Results in Chemistry最新文献

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Comparative study of the performance of solar cells based on cochineal and Black Dye N749 with several mordant and brighteners
IF 2.5
Results in Chemistry Pub Date : 2024-12-01 DOI: 10.1016/j.rechem.2024.101913
Rogelio Rodriguez, Susana Vargas
{"title":"Comparative study of the performance of solar cells based on cochineal and Black Dye N749 with several mordant and brighteners","authors":"Rogelio Rodriguez,&nbsp;Susana Vargas","doi":"10.1016/j.rechem.2024.101913","DOIUrl":"10.1016/j.rechem.2024.101913","url":null,"abstract":"<div><div>Even though there is a strong tendency to develop DSSCs based on natural dyes, while these reach a sufficiently high level of development to be commercialized, cells based on inorganic synthetic dyes, such as Ruthenium, will continue to be analyzed and improved. These improvements include new dyes, such as Black Dye N749 (BD), one of the most used synthetic dyes. A comparative analysis of the current output profiles of cells based on cochineal and black dye is reported. It was observed that BD has to be catalyzed to produce a high output current: by itself, this dye showed low output currents, but when it is catalyzed, its performance significantly improves. Cochineal shows, when used alone, a high output current. Different additives were tested: Alum and Sn as a mordant and mineral carbon as a catalyst, which contains ions of Fe<sup>2+</sup> and Fe<sup>3+</sup>; these significantly modify the shape (rising or decreasing) and intensity of the output current profiles. Unstable oscillations appear in the current profile when the cell is abruptly illuminated; a model was included to fit the experimental data.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101913"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Characterisation of iron doped manganese oxides for thermal energy storage
IF 2.5
Results in Chemistry Pub Date : 2024-12-01 DOI: 10.1016/j.rechem.2024.101923
Joseph Pandeinge Mwatukange, Ateeq Rahman, Zivayi Chiguvare
{"title":"Synthesis and Characterisation of iron doped manganese oxides for thermal energy storage","authors":"Joseph Pandeinge Mwatukange,&nbsp;Ateeq Rahman,&nbsp;Zivayi Chiguvare","doi":"10.1016/j.rechem.2024.101923","DOIUrl":"10.1016/j.rechem.2024.101923","url":null,"abstract":"<div><div>Iron-doped manganese oxides were synthesized using a co-precipitation method and thermodynamically characterized to demonstrate their potential as a thermochemical energy storage medium. Thermochemical energy storage, via chemical bonds that employ reversible redox reactions, is a promising approach to tackle solar thermal energy storage. Hysteresis loops observed confirm that the pore network consisted of mesopores that were not filled with pore condensate, and the narrow loop indicates a narrow size distribution. Barrett-Joyner-Halenda (BJH) studies of all the synthesized materials showed that they have a high mesoporous and specific area, essential for supplying reduced diffusion channels over the Mn oxides, Good conductivity through electron transfer, with the presence of active sites allow the study thermochemical approaches. The BJH studies showed the material MnOFe<sub>2</sub> (2.5:1) to have a higher pore area, which is effective in the adsorption process of the material.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101923"},"PeriodicalIF":2.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142742890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin
IF 2.5
Results in Chemistry Pub Date : 2024-11-28 DOI: 10.1016/j.rechem.2024.101918
Hannah L. Cure, Thomas A. Shell
{"title":"Physicochemical properties and cytochromes P-450 kinetics of the trifluoroacetamido derivative of phenacetin","authors":"Hannah L. Cure,&nbsp;Thomas A. Shell","doi":"10.1016/j.rechem.2024.101918","DOIUrl":"10.1016/j.rechem.2024.101918","url":null,"abstract":"<div><div>Substituting hydrogen atoms with fluorine alters physicochemical properties often resulting in improved drug action relative to the parent molecule. The high electronegativity of fluorine changes the electron density distribution of the molecule; however, the substitution does not significantly change the size of the molecule because hydrogen and fluorine have similar atomic radii. A trifluoroacetamido derivative (TFA-phenacetin) of phenacetin, an analgesic antipyretic drug, was synthesized to compare its lipophilicity to the parent molecule by determining octanol–water partition coefficients. TFA-phenacetin is over seven times more lipophilic than phenacetin, which suggests that TFA-phenacetin would have better bioavailability relative to phenacetin. The kinetics of cytochromes P-450 (CYP) catalyzed oxidation of phenacetin and TFA-phenacetin were compared using Sprague Dawley (SD) rat liver microsomes. Phenacetin and TFA-phenacetin have the same apparent binding affinity for the SD rat liver microsome CYP proteome and undergo CYP catalyzed oxidation at the same rate in the presence of SD rat liver microsomes.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101918"},"PeriodicalIF":2.5,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and molecular modeling of new triazole-bithiazole conjugates as antimicrobial agents 作为抗菌剂的新型三唑-双噻唑共轭物的合成与分子建模
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101925
Hadeer Mattar , Gadeer R.S. Ashour , Mansoor Alsahag , Ali Alisaac , Matokah M. Abualnaja , Adel I. Alalawy , Fatmah O. Sefrji , Nashwa M. El-Metwaly
{"title":"Synthesis and molecular modeling of new triazole-bithiazole conjugates as antimicrobial agents","authors":"Hadeer Mattar ,&nbsp;Gadeer R.S. Ashour ,&nbsp;Mansoor Alsahag ,&nbsp;Ali Alisaac ,&nbsp;Matokah M. Abualnaja ,&nbsp;Adel I. Alalawy ,&nbsp;Fatmah O. Sefrji ,&nbsp;Nashwa M. El-Metwaly","doi":"10.1016/j.rechem.2024.101925","DOIUrl":"10.1016/j.rechem.2024.101925","url":null,"abstract":"<div><div>A series of new triazole-bithiazole conjugates were synthesized through a sequence of reactions started by chloroacetylation of 2-amino-4-triazolyl-thiazole compound <strong>2</strong>. The various spectroscopic techniques, such as IR, NMR and MS, confirmed the suggested chemical structure of isolated hybrids. The DFT studies of the produced derivatives revealed twisted configuration except for the parent <strong>2</strong>, how was planar. In addition, the researched conjugates presented extended FMO’s energy gap (ΔE<sub>H-L</sub>) from 2.60 to 4.64 eV and could be sorted as <strong>5b</strong> &lt; <strong>9b</strong> &lt; <strong>5a</strong> &lt; <strong>9a</strong> &lt; <strong>4</strong> &lt; <strong>8</strong> &lt; <strong>2</strong> &lt; <strong>7</strong> &lt; <strong>3</strong>. The antibacterial and antifungal activity of the newly synthesized conjugates has been examined using the minimum inhibitory concentration (MIC) method against representative pathogens. The data revealed that conjugates <strong>9a</strong> and <strong>9b</strong> exhibited significant activity, compared to standard antimicrobial agents, ampicillin, and fluconazole. Moreover, the DNA gyrase enzyme inhibitory action of the synthesized triazole-bithiazoles was assessed and compared to novobiocin (Novo) as a standard inhibitor. Furthermore, the interaction of the synthesized conjugates with the amino acid residues of a target protein has been empathized <em>via</em> docking study, which cleared that conjugate <strong>9b</strong> has the greatest binding affinity among the produced conjugates, showing its potential as an antibacterial agent. Finally, the pharmacokinetic properties of synthesized hybrids were ascribed using the SwissADME indicating good bioavailability for conjugates <strong>3</strong>, <strong>4</strong>, and <strong>7</strong>, while others, including <strong>5a</strong>, <strong>5b</strong>, <strong>8</strong>, <strong>9a</strong>, and <strong>9b</strong>, faced challenges related to low GI absorption and Lipinski violations.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101925"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142721679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A manganese phthalocyanine histidine composite-modified carbon paste electrode as a biomimetic sensor for bisphenol A determination
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101927
Amadou Soukairatou Moustapha , Corneille Bakouan , Abdoulkadri Ayouba Mahamane , Boubié Guel
{"title":"A manganese phthalocyanine histidine composite-modified carbon paste electrode as a biomimetic sensor for bisphenol A determination","authors":"Amadou Soukairatou Moustapha ,&nbsp;Corneille Bakouan ,&nbsp;Abdoulkadri Ayouba Mahamane ,&nbsp;Boubié Guel","doi":"10.1016/j.rechem.2024.101927","DOIUrl":"10.1016/j.rechem.2024.101927","url":null,"abstract":"<div><div>A biomimetic sensor was prepared from carbon paste electrode (CPE) modified with manganese phthalocyanine (MnPc) and histidine (His), and used for the determination of bisphenol A (BPA). The electrochemical biomimetic sensor (MnPc-His-CPE) gave significant current responses for BPA oxidation in comparison with CPE and MnPc-CPE, individually. The morphological and chemical characterizations of the sensor surface were studied by FT-IR, UV-visible Spectrophotometry, and SEM. The electrochemical behavior of the sensor and the oxidation behavior of BPA at the MnPc-His-CPE/BPA interface were investigated by cyclic voltammetry (CV), chronocoulometry (CC), square wave voltammetry (SWV), and electrochemical impedance spectroscopy (EIS). Square wave voltammetry (SWV), applied as a sensitive analytical method for BPA determination, led to a good linear correlation between BPA concentration and peak current in the range from 2.10<sup>−8</sup> mol.L<sup>−1</sup> to 5.10<sup>−5</sup> mol.L<sup>−1</sup> and a detection limit of 4.63 nM (S/N = 3). The relative standard deviation was 4.10 % (n = 10). The proposed sensor was found to be highly selective for BPA. In addition, the reproducibility and stability of the sensor were found to be satisfactory. The accuracy of the electrochemical biomimetic sensor was compared with HPLC method. The sensor has been successfully applied for the determination of BPA from real water samples with a good recovery, ranging from 91.40 % to 106.30 %.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101927"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent progress on anti-cancer activity of thiadiazoles: A review
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101939
C.R. Santhosh , Sampath Chinnam , Nagaraju Kottam , Amreen S , Guddekoppa S. Ananthnag , G.M. Madhu , Samata Gadde , Viola Tressa Fernandes , Haritha Arnipalli
{"title":"Recent progress on anti-cancer activity of thiadiazoles: A review","authors":"C.R. Santhosh ,&nbsp;Sampath Chinnam ,&nbsp;Nagaraju Kottam ,&nbsp;Amreen S ,&nbsp;Guddekoppa S. Ananthnag ,&nbsp;G.M. Madhu ,&nbsp;Samata Gadde ,&nbsp;Viola Tressa Fernandes ,&nbsp;Haritha Arnipalli","doi":"10.1016/j.rechem.2024.101939","DOIUrl":"10.1016/j.rechem.2024.101939","url":null,"abstract":"<div><div>Cancer, a life-threatening condition which has become one of the deadliest disease impacting human health. Conventional drugs have significant side effects and are prone to drug resistance, whereas innovative therapies are costly and place a large load on patients. Despite the fact that several decades of medication research and discovery have produced a number of helpful chemotherapeutic drugs, the hunt for novel chemical entities with enhanced efficacy and safety is still ongoing. Thiadiazoles acts as inhibitors against several specific enzymes or signaling pathways. These compounds are frequently utilized when combined with other anti-cancer drugs to improve their efficacy. Thiadiazoles exhibit beneficial synergistic effects when used with other anticancer treatments like chemotherapy or targeted therapy. They have shown considerable anti-cancer action against various cancer cell lines. The review covers recent anti-cancer research findings from 2021 to 2024. This review aimed to give an overall description of thiadiazoles and analogs which demonstrated potential anti-cancer properties.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101939"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2-Amino-6-methylbenzothiazole as corrosion inhibitor for low carbon steel in acidic solution: Experimental and theoretical studies
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101922
Klodian Xhanari , Muhamed Farruku , Avni Berisha , Bujar Seiti , Kledi Xhaxhiu , Efrosini Kokalari , Alketa Lame
{"title":"2-Amino-6-methylbenzothiazole as corrosion inhibitor for low carbon steel in acidic solution: Experimental and theoretical studies","authors":"Klodian Xhanari ,&nbsp;Muhamed Farruku ,&nbsp;Avni Berisha ,&nbsp;Bujar Seiti ,&nbsp;Kledi Xhaxhiu ,&nbsp;Efrosini Kokalari ,&nbsp;Alketa Lame","doi":"10.1016/j.rechem.2024.101922","DOIUrl":"10.1016/j.rechem.2024.101922","url":null,"abstract":"<div><div>The corrosion susceptibility of S235 steel samples in 1 M HCl solution, with and without addition of 2-amino-6-methylbenzothiazole (AMBT) was evaluated using weight loss (WL), chronopotentiometry, electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PD) techniques. The corrosion inhibition efficiency of AMBT was investigated at 298 to 318 K, with and without addition of 0.5 wt.% KI. The highest corrosion inhibition efficiency (i.e. 83.30%) was achieved upon addition of 5 mM AMBT. PD curve measurements after 24 h immersion revealed that AMBT behaves as a mixed-type inhibitor, predominantly affecting the cathodic corrosion reaction. Thermodynamic calculations showed that AMBT adheres to the Langmuir adsorption isotherm. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) was used to confirm the adsorption of AMBT, while its influence on the morphology of the S235 steel samples was also investigated by scanning electron microscopy (SEM). Density Functional Theory (DFT) calculations, along with Monte Carlo (MC) and Molecular Dynamics (MD) simulations, were employed to investigate AMBT’s corrosion inhibition behaviour at the molecular level. The simulations confirmed that AMBT strongly adsorbs on the Fe(110) surface through a combination of physisorption and chemisorption mechanisms. This study offers detailed insights into AMBT’s effectiveness as a corrosion inhibitor.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101922"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-dimensional computational fluid dynamics (3D-CFD) simulation of hydrogen transport to investigate the effect of output voltage and inlet anode velocity on proton exchange membrane fuel cell performances
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101929
Abdelaziz Samris , Hamid Mounir
{"title":"Three-dimensional computational fluid dynamics (3D-CFD) simulation of hydrogen transport to investigate the effect of output voltage and inlet anode velocity on proton exchange membrane fuel cell performances","authors":"Abdelaziz Samris ,&nbsp;Hamid Mounir","doi":"10.1016/j.rechem.2024.101929","DOIUrl":"10.1016/j.rechem.2024.101929","url":null,"abstract":"<div><div>A proton exchange membrane fuel cell (PEMFC) stands out as a highly efficient device for hydrogen utilization. This study presents a three-dimensional simulation that integrates computational fluid dynamics (CFD) to accurately and swiftly predict the PEM fuel cell performance. Initially, the proposed model undergoes validation using existing literature data. Subsequently, it is deployed to simulate the distribution and evolution of various parameters including current density, hydrogen and oxygen mass fractions, pressure and temperature in the PEM fuel cell. The findings reveal that the optimization of current density can be obtained by increasing the consumption rates of hydrogen and oxygen. In the scenarios investigated, a decrease in output voltage from 0.6 V to 0.46 V leads to a notable increase in current density from <span><math><mrow><mn>0.8447</mn><mi>A</mi><mo>/</mo><msup><mrow><mi>C</mi><mi>m</mi></mrow><mn>2</mn></msup></mrow></math></span> to <span><math><mrow><mn>0.9944</mn><mi>A</mi><mo>/</mo><msup><mrow><mi>C</mi><mi>m</mi></mrow><mn>2</mn></msup></mrow></math></span>. The results, also, show that the maximum power density in this study reaches <span><math><mrow><mn>0.596</mn><mi>W</mi><mo>/</mo><msup><mrow><mi>C</mi><mi>m</mi></mrow><mn>2</mn></msup></mrow></math></span> when inlet velocity of anode channel is fixed at <span><math><mrow><mn>0.5</mn><mi>m</mi><mo>/</mo><mi>s</mi></mrow></math></span>. On the other hand, when we increase the inlet velocity to <span><math><mrow><mn>0.5</mn><mi>m</mi><mo>/</mo><mi>s</mi></mrow></math></span>, the reduced residence time and potential diffusion limitations can lower the mass fraction of hydrogen participating in the electrochemical reaction.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101929"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uranium (VI) ion removal using a novel high adsorption COFs/GO/CH aerogel nanocomposite for wastewater treatment 利用新型高吸附 COFs/GO/CH 气凝胶纳米复合材料去除废水中的铀(VI)离子
IF 2.5
Results in Chemistry Pub Date : 2024-11-26 DOI: 10.1016/j.rechem.2024.101933
Mohammed D. Majeed, Mahmoud Roushani
{"title":"Uranium (VI) ion removal using a novel high adsorption COFs/GO/CH aerogel nanocomposite for wastewater treatment","authors":"Mohammed D. Majeed,&nbsp;Mahmoud Roushani","doi":"10.1016/j.rechem.2024.101933","DOIUrl":"10.1016/j.rechem.2024.101933","url":null,"abstract":"<div><div>Uranium is a highly radioactive metal that poses significant health risks. Developing efficient methods for removing uranium from wastewater is crucial, as uranium contamination can have far-reaching consequences. The newly synthesized adsorbent material, COFs/GO/CH aerogel nanocomposite contains covalent organic frameworks, graphene oxide and chitosan. This adsorbent is tested under different conditions, including contact time, concentration, pH, dosage, temperature, and the presence of other ions. The maximum adsorption capacity of COFs/GO/CH for U(VI) as 1191 mg/g at pH 6.0. This adsorbent not only demonstrated high efficiency in eluting uranium from aqueous solutions, but also showed affinity towards uranium in mixed metal solutions. The adsorption process followed the pseudo-second-order kinetic model and Langmuir isotherm, indicating a combination of physisorption and chemisorption mechanisms. The structure of COFs/GO/CH is characterized using various analytical techniques such as Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopes (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), X-ray diffraction (XRD) Brunauer-Emmett-Teller (BET) and zeta potential (ZP). Importantly, the nanocomposite COFs/GO/CH aerogel is found to be stable, ready for regeneration and reuse over five successive cycles, while maintaining efficient U(VI) removal from wastewater.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"12 ","pages":"Article 101933"},"PeriodicalIF":2.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2
IF 2.5
Results in Chemistry Pub Date : 2024-11-25 DOI: 10.1016/j.rechem.2024.101931
Yae Jin Yoon , Yu-Jin Lee , Jiyeon Choi , Seung-Wook Chi , Sangku Lee , Kyung Chan Park , Byoung-Mog Kwon , Dong Cho Han
{"title":"2′-Hydroxycinnamaldehyde induces ROS-mediated apoptosis in cancer cells by targeting PRX1 and PRX2","authors":"Yae Jin Yoon ,&nbsp;Yu-Jin Lee ,&nbsp;Jiyeon Choi ,&nbsp;Seung-Wook Chi ,&nbsp;Sangku Lee ,&nbsp;Kyung Chan Park ,&nbsp;Byoung-Mog Kwon ,&nbsp;Dong Cho Han","doi":"10.1016/j.rechem.2024.101931","DOIUrl":"10.1016/j.rechem.2024.101931","url":null,"abstract":"<div><div>2′-Hydroxycinnamaldehyde (HCA) is a component of the commonly used spice cinnamon, which has beneficial effects on cancer, allergies, bacterial/viral infections, and Alzheimer’s disease. Our previous study showed that HCA induced reactive oxygen species (ROS) and apoptosis in cancer cells, and pretreatment of cancer cells with antioxidants abolished HCA-mediated ROS production and apoptosis. This indicates that ROS are critical effector for HCA activity. However, the molecular target of HCA for ROS induction has not been identified. In the present study, we identified peroxiredoxin 1 (PRX1) and peroxiredoxin 2 (PRX2) as target proteins of HCA using affinity chromatography, and further confirmed these association using a cellular thermal shift assay (CETSA). In addition, we used mutagenesis to identify important cysteine residues in PRX1 for HCA binding. PRX1 has four cysteines (Cys52, Cys71, Cys83, and Cys173), and when Cys173 (but not the other cysteine sites) was mutated to serine, it was unable to bind biotin-conjugated HCA, suggesting that Cys173 is important for HCA binding. Treatment of SW620 cancer cells transfected by control vector with 20 μM HCA increased ROS levels by 5.2-fold compared to DMSO-treated cells. However, downregulation of target proteins PRX1 and PRX2 using shRNAs (short hairpin RNA) significantly reduced HCA-mediated ROS induction (1.6-fold), supporting that PRX1 and PRX2 are targets of HCA for ROS elevation. Additionally, intraperitoneal injection of 50 mg/kg HCA inhibited SW620 tumor growth, resulting in a 59.9 % reduction in tumor volume. CETSA analysis of tumor tissues showed that PRX1 and PRX2 were bound and thus inactivated by HCA in a mouse xenograft model. These findings demonstrate that PRX1 and PRX2 are molecular target proteins responsible for HCA-induced ROS elevation and cancer cell death.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"13 ","pages":"Article 101931"},"PeriodicalIF":2.5,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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