Guodong Zheng , Wuxia Liu , Yining Kang , Bing Xu , Xiaoou Qiu , Tingting Du , Shenqian Xu , Ruohua Chen , Hui Cheng , Chen Cai
{"title":"Probing the role of zinc ion in metallo-β-lactamase inhibitor binding by using multiple molecular dynamics simulations","authors":"Guodong Zheng , Wuxia Liu , Yining Kang , Bing Xu , Xiaoou Qiu , Tingting Du , Shenqian Xu , Ruohua Chen , Hui Cheng , Chen Cai","doi":"10.1016/j.rechem.2025.102171","DOIUrl":"10.1016/j.rechem.2025.102171","url":null,"abstract":"<div><div>The hydrolysis of the β-lactam ring of antibiotics mediated by Verona Integrin-encoded metallo-β-lactamase 2 (VIM-2) in the presence of two zinc ions (Zn1 and Zn2) leads to significant resistance toward β-lactam antibiotics. Here, multiple molecular dynamics (MD) simulations were performed on two systems, including VIM-2 with two Zn1 and Zn2 ions and a single Zn1 ion, to unravel the molecular mechanism of conformational changes of VIM-2 induced by the removal of Zn2 ion and the role of Zn2 in the binding of the VIM-2 inhibitor (ANT431). The results suggest that the binding of two zinc ions stabilizes the two flexible L3 and L10 loops constituting the binding site for ANT431, whereas in the presence of a single Zn1 ion, the L3 and L10 loops exhibit an enhanced conformational flexibility. Further structural analyses reveal that the binding of two zinc ions maintains a closed conformation of ANT431 binding site, while the ANT431 binding site mainly exists as an open conformation without the Zn2 ion. Consistently, ANT431 remains stable in the active site of VIM-2 in the presence of two zinc ions, while it escapes from the active site in the presence of a single Zn1 ion. We anticipate that our results may offer useful dynamical information pertaining to conformational changes of VIM-2 for the design of potent and selective inhibitors to alleviate drug resistance of VIM-2 toward antibiotics.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102171"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Archana R. Patil , Basappa C. Yallur , Geetika Pant , Eliza Ahmed , S.G. Prasanna Kumar , Sheetal R. Batakurki , Anjanapura V. Raghu
{"title":"Scaffolds of biologically active heterocyclic compounds for discovery of potential drug against SARS-CoV-2","authors":"Archana R. Patil , Basappa C. Yallur , Geetika Pant , Eliza Ahmed , S.G. Prasanna Kumar , Sheetal R. Batakurki , Anjanapura V. Raghu","doi":"10.1016/j.rechem.2025.102154","DOIUrl":"10.1016/j.rechem.2025.102154","url":null,"abstract":"<div><div>The unabated increase of severe acute respiratory syndrome coronavirus has wreaked havoc at a very large scale. In various direct and indirect ways, the non-living realm is also impacted. Severe health emergencies have broken out globally since 2002, with the advent of SARS CoV that was followed by the MERS CoV outbreak in 2012. The pandemic caused by the novel coronavirus, SARS CoV-2, that broke out in December 2019 in China has led to an approximate 76, 77,26, 861 confirmed cases and the death toll reported by the World Health Organization stands at 69,48,764 deaths. The WHO reported on 8 July 2023 that a total of 13.4 billion doses of vaccine have been administered globally. Heterocyclic scaffolds are exhaustively utilised since many decades for use as antimalarial, antitubercular, anti-inflammatory, antidiabetic, antimicrobial, anticancer and antiviral agents. In this review, therefore, we are emphasizing the expected role of cyclic frameworks and its compounds of nine common biologically important imidazoles, benzimidazoles, indoles, oxazoles, pyrazoles, pyridines, pyrimidines, pyrroles, and thiazoles in the design and discovery of novel drugs for combating SARS CoV-2. This has been done by the exploration of available scientific articles and literature that show a variety of heterocyclic moieties that target MERS, SARS and SARS CoV-2 viruses. The heterocyclic moiety and its derivatives discussed in this investigation may be considered essential sources for creating new approaches to treating the SARS coronavirus.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102154"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143600389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent advances in organic fluorophore-based Schiff base metal complexes: Applications in biomedicine and related fields","authors":"Mani Rajasekar , Jennita Mary , Meenamigai Sivakumar , Showparnickaa Subburao Ravichandran , Dharshini Srinivasan","doi":"10.1016/j.rechem.2025.102166","DOIUrl":"10.1016/j.rechem.2025.102166","url":null,"abstract":"<div><div>Schiff bases are formed through the condensation of primary amines with aldehydes or ketones. Due to their simple synthesis and versatile properties, they are highly favored as ligands in coordination chemistry. They are widely applied in fields such as biology, industry, food packaging, dyes, polymers, and oxygen detectors. Schiff base ligands are crucial in forming transition metal complexes, which serve as precursors for synthesizing metal and metal chalcogenide nanoparticles. Organic Fluorophore Schiff bases containing fluorophore groups have gained attention for their enhanced photophysical properties and broad pharmacological activities. Their metal complexes are efficient in catalyzing organic oxidation reactions. The structural diversity and ability to chelate metals make these compounds highly adaptable for various applications. This review explores the preparation, physical, biological properties, and catalytic applications of Organic Fluorophore Schiff bases metal complexes for biomedical applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102166"},"PeriodicalIF":2.5,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143593029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramki Chakaravarthy , S. Suresh , R. Gomathi , Yirong Geng , Wei Ren , R. Ezhil Vizhi
{"title":"Nucleation kinetics, FTIR, DFT and Hirshfeld surface analysis of sodium hydrogen oxalate hydrate (NaHC2O4∙H2O) single crystal","authors":"Ramki Chakaravarthy , S. Suresh , R. Gomathi , Yirong Geng , Wei Ren , R. Ezhil Vizhi","doi":"10.1016/j.rechem.2025.102164","DOIUrl":"10.1016/j.rechem.2025.102164","url":null,"abstract":"<div><div>NaHC<sub>2</sub>O<sub>4</sub>∙H<sub>2</sub>O single crystals were obtained via a low-temperature solution growth process. For recrystallization, a few excellent and faultless seed crystals were selected and a transparent single crystal of NaHC<sub>2</sub>O<sub>4</sub>∙H<sub>2</sub>O measuring 18 × 10 × 5 mm<sup>3</sup> was formed in 15 days. The extracted crystals were stable, non-hygroscopic, and had a noticeable clarity. The thermodynamics processes are examined, focusing on supersaturation, nucleation, and the size of the nucleus in the context of homogeneous nucleation. Additionally, the induction time, critical supersaturation ratio for crystallization, and the width of the metastable zone are analyzed using the solubility data of the crystallized substance. NaHC₂O₄·H₂O single crystal crystallized in triclinic crystal structure and shows a centrosymmetric space group, was recorded and analyzed using single crystal X-ray diffraction (XRD) and this crystal is one among the triclinic system. Stretching vibrations of the molecules in the NaHC₂O₄·H₂O single crystal were identified through Fourier transform infrared spectroscopy (FTIR) at different temperature (30, 100, 200, 300, 400 and 500 °C) and Fourier transform Raman spectroscopy (FT-Raman) analysis. The band structure and density of states calculations were performed using Density Functional Theory (DFT), and the energy gap was determined as 4.83 eV. The molecular interactions of the grown crystal were analyzed using Hirshfeld surface analysis. The corresponding 2D fingerprint plots have been discussed in detail to provide further insights into these interactions. The confirmation of frequency doubling from the mirror image structure is caused by the dehydration of the structural water molecules under laser irradiation and the results are detailed in the discussion sections.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102164"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John E. Philo, Zachary C. Brandeburg, Tasfia R. Hasin, Ian J. Costello, Robert J. Sheaff, Angus A. Lamar
{"title":"Targeting mitochondrial ATP production of glioblastoma using sulfonamide and amide analogs of amantadine and memantine as metabolic inhibitors","authors":"John E. Philo, Zachary C. Brandeburg, Tasfia R. Hasin, Ian J. Costello, Robert J. Sheaff, Angus A. Lamar","doi":"10.1016/j.rechem.2025.102170","DOIUrl":"10.1016/j.rechem.2025.102170","url":null,"abstract":"<div><div>A library of 67 analogs of amantadine and memantine has been synthesized and screened for activity against 4 mammalian cell lines, including U-87 (glioblastoma). The library was screened using both a traditional cytotoxicity assay and a rapid assay to detect activity as metabolic inhibitors of ATP production. Two protocols were employed to identify activity targeting mitochondrial ATP (TCA cell cycle) production. In Protocol A (DMEM media + 2-DG), 16 compounds were identified as strong hits against U-87 cells at 50 μM. Using Protocol B (L-15 media), 10 compounds were identified as strong hits at 12.5 μM against U-87 cells. Several compounds were identified as hits toward U-87 cells using the rapid assay that were not identified using the traditional cytotoxicity assay. The IC<sub>50</sub> values of the hits against U-87 cells were determined against U-87 and non-cancerous HDF cells. The investigation has resulted in the identification of several compounds with the predicted ability to cross the blood-brain barrier that display high potency (0.82 μM for compound <strong>20</strong>) and selectivity (selectivity index value ≥7 for compound <strong>24</strong>) toward U-87 cells.</div><div>2009 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102170"},"PeriodicalIF":2.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enas Abdullah Al-Mahdi , A.M. Abdulwahab , Adnan Alnehia , Ahmed AL-Osta , Abdel-Baset Al-Odayni
{"title":"Characterization of Zn-doped CuSCN Nano-powders synthesized via an in situ method for enhanced optical and structural properties","authors":"Enas Abdullah Al-Mahdi , A.M. Abdulwahab , Adnan Alnehia , Ahmed AL-Osta , Abdel-Baset Al-Odayni","doi":"10.1016/j.rechem.2025.102140","DOIUrl":"10.1016/j.rechem.2025.102140","url":null,"abstract":"<div><div>This study investigates the influence of zinc doping on the physical properties of copper thiocyanate (CuSCN) nanopowders synthesized using an in situ method. Pure and zinc-doped CuSCN nanopowders were synthesized and characterized through a multi-technique approach, including scanning electron microscopy (SEM), UV–visible spectrophotometry, X-ray diffraction (XRD), electrical measurements, and antibacterial assays. XRD analysis confirmed the rhombohedral structure of all samples, with a slight increase in crystallite size observed in zinc-doped samples (1 % to 7 %) from 39.46 nm to 41.84 nm. The synthesized nanopowders exhibited antibacterial activity against both <em>P. aeruginosa</em> and <em>S. aureus</em>. Optical characterization revealed a decrease in both direct and indirect optical band gap energies with increasing zinc content. Furthermore, Zn doping resulted in an enhancement in the dc electrical conductivity of CuSCN. These findings suggest that zinc doping can improve the optoelectronic properties of CuSCN, making it a promising candidate for applications such as hole transport layers (HTLs) in solar cell devices.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102140"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Yareli Flores-Ramírez , Martina Alejandra Chacón-López , René Antaño-López , Alejandra Álvarez-López , Efigenia Montalvo-González , Alejandro Pérez-Larios , Rosa Isela Ortiz-Basurto , Aarón Rodríguez-López , Ulises Miguel López-García
{"title":"Effect of the anodic potential applied in the electrochemical synthesis of magnetite-chitosan nanoparticles on their physicochemical characteristics","authors":"Ana Yareli Flores-Ramírez , Martina Alejandra Chacón-López , René Antaño-López , Alejandra Álvarez-López , Efigenia Montalvo-González , Alejandro Pérez-Larios , Rosa Isela Ortiz-Basurto , Aarón Rodríguez-López , Ulises Miguel López-García","doi":"10.1016/j.rechem.2025.102143","DOIUrl":"10.1016/j.rechem.2025.102143","url":null,"abstract":"<div><div>Magnetite nanoparticles (MNp) have demonstrated applications in different areas due to their properties, such as magnetism, adsorption, biocompatibility, low toxicity, and antimicrobial activity, which mainly depend on the synthesis methods. However, current methods have some drawbacks, such as the presence of maghemite, the oxidation process and the poor control of particle size and distribution. Therefore, the synthesis by electrochemical methods of MNp is proposed, applying three different anodic potentials (0.8, 0.3 and − 0.2 V vs. Hg|Hg<sub>2</sub>Cl<sub>2</sub>) and its surface modification with chitosan (CS). In addition, in order to identify the effect of the anodic potentials in obtaining MNp and MNp modified with chitosan (MNp-CS), the characterization of these magnetic materials by physicochemical methods was carried out, through which it was demonstrated the obtaining of MNp and MNp-CS by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and UV–vis spectrophptometry, in addition, it was observed that the MNp-CS synthesized at the anodic potentials of 0. 8 V and 0.3 V vs. Hg|Hg<sub>2</sub>Cl<sub>2</sub> show higher colloidal stability, pore volume, specific surface area and magnetic properties, which could contribute to their efficiency to adsorb metal ions, dyes, and microorganisms.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102143"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eduardo A. Veliz , Athina Yoham , Anastasiya Drandarov , Esther L. Abadi , Emanuella M. Brito , Maria Moreno Hollweg , Venkatesh Shanbhag , Roger M. Leblanc , Steven Vanni , Regina M. Graham
{"title":"Cytotoxic effects of Methoxy-substituted Chalcones on glioblastoma stem cells: Computational target prediction and therapeutic insights","authors":"Eduardo A. Veliz , Athina Yoham , Anastasiya Drandarov , Esther L. Abadi , Emanuella M. Brito , Maria Moreno Hollweg , Venkatesh Shanbhag , Roger M. Leblanc , Steven Vanni , Regina M. Graham","doi":"10.1016/j.rechem.2025.102122","DOIUrl":"10.1016/j.rechem.2025.102122","url":null,"abstract":"<div><div>The prognosis for patients diagnosed with glioblastoma remains dismal with an average survival of about 15 months. Recently, it has been shown that glioblastoma stem-like cells (GSCs) drive tumor progression and are responsible for tumor regrowth following treatment; therefore, successful elimination of this cell population is necessary for disease eradication. Methoxy substituted chalcones have demonstrated anti-cancer effects with diverse molecular mechanisms. In this study, we synthesized 24 methoxy containing compounds, including 5 novel compounds, and tested their cytotoxicity toward 3 GSC lines and 2 non-tumor cell lines. We identified 13 compounds demonstrating an average GSC IC<sub>50</sub> value below 10 μM, many of which were less toxic to the non-cancer cell lines. <em>In silico</em> reverse screening identified probable targets for 7 out of the 13 active compounds. Some targets have been well-investigated such as the epidermal growth factor receptor; however, others such as 17-beta hydroxysteroid dehydrogenase type 3 warrant further study.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102122"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lin Chen , Si-Lu Sun , He-Yang Zhong , Dan Wan , Fei Feng , Shuai Huang , Xian-Li Zhou
{"title":"New series of aromatic amides hybrids derivatives as anti-Alzheimer's drugs: Design, synthesis, biological activity and computational studies","authors":"Lin Chen , Si-Lu Sun , He-Yang Zhong , Dan Wan , Fei Feng , Shuai Huang , Xian-Li Zhou","doi":"10.1016/j.rechem.2025.102138","DOIUrl":"10.1016/j.rechem.2025.102138","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a degenerative disease of the central nervous system with complex pathogenesis there is an urgent need to develop more relevant agents. Since Gx-50 has some anti-AD activity and its cinnamic acid fragment can be regarded as an advantaged fragment, it was suggested to splice it and similar fragment to compound <strong>3</strong> which showed anti-AD activities in previous work. Then 20 compounds were obtained and among them, compound <strong>1b</strong> has better acetylcholinesterase inhibitory activity (IC<sub>50</sub> = 0.29 μM), which was equivalent to the positive drug donepezil, and its molecular docking showed cinnamic acid part of compound <strong>1b</strong> provide more bind possibilities with hAChE. Also, compound <strong>1b</strong> showed neuroprotection effect (cell survival rate is 76.72 % at 12.5 μM), and revealed by ROS analysis and immunofluorescence, its neuroprotection activity may act by reducing ROS-induced oxidative stress. Besides, <strong>10b</strong> also exhibits activity in inhibiting acetylcholinesterase (IC<sub>50</sub> = 0.31 μM) and A<em>β</em> aggregation (IC<sub>50</sub> = 25.0 μM), making it potential for further development. In summary, it studied the feasibility of molecular hybridization, adn provided new promising multi-functional agent for anti-AD.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102138"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naseem Akhter , Amina Liaquat , Farah Murtaza , Asma Yaqoob , Shabnum Sharif , Nagina Jummah , Muhammad Imran Khan , Abdallah Shanableh , Leonid G. Voskressensky , Rafael Luque
{"title":"One-step phytosynthesis of Co3O4 nanoparticles and study of their catalytic, antioxidant, antibiofilm and antibacterial activities","authors":"Naseem Akhter , Amina Liaquat , Farah Murtaza , Asma Yaqoob , Shabnum Sharif , Nagina Jummah , Muhammad Imran Khan , Abdallah Shanableh , Leonid G. Voskressensky , Rafael Luque","doi":"10.1016/j.rechem.2025.102151","DOIUrl":"10.1016/j.rechem.2025.102151","url":null,"abstract":"<div><div>Co<sub>3</sub>O<sub>4</sub> nanoparticles (NPs) were synthesized using <em>Citrus lemon</em> leaf extract, a novel green method. The synthesized NPs were extensively characterized using FTIR, UV-VIS, XRD, and SEM techniques, confirming their synthesis and properties. These NPs demonstrated promising catalytic efficiency (% degradation = 75.16 %), antioxidant potential (IC50 = 0.7 mg/ml), anti-biofilm activity (IC50 = 0.096 ± 0.005 mg/ml for <em>E. coli</em>, 0.08 ± 0.007 mg/ml for <em>S. aureus</em>) and antibacterial effects (ZOI = 28 mm for <em>E. coli</em>, 23 mm for <em>S. aureus</em>). This green synthesis method offers scalability and cost-effectiveness as compared to the energy-intensive and wasteful traditional methods. Our study exemplifies a commitment to advancing scientific progress through sustainable practices, contributing to global sustainable development goals.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102151"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}