tertiary care hospital. Demographic data, clinical specimen sources, and antimicrobial susceptibility results were retrieved from the laboratory database. Identification was performed using conventional methods and MALDI-TOF MS, while antimicrobial susceptibility was determined according to EUCAST guidelines. Linear regression analysis was applied to evaluate resistance trends over time.</p><p><strong>Results: </strong>A total of 673 non-duplicate isolates were included, predominantly from urine (68.6%), followed by wound (19.2%), blood (4.7%), respiratory (3.6%), abscess (1.9%), and sterile body fluid (1.0%) specimens. The annual incidence ranged from 0.47% in 2015 to 1.9% in 2024, with a transient decline during 2020-2022, likely related to the COVID-19 pandemic. Male patients accounted for 63% of isolates, with a median age of 52 years. Meropenem and amikacin showed the highest overall activity (>98% susceptibility), while cefoxitin demonstrated the lowest efficacy (≈50%). Trend analysis revealed statistically significant increases in resistance to amikacin, imipenem, meropenem, ertapenem, ceftriaxone, ceftazidime, cefoxitin, cefepime, piperacillin-tazobactam, trimethoprim-sulfamethoxazole, and ciprofloxacin (all p<0.05), whereas gentamicin showed no significant change. Notably, carbapenem and aminoglycoside resistance increased markedly after 2022.</p><p><strong>Conclusion: </strong>This study highlights the rising clinical importance of <i>M. morganii</i>, with increasing resistance across multiple antibiotic classes, including carbapenems. The findings underscore the need for continuous surveillance, prudent antimicrobial use, and further genomic studies to elucidate resistance mechanisms and guide effective therapy.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"231-236"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Zonulin Levels in Patients with Heroin Addiction.","authors":"Yusuf Cokunlu, Kamile Yucel, Ikbal Inanli, Sevdenur Kahraman, Aykut Senol","doi":"10.14744/SEMB.2026.52028","DOIUrl":"10.14744/SEMB.2026.52028","url":null,"abstract":"<p><strong>Objectives: </strong>Opioid use has been associated with alterations in gut-brain axis signaling and intestinal barrier function. Zonulin, a key regulator of intestinal permeability, has been implicated in various neuropsychiatric and inflammatory conditions; however, its role in heroin addiction and remission remains poorly understood. This study aimed to investigate serum zonulin levels in patients with heroin addiction (HA) during active heroin use (AHU) and remission (R) and to compare these levels with those of healthy controls (C).</p><p><strong>Methods: </strong>A total of 104 male participants were included: patients with AHU, patients in remission under buprenorphine/naloxone maintenance treatment, and C. Serum zonulin levels were measured using an enzyme-linked immunosorbent assay. Group comparisons and correlation analyses were performed, and receiver operating characteristic (ROC) analysis was used to evaluate the discriminatory value of zonulin.</p><p><strong>Results: </strong>The scores of addiction diagnostic criteria, the severity of craving, and the total API score were significantly higher in the AHU group than in the R group. The difference between the groups was significant when the R, AHU, and C groups were compared for zonulin levels (p=0.02). This difference was due to zonulin levels being higher in the R group than in the C group. When the HA (R+AHU) and C groups were compared for zonulin levels, zonulin levels were significantly higher in the HA group than in the C group (p=0.00). In the ROC analysis, the highest area under the curve (AUC) values were obtained in the R-C group comparison and the HA-C group comparison (AUC=0.683 and AUC=0.650, respectively).</p><p><strong>Conclusion: </strong>These findings suggest that increased intestinal permeability, as reflected by elevated serum zonulin levels, may persist during the remission phase of heroin addiction. However, given the cross-sectional design and the fact that remission was defined as a medication-stabilized state under buprenorphine treatment, these results should be interpreted cautiously. Longitudinal studies incorporating follow-up assessments and gut microbiota analyses are warranted to clarify the temporal dynamics and clinical significance of zonulin alterations in heroin addiction.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"244-253"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative Systemic Coagulation Inflammation Index may be a Predictor of Worse Outcomes After Carotid Endarterectomy.","authors":"Mesut Engin, Orhan Guvenc, Ahmet Kagan As, Ufuk Aydin, Yusuf Ata, Senol Yavuz","doi":"10.14744/SEMB.2026.62558","DOIUrl":"10.14744/SEMB.2026.62558","url":null,"abstract":"<p><strong>Objectives: </strong>Stroke is a significant disease associated with high mortality and morbidity rates, and carotid artery stenosis (CAS) is one of its most important causes. Although endovascular applications have increased in the treatment of CAS, carotid endarterectomy (CEA) surgery remains prominent. The systemic coagulation inflammation index (SCII) has emerged as an important marker indicating coagulation and inflammatory status. In this study, we aimed to investigate the effect of SCII values on worse outcomes during 30-day follow-up in patients who underwent CEA.</p><p><strong>Methods: </strong>This retrospective study consecutively included patients who underwent carotid endarterectomy at our clinic between January 1, 2020, and June 1, 2025. Patients who did not develop worse outcomes within the first 30 days after surgery were assigned to Group 1, and those who did were assigned to Group 2. Worse outcomes in the study were defined as stroke, myocardial infarction, and death.</p><p><strong>Results: </strong>A total of 594 patients underwent elective CEA surgery. The 546 patients in Group 1 and the 48 patients in Group 2 had median ages of 71 (44-88) and 69 (41-91) years, respectively (p=0.185). As a result of the multivariate analysis, the presence of coronary artery disease (OR: 1.690, 95% CI: 1.210-1.984, p=0.032) and high SCII values (OR: 1.780, 95% CI: 1.270-2.894, p<0.001) were determined as independent predictors of worse outcomes after CEA surgery.</p><p><strong>Conclusion: </strong>Our results indicated that high SCII values were associated with worse outcomes within 30 days after CEA. In patients undergoing CEA, SCII values can be calculated preoperatively to identify at-risk patient groups; therefore, measures can be taken for patient management and follow-up in the postoperative period.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"180-187"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148424944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pediatric Patients Diagnosed with Encephalitis: Single Center Experience.","authors":"Burcin Aygun Cosarpinar, Eda Sahin Izci, Ayse Turgut Sahin, Lutfiye Sahin Keskin, Nazan Dalgic","doi":"10.14744/SEMB.2026.03295","DOIUrl":"10.14744/SEMB.2026.03295","url":null,"abstract":"<p><strong>Objectives: </strong>Encephalitis is a potentially fatal inflammation of the brain parenchyma characterized by neurologic dysfunction. Although the etiology of most encephalitis cases cannot be determined, viruses are the most common known causative agents. In this study, pediatric patients diagnosed with encephalitis were evaluated in terms of etiology, clinical findings, laboratory and imaging results, treatment, and prognosis.</p><p><strong>Methods: </strong>A total of 115 patients aged 1 month to 18 years who were diagnosed with encephalitis between January 2008 and December 2020 were retrospectively evaluated in the Pediatric Infection Clinic of our hospital.</p><p><strong>Results: </strong>The study included 115 children, of whom 36% (n=41) were girls and 64% (n=74) were boys. The disease was most frequently observed in children younger than 5 years of age (48%). The most common symptoms at admission were fever (54.8%), convulsions (46%), and impaired consciousness (27%). The etiology was identified in 67% of the patients; viral agents were the most common cause (44%). Varicella zoster virus (VZV) was the most common etiologic agent (26.9%). Acyclovir treatment was initiated in 94% (n=108) of the patients. Sequelae developed in 6% (n=7) of the patients, and mortality occurred in 1.7% (n=2).</p><p><strong>Conclusion: </strong>In the presence of suspected encephalitis, antiviral treatment should be initiated early, considering the mortality and morbidity associated with the disease, and then continued with treatment appropriate to the identified etiology. Studies investigating etiology will be useful in determining the prognosis of encephalitis cases.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"60 2","pages":"213-221"},"PeriodicalIF":1.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}