Results in Chemistry最新文献

{"title":"Fabrication, microstructure and hemostatic activity of Cu-Zn manganite nanoparticles","authors":"H. Shashidharagowda ,&nbsp;Shridhar Mathad ,&nbsp;Shridhar Malladi ,&nbsp;C.G. Kusuma ,&nbsp;Vinod Gubbiveeranna ,&nbsp;S. Nagaraju ,&nbsp;H. Ravi Kumar ,&nbsp;Sahebagouda Jambaladinni ,&nbsp;Huda Wazzan ,&nbsp;Anish Khan ,&nbsp;Khalid A Alzahrani ,&nbsp;Hadi M Marwani ,&nbsp;Mohammad A. Wazzan ,&nbsp;Asmaa M. Malash","doi":"10.1016/j.rechem.2024.101841","DOIUrl":"10.1016/j.rechem.2024.101841","url":null,"abstract":"<div><div>Copper subbed zinc manganite Zn(1-x)CuxMn₂O₄ (x = 0.05,0.15,0.25,0.35,0.45,0.55) (BCZMO) NPs were prepared by sol–gel co-precipitation technique at surrounding temperature. BCZMO NPs were analyzed by XRD, SEMfor microstructure characterizations. XRD study confirms the tetragon structure of BCZMO NPs and effect of copper on ZMO NPs. SEM micrographs supports our findings. The BCZMO NPs interfered in blood coagulation and exhibited pro-coagulant property. BCZMO NPs decreased the coagulation time of citrated plasma from control 4.31 min to 1.35 min. In addition, the BCZMO NPs aggregated platelets up to 80 % at a concentration of 600 µg while the agonist epinephrine prompted platelet collection of around 90 % at 10 mM <span><span>concentration.No</span><svg><path></path></svg></span> kind of hemolytic activity in RBC cells shown by these BCZMO-NPs insisting their non-toxic nature. These BCZMO-NPs exhibited pro-coagulant effect with their interference in blood coagulation cascade and initiation in platelet aggregation. Thus, BCZMO NPs can be a potential candidate in biomedical field as hemostatic agents.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101841"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revolutionizing sensing technologies: Crafting a green, ultra-sensitive bismuth optical sensor via fixation of 5-(2′,4′-dimethyl-phenylazo)-6-hydroxypyrimidine-2,4-dione on PVC membrane","authors":"Salah M. El-Bahy ,&nbsp;Ahmad O. Babalghith ,&nbsp;Refat El-Sayed ,&nbsp;Khaled F. Debbabi ,&nbsp;Alaa S. Amin","doi":"10.1016/j.rechem.2024.101822","DOIUrl":"10.1016/j.rechem.2024.101822","url":null,"abstract":"<div><div>An innovative and exceptionally responsive optical sensing device engineered to selectively identify Bi(III) ions in water-based solutions. The sensing component, 5-(2′,4′-dimethylphenylazo)-6-hydroxypyrimidine-2,4-dione (DMPAHPD), is incorporated into a plasticized polyvinyl chloride (PVC) membrane. The sensor demonstrates an exceptional selectivity for Bi(III) within a broad dynamic range spanning from 7.5 × 10⁻¹⁰ to 4.2 × 10⁻⁵ M at pH 2.25. Notably, it achieves lower quantification and detection limits of 7.25 × 10⁻¹⁰ and 2.15 × 10⁻¹⁰ M, respectively. The optode membrane’s response to Bi(III) proves to be entirely reversible, demonstrating remarkable selectivity for Bi(III) ions over a diverse range of other cations and anions. The sensor exhibits favorable performance characteristics, including good reversibility, a wide dynamic range, a prolonged lifespan, sustained response stability over the long term, and high reproducibility. This visual chemical sensor exhibits potential for real-world usage, offering consistent outcomes when assessing Bi(III) levels in matrices such as water, soil, plants, biological and synthetic mixtures. Importantly, the sensor’s performance is comparable to corresponding data achieved from inductively coupled plasma atomic emission spectroscopy (ICP-AES).</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101822"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaped and structured Pt-3d-transition metal alloy nanocrystals as electrocatalysts for the oxygen reduction reaction","authors":"Siphelo Ngqoloda ,&nbsp;Nyiko Chauke ,&nbsp;Thelma Ngwenya ,&nbsp;Mpfunzeni Raphulu","doi":"10.1016/j.rechem.2024.101831","DOIUrl":"10.1016/j.rechem.2024.101831","url":null,"abstract":"<div><div>Proton exchange membrane fuel cells (PEMFCs) have attracted extensive interest in both automotive and stationary applications. However, the drawback hindering the large-scale commercialization of PEMFCs is related to problems such as insufficient power density, high cost, and short operation duration. The major reason for these problems is the sluggish oxygen reduction reaction (ORR) kinetics which takes place on the cathode side of the fuel cell<!--> <!-->due to the poor catalytic activity and durability of the<!--> <!-->expensive<!--> <!-->Platinum (Pt)-based catalyst employed. Subsequently, current research efforts are focusing on the design and development of an advanced Pt-based catalyst that is highly active and durable. As a result, alloying Pt with<!--> <em>3d</em>-transition metals has been known to improve the ORR kinetics, especially of faceted polyhedrons, hollow nanostructures, and one-dimensional nanocrystals. This review therefore focuses on the synthesis protocols<!--> <!-->of the shaped and structured Pt-<em>3d</em>-transition metal (Pt-TM) alloys. As such, the synthesis control of the shape/structure, size, and chemical composition of various Pt-TM nano-alloys will be extensively reviewed here followed by a discussion of their electrocatalytic activity as applied in ORR reactions. Lastly, it discusses the outlook on the potential challenges and prospects of shape/structure-controlled electrocatalysts.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101831"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile fabrication of Cu/kaolin nanocomposite as highly efficient heterogeneous catalyst for 4-nitrophenol reduction in aqueous solution","authors":"Zinabu Gashaw Asmare ,&nbsp;Belete Asefa Aragaw ,&nbsp;Minaleshewa Atlabachew ,&nbsp;Amare Aregahegn Dubale","doi":"10.1016/j.rechem.2024.101836","DOIUrl":"10.1016/j.rechem.2024.101836","url":null,"abstract":"<div><div>Hazardous organic pollutants in industrial wastewaters are becoming a major global challenge that threatens life on earth and particularly poses a serious health risk to human beings. 4-Nitrophenol (4-NP) is a highly hazardous organic contaminant that has been extensively utilized across multiple industries, and their wastewater disposal into water streams leads to a higher accumulation of 4-NP. It is therefore important for both academia and industry to make catalysts that are cheap, very effective, good for the environment, easy to recover, and can be used more than once for reducing 4-NP in normal conditions. This paper reports the synthesis, characterization, and application of Cu/kaolin nanocomposite (NC) as an efficient heterogeneous catalyst for decomposing 4-NP, a model organic molecule. The catalyst was synthesized by incorporating a copper precursor into layered kaolin clay and directly reducing the metal precursor using sodium borohydride (NaBH₄). The morphology, structure, surface property, and interaction of the resulting Cu/kaolin NC were characterized by ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron spectroscopy/energy-dispersive X-ray spectroscopy, selected area electron diffraction, X-ray diffraction, and N₂ adsorption/desorption, and the results clearly demonstrated the growth of copper nanoparticles on the kaolin surface. It was discovered that the Cu nanoparticles (NPs) on the kaolin surface had a crystallite size of about 23.6 nm. The significance of Cu NPs and the high catalytic activity of the synthesized Cu/kaolin NC toward 4-NP reduction by NaBH₄ were evaluated by the catalytic reduction experiments. Among the different nanocomposites synthesized, 30-Cu/kaolin showed the highest catalytic activity for 4-NP reduction, with a reduction efficiency of over 99 % within 4 min with a pseudo-first-order rate constant, k_app, of 1.23 min⁻¹. Furthermore, the reusability test indicated that Cu/kaolin NC can be reused for up to six runs efficiently without significant decrease in its catalytic performance, indicating the nanocomposite has excellent stability and great potential applications in industrial and agricultural wastewater treatment.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101836"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic approaches and biological evaluation of nitrogen bridgehead thiazolo[3,2-a]pyrimidines","authors":"Mohamed Abdel-Megid ,&nbsp;Kamelia M. El-mahdy ,&nbsp;Azza.M. Elkazak ,&nbsp;Sylvia E. Zarif ,&nbsp;Mostafa E. Salem","doi":"10.1016/j.rechem.2024.101807","DOIUrl":"10.1016/j.rechem.2024.101807","url":null,"abstract":"<div><div>Thiazolopyrimidines are bicyclic compounds formed by the fusion of thiazole and pyrimidine rings in a single molecular frame. The fusion of these two heterocyclic systems containing bridgehead nitrogen atom is attracting the attention of many medicinal chemists throughout the worldwide to explore the framework for its potential. This review article is an attempt to cover the literature survey of thiazolopyrimidine ring structures with bridging-head nitrogen covers thiazolo[3,2-<em>a</em>]pyrimidines, preparation of the ring system <em>via</em> thioxopyrimidines, thiazoles and other miscellaneous approaches. In addition, some properties related to a broad bioactivity and pharmacology have been reported.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101807"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Synthesis, spectroscopy and biological investigation via DFT, ADMET and molecular docking of Thiadiazole/Oxadiazole based bis-Schiff bases: A potential towards diabetes and microbes” [Results Chem. 11 (2024) 101787]","authors":"Sania Parveen ,&nbsp;Shoaib Khan ,&nbsp;Tayyiaba Iqbal ,&nbsp;Ayed A. Dera ,&nbsp;Rafaqat Hussain ,&nbsp;Yousaf Khan","doi":"10.1016/j.rechem.2024.101809","DOIUrl":"10.1016/j.rechem.2024.101809","url":null,"abstract":"","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101809"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green hetero-alkali catalyst in optimized waste lard oil transesterification for biodiesel synthesis","authors":"Chinyere B. Ezekannagha ,&nbsp;Okechukwu D. Onukwuli ,&nbsp;Ikechukwu A. Nnanwube ,&nbsp;Uchenna L. Ezeamaku ,&nbsp;Chukwudi M. Ohaegbulam","doi":"10.1016/j.rechem.2024.101797","DOIUrl":"10.1016/j.rechem.2024.101797","url":null,"abstract":"<div><div>Climate change in addition to the imminent depletion of the fossil fuel reserve has necessitated the search for a sustainable alternative fuel. In this research, the catalytic capability of a green heterogeneous alkali catalyst, thermally activated banana-plantain-peel-ash catalyst was examined in optimized waste lard oil (WLO) transesterification process in lard-oil-methyl-ester (LOME) synthesis. The catalyst was derived from a banana-plantain-peel-ash mixture and subjected to a calcination process while the catalyst properties were described via Scanning electron microscope-Energy dispersive atomic-x-ray-spectroscopy (SEM-EDX), X-ray diffraction-(XRD), Fourier Transform Infra-Red (FTIR) as well as Brunauer-Emmett-Teller (BET). Optimization of the waste lard oil transesterification process was conducted with the Desirability Explore Algorithm (DEA) in Central Composite Design (CCD) of Response Surface Methodology (RSM). A 99.9 % conversion of WLO to LOME was attained at the optimum reaction settings of 57 °C temperature, catalyst amount-2.5 wt%, time-1.5 h, and methanol to WLO molar ratio of 10.5:1 with a total desirability of 0.99 which was evaluated experimentally as 99 %. In the LOME synthesis procedure, the resulting empirical model demonstrated statistical significance and suitability based on its high F-value of 35.59 and infinitesimal p-value of less than 0.0001. The determined LOME fuel qualities met the applicable standard specifications (ASTM-D6751 and EN-14241) hence, have the potential to function as a diesel fuel substitute. The fused influence of WLO and the thermally activated bio-mixture catalyst was highly effective in biodiesel synthesis. Thus; a promising cheap feedstock source for green and sustainable biodiesel production was achieved.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101797"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A promising α-glucosidase and α-amylase inhibitors based on benzimidazole-oxadiazole hybrid analogues: Evidence based in vitro and in silico studies","authors":"Hayat Ullah ,&nbsp;Imad Uddin ,&nbsp;Hafeeza Zafar Ali ,&nbsp;Wagma Hassan ,&nbsp;Gul Mehnaz ,&nbsp;Laiba Maryam ,&nbsp;Maliha Sarfraz ,&nbsp;Muhammad Saleem Khan ,&nbsp;Mohammad Shahidul Islam ,&nbsp;Zainab M. Almarhoon ,&nbsp;Rashid Iqbal ,&nbsp;Muhammad Nabi","doi":"10.1016/j.rechem.2024.101832","DOIUrl":"10.1016/j.rechem.2024.101832","url":null,"abstract":"<div><div>The present study reports the design and synthesis of new benzimidazole-oxadiazole compounds as potent inhibitors of α-glucosidase and α-amylase. The synthesized molecules were characterized through different techniques such as ¹HNMR, ¹³CNMR, HREI-MS and evaluated for their <em>in vitro</em> inhibitory activities against these enzymes. Among the compounds screened, compound <strong>8</strong> demonstrated the highest inhibitory activity against both <em>α</em>-glucosidase (IC₅₀ = 11.60 µM) and <em>α</em>-amylase (IC₅₀ = 6.20 µM). Molecular docking analyses were conducted to investigate the binding modes and interactions of the active compounds within the enzyme active sites. The results demonstrate that several benzimidazole-oxadiazole hybrids exhibited potent inhibitory effects on both α-glucosidase and α-amylase, suggesting their promise as antidiabetic agents<strong>.</strong></div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101832"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the bioactive potential of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives: A comprehensive review","authors":"Tomasz Szostek ,&nbsp;Dagmara Otto-Ślusarczyk ,&nbsp;Piotr Roszkowski ,&nbsp;Marta Struga ,&nbsp;Daniel Szulczyk","doi":"10.1016/j.rechem.2024.101828","DOIUrl":"10.1016/j.rechem.2024.101828","url":null,"abstract":"<div><div>Thiazolidinone is a scaffold known for its diverse biological activities, drawing the interest of researchers seeking to explore its potential. Numerous libraries of molecules with diverse structures and properties can be created based on this scaffold. We propose the extraction of compounds with a defined central skeleton, resulting from a repeatable methodology of synthesis, to analyze the biological properties of a heterogeneous set of molecules. This review offers a comprehensive overview of recent research, focusing on a homogeneous group of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives. It highlights the most promising compounds that have emerged from recent studies, their molecular targets, and the underlying mechanisms contributing to their biological activity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101828"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rational design, synthesis and biological evaluation 1,2,3-triazole aryl attached (4,6-dimethoxy-1,3,5-triazin-2-yl)thiazole derivatives as anticancer agents","authors":"Renuka Charugandla ,&nbsp;Sridhar Chidara ,&nbsp;Ashok Dasari ,&nbsp;Somaiah Nalla ,&nbsp;Raghu Babu Korupolu ,&nbsp;S.K. Raziya ,&nbsp;Kishore Babu Bonige","doi":"10.1016/j.rechem.2024.101806","DOIUrl":"10.1016/j.rechem.2024.101806","url":null,"abstract":"<div><div>A new library of 1,2,3-triazole aryl-attached (4,6-dimethoxy-1,3,5-triazin-2-yl) thiazoles (<strong>11a–j</strong>) has been designed and synthesized and its structures were characterized by ¹H NMR ¹³C NMR and mass spectral data. Further, these derivatives (<strong>11a-j</strong>) were evaluated for their anticancer activity against four human cancer cell lines, including PC3 (prostate cancer), A549 (lung cancer), MCF-7 (breast cancer) and A2780 (ovarian cancer) by employing the MTT method, and the obtained results were compared with etoposide. Among all the examined compounds, <strong>11a, 11b, 11c, 11i</strong> and <strong>11j</strong> displayed the most promising activity. Particularly, two compounds <strong>11a</strong> and <strong>11b</strong> possessed good activity.</div></div>","PeriodicalId":420,"journal":{"name":"Results in Chemistry","volume":"11 ","pages":"Article 101806"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}