Medical Bulletin of Sisli Etfal Hospital最新文献

{"title":"Evaluation of the Psychosocial Burden of Hidradenitis Suppurativa and Relevant Factors: A Prospective Single-Center Study.","authors":"Ilknur Kivanc Altunay, Cemre Akpulat Tekin, Sena Inal Aptoula, Asli Aksu, Birgul Ozkesici Kurt","doi":"10.14744/SEMB.2024.40374","DOIUrl":"https://doi.org/10.14744/SEMB.2024.40374","url":null,"abstract":"<p><strong>Objectives: </strong>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder in which patients with HS experience profound deterioration in their overall well-being, psychological state and quality of life. This study aimed to evaluate the psychological impact of HS and examined its associations with relevant factors, including sociodemographic and disease-related characteristics.</p><p><strong>Methods: </strong>A prospective, single-center study was conducted involving 80 patients with HS. The demographic and clinical characteristics of patients were recorded. Depression Anxiety Stress Scale-21 (DASS-21), Dermatology Life Quality Index (DLQI), and General Health Questionnaire-12 (GHQ-12) were used to assess the psychosocial impact of HS.</p><p><strong>Results: </strong>A significant proportion of patients with HS had severe and extremely severe scores in depression, anxiety and stress, with 48.75%, 52.5%, and 48.75% of patients, respectively. Sixty percent of the patients exhibited high psychological disorders while 53.8% experienced severe impairment in their quality of life (QoL). Sociodemographic and clinical factors were evaluated for associations with the scales used in this study. DASS-21 Anxiety (DASS-21A) was significantly positively correlated with lower education levels and higher body mass index (BMI) (p<0.05). There were no significant correlations between the Hurley stages and the other three scales, except for the DASS-21 Stress (DASS-21S) subscale. Patients with a family history had higher DASS-21A, DASS-21 Depression (DASS-21D), DASS-21S, and GHQ-12 (both Likert and traditional scoring) scores compared to those without a family history (p<0.05). Additionally, a positive family history significantly predicted higher scores on DASS-21A, DASS-21D, and DASS-21S (p=0.002; p=0.019; p=0.022, respectively).</p><p><strong>Conclusion: </strong>Our findings confirm that a significant proportion of patients with HS had high or extremely high levels on all three scales assessing the psychological burden of HS. Patients were negatively affected psychologically at each Hurley stage. Family history proved to be a strong predictive factor contributing to impaired psychosocial status among individuals with HS. Thus, dermatologists should provide extra care, especially for those with family members affected by this condition.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"28-34"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Antifibrotic Effects of Plasminogen Activator Inhibitor-1 Antagonists are Observed in Rats with Epidural Fibrosis.","authors":"Pinar Kuru Bektasoglu, Adnan Somay, Julide Hazneci, Ali Borekci, Bora Gurer","doi":"10.14744/SEMB.2024.75301","DOIUrl":"https://doi.org/10.14744/SEMB.2024.75301","url":null,"abstract":"<p><strong>Objectives: </strong>Epidural fibrosis occurs after laminectomy as part of the local repair mechanisms. Adhesion around the nervous tissue could cause pain and disability. In the current study, we investigated the possible antifibrotic effects of the plasminogen activator inhibitor-1 (PAI-1) antagonists in a rat laminectomy model.</p><p><strong>Methods: </strong>The rats were randomly assigned to the control, the TM5441, and the TM5484 groups (n=6 per group). In the control group, just a laminectomy was performed. In the treatment groups, intragastric administration of PAI-1 antagonists was done after skin closure. Epidural fibrosis was investigated macroscopically and histopathologically four weeks later.</p><p><strong>Results: </strong>In the TM5441 and TM5484 groups, the macroscopic epidural fibrosis score was less than the control group (p<0.001 for both groups). Microscopic epidural fibrosis score was also decreased in the TM5441 and TM5484 groups (p>0.05 for both groups). Fibroblast cell density classification scores in the TM5441 and TM5484 groups were lower when compared to the control group (p>0.05 for both groups). Fibrosis thickness was lower in the TM5441 and TM5484 groups when compared to the control group (p<0.01 for both groups).</p><p><strong>Conclusion: </strong>Plasminogen activator inhibitor-1 antagonists could be a treatment alternative for the prevention of epidural fibrosis.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"59 1","pages":"59-63"},"PeriodicalIF":1.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular Treatment in Symptomatic Intracranial Artery Stenosis: Experience from Two Centers.","authors":"Eyup Camurcuoglu, Mehmet Tahtabasi, Umut Erdem, Ahmet Serdar Ozdemir, Veysel Kaya","doi":"10.14744/SEMB.2024.75317","DOIUrl":"10.14744/SEMB.2024.75317","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the efficacy of endovascular treatment and clinical outcomes in individuals with symptomatic intracranial stenosis who had not responded adequately to medical intervention.</p><p><strong>Methods: </strong>The study included 32 patients who received endovascular treatment due to high-grade (70%-99% severity) intracranial atherosclerotic stenosis from December 2021 to December 2023. The patients had not experienced any acute ischemic or hemorrhagic infarction within the last three weeks, had a Modified Rankin Scale score of ≤3 at baseline, and developed a transient ischemic attack or non-disabling stroke despite having received the best medical treatment. Technical and clinical success, mortality, and complication rates were recorded.</p><p><strong>Results: </strong>Of the 32 patients included in the study, 62.5% (n=20) were male, and the mean age was 66.4±10.09 years. Stenting was performed on the intracranial internal carotid artery in 43.8% (n=14) of the patients, the intradural vertebral artery in 37.5% (n=12), the middle cerebral artery in 12.5% (n=4), and the basilar artery in 6.3% (n=2). The technical success rate was 100%, and the clinical success rate was 87.5%. The mean degree of stenosis before the procedure was 91.7±6.3%, and the degree of residual stenosis after the procedure was 22.1±4.7%. The Neuroform Atlas® stent system was used in 18 cases (56.3%), Credo® stents in eight (25%), coronary balloon-expandable stents in four (12.5%), and the LVIS® stent system in two (6.3%). Twenty-eight (87.5%) patients did not have any symptoms in the first 30 days, while two (6.2%) patients had an ischemic stroke, one (3.1%) patient had a hemorrhagic stroke, and one (3.1%) died.</p><p><strong>Conclusion: </strong>Endovascular treatment in carefully selected patients, a tailored selection of treatment subtypes, and an experienced multidisciplinary team overseeing the patient before, during, and after the procedure have the potential to provide safe and effective treatment for patients with symptomatic intracranial atherosclerotic stenosis.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"430-436"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Underappreciated Etiology of Groin Mass: Great Saphenous Vein Aneurysm.","authors":"Fatih Yanar, Orhan Agcaoglu, Oguzhan Sal, Berke Sengun, Ibrahim Fethi Azamat, Dilek Yilmazbayhan, Fatih Ata Genc","doi":"10.14744/SEMB.2024.50329","DOIUrl":"10.14744/SEMB.2024.50329","url":null,"abstract":"<p><p>Inguinal masses have a large variety of causes, ranging from inguinal hernias to soft tissue sarcomas. One of the less prevalent causes is vascular origin. Venous aneurysms, unlike their arterial counterparts, are seen seldomly and experience in management of these cases is scarce. A 32-year-old male patient was referred to our clinic due to an enlarging left inguinal mass with a preliminary diagnosis of inguinal hernia. Doppler ultrasonography revealed an eight cm in diameter aneurysmatic Great Saphenous Vein segment located just below the inguinal ligament. Dilated segment was excised without complete resection. Removal of the dilated segment and performing complete venous resection depending on venous valvular failure constitutes surgical repair of Great Saphenous Vein aneurysms. Surgical approach should be primarily selected if Great Saphenous Vein aneurysm is detected due to its debilitating nature and possible rupture.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"505-508"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adipsin and Leptin Levels in Type 2 Diabetic Patients on Sitagliptin and Metformin Versus Metformin Therapy.","authors":"Sura Khalid Mohammed, Zainab Haitham Fathi, Jehan Abdulwahab Mohammad","doi":"10.14744/SEMB.2024.74483","DOIUrl":"10.14744/SEMB.2024.74483","url":null,"abstract":"<p><strong>Objectives: </strong>Adipsin and leptin are adipokines that link adipose tissue dysfunction and increased fat accumulation to obesity-related metabolic disorders. This study aimed to assess the effects of sitagliptin/metformin versus metformin monotherapy on the levels of adipsin, leptin, and lipid profile in type 2 diabetic patients.</p><p><strong>Methods: </strong>This comparative case-control study included 120 participants divided into four groups: healthy participants, newly diagnosed type 2 diabetic patients, metformin-treated patients, and sitagliptin/metformin-treated patients.</p><p><strong>Results: </strong>Newly diagnosed type 2 diabetic patients revealed significantly lower adipsin levels, with concomitant higher leptin levels compared to the healthy control group. Adipsin levels were significantly higher and leptin levels were significantly lower in both drug-treated patients compared to newly diagnosed group. Compared to healthy control, there were significantly higher levels of hemoglobin A1c (HbA1c), fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and atherogenic index (AI) in the newly diagnosed patients, with significantly lower high-density lipoprotein (HDL) levels. Interestingly, in both treated groups, HbA1c, FBG, TC, TG, VLDL, and AI were significantly decreased compared to newly diagnosed patients. Concomitantly, there are significantly higher levels of HDL in drug-treated group compared to untreated patients.</p><p><strong>Conclusion: </strong>Adipsin is low and leptin is high in diabetic patients which support its possible use as a biomarker for type 2 diabetes. Accordingly, the modification of these adipokines, via the use of drug therapy, has advantageous effects on the cardiovascular system in diabetic patients. Specifically, sitagliptin/metformin regulates adipsin, leptin, and lipid profile to a greater extent than metformin.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"491-500"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729846/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, Attitudes and Practices of Pediatricians About COVID-19 Vaccination to Children: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.14744/SEMB.2024.28159","DOIUrl":"https://doi.org/10.14744/SEMB.2024.28159","url":null,"abstract":"","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"524-525"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drayer Syndrome due to Chromosome 15q26.3 Deletion: Response to Growth Hormone Treatment.","authors":"Busra Tetik Dincer, Ebru Misirli Ozdemir, Umran Cetincelik, Ahmet Ucar","doi":"10.14744/SEMB.2024.01879","DOIUrl":"10.14744/SEMB.2024.01879","url":null,"abstract":"<p><p>Chromosome 15q26 deletion is a rare condition that causes short stature and is associated with intrauterine growth restriction (IUGR), failure to thrive, congenital heart disease and many congenital malformations. The insulin growth factor receptor (IGF-1R) on chromosome 15 has many important roles, especially in growth regulation. Our case is an 18-month-old small for gestational age girl who presented with severe short stature, microcephaly and minor dysmorphic features. Chromosome microarray revealed 15q26 deletion including the IGF1R gene. Recombinant growth hormone (rGH) has been used in patients with IGF-1R defects with variable treatment responses. The reason for rGH unresponsiveness in some patients with terminal chromosome 15q deletion is still unclear. Herein we discuss the use of rGH in a patient with heterozygous IGF1R deletion and emphasize the need for further follow-up regarding other endocrine disorders.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"521-523"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management of Acute Appendicitis in a Patient with Diagnosed but \"Unprepared\" Pheochromocytoma: A Case Report.","authors":"Burak Dincer, Zulfiye Sumeyye Kuzu, Recep Murat Potas, Fatih Berke Arican, Sinan Omeroglu","doi":"10.14744/SEMB.2024.54188","DOIUrl":"10.14744/SEMB.2024.54188","url":null,"abstract":"<p><p>Pheochromocytoma is a rare tumor originating from the adrenal gland, characterized by the secretion of catecholamines. Due to the risk of hypertensive crises associated with catecholamine release, surgical procedures in pheochromocytoma patients are risky. In this case report, laparoscopic appendectomy for acute appendicitis in a patient who has pheochromocytoma will be presented. A 49-year-old female patient presented with abdominal pain. Physical examination showed guarding and rebound in the right lower quadrant. The patient, who had leukocytosis in the investigations, showed signs of acute appendicitis and a 5 cm right adrenal mass on the abdominal computed tomography. A previous abdominal magnetic resonance imaging by the endocrinology department six months ago revealed a 39x32 mm mass in the right adrenal gland and elevated urinary catecholamine levels. It was learned that the patient had not attended follow-up appointments during this period. The patient was consulted by endocrinology and an emergency laparoscopic appendectomy was performed. The patient, discharged on the 2nd day after surgery, did not experience any complications. The patient was referred to endocrinology, and preoperative preparations for pheochromocytoma surgery were initiated. In cases of emergency in patients diagnosed with pheochromocytoma emergency surgery can be performed with appropriate preoperative preparation.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"509-512"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Plasma Asymmetric Dimethylarginine Concentrations and Inflammation Markers in Non-small Cell Lung Cancer.","authors":"Mufide Arzu Ozkarafakili, Zeynep Mine Yalcinkaya Kara, Ahmet Murat Musluman, Tuba Tulin Bek","doi":"10.14744/SEMB.2024.29939","DOIUrl":"10.14744/SEMB.2024.29939","url":null,"abstract":"<p><strong>Objectives: </strong>Nonsmall cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. Asymmetric dimethylarginine (ADMA) is an emerging molecule that is highlighted in carcinogenesis and tumor progression in lung cancer. Since elevated concentrations of ADMA are observed in lung cancer patients, we aimed to explore its associations with inflammation markers and established prognostic indices.</p><p><strong>Methods: </strong>78 newly diagnosed non-small cell lung cancer patients who were presented with brain metastases at the initial admission and 41 Stage 1 patients with NSCLC were included in the study. ADMA concentrations among the groups were correlated. Further, the relationship between ADMA levels and the other inflammatory markers was analyzed.</p><p><strong>Results: </strong>ADMA levels were significantly higher in the group of NSCLC patients with brain metastases than in the Stage 1 patients control group (p<0.001). A significant negative correlation was found between ADMA levels and BMI, albumin and hemoglobin (p<0.001), whereas it was positively correlated with platelet, WBC, neutrophil-to-lymphocyte ratio, RDW, RDW/albumin ratio, LDH, CRP, fibrinogen, platelet, and CRP/albumin ratio (p<0.001).</p><p><strong>Conclusion: </strong>Increased circulating concentrations of ADMA were significantly correlated with higher NLR, CRP and LDH; which were accepted as indicators of poor prognosis in NSCLC patients. ADMA might contribute to tumor growth and dissemination via systemic inflammatory pathways.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"460-467"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Quality of Life and Psychosocial Status in Children with Inflammatory Bowel Disease.","authors":"Busra Tetik Dincer, Nafiye Urganci, Ezgi Sen, Ayse Merve Usta","doi":"10.14744/SEMB.2024.87003","DOIUrl":"https://doi.org/10.14744/SEMB.2024.87003","url":null,"abstract":"<p><strong>Objectives: </strong>Inflammatory bowel disease (IBD) in children is a chronic condition that affects the psychosocial status and physical activities of children and their parents. This study aimed to investigate the impact of IBD on the quality of life of adolescents and their families and the variability of behavioral and emotional adjustment issues compared to a healthy control group.</p><p><strong>Methods: </strong>This study was designed as a prospective controlled study. A total of 159 cases were included, consisting of 84 IBD patients aged between 8-17 years and 75 healthy control subjects. All children and their parents included in the study were administered the Pediatric Quality of Life Inventory (PedsQL) and the Strengths and Difficulties Questionnaire (SDQ) for adolescents and parents.</p><p><strong>Results: </strong>The median ages of the IBD children and the control group were 13.5 and 13, respectively. Of all 154 cases, 87 were female and 72 were male. Among the patients diagnosed with IBD, 39 had Crohn's disease, 37 had ulcerative colitis, and 8 had indeterminate colitis. It was observed that both the PedsQL and SDQ scores of children and parents with IBD were statistically significantly lower in both physical and psychosocial scoring (p=0.01 and p<0.001, respectively). A weak but statistically significant correlation was observed between the PedsQL and SDQ results applied to parents (rho=-0.214, p=0.007) and children (rho=-0.208, p=0.008).</p><p><strong>Conclusion: </strong>The lower PedsQL and SDQ scores in children with IBD and their parents suggest that IBD negatively affects psychosocial, physical, and behavioral adaptations in children.</p>","PeriodicalId":42218,"journal":{"name":"Medical Bulletin of Sisli Etfal Hospital","volume":"58 4","pages":"447-451"},"PeriodicalIF":1.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143013550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}