Medical Bulletin of Sisli Etfal Hospital最新文献

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Evaluation of the Psychosocial Burden of Hidradenitis Suppurativa and Relevant Factors: A Prospective Single-Center Study. 化脓性汗腺炎的心理社会负担评估及相关因素:一项前瞻性单中心研究。
IF 1
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2024.40374
Ilknur Kivanc Altunay, Cemre Akpulat Tekin, Sena Inal Aptoula, Asli Aksu, Birgul Ozkesici Kurt
{"title":"Evaluation of the Psychosocial Burden of Hidradenitis Suppurativa and Relevant Factors: A Prospective Single-Center Study.","authors":"Ilknur Kivanc Altunay, Cemre Akpulat Tekin, Sena Inal Aptoula, Asli Aksu, Birgul Ozkesici Kurt","doi":"10.14744/SEMB.2024.40374","DOIUrl":"https://doi.org/10.14744/SEMB.2024.40374","url":null,"abstract":"<p><strong>Objectives: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder in which patients with HS experience profound deterioration in their overall well-being, psychological state and quality of life. This study aimed to evaluate the psychological impact of HS and examined its associations with relevant factors, including sociodemographic and disease-related characteristics.</p><p><strong>Methods: </strong>A prospective, single-center study was conducted involving 80 patients with HS. The demographic and clinical characteristics of patients were recorded. Depression Anxiety Stress Scale-21 (DASS-21), Dermatology Life Quality Index (DLQI), and General Health Questionnaire-12 (GHQ-12) were used to assess the psychosocial impact of HS.</p><p><strong>Results: </strong>A significant proportion of patients with HS had severe and extremely severe scores in depression, anxiety and stress, with 48.75%, 52.5%, and 48.75% of patients, respectively. Sixty percent of the patients exhibited high psychological disorders while 53.8% experienced severe impairment in their quality of life (QoL). Sociodemographic and clinical factors were evaluated for associations with the scales used in this study. DASS-21 Anxiety (DASS-21A) was significantly positively correlated with lower education levels and higher body mass index (BMI) (p<0.05). There were no significant correlations between the Hurley stages and the other three scales, except for the DASS-21 Stress (DASS-21S) subscale. Patients with a family history had higher DASS-21A, DASS-21 Depression (DASS-21D), DASS-21S, and GHQ-12 (both Likert and traditional scoring) scores compared to those without a family history (p<0.05). Additionally, a positive family history significantly predicted higher scores on DASS-21A, DASS-21D, and DASS-21S (p=0.002; p=0.019; p=0.022, respectively).</p><p><strong>Conclusion: </strong>Our findings confirm that a significant proportion of patients with HS had high or extremely high levels on all three scales assessing the psychological burden of HS. Patients were negatively affected psychologically at each Hurley stage. Family history proved to be a strong predictive factor contributing to impaired psychosocial status among individuals with HS. Thus, dermatologists should provide extra care, especially for those with family members affected by this condition.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"28-34"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Antifibrotic Effects of Plasminogen Activator Inhibitor-1 Antagonists are Observed in Rats with Epidural Fibrosis. 观察纤溶酶原激活物抑制剂-1拮抗剂对硬膜外纤维化大鼠的抗纤维化作用。
IF 1
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2024.75301
Pinar Kuru Bektasoglu, Adnan Somay, Julide Hazneci, Ali Borekci, Bora Gurer
{"title":"The Antifibrotic Effects of Plasminogen Activator Inhibitor-1 Antagonists are Observed in Rats with Epidural Fibrosis.","authors":"Pinar Kuru Bektasoglu, Adnan Somay, Julide Hazneci, Ali Borekci, Bora Gurer","doi":"10.14744/SEMB.2024.75301","DOIUrl":"https://doi.org/10.14744/SEMB.2024.75301","url":null,"abstract":"<p><strong>Objectives: </strong>Epidural fibrosis occurs after laminectomy as part of the local repair mechanisms. Adhesion around the nervous tissue could cause pain and disability. In the current study, we investigated the possible antifibrotic effects of the plasminogen activator inhibitor-1 (PAI-1) antagonists in a rat laminectomy model.</p><p><strong>Methods: </strong>The rats were randomly assigned to the control, the TM5441, and the TM5484 groups (n=6 per group). In the control group, just a laminectomy was performed. In the treatment groups, intragastric administration of PAI-1 antagonists was done after skin closure. Epidural fibrosis was investigated macroscopically and histopathologically four weeks later.</p><p><strong>Results: </strong>In the TM5441 and TM5484 groups, the macroscopic epidural fibrosis score was less than the control group (p<0.001 for both groups). Microscopic epidural fibrosis score was also decreased in the TM5441 and TM5484 groups (p>0.05 for both groups). Fibroblast cell density classification scores in the TM5441 and TM5484 groups were lower when compared to the control group (p>0.05 for both groups). Fibrosis thickness was lower in the TM5441 and TM5484 groups when compared to the control group (p<0.01 for both groups).</p><p><strong>Conclusion: </strong>Plasminogen activator inhibitor-1 antagonists could be a treatment alternative for the prevention of epidural fibrosis.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"59-63"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Nasal Surgeries on the Acoustics of Nasal Consonants. 鼻手术对鼻辅音声学的影响。
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2025.82258
Ozan Tuysuz, Mehmet Akif Kilic, Serdal Celik, Suat Turgut
{"title":"The Effects of Nasal Surgeries on the Acoustics of Nasal Consonants.","authors":"Ozan Tuysuz, Mehmet Akif Kilic, Serdal Celik, Suat Turgut","doi":"10.14744/SEMB.2025.82258","DOIUrl":"10.14744/SEMB.2025.82258","url":null,"abstract":"<p><strong>Objectives: </strong>In this study, it is aimed to examine the effects of septoplasty, functional endoscopic sinus surgery and septorhinoplasty on the acoustics of Turkish nasal consonants.</p><p><strong>Methods: </strong>The prospective study was conducted by taking voice recordings of 72 patients preoperative, 1st and 3rd months postoperative and based on changes in nasalance values. Patients were asked to read aloud the predetermined speech materials. The speech materials were recorded and analyzed using the Praat Assisted Nasalance Meter (PANM) system. The effect of the type of surgery was investigated for the change of nasalance values in the 1st and 3rd months after surgery compared to the preoperative value.</p><p><strong>Results: </strong>Septoplasty and functional endoscopic sinus surgery groups showed significant increases in nasal consonants and nasal sentence nasalance values in both male and female after surgery compared to the preoperative value. (p<0.05) In the septorhinoplasty group, no significant changes were observed in the values after surgery compared to the preoperative value in male patients (p>0.05). In the female septorhinoplasty group, nasalance values decreased after surgery compared to the preoperative value, but no significant differences were detected. (p>0.05).</p><p><strong>Conclusion: </strong>Comprehensive information about the potential for resonance changes following rhinological surgery should be provided to professional voice users. Clear communication of results can support more informed decision making, manage patient expectations, and reduce the risk of postoperative dissatisfaction with voice quality.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"164-172"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Pancreatic Morphology via Endosonography in Alcohol-Induced Chronic Liver Disease. 酒精性慢性肝病胰腺形态的超声评估
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2025.15975
Sezgin Vatansever, Elvan Isik, Hakan Camyar, Sinan Akay, Emrah Alper
{"title":"Assessing Pancreatic Morphology via Endosonography in Alcohol-Induced Chronic Liver Disease.","authors":"Sezgin Vatansever, Elvan Isik, Hakan Camyar, Sinan Akay, Emrah Alper","doi":"10.14744/SEMB.2025.15975","DOIUrl":"10.14744/SEMB.2025.15975","url":null,"abstract":"<p><strong>Objectives: </strong>Alcohol consumption is a major risk factor for liver cirrhosis and chronic pancreatitis (CP). The interplay between pancreatic changes and alcoholic cirrhosis remains poorly understood due to limited diagnostic tools. Endosonography (EUS) offers high sensitivity for detecting pancreatic morphological changes, even in early fibrosis stages.</p><p><strong>Methods: </strong>Between February 2010 and February 2017, 71 male patients diagnosed with alcoholic cirrhosis based on clinical, biochemical, and imaging findings were enrolled. Cirrhosis and pancreatitis from other causes were excluded. EUS, performed under midazolam and propofol sedation using a radial probe, classified pancreatic morphology per Rosemont criteria: normal, indeterminate for CP, suggestive of CP, or consistent with CP. Clinical data, including alcohol and smoking history, liver function, and portal hypertension markers, were recorded.</p><p><strong>Results: </strong>EUS identified normal pancreatic morphology in 28 patients (39.4%), indeterminate findings in 18 (25.4%), and CP-consistent or suggestive changes in 25 (35.2%). Logistic regression revealed no significant association between pancreatic changes and age, smoking, alcohol intake, BMI, spleen size, INR, platelet count, diabetes mellitus (DM), or compensated cirrhosis. Kaplan-Meier analysis revealed no significant survival difference between patients with normal pancreatic morphology (median 3.9 years) and those with abnormal morphology (median 3.1 years; p=0.792). One patient (1.4%) with normal morphology developed pancreatic cancer after 3.3 years. Hepatic and extrahepatic malignancy incidence reached 18% over five years, with hepatocellular carcinoma (HCC) at 4.3%, yet no statistically significant association was found between pancreatic changes and malignancy development (p=0.639). Portal hypertension severity and mortality showed no correlation with pancreatic findings.</p><p><strong>Conclusion: </strong>EUS proves valuable for assessing pancreatic changes in alcoholic cirrhosis, illuminating the complex relationship between alcohol consumption and pancreatic morphology.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"212-217"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Newborn Case of Esophagus and Vocal Cord Burn After CS (O-Chlorobenzylindene Malononitrile) Gas Inhalation. 新生儿吸入o -氯苄二烯丙二腈气体致食管声带烧伤1例。
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2024.41882
Yucel Pekal, Musa Turgut, Gulay Sonmez Demir, Ece Koyuncu, Osman Uzunlu, Ozmert M A Ozdemir
{"title":"A Newborn Case of Esophagus and Vocal Cord Burn After CS (O-Chlorobenzylindene Malononitrile) Gas Inhalation.","authors":"Yucel Pekal, Musa Turgut, Gulay Sonmez Demir, Ece Koyuncu, Osman Uzunlu, Ozmert M A Ozdemir","doi":"10.14744/SEMB.2024.41882","DOIUrl":"10.14744/SEMB.2024.41882","url":null,"abstract":"<p><p>Among the agents used for self-defense, O-chlorobenzylidene malononitrile (CS) is the most commonly used substance. It has been suggested that CS use is characterized by rapid onset of action, short duration of action, and minimal side effects. When the clinical situations and case series resulting from exposure to CS were examined, we saw that no cases of exposure during the neonatal period were identified. A male baby born at 40 weeks, weighing 3260 grams, was brought to the emergency room on the 24<sup>th</sup> postnatal day with bruising and respiratory distress due to a stranger spraying CS into his mouth. There was a widespread hyperemic erosive lesion in the mouth, tongue exfoliation, and leg ecchymosis. Widespread edema and hyperemia were observed in the vocal cords, and the patient was intubated and followed up. An epithelial defect involving the corneal limbus and conjunctiva was detected in the upper and lower eyelid membranes. Endoscopy revealed a grade 2 burn in the esophagus, and normal pseudomembrane and gastric mucosa in some areas. It was observed that the lesions around the patient's mouth and tongue completely resolved. After discharge, the esophagus-stomach-duodenum radiograph showed no suspicion of obstruction. At the 3rd-month post-discharge check-up, his eye examination was normal, and his stridor and wheezing at rest continued. This case, in which we have shown that CS used for self-defense or riot suppression, seriously threatens the life of a newborn patient for the first time and may perhaps cause permanent morbidities during follow-up, suggests the need to restrict access to such substances.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"258-261"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of AQUAfilling® Filler Application Complications. AQUAfilling®填料应用并发症的处理。
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2024.04864
Furkan Cestepe, Busra Guclu, Larasu Yildiran, Kamuran Zeynep Sevim
{"title":"Management of AQUAfilling® Filler Application Complications.","authors":"Furkan Cestepe, Busra Guclu, Larasu Yildiran, Kamuran Zeynep Sevim","doi":"10.14744/SEMB.2024.04864","DOIUrl":"10.14744/SEMB.2024.04864","url":null,"abstract":"<p><p>In recent years, the use of AQUAfilling® filler has become widespread, particularly in breast and gluteal augmentation, which are among the most common aesthetic surgical procedures. Although AQUAfilling® filler is claimed to be biocompatible with human tissue, the number of complications associated with it continues to increase. The invasion of AQUAfilling® filler into the parenchyma, as well as the toxicity and oncogenicity of its main component, polyacrylamide, remain uncertain and require further investigation. In this study, we present three female patients with a history of AQUAfilling® filler injection for breast and gluteal augmentation who experienced long-term major complications. We aim to emphasize the significance of long-term complications of AQUAfilling® filler material and contribute to the reconstruction options in managing these complications.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"251-254"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Re-emerging Disease Linked to Complementary Medicine: Argyria. 一种与补充医学有关的重新出现的疾病:银中毒。
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2024.55553
Ahmet Kayaalti, Asli Aksu Cerman, Ilknur Kivanc Altunay, Birgul Ozkesici Kurt
{"title":"A Re-emerging Disease Linked to Complementary Medicine: Argyria.","authors":"Ahmet Kayaalti, Asli Aksu Cerman, Ilknur Kivanc Altunay, Birgul Ozkesici Kurt","doi":"10.14744/SEMB.2024.55553","DOIUrl":"10.14744/SEMB.2024.55553","url":null,"abstract":"<p><p>Argyria can be described as the deposition of silver in the skin taken orally or through direct skin inoculation, causing discoloration of the skin and mucosa. In recent years, the increasing trend of people towards complementary medicine and marketing the colloidal form of silver is causing a resurgence of cases of argyria. Therefore, we aim to report a 16-year-old male patient who applied to our outpatient clinic and highlight this increasing trend by presenting a patient case. In the presented case, discoloration of the skin is much more pronounced on sun-exposed areas as in the literature, with the catalytic effect of sunlight on silver. In order to avoid this permanent situation, the authorities should take measures such as restricting the sale of products containing silver or limiting the silver content of products. Raising awareness is strongly recommended.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"248-250"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression and Anxiety in Parkinson's Disease: Prevalence and Associated Risk Factors. 帕金森病的抑郁和焦虑:患病率和相关危险因素
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2025.90767
Ceren Alis, Derya Selcuk Demirelli, Elvin Ay, Gencer Genc
{"title":"Depression and Anxiety in Parkinson's Disease: Prevalence and Associated Risk Factors.","authors":"Ceren Alis, Derya Selcuk Demirelli, Elvin Ay, Gencer Genc","doi":"10.14744/SEMB.2025.90767","DOIUrl":"10.14744/SEMB.2025.90767","url":null,"abstract":"<p><strong>Objectives: </strong>Parkinson's disease (PD) is a neurodegenerative disorder with both motor and non-motor symptoms, including depression and anxiety, which significantly impact patients' quality of life. The predictors of these psychiatric symptoms remain incompletely understood. This study aims to evaluate the prevalence and potential predictors of depression and anxiety in PD.</p><p><strong>Methods: </strong>A prospective study was conducted on 99 idiopathic PD patients. Depression and anxiety were assessed using the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7) scale. A range of clinical and demographic variables, including motor symptoms, sleep disturbances, and quality of life, were analyzed using regression models.</p><p><strong>Results: </strong>Of the patients, 57.5% had depression, 48.4% had anxiety, and 36.3% had both. Significant predictors of depression included the use of apomorphine, which was associated with lower PHQ-9 scores (p=0.031), and the presence of restless legs syndrome (RLS), which was linked to higher depression scores (p=0.037). For anxiety, younger age was a significant predictor (p=0.007). Both depression and anxiety scores correlated with lower quality of life (p<0.001 for both).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of depression and anxiety in PD, with significant predictors including RLS for depression and younger age for anxiety. Apomorphine use appears protective against depression. Both depression and anxiety disrupt quality of life. These findings underscore the importance of routine psychiatric screening and comprehensive management of depression and anxiety in PD, aiming to improve patient outcomes.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"200-205"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Oral Isotretinoin on Skin and Serum Levels of FoxO3, TRAIL and p53 and Metabolic Parameters. 口服异维甲酸对皮肤和血清FoxO3、TRAIL和p53水平及代谢参数的影响
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2025.90907
Yavuz Semiz, Mehmet Alp Matur, Damla Demir, Ezgi Aktas
{"title":"Effects of Oral Isotretinoin on Skin and Serum Levels of FoxO3, TRAIL and p53 and Metabolic Parameters.","authors":"Yavuz Semiz, Mehmet Alp Matur, Damla Demir, Ezgi Aktas","doi":"10.14744/SEMB.2025.90907","DOIUrl":"10.14744/SEMB.2025.90907","url":null,"abstract":"<p><strong>Objectives: </strong>Isotretinoin-mediated apoptosis is considered the main cause of anti-acne side effects of isotretinoin. The aim of this study is to investigate the effects of oral isotretinoin therapy on the skin and serum levels of forkhead box transcription factor (FoxO)-3, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), p53 and metabolic parameters and examine the relationship between these parameters.</p><p><strong>Methods: </strong>Sixteen acne vulgaris patients who were administered the appropriate cumulative dose of oral isotretinoin were enrolled in this prospective study.</p><p><strong>Results: </strong>The decreases in the values of body mass index, waist circumference, systolic blood pressure (BP), CRP, and ferritin from the baseline to the end of the treatment were statistically significant (p=0.028, p=0.029, p=0.008, p=0.046, and p=0.003, respectively). The increases in the levels of serum low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), total cholesterol, gamma-glutamyl transferase (GGT), and FoxO3 from the baseline to the end of the treatment were statistically significant (p=0.001, p=0.004, p<0.001, p=0.010, p=0.007, respectively). In terms of changes from the baseline to the end of the treatment, serum FoxO3 levels were positively correlated with the changes in serum TRAIL levels (r=0.674, p=0.004). The changes in serum FoxO3 levels were positively correlated with the changes in fasting blood glucose levels (r=0.540, p=0.031). The changes in serum TRAIL levels were positively correlated with the changes in the values of systolic BP (r=0.552, p=0.027) and diastolic BP (r=0.511, p=0.043). The changes in serum p53 levels and serum LDL-C levels were also positively correlated (r=0.499, p=0.049).</p><p><strong>Conclusion: </strong>Isotretinoin therapy caused an increase in skin and serum levels of FoxO3 and TRAIL and a decrease in serum and skin p53 values. However, only the increase in serum FoxO3 levels was statistically significant. The observed reduction in p53 levels implies that the isotretinoin-related side effects may not rely on p53-mediated apoptosis, and it may be considered that its safety profile is better than expected. The correlations between the changes during isotretinoin therapy in metabolic parameters and TRAIL, p53, and FoxO3 values suggest that isotretinoin's metabolic side effects may involve these molecules.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"186-193"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational Diseases and Safety among Orthopedic Surgeons in Türkiye. 日本骨科医生的职业病与安全。
IF 0.9
Medical Bulletin of Sisli Etfal Hospital Pub Date : 2025-02-07 eCollection Date: 2025-01-01 DOI: 10.14744/SEMB.2025.44442
Merdan Artuc, Hilmi Karadeniz, Tahir Mutlu Duymus, Erhan Sukur, Engin Carkci, Mehmet Akif Cacan, Ibrahim Azboy
{"title":"Occupational Diseases and Safety among Orthopedic Surgeons in Türkiye.","authors":"Merdan Artuc, Hilmi Karadeniz, Tahir Mutlu Duymus, Erhan Sukur, Engin Carkci, Mehmet Akif Cacan, Ibrahim Azboy","doi":"10.14744/SEMB.2025.44442","DOIUrl":"10.14744/SEMB.2025.44442","url":null,"abstract":"<p><strong>Objectives: </strong>Occupational diseases are often underestimated and overlooked among orthopedic surgeons. This study aimed to investigate the prevalence of occupational injuries and their impact on orthopedic surgeons in Türkiye.</p><p><strong>Methods: </strong>A modified version of the physical discomfort Web-based anonymous survey and the Short Form-36 (SF-36) were sent via email to all members of the Turkish Association of Orthopedics and Traumatology (TOTBID) mailing list. The data were collected and analyzed.</p><p><strong>Results: </strong>A total of 217 orthopedic surgeons completed the survey. The most common musculoskeletal disorders were low back pain (73%), wrist tendinitis (36%), lateral epicondylitis (29%) and shoulder pain (28%). Additionally, 98% of surgeons had experienced needle stick or sharp instrument injuries at least once, and fewer than one-third of them received special treatment from their institutions. The behavior of not using any protective equipment was found to be associated with the surgeon's age (p=0.03).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of occupational health injuries among orthopedic surgeons in Türkiye. The findings of this study may raise awareness among orthopedic surgeons about occupational health injuries and encourage the implementation of prevention strategies, early recognition of these injuries, and timely, definitive interventions.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 2","pages":"145-150"},"PeriodicalIF":0.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12314457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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