Results in Chemistry最新文献

{"title":"New structural scaffolds to enhance the metabolic stability of arginine-derived PAD4 inhibitors","authors":"Yijiang Jia ,&nbsp;Sina Bahraminejad ,&nbsp;Chenyao Jiang ,&nbsp;Ayijiang Taledaohan ,&nbsp;Dejian Ma ,&nbsp;Jianxiong Jiang ,&nbsp;Yuji Wang ,&nbsp;Jiawang Liu","doi":"10.1016/j.rechem.2025.102162","DOIUrl":"10.1016/j.rechem.2025.102162","url":null,"abstract":"<div><div>Although arginine-derived PAD inhibitors represented by Cl-amidine (<strong>2</strong>) showed strong inhibition of PAD4 enzymes and exhibited efficacies in a variety of cellular assays and animal studies, their metabolic instability is a significant challenge for pre-clinical and clinical research. On the basis of the structure of a well-known PAD4 inhibitor BB-Cl-amidine (<strong>3</strong>), we designed two metabolically stable scaffolds, providing two arginine-derived PAD4 inhibitors (<strong>7</strong> and <strong>8</strong>). We evaluated their PAD4 enzyme inhibitory activity <em>in vitro</em> and assessed their metabolic stability using liver microsomal assays. These compounds exhibited PAD4 enzyme inhibitory activity (<strong>7</strong>, IC₅₀ = 124.93 ± 10.21 μM; <strong>8</strong>, IC₅₀ = 46.49 ± 4.46 μM). Hydrolysis of haloacetamidine warheads into hydroxyacetamidine, Compound <strong>7</strong> (t_1/2 &gt; 60 min), significantly improved the metabolic stability of the lead BB-Cl-amidine (t_1/2 = 18.11 min). Compound <strong>8</strong> (t_1/2 &gt; 60 min), the isostere of <strong>7</strong>, also displayed enhanced metabolic stability. Therefore, these two structural scaffolds represent promising new leads for stable PAD4 inhibitors and valuable tools for exploring the reactive cavity of PAD enzymes.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102162"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143563092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of sol-gel and co-precipitation techniques for synthesizing Calotropis Procera-mediated bismuth ferrite for biomedical and environmental applications","authors":"Akasha Fatima ,&nbsp;Muhammad Shahid Khan ,&nbsp;Rabia Ayoub ,&nbsp;Tahira Jabeen ,&nbsp;Yilan Zeng ,&nbsp;Waqar Azeem ,&nbsp;Sana Javaid ,&nbsp;Martin Motola","doi":"10.1016/j.rechem.2025.102149","DOIUrl":"10.1016/j.rechem.2025.102149","url":null,"abstract":"<div><div>Bismuth ferrite (BiFeO₃) nanoparticles were synthesized using <em>Calotropis procera</em> leave extract via sol-gel and co-precipitation methods, yielding distinct structural and functional properties. The sol-gel method produced rhombohedral, rod-like nanoparticles with a crystallite size of 30.25 nm and a lower band gap of 2.31 eV. These characteristics contributed to superior photocatalytic degradation of Rhodamine B, achieving 90.1 % efficiency, alongside enhanced antibacterial activity against <em>Bacillus cereus</em> and <em>Cocci</em>, and higher antioxidant performance with a DPPH radical scavenging rate of 79.99 %. Conversely, the co-precipitation method resulted in rhombohedral, needle-like nanoparticles with a smaller crystallite size of 18.02 nm and a higher band gap of 3.6 eV, leading to lower Rhodamine B degradation efficiency (88.6 %) and reduced antibacterial and antioxidant activities. These findings highlight the effectiveness of the induction of <em>Calotropis procera</em> leave extract and sol-gel method in producing BiFeO₃ nanoparticles with superior properties for environmental and biomedical applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102149"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of a quaternary composite based on RGO/MWCNTs/choline chloride + malonic acid for methyl orange dye adsorption","authors":"Zainab Hussein Abd Al-khuder,&nbsp;Faiq F. Karam","doi":"10.1016/j.rechem.2025.102133","DOIUrl":"10.1016/j.rechem.2025.102133","url":null,"abstract":"<div><div>The objective of this study is to synthesis a quaternary composite of reduced graphene oxide (RGO), miltiwaled carbon nanotube (MWCNTs), choline chloride, and malonic acid by using discrete flame deposition technology to make multi-walled carbon nanotubes. Ascorbic acid was used to produce reduced graphene oxide through reduction and subsequently synthesize the deep eutectic solvent. The product was characterized using several techniques: such as Raman spectroscopy, X-ray difruction (XRD), Fourier transform infrared (FTIR), and field emission scanning electron microscopy (FESEM). The current study used a mixed material made of Deeb Eutictic Sol(DES) like choline chloride and Malonic acid with RGO and MWCNTs to adsorb and remove the dye methyl orange (MO). Some techniques such as: HNMR, C13 and IR tests, were used to examine the data for the eutectic solvents of malonic acid and choline chloride. Efffect of some parametrs upon adsorption of dye were investigated such as weight of adsorbent, the contact time between dye with composite, as well as the temperature, pH and ionic density. Also investigation on the adsorption kinetics, and isotherms were studied. The results showed that according to Giles classification, the adsorption curve on the surface of the prepared compound is (S3) for methyl orange dye, which follows the Freundlich model and enables adsorption. The results of the adsorption study of methyl orange dye at different temperatures showed that the amount of adsorbed dye increases with decreasing temperature, indicating that the adsorption process was thermal and exothermic. The adsorption process of methyl orange dye was studied, where it was found that the highest amount of dye adsorbed on the surface of the prepared compound was pH = 4. The results also showed the effect of ionic strength on the adsorption process of salts (NaCl, CaCO3) where it was found that CaCO3 salts with greater solubility affect the amount of adsorbed material compared to NaCl salts. The results also indicated that the adsorption temperature equation applies to Freundlich and Mecan and does not apply to Langmuir. Therefore, the adsorption is physical adsorption because the surface energy of the adsorbent materials is heterogeneous and multilayered and the enthalpy value for us was a negative value, which confirms the type of adsorption since the adsorption here is physical. The results also showed that the adsorption kinetics study of methyl orange dye is of the pseudo-second order, and its surface adsorption ability was tested by reactivating it after each use by washing it with distilled water, and it was found that it has the ability to adsorption after the activation process with the same efficiency, then a decrease occurs in its surface adsorption ability.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"15 ","pages":"Article 102133"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CNSL green catalyst of sulfone-based Schiff base ligand and its metal(II) complexes: Antibacterial, anticancer and molecular docking studies","authors":"C. Krishna Moorthy ,&nbsp;T. Gomathi ,&nbsp;M. Kannan ,&nbsp;T. Mohana Priya","doi":"10.1016/j.rechem.2025.102131","DOIUrl":"10.1016/j.rechem.2025.102131","url":null,"abstract":"<div><div>Nowadays, the use of many organic solvents poses a serious threat to the atmosphere due to the release of toxic by-products. Therefore, the use of solvent-free green catalysts to solve this problem has brought about a significant change in the field of chemistry. Based on this, a Schiff base ligand is synthesized from the condensation of dapsone (4,4′-sulfonyldianiline) and 4-dimethylaminobenzaldehyde in the presence of green catalyst especially cashwnut shell liquid (CNSL) catalyst. Furthermore, metal(II) complexes Co(II), Ni(II), Cu(II) and Zn(II) were synthesized from a new Schiff base ligand. The composition of the Schiff base ligand and its metal(II) complexes was analyzed by various analytical techniques such as UV, IR, NMR (H¹ &amp; C¹³), Mass spectra and SEM analysis. Schiff base ligand and its complexes were tested <em>in vitro</em> to evaluate their antimicrobial activity against <em>Escherichia coli, Staphylococcus aureus</em> and <em>Candida albicans</em> using a well diffusion method. Schiff base ligand and its complexes were found to exhibit significant antimicrobial activity against all tested bacterial species. The anticancer properties of the Schiff base ligand and its copper(II) complex are evaluated using MTT assay on the human breast cancer cell line MCF-7. Molecular docking study of Cu(II) complex with the target protein HER2 revealed good binding potential.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102131"},"PeriodicalIF":2.5,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143487306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron metal–organic frameworks: Synthesis, characterization and application in phenol degradation in wastewater","authors":"Neeraj Kumar,&nbsp;Pranshi Verma,&nbsp;Archana Thakur","doi":"10.1016/j.rechem.2025.102144","DOIUrl":"10.1016/j.rechem.2025.102144","url":null,"abstract":"<div><div>This study reports the synthesis of two iron(III)-based metal–organic frameworks, Fe–MOFs (1) and (2), characterized through various techniques and their catalytic application in phenol degradation. The hydrothermal synthesis involved ferric nitrate nonahydrate, glutaric acid, and phloroglucinol for Fe-MOF (1) and ferric nitrate nonahydrate, glutaric acid and thiocynuric acid for Fe-MOF (2). Characterization of the Fe-MOFs was accomplished via infrared (IR) spectroscopy, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray (EDX) analysis, powder X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA), which confirmed the synthesis. This study highlighted the significant catalytic activity of these Fe-MOFs (1) and (2) for phenol degradation studies in the presence of hydrogen peroxides. The optimal phenol degradation occurred at pH values ranging from 4–5, temperatures ranging from 30–40 °C, 0.01–0.02 g/L of the Fe-MOFs and 10 mmol of hydrogen peroxide. The results of the kinetics of phenol degradation indicated that degradation followed pseudo-first-order kinetics under different parameters. The thermodynamic kinetic studies also revealed a greater activation energy for Fe-MOF (1), whereas Fe-MOF (2) had a greater negative Gibbs energy, indicating greater spontaneity. This study highlights the application of iron-based metal–organic frameworks as catalysts for phenol degradation in wastewater.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102144"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peristaltic nanofluid flow analysis inside wavy channels for pharmacological applications","authors":"S.E. Ghasemi ,&nbsp;A.A. Ranjbar","doi":"10.1016/j.rechem.2025.102128","DOIUrl":"10.1016/j.rechem.2025.102128","url":null,"abstract":"<div><div>This study presents a two-phase model to simulate and analyze the peristaltic flow of nanofluids through a wavy-shaped channel, with significant applications in drug delivery systems in pharmacology and blood pumps. The research aims to investigate the temperature field and nanoparticle volume fraction, providing insights into heat and mass transfer behaviors in biomedical and industrial applications. The Adams-Bashforth numerical method has been employed to obtain the model results, ensuring accuracy and reliability. A comparison with two published works demonstrates high precision and consistency in the findings. Key results indicate a direct correlation between the Brownian motion parameter (N_b) and the temperature profile, where an increase in N_b from 3 to 7 leads to a 27 % rise in temperature at η = 0.3. Additionally, an increase in N_b enhances the nanofluid concentration, with a 15 % rise in nanoparticle fraction observed at η = 0.5. These findings contribute to optimizing nanofluid-based biomedical devices and improving thermal management in engineering applications.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102128"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The AMPK-SIRT1 Axis: Redefining type 2 diabetes mellitus management","authors":"Mighty Kemelo ,&nbsp;Phillip Moseki","doi":"10.1016/j.rechem.2025.102139","DOIUrl":"10.1016/j.rechem.2025.102139","url":null,"abstract":"<div><div>Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder strongly associated with obesity and excessive fat accumulation in the liver and pancreas leading to insulin resistance and hyperglycemia. While lifestyle modifications are the first-line approach to managing T2DM, many patients require oral hypoglycemic medications to regulate and maintain blood glucose levels. Although the precise mechanisms of action for these drugs remain unclear, emerging evidence suggests that they may exert their effects through the AMP-activated protein kinase (AMPK) and/or Sirtuin 1 (SIRT1) pathways. Activation of the AMPK pathway promotes fatty acid oxidation, suppresses cholesterol biosynthesis, and enhances glucose uptake. Similarly, SIRT1, an NAD⁺-dependent deacetylase, regulates many proteins involved in glucose homeostasis and insulin signaling. This review explores the therapeutic potential of AMPK and SIRT1 in T2DM. It provides an in-depth analysis of AMPK's role in T2DM pathogenesis and highlights the benefits of AMPK modulation by polyphenols. Additionally, it delves into the mechanisms of oral hypoglycemic drugs, emphasizing the significance of AMPK activation. Furthermore, the review discusses the impact of calorie restriction and SIRT1 activation in T2DM, considering both non-pharmacological interventions and synthetic SIRT1 activation as viable therapeutic options.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102139"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walnut Shell as a bio-activated carbon for elimination of malachite green from its aqueous solution: Adsorption isotherms, kinetics and thermodynamic studies","authors":"Lekaa Hussein Abid ,&nbsp;Zainab Haider Mussa ,&nbsp;Issa Farhan Deyab ,&nbsp;Lubna Raad Al-Ameer ,&nbsp;Haider Falih Shamikh Al-Saedi ,&nbsp;Fouad Fadhil Al-Qaim ,&nbsp;Hesam Kamyab ,&nbsp;Saravanan Rajendran ,&nbsp;Ahmed Falah Imran ,&nbsp;Zaher Mundher Yaseen","doi":"10.1016/j.rechem.2025.102124","DOIUrl":"10.1016/j.rechem.2025.102124","url":null,"abstract":"<div><div>Large amounts of hazardous and synthetic dye are produced by the textile industry. Nevertheless, the literature still lacks an effective method for removing hazardous synthetic dye, specifically malachite green, from wastewater. To fill this gap, this study used a batch method to evaluate the adsorption of malachite green onto an adsorbent derived from walnut shells (ACWS). According to previous studies, zinc chloride is rarely used as a chemical agent for activating walnut shells. Moreover, very little carbon has been used to eliminate the dye. To identify the ideal conditions, this paper examined the effects of washing, carbonization temperature, contact duration, adsorbent dosage, and dye concentration on the adsorption capacity and removal percentage. The Freundlich and Langmuir models were used to analyze the experimental isotherm data. The equilibrium adsorption data fit the Langmuir equation more closely, as evidenced by a high correlation factor (R² = 0.9970). The data also showed an acceptable fit with the Freundlich model, with the “n” constant ranging from 2 to 10. The parameter values for the aforementioned models were as follows: Qm = 588.23 mg/g, KL = 0.0602 L/mg, KF = 201, and 1/<em>n</em> = 0.1838. The adsorption process of malachite green onto ACWS was further investigated using both first- and second-pseudo-order models. The kinetics of adsorption, with a determination coefficient (R²) of 0.9943, closely followed a pseudo-second-order kinetic model. The rate constants were found to be 0.0274 min⁻¹ for the pseudo-first-order and 0.0033 g/min·mg for the pseudo-second-order kinetics. The thermodynamic parameters were determined from the adsorption isotherms at various temperatures, yielding free energy ΔG° values ranging from −5.5241 to −9.27 kJ/mol, a positive enthalpy change ΔH° of 31.0538 kJ/mol, and an entropy change ΔS° of 124.84 J/mol·K. The positive ΔH° and negative ΔG° indicate that the overall adsorption of MG is endothermic and spontaneous.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102124"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential hydrogen storage complexes: Short-time microwave-assisted synthesis, characterization, thermodynamic, and international relations","authors":"Mohammed N. Jassim ,&nbsp;Nora A. Salih ,&nbsp;Aia S. Lafta ,&nbsp;Ream A. Hussain ,&nbsp;Mustafa A. Alheety","doi":"10.1016/j.rechem.2025.102135","DOIUrl":"10.1016/j.rechem.2025.102135","url":null,"abstract":"<div><div>This work included preparing and characterizing new platinum complexes with the ligand 3,4,5-trimethoxybenzoic acid (TMB). The reactions were carried out using an autoclave in microwave within 3 min only in an alkali medium of triethylamine, where two moles of TMB reacted with one mole of platinum ion and two moles of PPh₃, or with one mole of diphosphines (Bis(diphenylphosphino)x; x = methane (dppm), ethane (dppe), propane (dppp), ferrocene (dppf)). The prepared complexes were characterized by measuring melting points and by the techniques of (C.H.N), molar electrical conductivity, FT-IR and ¹H NMR. The characterization results demonstrated that the TMB ligand behaves as a bidentate ligand through the oxygen atom of the carboxylic groups, and its geometric shape is a square planar around the platinum ion. The complex formed with high yield ([Pt(TMB)₂(dppf)]) was used in hydrogen storage application. The storage isotherm showed that the complex has a high storage capacity of about 4.2 wt% at 61 bar under low temperature (77 K). The study showed that the thermodynamic functions were − 0.67KJ/mol and − 3.6 <em>J</em>/mol H₂ for enthalpy and entropy, indicating the occurrence of physical hydrogen storage.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102135"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating Xanthium spinosum extract as an eco-friendly corrosion inhibitor for Aluminium in acidic environments: A green approach to metal protection","authors":"Mahmoud N. EL-Haddad,&nbsp;A.S. Fouda","doi":"10.1016/j.rechem.2025.102136","DOIUrl":"10.1016/j.rechem.2025.102136","url":null,"abstract":"<div><div>The impact of <em>Xanthium spinosum</em> (Xs) extract on the dissolution of aluminium (Al) in hydrochloric acid (HCl) solution was assessed through various methods, including gravimetric (GM) analysis, potentiodynamic polarization (PDP), electrochemical impedance spectroscopy (EIS), and electrochemical frequency modulation spectroscopy (EFM). The surface morphology of the corroded Al was analyzed using atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). Gravimetric measurements indicated that a concentration of 300 ppm of Xs at 298 K resulted in an inhibition efficiency of 93.1 %. The adsorption of Xs onto Al conformed to the Langmuir isotherm model, while PDP analysis classified Xs as a mixed-type inhibitor. EIS data displayed a capacitive loop at high frequencies and an inductive loop at low frequencies. The reliability of EFM data was supported by CF² and CF³ values. The inhibition mechanism was clarified through experimental findings, along with AFM and XPS analyses, confirming Xs as an effective and environmentally friendly corrosion inhibitor.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"14 ","pages":"Article 102136"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}